Regulation and selectivity of leukocyte emigration

Gallatin, 1983, A cell-surface molecule involved in organ-specific homing of lymphocytes, Nature, 304, 30, 10.1038/304030a0

Tedder, 1989, Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1, 170, 123

Siegelman, 1989, Mouse lymph node homing receptor cDNA clone encodes a glycoprotein revealing tandem interaction domains, Science, 243, 1165, 10.1126/science.2646713

Lasky, 1989, Cloning of a lymphocyte homing receptor reveals a lectin domain, Cell, 56, 1045, 10.1016/0092-8674(89)90637-5

Smith, 1991, Chemotactic factors regulate lectin adhesion molecule 1 (LECAM-1)dependent neutrophil adhesion to cytokine-stimulated endothelial cells in vitro, J Clin Invest, 87, 609, 10.1172/JCI115037

Spertini, 1991, Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion and transmigration, J Immunol, 147, 2565, 10.4049/jimmunol.147.8.2565

Knol, 1994, Comparison of human eosinophil and neutrophil adhesion to endothelial cells under nonstatic conditions, J Immunol, 153, 2161, 10.4049/jimmunol.153.5.2161

Spertini, 1992, Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under non-static conditions, J Exp Med, 175, 1789, 10.1084/jem.175.6.1789

Bevilacqua, 1985, Interleukin-1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes and related leukocyte cell lines, J Clin Invest, 76, 2003, 10.1172/JCI112200

Bevilacqua, 1987, Identification of an inducible endothelial-leukocyte adhesion molecule, 84, 9238

Bevilacqua, 1989, Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins, Science, 243, 1160, 10.1126/science.2466335

Berg, 1991, The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1, J Exp Med, 174, 1461, 10.1084/jem.174.6.1461

Walcheck, 1993, Bovine γ/δ T cells bind E-selectin via a novel glycoprotein receptor: first characterization of a lymphocyte/E-selectin interaction in an animal model, J Exp Med, 178, 853, 10.1084/jem.178.3.853

Bochner, 1991, Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules, J Exp Med, 173, 1553, 10.1084/jem.173.6.1553

Weller, 1991, Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1, 88, 7430

Dobrina, 1991, Mechanisms of eosinophil adherence to cultured vascular endothelial cells, 88, 20

McEver, 1984, A monoclonal antibody to a membrane glycoprotein binds only to activated platelets, J Biol Chem, 259, 9799, 10.1016/S0021-9258(17)42770-0

Hsu-Lin, 1984, A platelet membrane protein expressed during platelet activation and secretion, J Biol Chem, 259, 9121, 10.1016/S0021-9258(17)47274-7

Lawrence, 1991, Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequesite for adhesion through integrins, Cell, 65, 859, 10.1016/0092-8674(91)90393-D

McEver, 1991, GMP-140: a receptor for neutrophils and monocytes on activated platelets and endothelium, J Cell Biochem, 45, 156, 10.1002/jcb.240450206

Symon, 1994, Eosinophil adhesion to nasal polyp endothelium is P-selectin-dependent, J Exp Med, 180, 371, 10.1084/jem.180.1.371

Moore, 1992, P-selectin (CD62) binds to subpopulations of human memory T lymphocytes and natural killer cells, Biochem Biophys Res Commun, 186, 173, 10.1016/S0006-291X(05)80790-9

Kunzendorf, 1993, T cells bind to the endothelial adhesion molecule GMP-140 (P-selectin), Transplantation, 56, 1213, 10.1097/00007890-199311000-00031

Damle, 1992, GMP-140 (P-selectin, CD62) binds to chronically stimulated but not resting CD4+ T lymphocytes and regulates their production of proinflammatory cytokines, Eur J Immunol, 22, 1789, 10.1002/eji.1830220718

Lowe, 1990, ELAM-1-dependent cell adhesion to vascular endothelium determined by a transfected human fucosyltransferase cDNA, Cell, 63, 475, 10.1016/0092-8674(90)90444-J

Phillips, 1990, ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex, Science, 250, 1130, 10.1126/science.1701274

Walz, 1990, Recognition by ELAM-1 of the sialyl-Le determinant on myeloid and tumor cells, Science, 250, 1132, 10.1126/science.1701275

Foxall, 1992, The three members of the selectin receptor family recognize a common carbohydrate epitope, the sialyl Lewisx oligosaccharide, J Cell Biol, 117, 895, 10.1083/jcb.117.4.895

Tyrrell, 1991, Structural requirements for the carbohydrate ligand of E-selectin, 88, 10372

Imai, 1993, Sulphation requirement for G1yCAM-1, an endothelial ligand for L-selectin, Nature, 361, 555, 10.1038/361555a0

Hemmerich, 1994, Sulfation-dependent recognition of high endothelial venules (HEV)-ligands by L-selectin and MECA 79, and adhesion-blocking monoclonal antibody, J Exp Med, 180, 2219, 10.1084/jem.180.6.2219

Hemmerich, 1994, Identification of the sulfated monosaccharides of GlyCAM-1, and endothelial-derived ligand for L-selectin, Biochemistry, 33, 4820, 10.1021/bi00182a010

Hemmerich, 1994, 6′-Sulfated sialyl Lewis x is a major capping group of G1yCAM-1, Biochemistry, 33, 4830, 10.1021/bi00182a011

Sako, 1993, Expression cloning of a functional glycoprotein ligand for P-selectin, Cell, 75, 1179, 10.1016/0092-8674(93)90327-M

Moore, 1994, The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, 0-linked poly-N-acetyllactosamine, J Biol Chem, 269, 23318, 10.1016/S0021-9258(17)31656-3

Lasky, 1992, An endothelial ligand for L-selectin is a novel mucin-like molecule, Cell, 69, 927, 10.1016/0092-8674(92)90612-G

Berg, 1993, L-selectin-mediated lymphocyte rolling on MAdCAM-1, Nature, 366, 695, 10.1038/366695a0

Baumhueter, 1993, Binding of L-selectin to the vascular sialomucin CD34, Science, 262, 436, 10.1126/science.7692600

Baumhueter, 1994, Global vascular expression of murine CD34, a sialomycin-like endothelial ligand for L-selectin, Blood, 84, 2554, 10.1182/blood.V84.8.2554.2554

Shimizu, 1993, Mucins in the mainstream, Nature, 366, 630, 10.1038/366630a0

Norgard-Sumnicht, 1993, Calcium-dependent heparin-like ligands for L-selectin in nonlymphoid endothelial cells, Science, 261, 480, 10.1126/science.7687382

Bargatze, 1994, Neutrophils roll on adherent neutrophils bound to cytokine-induced endothelial cells via L-selectin on the rolling cell, J Exp Med, 180, 1785, 10.1084/jem.180.5.1785

Kuijpers, 1992, CD66 nonspecific cross-reacting antigens are involved in neutrophil adherence to cytokine-activated endothelial cells, J Cell Biol, 118, 457, 10.1083/jcb.118.2.457

Kotovuori, 1993, The vascular Eselectin binds to the leukocyte integrins CD11/CD18, Glycobiology, 3, 131, 10.1093/glycob/3.2.131

Picker, 1991, The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140, Cell, 66, 921, 10.1016/0092-8674(91)90438-5

Kishimoto, 1991, Antibodies against human neutrophil LECAM-1 (LAM-1/Leu-8/DREG-56 antigen) and endothelial ELAM-1 inhibit a common CD18-independent adhesion pathway in vitro, Blood, 78, 805, 10.1182/blood.V78.3.805.805

Ley, 1993, L-selectin can mediate leukocyte rolling in untreated mesenteric venules in vivo independent of E- or P-selectin, Blood, 82, 1632, 10.1182/blood.V82.5.1632.1632

Lawrence, 1993, Neutrophils roll on E-selectin, J Immunol, 151, 6338, 10.4049/jimmunol.151.11.6338

Alon, 1994, Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow, J Cell Biol, 127, 1485, 10.1083/jcb.127.5.1485

Olofsson, 1994, E-selectin mediates leukocyte rolling in interleukin-1-treated rabbit mesentery venules, Blood, 84, 2749, 10.1182/blood.V84.8.2749.2749

Asako, 1994, Role of H1 receptors and P-selectin in histamine-induced leukocyte rolling and adhesion in postcapillary venules, J Clin Invest, 93, 1508, 10.1172/JCI117129

Ley, 1994, Histamine can induce leukocyte rolling in rat mesenteric venules, Am J Physiol, 267, H1017

Zimmerman, 1994, Thrombin receptor peptide-mediated leukocyte rolling in rat mesenteric venules: roles of P-selectin and sialyl Lewis X, Am J Physiol, 267, H1049

Nolte, 1994, Leukocyte rolling in venules of striated muscle and skin is mediated by P-selectin, not by L-selectin, Am J Physiol, 267, H1637

Ley, 1991, Lectin-like cell adhesion molecule 1 mediates leukocyte rolling in mesenteric venules in vivo, Blood, 77, 2553, 10.1182/blood.V77.12.2553.2553

Sriramarao, 1994, L-selectin and very late antigen-4 integrin promote eosinophil rolling at physiological shear rates in vivo, J Immunol, 153, 4238, 10.4049/jimmunol.153.9.4238

Luscinskas, 1994, Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of Lselectin, β1-integrins, and β2-integrins, J Cell Biol, 125, 1417, 10.1083/jcb.125.6.1417

Berger, 1984, Human neutrophils increase expression of C3bi as well as C3b receptors upon activation, J Clin Invest, 74, 1566, 10.1172/JCI111572

Schleiffenbaum, 1989, The cell surface glycoprotein Mac-1 (CD11b/CD18) mediates neutrophil adhesion and modulates degranulation independently of its quantitative cell surface expression, J Immunol, 142, 3537, 10.4049/jimmunol.142.10.3537

Schleiffenbaum, 1990, The TNF receptor and human neutrophil function: Deactivation and cross-deactivation of TNF-induced neutrophil responses by receptor down-regulation, J Clin Invest, 86, 184, 10.1172/JCI114683

Walker, 1993, Increased expression of CDllb and functional changes in eosinophils after migration across endothelial cell monolayers, J Immunol, 150, 4061, 10.4049/jimmunol.150.9.4061

Neeley, 1993, Selective regulation of expression of surface adhesion molecules Mac-1, L-selectin, and VLA-4 on human eosinophils and neutrophils, Am J Respir Cell Mol Biol, 8, 633, 10.1165/ajrcmb/8.6.633

Singer, 1989, Adhesomes: specific granules containing receptors for laminin, C3bi/ fibrinogen, fibronectin, and vitronectin in human polymorphnuclear leukocytes and monocytes, J Cell Biol, 109, 3169, 10.1083/jcb.109.6.3169

Griffin, 1990, Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes and their precursors, J Immunol, 145, 576, 10.4049/jimmunol.145.2.576

Tanaka, 1993, T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1β, Nature, 361, 79, 10.1038/361079a0

Zimmermann, 1990, Endothelial cell-associated platelet-activating factor: a novel mechanism for signaling intercellular adhesion, J Cell Biol, 110, 529, 10.1083/jcb.110.2.529

Huber, 1991, Regulation of transendothelial neutrophil migration by endogenous interleukin-8, Science, 254, 99, 10.1126/science.1718038

Lorant, 1991, Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a iuxtacrine system for adhesion and activation of neutrophils, J Cell Biol, 115, 223, 10.1083/jcb.115.1.223

Kuijpers, 1992, Neutrophil migration across monolayers of cytokine-prestimulated endothelial cells: a role for platelet-activating factor and IL-8, J Cell Biol, 117, 565, 10.1083/jcb.117.3.565

Lo, 1991, Endothelial-leukocyte adhesion molecule 1 stimulates the adhesive activity of leukocyte integrin CR3 (CDllb/CD18, Mac-1, αm/β2) on human neutrophils, J Exp Med, 173, 1493, 10.1084/jem.173.6.1493

Tanaka, 1992, CD31 expressed on distinctive T cell subsets is a preferential amplifier of β1 integrin-mediated adhesion, J Exp Med, 176, 245, 10.1084/jem.176.1.245

Hemler, 1990, VLA proteins in the integrin family: structures, functions, and their role on leukocytes, Annu Rev Immunol, 8, 365, 10.1146/annurev.iy.08.040190.002053

Smyth, 1993, Regulation of vascular integrins, Blood, 81, 2827, 10.1182/blood.V81.11.2827.2827

Springer, 1990, Adhesion receptors of the immune system, Nature, 346, 425, 10.1038/346425a0

Marlin, 1987, Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1), Cell, 51, 813, 10.1016/0092-8674(87)90104-8

Staunton, 1990, The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus, Cell, 61, 243, 10.1016/0092-8674(90)90805-O

Staunton, 1989, Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1, Nature, 339, 61, 10.1038/339061a0

Diamond, 1991, Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation, Cell, 65, 961, 10.1016/0092-8674(91)90548-D

Sligh, 1993, Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1, 90, 8529

Diamond, 1990, ICAM-1 (CD54): a counter-receptor for Mac-1 (CDllb/ CD18), J Cell Biol, 111, 3129, 10.1083/jcb.111.6.3129

Lo, 1989, Two leukocyte receptors (CD11a/CD18 and CDllb/CD18) mediate transient adhesion to endothelium by binding to different ligands, J Immunol, 143, 3325, 10.4049/jimmunol.143.10.3325

Altieri, 1988, Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogen, J Cell Biol, 107, 1893, 10.1083/jcb.107.5.1893

Arnaout, 1988, Relative contribution of the leukocyte molecules Mo1, LFA-1, and p150,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue- and stimulus-specific, J Cell Physiol, 137, 305, 10.1002/jcp.1041370214

Slacker, 1991, Leukocyte integrin p150/95 (CDllc/CD18) functions as an adhesion molecule binding to a counter-receptor on stimulated endothelium, J Immunol, 146, 648, 10.4049/jimmunol.146.2.648

Carlos, 1994, Leukocyte-endothelial adhesion molecules, Blood, 84, 2068, 10.1182/blood.V84.7.2068.2068

Elices, 1990, VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site, Cell, 60, 577, 10.1016/0092-8674(90)90661-W

Tiisala, 1993, Down-regulation of monocytic VLA-4 leads to a decreased adhesion to VCAM-1, FEBS, 332, 19, 10.1016/0014-5793(93)80473-8

Schleimer, 1992, IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium, 148, 1086

Walsh, 1991, Human eosinophil, but not neutrophil, adherence to IListimulated human umbilical vascular endothelial cells is α4β1 (very late antigen-4) dependent, J Immunol, 146, 3419, 10.4049/jimmunol.146.10.3419

Osborn, 1989, Direct expression cloning of vascular cell adhesion molecule 1, a cytokineinduced endothelial protein that binds to lymphocytes, Cell, 59, 1203, 10.1016/0092-8674(89)90775-7

Osborn, 1992, Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1, J Exp Med, 176, 99, 10.1084/jem.176.1.99

Todd, 1984, Subcellular localization of the large subunit of Mol(Mola; formerly gp 110) a surface glycoprotein associated with neutrophil adhesion, J Clin Invest, 74, 1280, 10.1172/JCI111538

Anderson, 1986, Contributions of the Mac-1 glycoprotein family to adherence-dependent granulocyte functions: structure-function assessments employing subunit-specific monoclonal antibodies, J Immunol, 137, 15, 10.4049/jimmunol.137.1.15

Vedder, 1988, Increased surface expression of CD11b/CD18 (Mac-1) is not required for stimulated neutrophil adherence to cultured endothelium, J Clin Invest, 81, 676, 10.1172/JCI113372

Buyon, 1988, Dissociation between increased surface expression of gp165/95 and homotypic neutrophil aggregation, J Immunol, 140, 3156, 10.4049/jimmunol.140.9.3156

Wright, 1984, Communication between receptors for different ligands on a single cell: ligation of fibronectin receptors induces a reversible alteration in the function of complement receptors on cultured human monocytes, J Cell Biol, 99, 336, 10.1083/jcb.99.1.336

Dustin, 1989, T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1, Nature, 341, 619, 10.1038/341619a0

Diamond, 1993, A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen, J Cell Biol, 120, 545, 10.1083/jcb.120.2.545

Chatila, 1989, Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules, J Cell Biol, 109, 3435, 10.1083/jcb.109.6.3435

Buyon, 1990, Constitutive and induced phosphorylation of the α- and β-chains of the CD 11/CD 18 leukocyte integrin family, 144, 191

Hibbs, 1991, The cytoplasmic domain of the integrin lymphocyte function-associated antigen 1 β subunit: sites required for binding to intercellular adhesion molecule 1 and the phorbol ester-stimulated phosphorylation site, J Exp Med, 174, 1227, 10.1084/jem.174.5.1227

Smyth, 1992, Fibrinogen binding to purified platelet glycoprotein IIb-IIIa (integrin αIIbβ3) is modulated by lipids, J Biol Chem, 267, 15568, 10.1016/S0021-9258(19)49574-4

de Chaffoy de Corcelles, 1989, The role of endogenously formed diacylglycerol in the propagation and termination of platelet activation, J Biol Chem, 264, 3274, 10.1016/S0021-9258(18)94063-9

Watson, 1988, The action of the protein kinase C inhibitor, staurosporin, on human platelets, Biochem J, 249, 345, 10.1042/bj2490345

Hermanowski-Vosatka, 1992, Integrin modulating factor-1: a lipid that alters the function of leukocyte integrins, Cell, 68, 341, 10.1016/0092-8674(92)90475-R

Ginsberg, 1992, Inside-out integrin signalling, Curr Opin Cell Biol, 4, 766, 10.1016/0955-0674(92)90099-X

Keizer, 1988, A monoclonal antibody (NKI-L16) directed against a unique epitope on the a-chain of human leukocyte function-associated antigen 1 induces homotypic cell-cell interactions, J Immunol, 140, 1393, 10.4049/jimmunol.140.5.1393

Hibbs, 1991, Regulation of adhesion to ICAM-1 by the cytoplasmic domain of LFA-1 integrin β subunit, Science, 251, 1611, 10.1126/science.1672776

Burn, 1988, Dynamic membrane-cytoskeletal interactions: Specific association of integrin and talin arises in vivo after phorbol ester treatment of peripheral blood lymphocytes, 85, 497

Pardi, 1992, Antigen-receptor complex stimulation triggers protein kinase C-dependent CD11a/CD18-cytoskeleton association in T lymphocytes, J Cell Biol, 116, 1211, 10.1083/jcb.116.5.1211

Pyszniak, 1994, Cell surface distribution of high-avidity LFA-1 detected by soluble ICAM-1-coated microspheres, J Immunol, 152, 5241, 10.4049/jimmunol.152.11.5241

Koopman, 1992, Induction of homotypic T cell adhesion by triggering of leukocyte function-associated antigen-1 a (CD11a): differential effects on resting and activated T cells, Eur J Immunol, 22, 1851, 10.1002/eji.1830220726

Haverstick, 1992, Lymphocyte adhesion can be regulated by cytoskeleton-associated, PMA-induced capping of surface receptors, Am J Physiol, 262, C916, 10.1152/ajpcell.1992.262.4.C916

Muller, 1993, PECAM-1 is required for transendothelial migration of leukocytes, J Exp Med, 178, 449, 10.1084/jem.178.2.449

Moser, 1992, Migration of primed human eosinophils across cytokine-activated endothelial cell monolayers, Blood, 79, 2937, 10.1182/blood.V79.11.2937.2937

Chuluyan, 1993, VLA-4 integrin can mediate CD11/CD18-independent transendothelial migration of human monocytes, J Clin Invest, 92, 2768, 10.1172/JCI116895

Carlos, 1991, Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells: endothelial-leukocyte adhesion molecule-i and vascular cell adhesion molecule-1, Blood, 77, 2266, 10.1182/blood.V77.10.2266.2266

Meerschaert, 1994, Monocytes use either CD11/CD18 or VLA-4 to migrate across human endothelium in vitro, J Immunol, 152, 1915, 10.4049/jimmunol.152.4.1915

Moser, 1994, Transendothelial migration of eosinophils: unanswered questions, Ann NY Acad Sci, 725, 156, 10.1111/j.1749-6632.1994.tb39798.x

Huang, 1993, Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells, J Cell Biol, 120, 1371, 10.1083/jcb.120.6.1371

Moser, 1989, Interleukin 1 and tumor necrosis factor stimulate human vascular endothelial cells to promote transendothelial neutrophil passage, J Clin Invest, 83, 444, 10.1172/JCI113903

Wright, 1986, Phorbol esters cause sequential activation and deactivation of complement receptors on polymorphonuclear leukocytes, J Immunol, 136, 1759, 10.4049/jimmunol.136.5.1759

Hughes, 1992, Recruitment of CD11b/CD18 to the neutrophil surface and adherence-dependent cell locomotion, J Clin Invest, 90, 1687, 10.1172/JCI116041

Majno, 1969, Endothelial contraction induced by histamine-type mediators, 42, 647

Garcia, 1986, Thrombin-induced increase in albumin permeability across the endothelium, J Cell Physiol, 128, 96, 10.1002/jcp.1041280115

Vaporciyan, 1993, Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo, Science, 262, 1580, 10.1126/science.8248808

Springer, 1984, Inherited deficiency of the Mac-1, LFA-1, p150,95 glycoprotein family and its molecular basis, J Exp Med, 160, 1901, 10.1084/jem.160.6.1901

Etzioni, 1992, Brief report: recurrent severe infections caused by a novel leukocyte adhesion deficiency, N Engl J Med, 327, 1789, 10.1056/NEJM199212173272505

Lawrence, 1990, Effect of venous shear stress on CD18-mediated neutrophil adhesion to cultured endothelium, Blood, 75, 227, 10.1182/blood.V75.1.227.227

Kansas, 1990, Expression of the CD11/CD18, leukocyte adhesion molecule 1, and CD 44 adhesion molecules during normal myeloid and erythroid differentiation in humans, Blood, 76, 2483, 10.1182/blood.V76.12.2483.2483

Miller, 1986, Regulated expression of the Mac-1, LFA-1, p150,95 glycoprotein family during leukocyte differentiation, J Immunol, 137, 2891, 10.4049/jimmunol.137.9.2891

Teixido, 1992, Role of β1 and β2 integrins in the adhesion of human CD34h stem cells to bone marrow stroma, J Clin Invest, 90, 358, 10.1172/JCI115870

Simmons, 1992, Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells, Blood, 80, 388, 10.1182/blood.V80.2.388.bloodjournal802388

Soligo, 1990, Expression of integrins in human bone marrow, Br J Haematol, 76, 323, 10.1111/j.1365-2141.1990.tb06363.x

Bhatia, 1994, Interferon-a restores normal adhesion of chronic myelogenous leukemia hematopoietic progenitors to bone marrow stroma by correcting impaired β 1 integrin receptor function, J Clin Invest, 94, 384, 10.1172/JCI117333

Doerschuk, 1990, CD18-dependent and -independent mechanisms of neutrophil emigration in the pulmonary and systemic microcirculation of rabbits, J Immunol, 144, 2327, 10.4049/jimmunol.144.6.2327

Hawkins, 1992, Leukocyte adhesion deficiency: clinical and post-mortem observations, Pediatr Pathol, 12, 119, 10.3109/15513819209023288

Burns, 1994, Quantitation of ICAM-1 expression in mouse lung during pneumonia, J Immunol, 153, 3189, 10.4049/jimmunol.153.7.3189

Fisher, 1991, Thrombin-mediated release of lipids from pulmonary artery endothelial cells promotes neutrophil adherence, Circ Res, 68, 930, 10.1161/01.RES.68.4.930

Streeter, 1988, A tissue-specific endothelial cell molecule involved in lymphocyte homing, Nature, 331, 41, 10.1038/331041a0

Hamann, 1994, Role of α4-integrins in lymphocyte homing to mucosal tissues in vivo, J Immunol, 152, 3282, 10.4049/jimmunol.152.7.3282

Hattori, 1989, Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140, J Biol Chem, 264, 7768, 10.1016/S0021-9258(18)83104-0

Cotran, 1986, Induction and detection of a human endothelial activation antigen in vivo, J Exp Med, 164, 661, 10.1084/jem.164.2.661

Pober, 1986, Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon, J Immunol, 137, 1893, 10.4049/jimmunol.137.6.1893

McEver, 1989, GMP-140, a platelet a-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palace bodies, J Clin Invest, 84, 92, 10.1172/JCI114175

Sanders, 1992, Molecular cloning and analysis of in vivo expression of murine P-selectin, Blood, 80, 795, 10.1182/blood.V80.3.795.795

Moser, 1992, IL-4 controls the selective endothelium-driven transmigration of eosinophils from allergic individuals, J Immunol, 149, 1432, 10.4049/jimmunol.149.4.1432

Spertini, 1991, Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin, Nature, 349, 691, 10.1038/349691a0

Moser, 1993, Interleukin-4 induces tissue eosinophilia in mice: correlation with its in vitro capacity to stimulate the endothelial cell-dependent selective transmigration of human eosinophils, J Lab Clin Med, 122, 567

Nagel, 1994, Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells, J Clin Invest, 94, 885, 10.1172/JCI117410

Coughlan, 1994, P-selectin and platelet-activating factor mediate initial endotoxin-induced neutropenia, J Exp Med, 179, 329, 10.1084/jem.179.1.329

Kishimoto, 1989, Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors, Science, 245, 1238, 10.1126/science.2551036

Kahn, 1994, Membrane proximal cleavage of L-selectin: Identification of the cleavage site and a 6-kD transmembrane peptide fragment of L-selectin, J Cell Biol, 125, 461, 10.1083/jcb.125.2.461

Jutila, 1989, Function and regulation of the neutrophil MEL-14 antigen in vivo: comparison with LFA-1 and MAC-1, J Immunol, 143, 3318, 10.4049/jimmunol.143.10.3318

Ley, 1993, Intravenous interleukin-8 inhibits granulocyte emigration from rabbit mesenteric venules without altering L selectin expression or leukocyte rolling, J Immunol, 151, 6347, 10.4049/jimmunol.151.11.6347

Green, 1994, The cytoplasmic domain of P-selectin contains a sorting determinant that mediates rapid degradation in lysosomes, J Cell Biol, 124, 435, 10.1083/jcb.124.4.435

Schleiffenbaum, 1992, Soluble L-selectin is present in human plasma at high levels and retains functional activity, J Cell Biol, 119, 229, 10.1083/jcb.119.1.229

Spertini, 1992, ELISA for quantification of L-selectin shed from leukocytes in vivo, J Immunol Methods, 156, 115, 10.1016/0022-1759(92)90017-N

Donnelly, 1994, Role of selectins in development of adult respiratory distress syndrome, Lancet, 344, 215, 10.1016/S0140-6736(94)92995-5

Brustein, 1992, Identification of a soluble form of a ligand for the lymphocyte homing receptor, J Exp Med, 176, 1415, 10.1084/jem.176.5.1415

Kikuta, 1994, Localization of ligands for L-selectin in mouse peripheral lymph node high endothelial cells by colloidal gold conjugates, Blood, 84, 3766, 10.1182/blood.V84.11.3766.bloodjournal84113766

Ishiwata, 1994, Alternatively spliced isoform of P-selectin is present in vivo as a soluble molecule, J Biol Chem, 269, 23708, 10.1016/S0021-9258(17)31573-9

Gearing, 1993, Circulating adhesion molecules in disease, Immunol Today, 14, 506, 10.1016/0167-5699(93)90267-O

Dunlop, 1992, Characterization of GMP-140 (P-selectin) as a circulating plasma protein, J Exp Med, 175, 1147, 10.1084/jem.175.4.1147

Gamble, 1990, Prevention of activated neutrophil adhesion to endothelium by soluble adhesion protein GMP 140, Science, 249, 414, 10.1126/science.1696029

Wong, 1991, Adhesion protein GMP140 inhibits superoxide anion release by human neutrophils, 88, 2397

Ushiyama, 1993, Structural and functional characterization of monomeric soluble P-selectin and comparison with membrane P-selectin, J Biol Chem, 268, 15229, 10.1016/S0021-9258(18)82460-7

Cooper, 1994, P-selectin interacts with a β2-integrin to enhance phagocytosis, J Immunol, 153, 3199, 10.4049/jimmunol.153.7.3199

Moy, 1993, Cloning of an inflammation-specific phosphatidyl inositol-linked form of murine vascular cell adhesion molecule-1, J Biol Chem, 268, 8835, 10.1016/S0021-9258(18)52949-5

Pigott, 1992, Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells, Biochem Biophys Res Common, 187, 584, 10.1016/0006-291X(92)91234-H

Rothlein, 1991, A form of circulating ICAM-1 in human serum, J Immunol, 147, 3788, 10.4049/jimmunol.147.11.3788

Newman, 1993, Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock, J Immunol, 150, 644, 10.4049/jimmunol.150.2.644

Lobb, 1991, Expression and functional characterization of a soluble form of endothelialleukocyte adhesion molecule 1, J Immunol, 147, 124, 10.4049/jimmunol.147.1.124

Carson, 1993, Serum ELAM-1 is increased in vasculitis, scleroderma, and systemic lupus erythematosus, J Rheumatol, 20, 809

Kim, 1994, Serum soluble E-selectin levels in Kawasaki disease, Scand J Rheumatol, 23, 283, 10.3109/03009749409103730

Sehmi, 1992, Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects, Blood, 79, 2952, 10.1182/blood.V79.11.2952.bloodjournal79112952

Ebisawa, 1994, Eosinophil transendothelial migration induced by cytokines. III. Effect of the chemokine RANTES, J Immunol, 153, 2153, 10.4049/jimmunol.153.5.2153

Schall, 1990, Selective attraction of monocytes and T-lymphocytes of the memory phenotype by cytokine RANTES, Nature, 347, 669, 10.1038/347669a0

Schleiffenbaum, 1990, A defect in chemotaxis from interleukin-2, N Engl J Med, 323, 682, 10.1056/NEJM199009063231014

Springer, 1994, Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm, Cell, 76, 301, 10.1016/0092-8674(94)90337-9

Walzog, 1994, Cross-linking of CD18 in human neutrophils induces an increase of intracellular free Ca2+, exocytosis of azurophilic granules, quantitative up-regulation of CD18, shedding of Lselectin, and actin polymerization, J Leukocyte Biol, 56, 625, 10.1002/jlb.56.5.625

Graham, 1993, Immune complex-stimulated neutrophil LTB4 production is dependent on β2 integrine, J Cell Biol, 120, 1509, 10.1083/jcb.120.6.1509

Yurochko, 1992, Integrins as a primary signal transduction molecule regulating monocyte immediate-early gene induction, 89, 9034

Akiyama, 1994, Transmembrane signal transduction by integrin cytoplasmic domains expressed in single-subunit chimeras, J Biol Chem, 269, 15961, 10.1016/S0021-9258(17)33955-8

Davis, 1990, Fibronectin promotes proliferation of naive and memory T cells by signalling through both the VLA-4 and VLA-5 integrin molecules, J Immunol, 145, 785, 10.4049/jimmunol.145.3.785

Fehr, 1979, Modulating influence of chemotactic factor-induced cell adhesiveness on granulocyte function, J Clin Invest, 64, 8, 10.1172/JCI109466

Waddell, 1994, Potentiation of the oxidative burst of human neutrophils, 269, 18485

Laudanna, 1994, Sulfatides trigger increase of cytosolic free calcium and enhanced expression of tumor necrosis factor-a and interleukin-8 mRNA in human neutrophils, 269, 4021

von Andrian, 1991, Two-step model of leukocyteendothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte β2 integrins in vivo, 88, 7538

Butcher, 1991, Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity, Cell, 67, 1033, 10.1016/0092-8674(91)90279-8

Gimbrone, 1989, Endothelial interleukin-8: a novel inhibitor of leukocyte-endothelial interactions, Science, 246, 1601, 10.1126/science.2688092

Moser, 1993, Chemotaxins inhibit neutrophil adherence to and transmigration across cytokine-activated endothelium: correlation to the expression of L-selectin, Eur J Immunol, 23, 1481, 10.1002/eji.1830230713

Luscinskas, 1992, The in vitro inhibitory effect of IL-8 and other chemoattractants on neutrophil-endothelial adhesive interactions, J Immunol, 149, 2163, 10.4049/jimmunol.149.6.2163

Smith, 1993, Leukocyte-endothelial interactions, Semin Hematol, 30, 45

Worthen, 1989, Mechanics of stimulated neutrophils: cell stiffening induces retention in capillaries, Science, 245, 183, 10.1126/science.2749255

Westlin, 1992, Interleukin-8 induces changes in human neutrophil actin conformation and distribution: relationship to inhibition of adhesion to cytokine-activated endotheium, J Leukocyte Biol, 52, 43, 10.1002/jlb.52.1.43

Dransfield, 1992, Interaction of leukocyte integrins with ligand is necessary but not sufficient for function, J Cell Biol, 116, 1527, 10.1083/jcb.116.6.1527

Dransfield, 1992, Divalent cation regulation of the function of the leukocyte integrin LFA-1, J Cell Biol, 116, 219, 10.1083/jcb.116.1.219

Wardlaw, 1994, Eosinophil adhesion in allergic inflammation, J Allergy Clin Immunol, 94, 1163, 10.1016/0091-6749(94)90327-1

Oppenheimer-Marks, 1991, Differential utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T lymphocytes, J Immunol, 147, 2913, 10.4049/jimmunol.147.9.2913

van Epps, 1989, Suppression of human lymphocyte chemotaxis and transendothelial migration by anti-LFA-1 antibody, J Immunol, 143, 3207, 10.4049/jimmunol.143.10.3207

Chan, 1993, VLA-4 integrin mediates lymphocyte migration on the inducible endothelial cell ligand VCAM-1 and the extracellular matrix ligand fibrobnectin, J Biol Chem, 268, 24655, 10.1016/S0021-9258(19)74516-5

Winn, 1993, CD18-independent neutrophil and mononuclear leukocyte emigration into the peritoneum of rabbits, J Clin Invest, 92, 1168, 10.1172/JCI116686

Fehr, 1985, Antiadhesive properties of biological surfaces are protective against stimulated granulocytes, J Clin Invest, 76, 535, 10.1172/JCI112003

Wright, 1986, Interferon--y depresses binding of ligand by C3b and C3bi receptors on cultured hunan monocytes, an effect reversed by fibronectin, J Exp Med, 163, 1245, 10.1084/jem.163.5.1245

Nathan, 1987, Neutrophil activation on biological surfaces, 80, 1550

Nathan, 1989, Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins, J Cell Biol, 109, 1341, 10.1083/jcb.109.3.1341

Miyamoto, 1995, Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function, Science, 267, 883, 10.1126/science.7846531

Carr, 1994, Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant, 91, 3652

Wilkinson, 1992, Identification of IL-8 as a locomotor attractant for activated human lymphocytes in mononuclear cell cultures with anti-CD3 or purified protein derivative of mycobacterium tuberculosis, J Immunol, 149, 2689, 10.4049/jimmunol.149.8.2689

Warringa, 1991, Modulation and induction of eosinophil chemotaxis by granulocyte-macrophage colony-stimulating factor and interleukin-3, Blood, 77, 2694, 10.1182/blood.V77.12.2694.2694

Schweizer, 1994, RANTES- and interleukin8-induced responses in normal human eosinophils: effects of priming with interleukin-5, Blood, 83, 3697, 10.1182/blood.V83.12.3697.3697

Groves, 1992, Effect of in vivo interleukin-1 on adhesion molecule expression in normal human skin, J Invest Dermatol, 98, 384, 10.1111/1523-1747.ep12499816

Barlow, 1994, Adhesion molecule expression and the inflammatory cell infiltrate in delayed pressure urticaria, Br J Dermatol, 131, 341, 10.1111/j.1365-2133.1994.tb08521.x

Bentley, 1993, Expression of endothelial and leukocyte adhesion molecules intercellular adhesion molecule-1, E-selectin, and vascular cell adhesion molecule-1 in the bronchial mucosa in steady-state and allergen-induced asthma, J Allergy Clin Immunol, 92, 857, 10.1016/0091-6749(93)90064-M

Silber, 1994, Recruitment of lymphocytes during cutaneous delayed hypersensitivity in nonhuman primates is dependent on E-selectin and vascular cell adhesion molecule 1, J Clin Invest, 93, 1554, 10.1172/JCI117134

Lewinsohn, 1987, Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes and other leukocytes, J Immunol, 138, 4313, 10.4049/jimmunol.138.12.4313

Smith, 1989, Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro, J Clin Invest, 83, 2008, 10.1172/JCI114111

Luscinskas, 1991, Cytokine-activated human endothelial monolayers support enhanced neutrophil transmigration via a mechanism involving both endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1, J Immunol, 146, 1617, 10.4049/jimmunol.146.5.1617

Furie, 1991, Monoclonal antibodies to leukocyte integrins CD11a/CD18 and CD11b/ CD18 or intercellular adhesion molecule-1 inhibit chemoattractant-stimulated neutrophil transendothelial migration in vitro, Blood, 78, 2089, 10.1182/blood.V78.8.2089.2089

Issekutz, 1992, The contribution of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) to the in vivo migration of polymorphonuclear leukocytes to inflammatory reactions in the rat, Immunology, 76, 655

Harlan, 1985, The role of neutrophil membrane glycoprotein gp-150 in neutrophil adherence to endothelium in vitro, Blood, 66, 167, 10.1182/blood.V66.1.167.167

Arfors, 1987, A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma leackage in vivo, Blood, 69, 338, 10.1182/blood.V69.1.338.338

Walsh, 1990, IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leukocyte integrin (CD11/ CD18)-dependent manner, Immunology, 71, 258

Ebisawa, 1992, Eosinophil transendothelial migration induced by cytokines. I. Role of endothelial and eosinophil adhesion molecules in IL-1β-induced transendothelial migration, J Immunol, 149, 4021, 10.4049/jimmunol.149.12.4021

Nakajima, 1994, Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced cosinophil and T cell recruitment into the tissue, J Exp Med, 179, 1145, 10.1084/jem.179.4.1145

Abraham, 1994, α4-Integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep, J Clin Invest, 93, 776, 10.1172/JCI117032

Pizcueta, 1994, Monoclonal antibody blockade of L-selectin inhibits mononuclear leukocyte recruitment to inflammatory sites in vivo, Am J Pathol, 145, 461

Mentzer, 1987, Alpha and beta subunits of the LFA-1 membrane molecule are involved in human monocyte-endothelial cell adhesion, J Cell Physiol, 130, 410, 10.1002/jcp.1041300314

Keizer, 1987, Role of p150,95 in adhesion, migration, chemotaxis and phagocytosis of human monocytes, Eur J Immunol, 17, 1317, 10.1002/eji.1830170915

Hakkert, 1991, Neutrophil and monocyte adherence to and migration across monolayers of cytokine-activated endothelial cells: the contribution of CD18, ELAM-1, and VLA-4, Blood, 78, 2721, 10.1182/blood.V78.10.2721.2721

Mountz, 1988, Prevention of lymphadenopathy in MRL-lpr/lpr mice by blocking peripheral lymph node homing with Mel-14 in vivo, J Immunol, 140, 2943

Bradley, 1994, Entry of naive CD4 T cells into peripheral lymph nodes requires L-selectin, J Exp Med, 180, 2401, 10.1084/jem.180.6.2401

Haskard, 1986, T lymphocyte adhesion to endothelial cells: mechanisms demonstrated by anti-LFA-1 monoclonal antibodies, J Immunol, 137, 2901

Issekutz, 1992, Inhibition of lymphocyte endothelial adhesion and in vivo lymphocyte migration to cutaneous inflammation by TA-3, a new monoclonal antibody to rat LFA-1, J Immunol, 149, 3394

Oppenheimer-Marks, 1990, Human T Lymphocyte adhesion to endothelial cells and transendothelial migration, 145, 140

Schwartz, 1990, Identification of surface proteins mediating adherence of CD11/CD18-deficient lymphoblastoid cells to cultured human endothelium, J Clin Invest, 85, 2019, 10.1172/JCI114668

Kavanaugh, 1991, Role of CD11/CD18 in adhesion and transendothelial migration of T cells, 146, 4149

Issekutz, 1991, Inhibition of in vivo lymphocyte migration to inflammation and homing to lymphoid tissues by the TA-2 monoclonal antibody, 147, 4178

Smeets, 1993, Phosphorylation of surface E-selectin and the effect of soluble ligand (sialyl Lewisx) on the half life of E-selectin, Eur J Immunol, 23, 147, 10.1002/eji.1830230124

Kuijpers, 1994, Cytokineactivated endothelial cells internalize E-.selectin into a lysosomal compartment of vesiculotubular shape, 152, 5060

Toothill, 1990, Characterization of the enhanced adhesion of neutrophil leukocytes to thrombin-stimulated endothelial cells, J Immunol, 145, 283

Nojima, 1990, VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin, J Exp Med, 172, 1185, 10.1084/jem.172.4.1185

Nortamo, 1991, The expression of human intercellular adhesion molecule-2 is refractory to inflammatory cytokines, Eur J Immunol, 21, 2629, 10.1002/eji.1830211049

de Fougerolles, 1994, Characterization of the function of intercellular adhesion molecule (ICAM)-3 and comparison with ICAM-1 and ICAM-2 in immune responses, J Exp Med, 179, 619, 10.1084/jem.179.2.619

del Pozo, 1994, Regulation of ICAM-3 (CD50) membrane expression on human neutrophils through a proteolytic shedding mechanism, Eur J Immunol, 24, 2586, 10.1002/eji.1830241104

Simmons, 1990, Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen, J Exp Med, 171, 2147, 10.1084/jem.171.6.2147

Albelda, 1991, Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule, J Cell Biol, 114, 1059, 10.1083/jcb.114.5.1059

Mebius, 1993, Expression of G1yCAM-1, and endothelial ligand for L-selectin, is affected by afferent lympatic flow, J Immunol, 151, 6769

Dowbenko, 1993, Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) mucin is expressed by lactating mammary gland epthelial cells and is present in milk, J Clin Invest, 92, 952, 10.1172/JCI116671

Lee, 1994, Induction of vascular addressins and adhesion molecules in the pancreas of IFN-γ transgenic mice, J Immunol, 152, 4597