Regulation of epigenetic homeostasis in uveal melanoma and retinoblastoma
Tài liệu tham khảo
Achberger, 2014, Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease, Mol. Immunol., 58, 182, 10.1016/j.molimm.2013.11.018
Adams, 1975, Modified nucleosides and bizarre 5′-termini in mouse myeloma mRNA, Nature, 255, 28, 10.1038/255028a0
Afshar, 2020, Next-generation sequencing of retinoblastoma identifies pathogenic alterations beyond RB1 inactivation that correlate with aggressive histopathologic features, Ophthalmology, 127, 804, 10.1016/j.ophtha.2019.12.005
Alarcón, 2015, HNRNPA2B1 is a mediator of m6A-dependent nuclear RNA processing events, Cell, 162, 1299, 10.1016/j.cell.2015.08.011
Albert, 1988, Recent studies of the retinoblastoma gene. What it means to the ophthalmologist, Arch. Ophthalmol., 106, 181, 10.1001/archopht.1988.01060130191021
Amaro, 2020, Potential onco-suppressive role of miR122 and miR144 in uveal melanoma through ADAM10 and C-met inhibition, Cancers, 12, 10.3390/cancers12061468
Ambrosini, 2019, Inhibition of NF-kappaB-Dependent signaling enhances sensitivity and overcomes resistance to BET inhibition in uveal melanoma, Cancer Res., 79, 2415, 10.1158/0008-5472.CAN-18-3177
An, 2015, miR-23b-3p regulates the chemoresistance of gastric cancer cells by targeting ATG12 and HMGB2, Cell Death Dis., 6, 10.1038/cddis.2015.123
Anastasiadou, 2018, Non-coding RNA networks in cancer, Nat. Rev. Cancer, 18, 5, 10.1038/nrc.2017.99
Aughton, 2020, MicroRNAs and uveal melanoma: understanding the diverse role of these small molecular regulators, Int. J. Mol. Sci., 21, 10.3390/ijms21165648
Babar, 2012, Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma, Proc. Natl. Acad. Sci. Unit. States Am., 109, E1695, 10.1073/pnas.1201516109
Bailey, 2018, Kinome-wide transcriptional profiling of uveal melanoma reveals new vulnerabilities to targeted therapeutics, Pigment Cell. Melanoma Res., 31, 253, 10.1111/pcmr.12650
Bande, 2020, The role of non-coding RNAs in uveal melanoma, Cancers, 12, 10.3390/cancers12102944
Barbagallo, 2020, LncRNA LINC00518 acts as an oncogene in uveal melanoma by regulating an RNA-based network, Cancers, 12, 10.3390/cancers12123867
Barisione, 2015, Potential role of soluble c-met as a new candidate biomarker of metastatic uveal melanoma, JAMA Ophthalmol., 133, 1013, 10.1001/jamaophthalmol.2015.1766
Bartel, 2018, Metazoan MicroRNAs, Cell, 173, 20, 10.1016/j.cell.2018.03.006
Bastonini, 2014, Chromatin barcodes as biomarkers for melanoma, Pigment Cell Melanoma Res., 27, 788, 10.1111/pcmr.12258
Bates, 2020, Epigenetic therapies for cancer, N. Engl. J. Med., 383, 650, 10.1056/NEJMra1805035
Baylin, 2011, A decade of exploring the cancer epigenome—biological and translational implications, Nat. Rev. Cancer, 11, 726, 10.1038/nrc3130
Baylin, 2011, A decade of exploring the cancer epigenome - biological and translational implications, Nat. Rev. Cancer, 11, 726, 10.1038/nrc3130
Baylin, 2011, A decade of exploring the cancer epigenome - biological and translational implications, Nat. Rev. Cancer, 11, 726, 10.1038/nrc3130
Bejerano, 2004, Ultraconserved elements in the human genome, Science, 304, 1321, 10.1126/science.1098119
Bennett, 2018, Targeting epigenetics in cancer, Annu. Rev. Pharmacol. Toxicol., 58, 187, 10.1146/annurev-pharmtox-010716-105106
Benson, 2015, Carboplatin with decitabine therapy, in recurrent platinum resistant ovarian cancer, alters circulating miRNAs concentrations: a pilot study, PLoS One, 10, 10.1371/journal.pone.0141279
Berdasco, 2017, DNA methylomes reveal biological networks involved in human eye development, functions and associated disorders, Sci. Rep., 7, 10.1038/s41598-017-12084-1
Berry, 2017, Potential of aqueous humor as a surrogate tumor biopsy for retinoblastoma, JAMA Ophthalmol., 135, 1221, 10.1001/jamaophthalmol.2017.4097
Beta, 2014, EpCAM knockdown alters microRNA expression in retinoblastoma--functional implication of EpCAM regulated miRNA in tumor progression, PLoS One, 9, 10.1371/journal.pone.0114800
Beta, 2013, Identification and insilico analysis of retinoblastoma serum microRNA profile and gene targets towards prediction of novel serum biomarkers, Bioinf. Biol. Insights, 7, 21, 10.4137/BBI.S10501
Bewersdorf, 2019, Epigenetic therapy combinations in acute myeloid leukemia: what are the options?, Ther. Adv. Hematol., 10, 10.1177/2040620718816698
Blanco, 2016, Stem cell function and stress response are controlled by protein synthesis, Nature, 534, 335, 10.1038/nature18282
Bohrer, 2010, Androgens suppress EZH2 expression via retinoblastoma (RB) and p130-dependent pathways: a potential mechanism of androgen-refractory progression of prostate cancer, Endocrinology, 151, 5136, 10.1210/en.2010-0436
Bokar, 1997, Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase, Rna, 3, 1233
Bononi, 2017, Germline BAP1 mutations induce a Warburg effect, Cell Death Differ., 24, 1694, 10.1038/cdd.2017.95
Booth, 2019, Neratinib and entinostat combine to rapidly reduce the expression of K-RAS, N-RAS, Galphaq and Galpha11 and kill uveal melanoma cells, Cancer Biol. Ther., 20, 700, 10.1080/15384047.2018.1551747
Bott, 2015, Oncogenic myc induces expression of glutamine synthetase through promoter demethylation, Cell Metabol., 22, 1068, 10.1016/j.cmet.2015.09.025
Bracken, 2003, EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer, EMBO J., 22, 5323, 10.1093/emboj/cdg542
Brantley, 2001, The molecular biology of retinoblastoma, Ocul. Immunol. Inflamm., 9, 1, 10.1076/ocii.9.1.1.3984
Brouwer, 2021, Conjunctival melanoma: new insights in tumour genetics and immunology, leading to new therapeutic options, Prog. Retin. Eye Res.
Bruzzese, 2009, Synergistic antitumor effect between vorinostat and topotecan in small cell lung cancer cells is mediated by generation of reactive oxygen species and DNA damage-induced apoptosis, Mol. Cancer Therapeut., 8, 3075, 10.1158/1535-7163.MCT-09-0254
Busch, 2017, Reduction of the tumorigenic potential of human retinoblastoma cell lines by TFF1 overexpression involves p53/caspase signaling and miR-18a regulation, Int. J. Cancer, 141, 549, 10.1002/ijc.30768
Busch, 2019, p53, miR-34a and EMP1-newly identified targets of TFF3 signaling in Y79 retinoblastoma cells, Int. J. Mol. Sci., 20, 10.3390/ijms20174129
Cai, 2016, 4C-seq revealed long-range interactions of a functional enhancer at the 8q24 prostate cancer risk locus, Sci. Rep., 6, 1
Calvaruso, 2001, Sodium phenylbutyrate induces apoptosis in human retinoblastoma Y79 cells: the effect of combined treatment with the topoisomerase I-inhibitor topotecan, Int. J. Oncol., 18, 1233
Candelaria, 2007, A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors, Ann. Oncol., 18, 1529, 10.1093/annonc/mdm204
Carlino, 2021, Immune checkpoint inhibitors in melanoma, Lancet, 398, 1002, 10.1016/S0140-6736(21)01206-X
Carthew, 2009, Origins and Mechanisms of miRNAs and siRNAs, Cell, 136, 642, 10.1016/j.cell.2009.01.035
Carvalho, 2017, A polymorphism in mir-34b/c as a potential biomarker for early onset of hereditary retinoblastoma, Cancer Biomarkers, 18, 313, 10.3233/CBM-160248
Castera, 2010, MDM2 as a modifier gene in retinoblastoma, J. Natl. Cancer Inst., 102, 1805, 10.1093/jnci/djq416
Castro-Magdonel, 2020, Circulating miRNome detection analysis reveals 537 miRNAS in plasma, 625 in extracellular vesicles and a discriminant plasma signature of 19 miRNAs in children with retinoblastoma from which 14 are also detected in corresponding primary tumors, PLoS One, 15, 10.1371/journal.pone.0231394
Castro-Magdonel, 2017, miRNome landscape analysis reveals a 30 miRNA core in retinoblastoma, BMC Cancer, 17, 458, 10.1186/s12885-017-3421-3
Chai, 2008, HDAC inhibitors act with 5-aza-2'-deoxycytidine to inhibit cell proliferation by suppressing removal of incorporated abases in lung cancer cells, PLoS One, 3, e2445, 10.1371/journal.pone.0002445
Chai, 2018, Dynamic chromosomal tuning of a novel GAU1 lncing driver at chr12p13.32 accelerates tumorigenesis, Nucleic Acids Res., 46, 6041, 10.1093/nar/gky366
Chai, 2016, The evolving functions of autophagy in ocular health: a double-edged sword, Int. J. Biol. Sci., 12, 1332, 10.7150/ijbs.16245
Chai, 2020, Generation of onco-enhancer enhances chromosomal remodeling and accelerates tumorigenesis, Nucleic Acids Res., 48, 12135, 10.1093/nar/gkaa1051
Chan, 2016, Phase I trial of vorinostat added to chemoradiation with capecitabine in pancreatic cancer, Radiother. Oncol., 119, 312, 10.1016/j.radonc.2016.04.013
Chang, 2003, Genetic alterations of p16INK4a and p14ARF genes in human bladder cancer, J. Urol., 170, 595, 10.1097/01.ju.0000067626.37837.3e
Chattopadhyay, 2016, Uveal melanoma: from diagnosis to treatment and the science in between, Cancer, 122, 2299, 10.1002/cncr.29727
Chen, 2017, HINT2 triggers mitochondrial Ca(2+) influx by regulating the mitochondrial Ca(2+) uniporter (MCU) complex and enhances gemcitabine apoptotic effect in pancreatic cancer, Cancer Lett., 411, 106, 10.1016/j.canlet.2017.09.020
Chen, 2013, MicroRNA-124a is epigenetically regulated and acts as a tumor suppressor by controlling multiple targets in uveal melanoma, Invest. Ophthalmol. Vis. Sci., 54, 2248, 10.1167/iovs.12-10977
Chen, 2019, 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs, Nat. Cell Biol., 21, 978, 10.1038/s41556-019-0361-y
Cheng, 2016, HIC1 modulates uveal melanoma progression by activating lncRNA-numb, Tumour Biol., 37, 12779, 10.1007/s13277-016-5243-3
Cheng, 2017, Expression of EZH2 in uveal melanomas patients and associations with prognosis, Oncotarget, 8, 76423, 10.18632/oncotarget.19462
Chiappinelli, 2015, Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses, Cell, 162, 974, 10.1016/j.cell.2015.07.011
Chokhachi Baradaran, 2020, Targeting epigenetic modifications in uveal melanoma, Int. J. Mol. Sci., 21, 10.3390/ijms21155314
Choy, 2002, Impaired expression and promotor hypermethylation of O6-methylguanine-DNA methyltransferase in retinoblastoma tissues, Invest. Ophthalmol. Vis. Sci., 43, 1344
Christman, 2002, 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy, Oncogene, 21, 5483, 10.1038/sj.onc.1205699
Chua, 2019, Stromal fibroblast growth factor 2 reduces the efficacy of bromodomain inhibitors in uveal melanoma, EMBO Mol. Med., 11, 10.15252/emmm.201809081
Clapier, 2009, The biology of chromatin remodeling complexes, Annu. Rev. Biochem., 78, 273, 10.1146/annurev.biochem.77.062706.153223
Cohen, 2008, Hypermethylation of CpG island loci of multiple tumor suppressor genes in retinoblastoma, Exp. Eye Res., 86, 201, 10.1016/j.exer.2007.10.010
Cohn, 1960, Pseudouridine, a carbon-carbon linked ribonucleoside in ribonucleic acids: isolation, structure, and chemical characteristics, J. Biol. Chem., 235, 1488, 10.1016/S0021-9258(18)69432-3
Coiffier, 2012, Results from a pivotal, open-label, phase II study of romidepsin in relapsed or refractory peripheral T-cell lymphoma after prior systemic therapy, J. Clin. Oncol., 30, 631, 10.1200/JCO.2011.37.4223
Comings, 1973, A general theory of carcinogenesis, Proc. Natl. Acad. Sci. U. S. A., 70, 3324, 10.1073/pnas.70.12.3324
Conkrite, 2011, miR-17∼92 cooperates with RB pathway mutations to promote retinoblastoma, Genes Dev., 25, 1734, 10.1101/gad.17027411
1970, Central dogma of molecular biology, Nature, 227, 561, 10.1038/227561a0
Crick, 1958, On protein synthesis
Cullen, 1993, Interaction between transcription regulatory regions of prolactin chromatin, Science, 261, 203, 10.1126/science.8327891
Dai, 2016, Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma, Sci. Rep., 6
Dai, 2018, RNA-binding protein trinucleotide repeat-containing 6A regulates the formation of circular RNA circ0006916, with important functions in lung cancer cells, Carcinogenesis, 39, 981, 10.1093/carcin/bgy061
Dalgard, 2009, Differential microRNA-34a expression and tumor suppressor function in retinoblastoma cells, Invest. Ophthalmol. Vis. Sci., 50, 4542, 10.1167/iovs.09-3520
Dalgard, 2008, Evaluation of the in vitro and in vivo antitumor activity of histone deacetylase inhibitors for the therapy of retinoblastoma, Clin. Cancer Res., 14, 3113, 10.1158/1078-0432.CCR-07-4836
Damato, 2018, Ocular treatment of choroidal melanoma in relation to the prevention of metastatic death - a personal view, Prog. Retin. Eye Res., 66, 187, 10.1016/j.preteyeres.2018.03.004
Damato, 2011, Estimating prognosis for survival after treatment of choroidal melanoma, Prog. Retin. Eye Res., 30, 285, 10.1016/j.preteyeres.2011.05.003
Damato, 2012, Detection and time to treatment of uveal melanoma in the United Kingdom: an evaluation of 2,384 patients, Ophthalmology, 119, 1582, 10.1016/j.ophtha.2012.01.048
Danda, 2013, Targeted expression of suicide gene by tissue-specific promoter and microRNA regulation for cancer gene therapy, PLoS One, 8, 10.1371/journal.pone.0083398
Das, 2020, Regulating methylation at H3K27: a trick or treat for cancer cell plasticity, Cancers, 12, 10.3390/cancers12102792
Daver, 2019, Efficacy, safety, and biomarkers of response to azacitidine and nivolumab in relapsed/refractory acute myeloid leukemia: a nonrandomized, open-label, phase II study, Cancer Discov., 9, 370, 10.1158/2159-8290.CD-18-0774
Decatur, 2016, Driver mutations in uveal melanoma: associations with gene expression profile and patient outcomes, JAMA Ophthalmol, 134, 728, 10.1001/jamaophthalmol.2016.0903
Dekker, 2002, Capturing chromosome conformation, Science, 295, 1306, 10.1126/science.1067799
Delmore, 2011, BET bromodomain inhibition as a therapeutic strategy to target c-Myc, Cell, 146, 904, 10.1016/j.cell.2011.08.017
Derrien, 2012, The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression, Genome Res., 22, 1775, 10.1101/gr.132159.111
Di Cerbo, 2013, Cancers with wrong HATs: the impact of acetylation, Briefings Funct. Genom., 12, 231, 10.1093/bfgp/els065
Dimaras, 2019, Retinoblastoma, the visible CNS tumor: a review, J. Neurosci. Res., 97, 29, 10.1002/jnr.24213
DiNardo, 2018, Durable remissions with ivosidenib in IDH1-mutated relapsed or refractory AML, N. Engl. J. Med., 378, 2386, 10.1056/NEJMoa1716984
Ding, 2016, PAUPAR lncRNA suppresses tumourigenesis by H3K4 demethylation in uveal melanoma, FEBS Lett., 590, 1729, 10.1002/1873-3468.12220
Doherty, 2017, Phenotypic plasticity in uveal melanoma is not restricted to a tumor subpopulation and is unrelated to cancer stem cell characteristics, Invest. Ophthalmol. Vis. Sci., 58, 5387, 10.1167/iovs.17-22272
Dominissini, 2012, Topology of the human and mouse m 6 A RNA methylomes revealed by m 6 A-seq, Nature, 485, 201, 10.1038/nature11112
Dominissini, 2016, The dynamic N 1-methyladenosine methylome in eukaryotic messenger RNA, Nature, 530, 441, 10.1038/nature16998
Dong, 2013, Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer, Cancer Cell, 23, 316, 10.1016/j.ccr.2013.01.022
Dong, 2012, MicroRNA-34b/c suppresses uveal melanoma cell proliferation and migration through multiple targets, Mol. Vis., 18, 537
Dratviman-Storobinsky, 2012, The role of RASSF1A in uveal melanoma, Invest. Ophthalmol. Vis. Sci., 53, 2611, 10.1167/iovs.11-7730
Dryja, 1984, Homozygosity of chromosome 13 in retinoblastoma, N. Engl. J. Med., 310, 550, 10.1056/NEJM198403013100902
Du, 2016, Chromatin interactions and candidate genes at ten prostate cancer risk loci, Sci. Rep., 6
Dubin, 1975, The methylation state of poly A-containing-messenger RNA from cultured hamster cells, Nucleic Acids Res., 2, 1653, 10.1093/nar/2.10.1653
DuBois, 2015, Phase I study of vorinostat as a radiation sensitizer with 131I-metaiodobenzylguanidine (131I-MIBG) for patients with relapsed or refractory neuroblastoma, Clin. Cancer Res., 21, 2715, 10.1158/1078-0432.CCR-14-3240
Dunn, 1988, Identification of germline and somatic mutations affecting the retinoblastoma gene, Science, 241, 1797, 10.1126/science.3175621
Eissenberg, 2010, Histone H3 lysine 4 (H3K4) methylation in development and differentiation, Dev. Biol., 339, 240, 10.1016/j.ydbio.2009.08.017
El Annan, 2010, Regulation of T-cell chemotaxis by programmed death-ligand 1 (PD-L1) in dry eye-associated corneal inflammation, Invest. Ophthalmol. Vis. Sci., 51, 3418, 10.1167/iovs.09-3684
Engreitz, 2016, Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression, Nat. Rev. Mol. Cell Biol., 17, 756, 10.1038/nrm.2016.126
Esteller, 2008, Epigenetics in cancer, N. Engl. J. Med., 358, 1148, 10.1056/NEJMra072067
Ewens, 2017, Phosphorylation of pRb: mechanism for RB pathway inactivation in MYCN-amplified retinoblastoma, Cancer Med., 6, 619, 10.1002/cam4.1010
Faiao-Flores, 2019, HDAC inhibition enhances the in vivo efficacy of MEK inhibitor therapy in uveal melanoma, Clin. Cancer Res., 25, 5686, 10.1158/1078-0432.CCR-18-3382
Falzone, 2019, Prognostic significance of deregulated microRNAs in uveal melanomas, Mol. Med. Rep., 19, 2599
Fan, 2015, Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis, Genome Biol., 16, 139, 10.1186/s13059-015-0705-2
Fan, 2019, A cohesin-mediated intrachromosomal loop drives oncogenic ROR lncRNA to accelerate tumorigenesis, Mol. Ther., 27, 2182, 10.1016/j.ymthe.2019.07.020
Fang, 2010, A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer, Cancer, 116, 4043, 10.1002/cncr.25204
Fang, 2014, The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer, Clin. Cancer Res., 20, 6504, 10.1158/1078-0432.CCR-14-1553
Fenaux, 2009, Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study, Lancet Oncol., 10, 223, 10.1016/S1470-2045(09)70003-8
Field, 2018, Punctuated evolution of canonical genomic aberrations in uveal melanoma, Nat. Commun., 9, 116, 10.1038/s41467-017-02428-w
Field, 2016, Epigenetic reprogramming and aberrant expression of PRAME are associated with increased metastatic risk in Class 1 and Class 2 uveal melanomas, Oncotarget, 7, 59209, 10.18632/oncotarget.10962
Field, 2019, BAP1 loss is associated with DNA methylomic repatterning in highly aggressive class 2 uveal melanomas, Clin. Cancer Res., 25, 5663, 10.1158/1078-0432.CCR-19-0366
Figueroa, 2010, Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation, Cancer Cell, 18, 553, 10.1016/j.ccr.2010.11.015
Friedman, 2009, Most mammalian mRNAs are conserved targets of microRNAs, Genome Res., 19, 92, 10.1101/gr.082701.108
Fujisawa, 2017, Functions of bromodomain-containing proteins and their roles in homeostasis and cancer, Nat. Rev. Mol. Cell Biol., 18, 246, 10.1038/nrm.2016.143
Furney, 2013, SF3B1 mutations are associated with alternative splicing in uveal melanoma, Cancer Discov., 3, 1122, 10.1158/2159-8290.CD-13-0330
Gao, 2017, Hypermethylation of MEG3 promoter correlates with inactivation of MEG3 and poor prognosis in patients with retinoblastoma, J. Transl. Med., 15, 268, 10.1186/s12967-017-1372-8
Gardner, 2014, c-MET expression in primary and liver metastases in uveal melanoma, Melanoma Res., 24, 617, 10.1097/CMR.0000000000000118
Giacinti, 2006, RB and cell cycle progression, Oncogene, 25, 5220, 10.1038/sj.onc.1209615
Giallongo, 2020, Loss of macroH2A1 decreases mitochondrial metabolism and reduces the aggressiveness of uveal melanoma cells, Aging, 12, 9745, 10.18632/aging.103241
Ginder, 1983, In vivo demethylation of chicken embryonic beta-type globin genes with 5-azacytidine, Prog. Clin. Biol. Res., 134, 501
Gollob, 2007, Decitabine up-regulates S100A2 expression and synergizes with IFN-gamma to kill uveal melanoma cells, Clin. Cancer Res., 13, 5219, 10.1158/1078-0432.CCR-07-0816
Goncalves, 2020, Decitabine limits escape from MEK inhibition in uveal melanoma, Pigment Cell Melanoma Res, 33, 507, 10.1111/pcmr.12849
Goodall, 2021, RNA in cancer, Nat. Rev. Cancer, 21, 22, 10.1038/s41568-020-00306-0
Goodyear, 2010, Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia, Blood, 116, 1908, 10.1182/blood-2009-11-249474
Greer, 2012, Histone methylation: a dynamic mark in health, disease and inheritance, Nat. Rev. Genet., 313, 343, 10.1038/nrg3173
Guarnerio, 2016, Oncogenic role of fusion-circRNAs derived from cancer-associated chromosomal translocations, Cell, 165, 289, 10.1016/j.cell.2016.03.020
Gunawardena, 2004, Hierarchical requirement of SWI/SNF in retinoblastoma tumor suppressor-mediated repression of Plk1, J. Biol. Chem., 279, 29278, 10.1074/jbc.M400395200
Guzman, 2020, Retinoblastoma tumor suppressor protein roles in epigenetic regulation, Cancers, 12, 10.3390/cancers12102807
Haas, 2014, Phase II trial of vorinostat in advanced melanoma, Invest. N. Drugs, 32, 526, 10.1007/s10637-014-0066-9
Han, 2019, METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner, Mol. Cancer, 18, 1, 10.1186/s12943-019-1036-9
Hanahan, 2011, Hallmarks of cancer: the next generation, Cell, 144, 646, 10.1016/j.cell.2011.02.013
Harada, 2002, Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines, Cancer Res., 62, 5897
Harbour, 2010, Frequent mutation of BAP1 in metastasizing uveal melanomas, Science, 330, 1410, 10.1126/science.1194472
Harbour, 2013, Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma, Nat. Genet., 45, 133, 10.1038/ng.2523
Harewood, 2017, Hi-C as a tool for precise detection and characterisation of chromosomal rearrangements and copy number variation in human tumours, Genome Biol., 18, 1, 10.1186/s13059-017-1253-8
Harland, 1988, Stability of RNA in developing Xenopus embryos and identification of a destabilizing sequence in TFIIIA messenger RNA, Development, 102, 837, 10.1242/dev.102.4.837
He, 2020, A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3, Mol. Cancer, 19, 115, 10.1186/s12943-020-01232-3
Hegi, 2005, MGMT gene silencing and benefit from temozolomide in glioblastoma, N. Engl. J. Med., 352, 997, 10.1056/NEJMoa043331
Heijkants, 2018, Combined inhibition of CDK and HDAC as a promising therapeutic strategy for both cutaneous and uveal metastatic melanoma, Oncotarget, 9, 6174, 10.18632/oncotarget.23485
Held, 2010, A role for the JARID1B stem cell marker for continuous melanoma growth, Pigment Cell Melanoma Res, 23, 481, 10.1111/j.1755-148X.2010.00726.x
Herman, 2003, Gene silencing in cancer in association with promoter hypermethylation, N. Engl. J. Med., 349, 2042, 10.1056/NEJMra023075
Herwig-Carl, 2019, Spatial intratumor heterogeneity in uveal melanoma: tumor cell subtypes with a presumed invasive potential exhibit a particular epigenetic staining reaction, Exp. Eye Res., 182, 175, 10.1016/j.exer.2019.04.001
Hindie, 2021, Adjuvant therapy in stage IIIA melanoma, Lancet Oncol., 22, e299, 10.1016/S1470-2045(21)00346-6
Holliday, 1987, The inheritance of epigenetic defects, Science, 238, 163, 10.1126/science.3310230
Holling, 2007, A role for EZH2 in silencing of IFN-gamma inducible MHC2TA transcription in uveal melanoma, J. Immunol., 179, 5317, 10.4049/jimmunol.179.8.5317
Horsman, 1990, Monosomy 3 and isochromosome 8q in a uveal melanoma, Cancer Genet. Cytogenet., 45, 249, 10.1016/0165-4608(90)90090-W
Hou, 2020, Machine learning-based integrative analysis of methylome and transcriptome identifies novel prognostic DNA methylation signature in uveal melanoma, Briefings Bioinf.
Hou, 2019, The interplay of MicroRNA-34a, LGR4, EMT-associated factors, and MMP2 in regulating uveal melanoma cells, Invest. Ophthalmol. Vis. Sci., 60, 4503, 10.1167/iovs.18-26477
Hsiao, 2017, Noncoding effects of circular RNA CCDC66 promote colon cancer growth and metastasis, Cancer Res., 77, 2339, 10.1158/0008-5472.CAN-16-1883
Hu, 1993, Studies of human uveal melanocytes in vitro: isolation, purification and cultivation of human uveal melanocytes, Invest. Ophthalmol. Vis. Sci., 34, 2210
Huang, 2019, LncRNA PVT1 knockdown affects proliferation and apoptosis of uveal melanoma cells by inhibiting EZH2, Eur. Rev. Med. Pharmacol. Sci., 23, 2880
Indovina, 2010, Downregulation and aberrant promoter methylation of p16INK4A: a possible novel heritable susceptibility marker to retinoblastoma, J. Cell. Physiol., 223, 143, 10.1002/jcp.22019
Inoue, 2016, Mutant IDH1 downregulates ATM and alters DNA repair and sensitivity to DNA damage independent of TET2, Cancer Cell, 30, 337, 10.1016/j.ccell.2016.05.018
Inoue, 2007, Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage, EMBO J., 26, 2083, 10.1038/sj.emboj.7601652
Ishak, 2016, An RB-EZH2 complex mediates silencing of repetitive DNA sequences, Mol. Cell, 64, 1074, 10.1016/j.molcel.2016.10.021
Issa, 2015, Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study, Lancet Oncol., 16, 1099, 10.1016/S1470-2045(15)00038-8
Iyer, 2015, The landscape of long noncoding RNAs in the human transcriptome, Nat. Genet., 47, 10.1038/ng.3192
Jager, 2018, The cancer genome Atlas Project: an integrated molecular view of uveal melanoma, Ophthalmology, 125, 1139, 10.1016/j.ophtha.2018.03.011
Jager, 2011, Macrophages in uveal melanoma and in experimental ocular tumor models: friends or foes?, Prog. Retin. Eye Res., 30, 129, 10.1016/j.preteyeres.2010.11.004
Jager, 2020, Uveal melanoma, Nat. Rev. Dis. Prim., 6, 24, 10.1038/s41572-020-0158-0
Jansen, 2019, Phase I clinical trial of decitabine (5-aza-2'-deoxycytidine) administered by hepatic arterial infusion in patients with unresectable liver-predominant metastases, ESMO Open, 4, 10.1136/esmoopen-2018-000464
Javed, 2020, LncRNA & Wnt signaling in colorectal cancer, Cancer Cell Int., 20, 326, 10.1186/s12935-020-01412-7
Jeck, 2013, Circular RNAs are abundant, conserved, and associated with ALU repeats, Rna, 19, 141, 10.1261/rna.035667.112
Jenuwein, 2001, Translating the histone code, Science, 293, 1074, 10.1126/science.1063127
Jespersen, 2019, Concomitant use of pembrolizumab and entinostat in adult patients with metastatic uveal melanoma (PEMDAC study): protocol for a multicenter phase II open label study, BMC Cancer, 19, 415, 10.1186/s12885-019-5623-3
Jespersen, 2019, Phase II multicenter open label study of pembrolizumab and entinostat in adult patients with metastatic uveal melanoma (PEMDAC study), Ann. Oncol., 30, v907, 10.1093/annonc/mdz394.068
Jia, 2011, N 6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO, Nat. Chem. Biol., 7, 885, 10.1038/nchembio.687
Jia, 2019, m(6)A modification suppresses ocular melanoma through modulating HINT2 mRNA translation, Mol. Cancer, 18, 161, 10.1186/s12943-019-1088-x
Jia, 2017, Novel insights into chromosomal conformations in cancer, Mol. Cancer, 16, 173, 10.1186/s12943-017-0741-5
Jia, 2017, Novel insights into chromosomal conformations in cancer, Mol. Cancer, 16, 1, 10.1186/s12943-017-0741-5
Jin, 2020, Verification of EZH2 as a druggable target in metastatic uveal melanoma, Mol. Cancer, 19, 52, 10.1186/s12943-020-01173-x
Jin, 2018, Neddylation blockade diminishes hepatic metastasis by dampening cancer stem-like cells and angiogenesis in uveal melanoma, Clin. Cancer Res., 24, 3741, 10.1158/1078-0432.CCR-17-1703
Jo, 2014, STAT3 inhibition suppresses proliferation of retinoblastoma through down-regulation of positive feedback loop of STAT3/miR-17-92 clusters, Oncotarget, 5, 11513, 10.18632/oncotarget.2546
Johnson, 2007, The let-7 microRNA represses cell proliferation pathways in human cells, Cancer Res., 67, 7713, 10.1158/0008-5472.CAN-07-1083
Johnson, 2005, RAS is regulated by the let-7 microRNA family, Cell, 120, 635, 10.1016/j.cell.2005.01.014
Jones, 2007, The epigenomics of cancer, Cell, 128, 683, 10.1016/j.cell.2007.01.029
Joshi, 2016, Expression of natural killer cell regulatory microRNA by uveal melanoma cancer stem cells, Clin. Exp. Metastasis, 33, 829, 10.1007/s10585-016-9815-9
Josling, 2012, The role of bromodomain proteins in regulating gene expression, Genes, 3, 320, 10.3390/genes3020320
Journee-de Korver, 2002, Thermotherapy in the management of choroidal melanoma, Prog. Retin. Eye Res., 21, 303, 10.1016/S1350-9462(02)00005-8
Kaliki, 2017, Uveal melanoma: relatively rare but deadly cancer, Eye, 31, 241, 10.1038/eye.2016.275
Kantarjian, 2006, Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study, Cancer, 106, 1794, 10.1002/cncr.21792
Karasawa, 2004, Inhibition of histone deacetylation by butyrate induces morphological changes in Y79 retinoblastoma cells, Jpn. J. Ophthalmol., 48, 542, 10.1007/s10384-004-0122-7
Karpf, 1999, Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator of transcription 1, 2, and 3 genes in colon tumor cells, Proc. Natl. Acad. Sci. U. S. A., 96, 14007, 10.1073/pnas.96.24.14007
Kashiwagi, 2010, Trichostatin A-induced TGF-beta type II receptor expression in retinoblastoma cell lines, Invest. Ophthalmol. Vis. Sci., 51, 679, 10.1167/iovs.09-4073
Kawano, 2010, Histone deacetylase inhibitors valproic acid and depsipeptide sensitize retinoblastoma cells to radiotherapy by increasing H2AX phosphorylation and p53 acetylation-phosphorylation, Int. J. Oncol., 37, 787
Khan, 2015, Characterization and pharmacologic targeting of EZH2, a fetal retinal protein and epigenetic regulator, in human retinoblastoma, Lab. Invest., 95, 1278, 10.1038/labinvest.2015.104
Khoja, 2019, Meta-analysis in metastatic uveal melanoma to determine progression free and overall survival benchmarks: an international rare cancers initiative (IRCI) ocular melanoma study, Ann. Oncol., 30, 1370, 10.1093/annonc/mdz176
Kilic, 2004, The RAS-BRAF kinase pathway is not involved in uveal melanoma, Melanoma Res., 14, 203, 10.1097/01.cmr.0000130006.46885.a0
Klein, 2010, The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia, Cancer Cell, 17, 28, 10.1016/j.ccr.2009.11.019
Klisovic, 2003, Depsipeptide (FR901228) inhibits proliferation and induces apoptosis in primary and metastatic human uveal melanoma cell lines, Invest. Ophthalmol. Vis. Sci., 44, 2390, 10.1167/iovs.02-1052
Klisovic, 2005, Depsipeptide inhibits migration of primary and metastatic uveal melanoma cell lines in vitro: a potential strategy for uveal melanoma, Melanoma Res., 15, 147, 10.1097/00008390-200506000-00002
Knudsen, 2019, Cell cycle and beyond: exploiting new RB1 controlled mechanisms for cancer therapy, Trends Cancer, 5, 308, 10.1016/j.trecan.2019.03.005
Knudson, 1971, Mutation and cancer: statistical study of retinoblastoma, Proc. Natl. Acad. Sci. U. S. A., 68, 820, 10.1073/pnas.68.4.820
Kooi, 2016, Somatic genomic alterations in retinoblastoma beyond RB1 are rare and limited to copy number changes, Sci. Rep., 6, 10.1038/srep25264
Kooi, 2015, Loss of photoreceptorness and gain of genomic alterations in retinoblastoma reveal tumor progression, EBioMedicine, 2, 660, 10.1016/j.ebiom.2015.06.022
Kouzarides, 2007, Chromatin modifications and their function, Cell, 128, 693, 10.1016/j.cell.2007.02.005
Krug, 1976, Influenza viral mRNA contains internal N6-methyladenosine and 5'-terminal 7-methylguanosine in cap structures, J. Virol., 20, 45, 10.1128/jvi.20.1.45-53.1976
Kuznetsoff, 2021, Dual screen for efficacy and toxicity identifies HDAC inhibitor with distinctive activity spectrum for BAP1-mutant uveal melanoma, Mol. Cancer Res., 19, 215, 10.1158/1541-7786.MCR-20-0434
LaFave, 2015, Loss of BAP1 function leads to EZH2-dependent transformation, Nat. Med., 21, 1344, 10.1038/nm.3947
Lajoie, 2015, The Hitchhiker's guide to Hi-C analysis: practical guidelines, Methods, 72, 65, 10.1016/j.ymeth.2014.10.031
Lamonica, 2006, Acetylation of GATA-1 is required for chromatin occupancy, Blood, 108, 3736, 10.1182/blood-2006-07-032847
Landreville, 2012, Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma, Clin. Cancer Res., 18, 408, 10.1158/1078-0432.CCR-11-0946
Larsen, 2014, MicroRNA expression analysis and Multiplex ligation-dependent probe amplification in metastatic and non-metastatic uveal melanoma, Acta Ophthalmol., 92, 541, 10.1111/aos.12322
Laurent, 2011, High PTP4A3 phosphatase expression correlates with metastatic risk in uveal melanoma patients, Cancer Res., 71, 666, 10.1158/0008-5472.CAN-10-0605
Lawrence, 2016, Lateral thinking: how histone modifications regulate gene expression, Trends Genet., 32, 42, 10.1016/j.tig.2015.10.007
Leng, 2016, The neuropilin‐1 receptor mediates enhanced tumor delivery of H2K polyplexes, J. Gene Med., 18, 134, 10.1002/jgm.2886
Leng, 2008, Double-strand break damage and associated DNA repair genes predispose smokers to gene methylation, Cancer Res., 68, 3049, 10.1158/0008-5472.CAN-07-6344
Li, 1993, Role for DNA methylation in genomic imprinting, Nature, 366, 362, 10.1038/366362a0
Li, 1992, Targeted mutation of the DNA methyltransferase gene results in embryonic lethality, Cell, 69, 915, 10.1016/0092-8674(92)90611-F
Li, 2019, MALAT1 regulates miR-34a expression in melanoma cells, Cell Death Dis., 10, 389, 10.1038/s41419-019-1620-3
Li, 2020, lncRNA HotairM1 depletion promotes self-renewal of cancer stem cells through HOXA1-nanog regulation loop, Mol. Ther. Nucleic Acids, 22, 456, 10.1016/j.omtn.2020.09.008
Li, 2020, ALKBH5 regulates anti-PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment, Proc. Natl. Acad. Sci. U. S. A., 117, 20159, 10.1073/pnas.1918986117
Li, 2020, ZNNT1 long noncoding RNA induces autophagy to inhibit tumorigenesis of uveal melanoma by regulating key autophagy gene expression, Autophagy, 16, 1186, 10.1080/15548627.2019.1659614
Li, 2017, NSUN2‐mediated m5C methylation and METTL3/METTL14‐mediated m6A methylation cooperatively enhance p21 translation, J. Cell. Biochem., 118, 2587, 10.1002/jcb.25957
Li, 2017, Coordinated circRNA biogenesis and function with NF90/NF110 in viral infection, Mol. Cell, 67, 214, 10.1016/j.molcel.2017.05.023
Li, 2016, HDACs and HDAC inhibitors in cancer development and therapy, Cold Spring Harb. Perspect. Med., 6, 10.1101/cshperspect.a026831
Li, 2019, Ras-PI3K-AKT signaling promotes the occurrence and development of uveal melanoma by downregulating H3K56ac expression, J. Cell. Physiol.
Li, 2019, Ras-ERK1/2 signaling promotes the development of uveal melanoma by downregulating H3K14ac, J. Cell. Physiol.
Liang, 2019, Translation of the circular RNA circbeta-catenin promotes liver cancer cell growth through activation of the Wnt pathway, Genome Biol., 20, 84, 10.1186/s13059-019-1685-4
Lin, 2016, The m6A methyltransferase METTL3 promotes translation in human cancer cells, Mol. Cell, 62, 335, 10.1016/j.molcel.2016.03.021
Liu, 2015, A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis, Cancer Cell, 27, 370, 10.1016/j.ccell.2015.02.004
Liu, 2020, Human embryonic stem cell-derived organoid retinoblastoma reveals a cancerous origin, Proc. Natl. Acad. Sci. U. S. A., 117, 33628, 10.1073/pnas.2011780117
Liu, 2013, Tumor-targeting TRAIL expression mediated by miRNA response elements suppressed growth of uveal melanoma cells, Mol. Oncol., 7, 1043, 10.1016/j.molonc.2013.08.003
Liu, 2014, MIR34A regulates autophagy and apoptosis by targeting HMGB1 in the retinoblastoma cell, Autophagy, 10, 442, 10.4161/auto.27418
Liu, 2015, N 6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions, Nature, 518, 560, 10.1038/nature14234
Liu, 2014, 5-Aza-2''-deoxycytidine inhibits retinoblastoma cell by reactivating epigenetically silenced RASSF1A gene, Int. J. Ophthalmol., 7, 51
Liu, 2021, Circ_0119872 promotes uveal melanoma development by regulating the miR-622/G3BP1 axis and downstream signalling pathways, J. Exp. Clin. Cancer Res., 40, 66, 10.1186/s13046-021-01833-w
Liu, 2014, Plasma microRNA-320, microRNA-let-7e and microRNA-21 as novel potential biomarkers for the detection of retinoblastoma, Biomed. Rep., 2, 424, 10.3892/br.2014.246
Liu, 2019, GDF11 upregulation independently predicts shorter overall-survival of uveal melanoma, PLoS One, 14
Liu, 2018, MiR-216a-5p/Hexokinase 2 axis regulates uveal melanoma growth through modulation of Warburg effect, Biochem. Biophys. Res. Commun., 501, 885, 10.1016/j.bbrc.2018.05.069
Livide, 2012, Epigenetic and copy number variation analysis in retinoblastoma by MS-MLPA, Pathol. Oncol. Res., 18, 703, 10.1007/s12253-012-9498-8
Lodygin, 2008, Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer, Cell Cycle, 7, 2591, 10.4161/cc.7.16.6533
Lovén, 2013, Selective inhibition of tumor oncogenes by disruption of super-enhancers, Cell, 153, 320, 10.1016/j.cell.2013.03.036
Lu, 2017, The long non-coding RNA RHPN1-AS1 promotes uveal melanoma progression, Int. J. Mol. Sci., 18, 10.3390/ijms18010226
Lu, 2017, LncRNA HOXA11-AS exerts oncogenic functions by repressing p21 and miR-124 in uveal melanoma, DNA Cell Biol., 36, 837, 10.1089/dna.2017.3808
Lu, 2020, Reprogramming to recover youthful epigenetic information and restore vision, Nature, 588, 124, 10.1038/s41586-020-2975-4
Luo, 1998, Rb interacts with histone deacetylase to repress transcription, Cell, 92, 463, 10.1016/S0092-8674(00)80940-X
Luo, 2016, Carvacrol alleviates prostate cancer cell proliferation, migration, and invasion through regulation of PI3K/Akt and MAPK signaling pathways, Oxidat. Med. Cell. Longev., 2016, 10.1155/2016/1469693
Lyu, 2019, Reduction of circular RNA expression associated with human retinoblastoma, Exp. Eye Res., 184, 278, 10.1016/j.exer.2019.03.017
Maat, 2008, Epigenetic regulation identifies RASEF as a tumor-suppressor gene in uveal melanoma, Invest. Ophthalmol. Vis. Sci., 49, 1291, 10.1167/iovs.07-1135
Maat, 2008, Pyrophosphorolysis detects B-RAF mutations in primary uveal melanoma, Invest. Ophthalmol. Vis. Sci., 49, 23, 10.1167/iovs.07-0722
Maat, 2007, Epigenetic inactivation of RASSF1a in uveal melanoma, Invest. Ophthalmol. Vis. Sci., 48, 486, 10.1167/iovs.06-0781
Maelandsmo, 1997, Differential expression patterns of S100A2, S100A4 and S100A6 during progression of human malignant melanoma, Int. J. Cancer, 74, 464, 10.1002/(SICI)1097-0215(19970822)74:4<464::AID-IJC19>3.0.CO;2-9
Malusa, 2015, Time-course gene profiling and networks in demethylated retinoblastoma cell line, Oncotarget, 6, 23688, 10.18632/oncotarget.4644
Marmorstein, 2014, Writers and readers of histone acetylation: structure, mechanism, and inhibition, Cold Spring Harbor Perspect. Biol., 6, 10.1101/cshperspect.a018762
Martin, 2006, Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma, Gastroenterology, 130, 2179, 10.1053/j.gastro.2006.03.024
Martin, 2013, Disruption of the histidine triad nucleotide-binding hint2 gene in mice affects glycemic control and mitochondrial function, Hepatology, 57, 2037, 10.1002/hep.26060
Martin, 2017, HUGIn: Hi-C unifying genomic interrogator, Bioinformatics, 33, 3793, 10.1093/bioinformatics/btx359
Martin, 2013, Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3, Nat. Genet., 45, 933, 10.1038/ng.2674
Marzi, 2012, Differentiation-associated microRNAs antagonize the Rb-E2F pathway to restrict proliferation, J. Cell Biol., 199, 77, 10.1083/jcb.201206033
Mashtalir, 2018, Modular organization and assembly of SWI/SNF family chromatin remodeling complexes, Cell, 175, 1272, 10.1016/j.cell.2018.09.032
McClure, 2018, Advances and challenges of HDAC inhibitors in cancer therapeutics, Adv. Cancer Res., 138, 183, 10.1016/bs.acr.2018.02.006
McEvoy, 2014, RB1 gene inactivation by chromothripsis in human retinoblastoma, Oncotarget, 5, 438, 10.18632/oncotarget.1686
McEvoy, 2015, Genetic and epigenetic discoveries in human retinoblastoma, Crit. Rev. Oncog., 20, 217, 10.1615/CritRevOncog.2015013711
McLaughlin-Drubin, 2013, Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines, Proc. Natl. Acad. Sci. U. S. A., 110, 16175, 10.1073/pnas.1310432110
Medina, 2010, OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma, Nature, 467, 86, 10.1038/nature09284
Memczak, 2013, Circular RNAs are a large class of animal RNAs with regulatory potency, Nature, 495, 333, 10.1038/nature11928
Mensink, 2008, Molecular cytogenetic analysis of archival uveal melanoma with known clinical outcome, Cancer Genet. Cytogenet., 181, 108, 10.1016/j.cancergencyto.2007.12.001
Meyer, 2015, 5′ UTR m6A promotes cap-independent translation, Cell, 163, 999, 10.1016/j.cell.2015.10.012
Michalak, 2019, The roles of DNA, RNA and histone methylation in ageing and cancer, Nat. Rev. Mol. Cell Biol., 20, 573, 10.1038/s41580-019-0143-1
Michlewski, 2019, Post-transcriptional control of miRNA biogenesis, RNA, 25, 1, 10.1261/rna.068692.118
Mishra, 2020, Inflammasomes in cancer: effect of epigenetic and autophagic modulations, Semin. Cancer Biol.
Munier, 2019, Conservative management of retinoblastoma: challenging orthodoxy without compromising the state of metastatic grace. "Alive, with good vision and no comorbidity, Prog. Retin. Eye Res., 73, 10.1016/j.preteyeres.2019.05.005
Nebbioso, 2018, Cancer epigenetics: moving forward, PLoS Genet., 14, 10.1371/journal.pgen.1007362
Nencetti, 2021, Identification of histone deacetylase inhibitors with (arylidene)aminoxy scaffold active in uveal melanoma cell lines, J. Enzym. Inhib. Med. Chem., 36, 34, 10.1080/14756366.2020.1835883
Nevedomskaya, 2016, Androgen receptor DNA binding and chromatin accessibility profiling in prostate cancer, Genom Data, 7, 124, 10.1016/j.gdata.2015.12.020
Ni, 2020, LncRNA CANT1 suppresses retinoblastoma progression by repellinghistone methyltransferase in PI3Kγ promoter, Cell Death Dis., 11, 306, 10.1038/s41419-020-2524-y
Niederkorn, 2009, Immune escape mechanisms of intraocular tumors, Prog. Retin. Eye Res., 28, 329, 10.1016/j.preteyeres.2009.06.002
Niesen, 2009, Rescue of major histocompatibility-DR surface expression in retinoblastoma-defective, non-small cell lung carcinoma cells by the MS-275 histone deacetylase inhibitor, Biol. Pharm. Bull., 32, 480, 10.1248/bpb.32.480
Nittner, 2012, Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation, Nat. Cell Biol., 14, 958, 10.1038/ncb2556
O'Connor, 2015, Belinostat in patients with relapsed or refractory peripheral T-cell lymphoma: results of the pivotal phase II BELIEF (CLN-19) study, J. Clin. Oncol., 33, 2492, 10.1200/JCO.2014.59.2782
Ohtani-Fujita, 1997, Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma, Cancer Genet. Cytogenet., 98, 43, 10.1016/S0165-4608(96)00395-0
Okano, 1999, DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development, Cell, 99, 247, 10.1016/S0092-8674(00)81656-6
Olsen, 2007, Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma, J. Clin. Oncol., 25, 3109, 10.1200/JCO.2006.10.2434
Orillion, 2017, Entinostat neutralizes myeloid-derived suppressor cells and enhances the antitumor effect of PD-1 inhibition in murine models of lung and renal cell carcinoma, Clin. Cancer Res., 23, 5187, 10.1158/1078-0432.CCR-17-0741
Osborne, 2004, Oct-1 maintains an intermediate, stable state of HLA-DRA promoter repression in Rb-defective cells: an Oct-1-containing repressosome that prevents NF-Y binding to the HLA-DRA promoter, J. Biol. Chem., 279, 28911, 10.1074/jbc.M403118200
Pan, 2015, BAP1 regulates cell cycle progression through E2F1 target genes and mediates transcriptional silencing via H2A monoubiquitination in uveal melanoma cells, Int. J. Biochem. Cell Biol., 60, 176, 10.1016/j.biocel.2015.01.001
Pan, 2016, P2RX7-V3 is a novel oncogene that promotes tumorigenesis in uveal melanoma, Tumour Biol., 37, 13533, 10.1007/s13277-016-5141-8
Pekarsky, 2010, Is miR-29 an oncogene or tumor suppressor in CLL?, Oncotarget, 1, 224, 10.18632/oncotarget.129
Peng, 2019, MIR155HG is a prognostic biomarker and associated with immune infiltration and immune checkpoint molecules expression in multiple cancers, Cancer Med., 8, 7161, 10.1002/cam4.2583
Philippeit, 2014, Epigenetic control of trefoil factor family (TFF) peptide expression in human retinoblastoma cell lines, Cell. Physiol. Biochem., 34, 1001, 10.1159/000366316
Piekarz, 2011, Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma, Blood, 117, 5827, 10.1182/blood-2010-10-312603
Piekarz, 2009, Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma, J. Clin. Oncol., 27, 5410, 10.1200/JCO.2008.21.6150
Poulaki, 2009, Molecular sequelae of histone deacetylase inhibition in human retinoblastoma cell lines: clinical implications, Invest. Ophthalmol. Vis. Sci., 50, 4072, 10.1167/iovs.09-3517
Poulaki, 2005, Human retinoblastoma cells are resistant to apoptosis induced by death receptors: role of caspase-8 gene silencing, Invest. Ophthalmol. Vis. Sci., 46, 358, 10.1167/iovs.04-0324
Prebet, 2014, Prolonged administration of azacitidine with or without entinostat for myelodysplastic syndrome and acute myeloid leukemia with myelodysplasia-related changes: results of the US Leukemia Intergroup trial E1905, J. Clin. Oncol., 32, 1242, 10.1200/JCO.2013.50.3102
Prensner, 2013, The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex, Nat. Genet., 45, 1392, 10.1038/ng.2771
Qi, 2020, Long non-coding RNA GAS5 targeting microRNA-21 to suppress the invasion and epithelial-mesenchymal transition of uveal melanoma, Cancer Manag. Res., 12, 12259, 10.2147/CMAR.S260866
Qi, 2020, Knockdown of long non-coding RNA LOC100132707 inhibits the migration of uveal melanoma cells via silencing JAK2, OncoTargets Ther., 13, 12955, 10.2147/OTT.S266596
Radberger, 2012, JARID1B protein expression and prognostic implications in uveal melanoma, Invest. Ophthalmol. Vis. Sci., 53, 4442, 10.1167/iovs.11-9296
Radhakrishnan, 2009, Analysis of chromosomal aberration (1, 3, and 8) and association of microRNAs in uveal melanoma, Mol. Vis., 15, 2146
Radosevich, 2007, Inhibition of MHC class II gene expression in uveal melanoma cells is due to methylation of the CIITA gene or an upstream activator, Exp. Mol. Pathol., 82, 68, 10.1016/j.yexmp.2006.03.005
Rago, 2020, The discovery of SWI/SNF chromatin remodeling activity as a novel and targetable dependency in uveal melanoma, Mol. Cancer Therapeut., 19, 2186, 10.1158/1535-7163.MCT-19-1013
Ragusa, 2015, miRNA profiling in vitreous humor, vitreal exosomes and serum from uveal melanoma patients: pathological and diagnostic implications, Cancer Biol. Ther., 16, 1387, 10.1080/15384047.2015.1046021
Raizis, 2020, DNA hypermethylation/boundary control loss identified in retinoblastomas associated with genetic and epigenetic inactivation of the RB1 gene promoter, Epigenetics, 1
Rajaii, 2014, The demethylating agent 5-Aza reduces the growth, invasiveness, and clonogenicity of uveal and cutaneous melanoma, Invest. Ophthalmol. Vis. Sci., 55, 6178, 10.1167/iovs.14-13933
Rajasekaran, 2019, Non-coding and coding transcriptional profiles are significantly altered in pediatric retinoblastoma tumors, Front. Oncol., 9, 221, 10.3389/fonc.2019.00221
Rao, 2014, A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping, Cell, 159, 1665, 10.1016/j.cell.2014.11.021
Reik, 2007, Stability and flexibility of epigenetic gene regulation in mammalian development, Nature, 447, 425, 10.1038/nature05918
Reik, 2001, Epigenetic reprogramming in mammalian development, Science, 293, 1089, 10.1126/science.1063443
Reik, 2001, Genomic imprinting: parental influence on the genome, Nat. Rev. Genet., 2, 21, 10.1038/35047554
Robertson, 2017, Integrative analysis identifies four molecular and clinical subsets in uveal melanoma, Cancer Cell, 32, 204, 10.1016/j.ccell.2017.07.003
Robertson, 2017, Integrative analysis identifies four molecular and clinical subsets in uveal melanoma, Cancer Cell, 33, 151, 10.1016/j.ccell.2017.12.013
Robertson, 2018, Integrative analysis identifies four molecular and clinical subsets in uveal melanoma, Cancer Cell, 33, 151, 10.1016/j.ccell.2017.12.013
Robertson, 2005, DNA methylation and human disease, Nat. Rev. Genet., 6, 597, 10.1038/nrg1655
Rosenfeld, 2009, Determination of enriched histone modifications in non-genic portions of the human genome, BMC Genom., 10, 143, 10.1186/1471-2164-10-143
Rossi, 2019, Immunological backbone of uveal melanoma: is there a rationale for immunotherapy?, Cancers, 11, 10.3390/cancers11081055
Rushlow, 2013, Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies, Lancet Oncol., 14, 327, 10.1016/S1470-2045(13)70045-7
Russo, 2016, Increased levels of miRNA-146a in serum and histologic samples of patients with uveal melanoma, Front. Pharmacol., 7, 424, 10.3389/fphar.2016.00424
Sabari, 2018, Coactivator condensation at super-enhancers links phase separation and gene control, Science, 361, 10.1126/science.aar3958
Sabari, 2017, Metabolic regulation of gene expression through histone acylations, Nat. Rev. Mol. Cell Biol., 18, 90, 10.1038/nrm.2016.140
Saengwimol, 2020, Silencing of the long noncoding RNA MYCNOS1 suppresses activity of MYCN-amplified retinoblastoma without RB1 mutation, Invest. Ophthalmol. Vis. Sci., 61, 8, 10.1167/iovs.61.14.8
Sakai, 1991, Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene, Am. J. Hum. Genet., 48, 880
Salzman, 2013, Cell-type specific features of circular RNA expression, PLoS Genet., 9, 10.1371/annotation/f782282b-eefa-4c8d-985c-b1484e845855
Salzman, 2012, Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types, PLoS One, 7, 10.1371/journal.pone.0030733
San-Miguel, 2014, Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial, Lancet Oncol., 15, 1195, 10.1016/S1470-2045(14)70440-1
Satoh, 2004, Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-gamma-induced HLA-DR expression in colorectal and gastric cancer cells, Oncogene, 23, 8876, 10.1038/sj.onc.1208144
Sawan, 2010, Histone modifications and cancer, Adv. Genet., 70, 57, 10.1016/B978-0-12-380866-0.60003-4
Schoumacher, 2016, Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status, Nat. Med., 22, 577, 10.1038/nm.4098
Schreiber, 2002, Signaling network model of chromatin, Cell, 111, 771, 10.1016/S0092-8674(02)01196-0
Schwanhäusser, 2011, Global quantification of mammalian gene expression control, Nature, 473, 337, 10.1038/nature10098
Shang, 2019, The novel roles of circRNAs in human cancer, Mol. Cancer, 18, 1, 10.1186/s12943-018-0934-6
Shi, 2020, Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation, Mol. Cancer, 19, 1, 10.1186/s12943-020-01194-6
Shi, 2020, Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation, Mol. Cancer, 19, 78, 10.1186/s12943-020-01194-6
Shi, 2017, Chidamide in relapsed or refractory peripheral T cell lymphoma: a multicenter real-world study in China, J. Hematol. Oncol., 10, 69, 10.1186/s13045-017-0439-6
Shields, 2017, Personalized prognosis of uveal melanoma based on cytogenetic profile in 1059 patients over an 8-year period: the 2017 harry S. Gradle lecture, Ophthalmology, 124, 1523, 10.1016/j.ophtha.2017.04.003
Shilatifard, 2012, The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis, Annu. Rev. Biochem., 81, 65, 10.1146/annurev-biochem-051710-134100
Shimada, 2012, ALKBH3 contributes to survival and angiogenesis of human urothelial carcinoma cells through NADPH oxidase and tweak/Fn14/VEGF signals, Clin. Cancer Res., 18, 5247, 10.1158/1078-0432.CCR-12-0955
Shintani, 2004, Autophagy in health and disease: a double-edged sword, Science, 306, 990, 10.1126/science.1099993
Silverman, 2002, Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B, J. Clin. Oncol., 20, 2429, 10.1200/JCO.2002.04.117
Singh, 2010, Nonhistone protein acetylation as cancer therapy targets, Expet Rev. Anticancer Ther., 10, 935, 10.1586/era.10.62
Singh, 2018, Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors, Proc. Natl. Acad. Sci. U. S. A., 115, E9391, 10.1073/pnas.1808903115
Smit, 2019, Aberrant MicroRNA expression and its implications for uveal melanoma metastasis, Cancers, 11, 10.3390/cancers11060815
Smit, 2020, Uveal melanoma: towards a molecular understanding, Prog. Retin. Eye Res., 75, 10.1016/j.preteyeres.2019.100800
Sommer, 1976, The methylation of adenovirus-specific nuclear and cytoplasmic RNA, Nucleic Acids Res., 3, 749, 10.1093/nar/3.3.749
Souri, 2020, HDAC inhibition increases HLA class I expression in uveal melanoma, Cancers, 12, 10.3390/cancers12123690
Souri, 2021, Expression of HDACs 1, 3 and 8 is upregulated in the presence of infiltrating lymphocytes in uveal melanoma, Cancers, 13, 10.3390/cancers13164146
Souri, 2021, MiRNAs correlate with HLA expression in uveal melanoma: both up- and downregulation are related to monosomy 3, Cancers, 13, 10.3390/cancers13164020
Squires, 2012, Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA, Nucleic Acids Res., 40, 5023, 10.1093/nar/gks144
Stark, 2019, A panel of circulating MicroRNAs detects uveal melanoma with high precision, Transl. Vis. Sci. Technol., 8, 12, 10.1167/tvst.8.6.12
Stein-Streilein, 2002, Anterior chamber associated immune deviation (ACAID): regulation, biological relevance, and implications for therapy, Int. Rev. Immunol., 21, 123, 10.1080/08830180212066
Stein, 2019, Molecular remission and response patterns in patients with mutant-IDH2 acute myeloid leukemia treated with enasidenib, Blood, 133, 676, 10.1182/blood-2018-08-869008
Stirzaker, 1997, Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors, Cancer Res., 57, 2229
Stone, 2017, Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden, Proc. Natl. Acad. Sci. U. S. A., 114, E10981, 10.1073/pnas.1712514114
Strub, 2021, Translation of single-cell transcriptomic analysis of uveal melanomas to clinical oncology, Prog. Retin. Eye Res., 10.1016/j.preteyeres.2021.100968
Stuart, 1997, CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival, J. Clin. Invest., 99, 396, 10.1172/JCI119173
Subramanian, 2015, Blocking the maturation of OncomiRNAs using pri-miRNA-17 approximately 92 aptamer in retinoblastoma, Nucleic Acid Therapeut., 25, 47, 10.1089/nat.2014.0507
Sun, 2020, Biomarkers in retinoblastoma, Int. J. Ophthalmol., 13, 325, 10.18240/ijo.2020.02.18
Sun, 2016, Long noncoding RNA MALAT1 promotes uveal melanoma cell growth and invasion by silencing of miR-140, Am. J. Transl. Res., 8, 3939
Taby, 2010, Cancer epigenetics, Ca - Cancer J. Clin., 60, 376, 10.3322/caac.20085
Takayama, 2007, Identification of novel androgen response genes in prostate cancer cells by coupling chromatin immunoprecipitation and genomic microarray analysis, Oncogene, 26, 4453, 10.1038/sj.onc.1210229
Tang, 2015, NSun2 delays replicative senescence by repressing p27 (KIP1) translation and elevating CDK1 translation, Aging, 7, 1143, 10.18632/aging.100860
Tang, 2021, lncRNA GAU1 induces GALNT8 overexpression and potentiates colorectal cancer progression, Gastroenterol. Res. Pract., 2021, 10.1155/2021/5960821
Taylor, 2007, Ocular immunosuppressive microenvironment, Chem. Immunol. Allergy, 92, 71, 10.1159/000099255
Terui, 2003, Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors, Cancer Res., 63, 8948
Thill, 2011, Expression of CD133 and other putative stem cell markers in uveal melanoma, Melanoma Res., 21, 405, 10.1097/CMR.0b013e328348db10
Thottassery, 2014, Novel DNA methyltransferase-1 (DNMT1) depleting anticancer nucleosides, 4'-thio-2'-deoxycytidine and 5-aza-4'-thio-2'-deoxycytidine, Cancer Chemother. Pharmacol., 74, 291, 10.1007/s00280-014-2503-z
Tian, 2020, Identification of microRNA-mRNA regulatory networks and pathways related to retinoblastoma across human and mouse, Int. J. Ophthalmol., 13, 535, 10.18240/ijo.2020.04.02
To, 2012, Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development, BMC Cancer, 12, 69, 10.1186/1471-2407-12-69
Tommasi, 2005, Tumor susceptibility of Rassf1a knockout mice, Cancer Res., 65, 92, 10.1158/0008-5472.92.65.1
Topper, 2017, Epigenetic therapy ties MYC depletion to reversing immune evasion and treating lung cancer, Cell, 171, 1284, 10.1016/j.cell.2017.10.022
Topper, 2020, The emerging role of epigenetic therapeutics in immuno-oncology, Nat. Rev. Clin. Oncol., 17, 75, 10.1038/s41571-019-0266-5
Tosi, 2005, Genetic and epigenetic alterations of RB2/p130 tumor suppressor gene in human sporadic retinoblastoma: implications for pathogenesis and therapeutic approach, Oncogene, 24, 5827, 10.1038/sj.onc.1208630
Triozzi, 2016, Association of tumor and plasma microRNA expression with tumor monosomy-3 in patients with uveal melanoma, Clin. Epigenet., 8, 80, 10.1186/s13148-016-0243-0
Truong, 2020, Chloroquine sensitizes GNAQ/11-mutated melanoma to MEK1/2 inhibition, Clin. Cancer Res., 26, 6374, 10.1158/1078-0432.CCR-20-1675
Tsai, 2010, Long noncoding RNA as modular scaffold of histone modification complexes, Science, 329, 689, 10.1126/science.1192002
Turcan, 2012, IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype, Nature, 483, 479, 10.1038/nature10866
Uchida, 2005, Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation, EMBO J., 24, 160, 10.1038/sj.emboj.7600486
van der Ent, 2014, Modeling of human uveal melanoma in zebrafish xenograft embryos, Invest. Ophthalmol. Vis. Sci., 55, 6612, 10.1167/iovs.14-15202
van der Velden, 2001, Promoter hypermethylation: a common cause of reduced p16(INK4a) expression in uveal melanoma, Cancer Res., 61, 5303
van der Velden, 2003, Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development, Int. J. Cancer, 106, 472, 10.1002/ijc.11262
van Poppelen, 2019, SRSF2 mutations in uveal melanoma: a preference for in-frame deletions?, Cancers, 11, 10.3390/cancers11081200
Van Raamsdonk, 2009, Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi, Nature, 457, 599, 10.1038/nature07586
Van Raamsdonk, 2010, Mutations in GNA11 in uveal melanoma, N. Engl. J. Med., 363, 2191, 10.1056/NEJMoa1000584
Vashishtha, 2020, Changes in microRNA expression associated with metastasis and survival in patients with uveal melanoma, Oncotarget, 11, 1435, 10.18632/oncotarget.27559
Venkatesan, 2016, Clinico-pathological association of delineated miRNAs in uveal melanoma with monosomy 3/disomy 3 chromosomal aberrations, PLoS One, 11, 10.1371/journal.pone.0146128
Venza, 2013, Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells, Pigment Cell Melanoma Res, 26, 193, 10.1111/pcmr.12049
Venza, 2014, Class I-specific histone deacetylase inhibitor MS-275 overrides TRAIL-resistance in melanoma cells by downregulating c-FLIP, Int. Immunopharm., 21, 439, 10.1016/j.intimp.2014.05.024
Venza, 2016, miR-92a-3p and MYCBP2 are involved in MS-275-induced and c-myc-mediated TRAIL-sensitivity in melanoma cells, Int. Immunopharm., 40, 235, 10.1016/j.intimp.2016.09.004
Venza, 2015, Epigenetic regulation of p14ARF and p16INK4A expression in cutaneous and uveal melanoma, Biochim. Biophys. Acta, 1849, 247, 10.1016/j.bbagrm.2014.12.004
Venza, 2017, DSS1 promoter hypomethylation and overexpression predict poor prognosis in melanoma and squamous cell carcinoma patients, Hum. Pathol., 60, 137, 10.1016/j.humpath.2016.10.018
Venza, 2016, DNA methylation-induced E-cadherin silencing is correlated with the clinicopathological features of melanoma, Oncol. Rep., 35, 2451, 10.3892/or.2016.4618
Venza, 2015, The overriding of TRAIL resistance by the histone deacetylase inhibitor MS-275 involves c-myc up-regulation in cutaneous, uveal, and mucosal melanoma, Int. Immunopharm., 28, 313, 10.1016/j.intimp.2015.06.024
Villegas, 2013, Retinoblastoma, Curr. Opin. Ophthalmol., 24, 581, 10.1097/ICU.0000000000000002
Vo, 2019, The landscape of circular RNA in cancer, Cell, 176, 869, 10.1016/j.cell.2018.12.021
Voelter, 2008, Infrequent promoter methylation of the MGMT gene in liver metastases from uveal melanoma, Int. J. Cancer, 123, 1215, 10.1002/ijc.23632
Volinia, 2006, A microRNA expression signature of human solid tumors defines cancer gene targets, Proc. Natl. Acad. Sci. Unit. States Am., 103, 2257, 10.1073/pnas.0510565103
Wang, 2014, An intragenic long noncoding RNA interacts epigenetically with the RUNX1 promoter and enhancer chromatin DNA in hematopoietic malignancies, Int. J. Cancer, 135, 2783, 10.1002/ijc.28922
Wang, 2018, Long noncoding RNA DANCR aggravates retinoblastoma through miR-34c and miR-613 by targeting MMP-9, J. Cell. Physiol., 233, 6986, 10.1002/jcp.26621
Wang, 2018, Epigenomics: technologies and applications, Circ. Res., 122, 1191, 10.1161/CIRCRESAHA.118.310998
Wang, 2008, miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130, Proc. Natl. Acad. Sci. U. S. A., 105, 2889, 10.1073/pnas.0800178105
Wang, 2019, PVT1 promotes cancer progression via MicroRNAs, Front. Oncol., 9, 609, 10.3389/fonc.2019.00609
Wang, 2017, In vitro and in vivo anti-uveal melanoma activity of JSL-1, a novel HDAC inhibitor, Cancer Lett., 400, 47, 10.1016/j.canlet.2017.04.028
Ward, 2010, The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate, Cancer Cell, 17, 225, 10.1016/j.ccr.2010.01.020
Ward, 2020, Association of IRF4 single-nucleotide polymorphism rs12203592 with melanoma-specific survival, Br. J. Dermatol., 183, 163, 10.1111/bjd.18881
Wei, 1975, Methylated nucleotides block 5′ terminus of HeLa cell messenger RNA, Cell, 4, 379, 10.1016/0092-8674(75)90158-0
Wen, 2016, Orchestrating epigenetic roles targeting ocular tumors, OncoTargets Ther., 9, 1001
Wilson, 2011, SWI/SNF nucleosome remodellers and cancer, Nat. Rev. Cancer, 11, 481, 10.1038/nrc3068
Woo, 2019, Human ALKBH3-induced m1A demethylation increases the CSF-1 mRNA stability in breast and ovarian cancer cells, Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 1862, 35, 10.1016/j.bbagrm.2018.10.008
Woo, 2019, Human ALKBH3-induced m(1)A demethylation increases the CSF-1 mRNA stability in breast and ovarian cancer cells, Biochim Biophys Acta Gene Regul Mech, 1862, 35, 10.1016/j.bbagrm.2018.10.008
Worley, 2008, Micro-RNAs associated with metastasis in uveal melanoma identified by multiplexed microarray profiling, Melanoma Res., 18, 184, 10.1097/CMR.0b013e3282feeac6
Wroblewska, 2020, The potential role of selected miRNA in uveal melanoma primary tumors as early biomarkers of disease progression, Genes, 11, 10.3390/genes11030271
Wu, 2011, Androgen receptor-driven chromatin looping in prostate cancer, Trends Endocrinol. Metabol., 22, 474, 10.1016/j.tem.2011.07.006
Wu, 2020, Long noncoding RNAs as potential biomarkers in retinoblastoma: a systematic review and meta-analysis, Cancer Cell Int., 20, 201, 10.1186/s12935-020-01281-0
Wu, 2019, Translation of yes-associated protein (YAP) was antagonized by its circular RNA via suppressing the assembly of the translation initiation machinery, Cell Death Differ., 26, 2758, 10.1038/s41418-019-0337-2
Wu, 2020, Suppression of long noncoding RNA MALAT1 inhibits the development of uveal melanoma via microRNA-608-mediated inhibition of HOXC4, Am. J. Physiol. Cell Physiol., 318, C903, 10.1152/ajpcell.00262.2019
Wu, 2020, lncRNA SNHG7 affects malignant tumor behaviors through downregulation of EZH2 in uveal melanoma cell lines, Oncol. Lett., 19, 1505
Xiang, 2014, Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus, Cell Res., 24, 513, 10.1038/cr.2014.35
Xin, 2019, Identification of a nine-miRNA signature for the prognosis of Uveal Melanoma, Exp. Eye Res., 180, 242, 10.1016/j.exer.2019.01.004
Xing, 2018, Downregulation of circular RNA hsa_circ_0001649 indicates poor prognosis for retinoblastoma and regulates cell proliferation and apoptosis via AKT/mTOR signaling pathway, Biomed. Pharmacother., 105, 326, 10.1016/j.biopha.2018.05.141
Xing, 2017, CANT1 lncRNA triggers efficient therapeutic efficacy by correcting aberrant lncing cascade in malignant uveal melanoma, Mol. Ther., 25, 1209, 10.1016/j.ymthe.2017.02.016
Xu, 2018, Genome-wide analysis of uveal melanoma metastasis-associated LncRNAs and their functional network, DNA Cell Biol., 37, 99, 10.1089/dna.2017.4015
Xu, 2017, High expression of lncRNA PVT1 independently predicts poor overall survival in patients with primary uveal melanoma, PLoS One, 12, 10.1371/journal.pone.0189675
Xu, 2016, ANRIL lncRNA triggers efficient therapeutic efficacy by reprogramming the aberrant INK4-hub in melanoma, Cancer Lett., 381, 41, 10.1016/j.canlet.2016.07.024
Xu, 2009, Retinoblastoma has properties of a cone precursor tumor and depends upon cone-specific MDM2 signaling, Cell, 137, 1018, 10.1016/j.cell.2009.03.051
Xu, 2014, Rb suppresses human cone-precursor-derived retinoblastoma tumours, Nature, 514, 385, 10.1038/nature13813
Xu, 2020, Epidemiological study of uveal melanoma from US surveillance, epidemiology, and end results program (2010-2015), J. Ophthalmol., 2020, 10.1155/2020/3614039
Xu, 2020, The role of the cancer testis antigen PRAME in tumorigenesis and immunotherapy in human cancer, Cell Prolif, 53, 10.1111/cpr.12770
Yan, 2009, MicroRNA-34a inhibits uveal melanoma cell proliferation and migration through downregulation of c-Met, Invest. Ophthalmol. Vis. Sci., 50, 1559, 10.1167/iovs.08-2681
Yang, 2021, Emerging roles of microRNAs and their implications in uveal melanoma, Cell. Mol. Life Sci., 78, 545, 10.1007/s00018-020-03612-w
Yang, 2011, The miRNA expression profile of the uveal melanoma, Sci. China Life Sci., 54, 351, 10.1007/s11427-011-4149-y
Yang, 2019, The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression, Mol. Cancer, 18, 4, 10.1186/s12943-018-0933-7
Yang, 2019, m(6)A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade, Nat. Commun., 10, 2782, 10.1038/s41467-019-10669-0
Yang, 2018, Novel circular RNA expression profile of uveal melanoma revealed by microarray, Chin. J. Cancer Res., 30, 656, 10.21147/j.issn.1000-9604.2018.06.10
Yang, 2017, 5-methylcytosine promotes mRNA export—NSUN2 as the methyltransferase and ALYREF as an m 5 C reader, Cell Res., 27, 606, 10.1038/cr.2017.55
Yang, 2015, miRNA signature identification of retinoblastoma and the correlations between differentially expressed miRNAs during retinoblastoma progression, Mol. Vis., 21, 1307
Yavuzyigitoglu, 2016, Uveal melanomas with SF3B1 mutations: a distinct subclass Associated with late-onset metastases, Ophthalmology, 123, 1118, 10.1016/j.ophtha.2016.01.023
Yoon, 2012, LincRNA-p21 suppresses target mRNA translation, Mol. Cell, 47, 648, 10.1016/j.molcel.2012.06.027
Youn, 2013, Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer, Nat. Immunol., 14, 211, 10.1038/ni.2526
Yu, 2020, A novel lncRNA-miRNA-mRNA competitive endogenous RNA network for uveal melanoma prognosis constructed by weighted gene co-expression network analysis, Life Sci., 260, 10.1016/j.lfs.2020.118409
Yu, 2021, Histone lactylation drives oncogenesis by facilitating m(6)A reader protein YTHDF2 expression in ocular melanoma, Genome Biol., 22, 85, 10.1186/s13059-021-02308-z
Yu, 2020, Histone deacetylase inhibitors differentially regulate c-Myc expression in retinoblastoma cells, Oncol. Lett., 19, 460
Yu, 2020, Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy, Nat. Commun., 11, 6297, 10.1038/s41467-020-20080-9
Zeng, 2021, The methylation level of TFAP2A is a potential diagnostic biomarker for retinoblastoma: an analytical validation study, PeerJ, 9, 10.7717/peerj.10830
Zeng, 2020, Bioinformatics analysis of multi-omics data identifying molecular biomarker candidates and epigenetically regulatory targets associated with retinoblastoma, Medicine (Baltim.), 99
Zhang, 2019, Metabolic regulation of gene expression by histone lactylation, Nature, 574, 575, 10.1038/s41586-019-1678-1
Zhang, 2013, Methylation of RASSF1A gene promoter is regulated by p53 and DAXX, Faseb. J., 27, 232, 10.1096/fj.12-215491
Zhang, 2020, m(6)A methyltransferase METTL3 promotes retinoblastoma progression via PI3K/AKT/mTOR pathway, J. Cell Mol. Med., 24, 12368, 10.1111/jcmm.15736
Zhang, 2012, A novel retinoblastoma therapy from genomic and epigenetic analyses, Nature, 481, 329, 10.1038/nature10733
Zhang, 2018, The miR-181 family promotes cell cycle by targeting CTDSPL, a phosphatase-like tumor suppressor in uveal melanoma, J. Exp. Clin. Cancer Res., 37, 15, 10.1186/s13046-018-0679-5
Zhang, 2019, MicroRNA-34 family: a potential tumor suppressor and therapeutic candidate in cancer, J. Exp. Clin. Cancer Res., 38, 53, 10.1186/s13046-019-1059-5
Zhang, 2021, A multi-omics study on cutaneous and uveal melanoma, Int. J. Ophthalmol., 14, 32, 10.18240/ijo.2021.01.05
Zhang, 2021, Novel molecular regulators of breast cancer stem cell plasticity and heterogeneity, Semin. Cancer Biol.
Zhang, 2020, Downregulation of MST4 underlies a novel inhibitory role of MicroRNA let-7a in the progression of retinoblastoma, Invest. Ophthalmol. Vis. Sci., 61, 28, 10.1167/iovs.61.6.28
Zhang, 2018, Analysis of the androgen receptor–regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression, Nat. Genet., 50, 814, 10.1038/s41588-018-0120-1
Zhang, 2014, Integrated analysis of DNA methylation and mRNA expression profiling reveals candidate genes associated with cisplatin resistance in non-small cell lung cancer, Epigenetics, 9, 896, 10.4161/epi.28601
Zhao, 2009, Identification of miRNAs associated with tumorigenesis of retinoblastoma by miRNA microarray analysis, Childs Nerv. Syst., 25, 13, 10.1007/s00381-008-0701-x
Zhao, 2019, m1A regulated genes modulate PI3K/AKT/mTOR and ErbB pathways in gastrointestinal cancer, Transl. Oncol., 12, 1323, 10.1016/j.tranon.2019.06.007
Zhao, 2019, m1A regulated genes modulate PI3K/AKT/mTOR and ErbB pathways in gastrointestinal cancer, Transl. Oncol., 12, 1323, 10.1016/j.tranon.2019.06.007
Zheng, 2013, ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility, Mol. Cell, 49, 18, 10.1016/j.molcel.2012.10.015
Zheng, 2016, Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs, Nat. Commun., 7, 1, 10.1038/ncomms11215
Zheng, 2017, Long non-coding RNA FTH1P3 facilitates uveal melanoma cell growth and invasion through miR-224-5p, PLoS One, 12, 10.1371/journal.pone.0184746
Zhou, 2021, Eye-preserving therapies for advanced retinoblastoma: a multicenter cohort of 1678 patients in China, Ophthalmology
Zhou, 2016, Oncogenic role of microRNA20a in human uveal melanoma, Mol. Med. Rep., 14, 1560, 10.3892/mmr.2016.5433
Zhou, 2016, Oncogenic role of microRNA-20a in human uveal melanoma, Mol. Med. Rep., 14, 1560, 10.3892/mmr.2016.5433
Zhou, 2016, Oncogenic role of microRNA-20a in human uveal melanoma, Mol. Med. Rep., 14, 1560, 10.3892/mmr.2016.5433
Zhou, 2019, Regulation of co-transcriptional pre-mRNA splicing by m6A through the low-complexity protein hnRNPG, Mol. Cell, 76, 70, 10.1016/j.molcel.2019.07.005
Zhou, 2015, Let-7b overexpression leads to increased radiosensitivity of uveal melanoma cells, Melanoma Res., 25, 119, 10.1097/CMR.0000000000000140
Zhu, 2001, DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors, Cancer Res., 61, 1327