Regulatory T cell deficient scurfy mice exhibit a Th2/M2-like inflammatory response in the skin

Sharma, 2016, Genetic control of the inflammatory T-cell response in regulatory T-cell deficient scurfy mice, Clin. Immunol., 136, 162, 10.1016/j.clim.2010.04.004 Bennett, 2001, The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3, Nat. Genet., 27, 20, 10.1038/83713 Fontenot, 2003, Foxp3 programs the development and function of CD4+CD25+ regulatory T cells, Nat. Immunol., 4, 330, 10.1038/ni904 Huter, 2017, Autoantibodies in scurfy mice and IPEX patients recognize keratin 14, J. Invest. Dermatol., 130, 1391, 10.1038/jid.2010.16 Hadaschik, 2015, Regulatory T cell-deficient scurfy mice develop systemic autoimmune features resembling lupus-like disease, Arthritis Res. Ther., 17, 35, 10.1186/s13075-015-0538-0 Chan, 2015, Report of the first international consensus on standardized nomenclature of antinuclear antibody HEp-2 cell patterns 2014–2015, Front. Immunol., 6, 412, 10.3389/fimmu.2015.00412 Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta C(T)) Method, Methods, 25, 402, 10.1006/meth.2001.1262 Raker, 2016, Myeloid cell populations and fibrogenic parameters in bleomycin- and HOCl-induced fibrosis, Exp. Dermatol., 25, 887, 10.1111/exd.13124 Wick, 2010, The immunology of fibrosis: innate and adaptive responses, Trends Immunol., 31, 110, 10.1016/j.it.2009.12.001 Lanier, 2013, Shades of grey?the blurring view of innate and adaptive immunity, Nat. Rev. Immunol., 13, 73, 10.1038/nri3389 Godfrey, 1991, Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education, Proc. Natl. Acad. Sci. U. S. A., 88, 5528, 10.1073/pnas.88.13.5528 Torgerson, 2007, Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells, J. Allergy Clin. Immunol., 120, 744, 10.1016/j.jaci.2007.08.044 Sage, 2015, T follicular regulatory cells in the regulation of B cell responses, Trends Immunol., 36, 410, 10.1016/j.it.2015.05.005 Wing, 2014, Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4, Immunity, 41, 1013, 10.1016/j.immuni.2014.12.006 Nathan, 1983, Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity, J. Exp. Med., 158, 670, 10.1084/jem.158.3.670 Kraling, 1995, Mononuclear cellular infiltrates in clinically involved skin from patients with systemic sclerosis of recent onset predominantly consist of monocytes/macrophages, Pathobiology, 63, 48, 10.1159/000163933 Higashi-Kuwata, 2010, Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis, Arthritis Res. Ther., 12, R128, 10.1186/ar3066 Christmann, 2010, The cytokine language of monocytes and macrophages in systemic sclerosis, Arthritis Res. Ther., 12, 146, 10.1186/ar3167 Italiani, 2014, From monocytes to M1/M2 macrophages: phenotypical vs. functional differentiation, Front. Immunol., 5, 514, 10.3389/fimmu.2014.00514 Murray, 2014, Macrophage activation and polarization: nomenclature and experimental guidelines, Immunity, 41, 14, 10.1016/j.immuni.2014.06.008 Stifano, 2016, Macrophage involvement in systemic sclerosis: do we need more evidence?, Curr. Rheumatol. Rep., 18, 2, 10.1007/s11926-015-0554-8