Regulation of Plasma Substance P and Skin Mast Cells by Odorants
Journal of Cutaneous Medicine and Surgery: Incorporating Medical and Surgical Dermatology - Tập 7 - Trang 287-291 - 2003
Tóm tắt
Background: Mast cells stimulate inflammation and itch sensation in the skin by releasing various mediators when they are activated. Stress exacerbates some skin diseases. We have reported that inhalation of certain odorants modulates immune reactions in the skin. Objective: The possible usage of odorants in the regulation of skin inflammation and itch sensation was to be examined. Methods: Female volunteers were subjected to interview stress with or without odorant inhalation. Mice were immobilized while inhaling odorants. Toluidene blue-stained sections were analyzed for activated mast cells. Plasma substance P level was determined by enzyme-linked immunoassay. Results: Interview stress induced plasma substance P only in volunteers who did not inhale odorants containing 2% 1,3-dimethoxy-5-methyl benzene (DMMB). Immobilization stress induced mast cell activation in mice and the activation was blocked by exposure to DMMB. Conclusions: Stress causes mast cell activation via an increase in substance P. The effect of stress is suppressed by inhalation of DMMB.
Tài liệu tham khảo
T Hokfelt JO Kellerth G Nilsson et al. (1975) ArticleTitleSubstance P: Localization in the central nervous system and in some primary sensory neurons. Science 190 889–890 Occurrence Handle242075
B Pernow P Substance (1983) ArticleTitle. Pharmacol Rev 35 85–141 Occurrence Handle1:CAS:528:DyaL2cXnsVE%3D Occurrence Handle6196797
O Hagermark T Hokfelt B Pernow (1978) ArticleTitleFlare and itch induced by substance P in human Skin. J Invest Dermatol 8 233–235
RC Benyon MA Lowman MK Church (1987) ArticleTitleHuman skin mast cells: Their dispersion, purification, and secretory characterization. J Immunol 138 861–867 Occurrence Handle1:CAS:528:DyaL2sXhtFOqsbs%3D Occurrence Handle2433332
LK Singh P Xinzhu N Alexacos et al. (1999) ArticleTitleAcute immobilization stress triggers skin mast cell degranulation via corticotropin releasing hormone, neurotensin, and substance P: a link to neurogenic skin disorders. Brain Behav Immun 13 225–239 Occurrence Handle1:CAS:528:DyaK1MXlsFyitLY%3D
J Hosoi K Inoue K Shojik et al. (2002) ArticleTitleInhibition of stress-induced increase in plasma and salivary cortisol by odorant inhalation. The Autonomic Nervous System 39 260–264
T Tsuchiya I Horii (1996) ArticleTitleEpidermal cell proliferating activity assessed by proliferating cell nuclear antigen (PCNA) decreases following immobilization-induced stress in male Syrian hamsters. Psychoneuroendocrinology 21 111–117 Occurrence Handle10.1016/0306-4530(95)00002-X Occurrence Handle1:STN:280:BymB28%2FpsFE%3D Occurrence Handle8778899
T Tsuchiya I Horii (1995) ArticleTitleImmobilization-induced stress decreases lipogenesis in sebaceous gland as well as plasma testosterone levels in male Syrian hamsters. Psychoneuroendocrinology 20 221–230 Occurrence Handle10.1016/0306-4530(94)00055-F Occurrence Handle1:CAS:528:DyaK2MXivFSqsbk%3D Occurrence Handle7899540
M Denda T Tsuchiya J Hosoi et al. (1998) ArticleTitleImmobilization-induced and crowded environment-induced stress delay barrier recovery in mouse skin. Br J Dermatol 138 780–785 Occurrence Handle10.1046/j.1365-2133.1998.02213.x Occurrence Handle1:STN:280:DyaK1czjtFCguw%3D%3D Occurrence Handle9666822
M Altemus B Rao FS Dhabhar et al. (2001) ArticleTitleStress-induced changes in skin barrier function in healthy women. J Invest Dermatol 117 309–317 Occurrence Handle1:CAS:528:DC%2BD3MXmvVyjsLY%3D Occurrence Handle11511309
M Denda T Tsuchiya K Shoji et al. (2000) ArticleTitleOdorant inhalation affects skin barrier homeostasis in mice and humans. Br J Dermatol 142 1007–1010 Occurrence Handle10.1046/j.1365-2133.2000.03486.x Occurrence Handle1:STN:280:DC%2BD3c3mvFygsw%3D%3D Occurrence Handle10809863
J Hosoi M Tanida T Tsuchiya (2001) ArticleTitleMitigation of stress-induced suppression of contact hypersensitivity by odorant inhalation. Br J Dermatol 145 716–719 Occurrence Handle10.1046/j.1365-2133.2001.04409.x Occurrence Handle1:CAS:528:DC%2BD3MXpt1Srtbo%3D Occurrence Handle11736894
C Kirschbaum KM Pirke DH Hellhammer (1993) ArticleTitleThe –Trier Social Stress Test— a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 28 76–81 Occurrence Handle1:STN:280:ByuD2sjjt1A%3D Occurrence Handle8255414
T Scolzen CA Armstrong NW Bunnett et al. (1998) ArticleTitleNeuropeptides in the skin: interations between the neuroendocrine and the skin immune system. Exp Dermatol 7 81–96 Occurrence Handle1:CAS:528:DyaK1cXivVCjs7o%3D Occurrence Handle9583747
RC Benyon MA Lowman MK Church (1987) ArticleTitleHuman skin mast cells: Their dispersion, purification, and secretory characterization. J Immunol 138 861–867 Occurrence Handle1:CAS:528:DyaL2sXhtFOqsbs%3D Occurrence Handle2433332
Joichi A, Yomogida K, Nakamura S, et al. The scent of roses: tea scented modern roses and ancient Chinese roses. In: Proceedings of the 20th International Federation of the societies of Cosmetic Chemists, September 1998: Societe Francaise de Cosmetologie, France 83 [abstr].
T Okabe M Hide O Koro et al. (2001) ArticleTitleThe release of leukotrien B4 from human skin in response to substance P: evidence for the functional heterogeneity of human skin mast cells among individuals. Clin Exp Immunol 124 150–156 Occurrence Handle10.1046/j.1365-2249.2001.01486.x Occurrence Handle1:CAS:528:DC%2BD3MXktl2ktLs%3D Occurrence Handle11359454