Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

Immunity - Tập 47 Số 5 - Trang 875-889.e10 - 2017
Madhav Kishore1, Kenneth Cheung1, Hongmei Fu1, Fabrizia Bonacina2, Guosu Wang1, David Coe1, Eleanor J. Ward1, Alessandra Colamatteo3, Maryam Jangani1, Andrea Baragetti2, Giuseppe Matarese4,3, David M. Smith5, Robert Haas1, Claudio Mauro1, David C. Wraith6, Klaus Okkenhaug7, Alberico L. Catapano2,8, Veronica De Rosa3, Giuseppe Danilo Norata2,9, Federica M. Marelli‐Berg1
1William Harvey Research Institute, Queen Mary University of London, London EC1M6BQ, UK
2Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan 20133, Italy
3Istituto per l’Endocrinologia e l’Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR), Naples 80131, Italy
4Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli “Federico II,” Naples 80131, Italy
5Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Cambridge, Cambridgeshire CB40WG, UK
6Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK
7Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, UK
8IRCCS Multimedica Hospital, Milan 20138, Italy
9School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6102, Australia

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