Reduced orbitofrontal cortical thickness in male adolescents with internet addiction

Behavioral and Brain Functions - 2013
Soon-Beom Hong1, Jae-Won Kim2, Eun‐Jung Choi3, Ho-Hyun Kim4, Jeong-Eun Suh5, Chang-Dai Kim6, Paul Klauser1, Sarah Whittle1, Murat Yücel1, Christos Pantelis1, Siyan Yi3
1Melbourne Neuropsychiatry Center, Department of Psychiatry, University of Melbourne and Melbourne Health, Parkville, Victoria, Australia
2Division of Child and Adolescent Psychiatry, Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Republic of Korea
3Department of Child Development and Family Studies, College of Human Ecology, Seoul National University, Seoul, Republic of Korea
4Interdisciplinary Program (Early Childhood Education Major), College of Education, Seoul National University, Seoul, Republic of Korea
5Center for Campus Life & Culture, Seoul National University, Seoul, Republic of Korea
6Department of Education (Educational Counseling Major), College of Education, Seoul National University, Seoul, Republic of Korea

Tóm tắt

Abstract Background The orbitofrontal cortex (OFC) has consistently been implicated in the pathology of both drug and behavioral addictions. However, no study to date has examined OFC thickness in internet addiction. In the current study, we investigated the existence of differences in cortical thickness of the OFC in adolescents with internet addiction. On the basis of recently proposed theoretical models of addiction, we predicted a reduction of thickness in the OFC of internet addicted individuals. Findings Participants were 15 male adolescents diagnosed as having internet addiction and 15 male healthy comparison subjects. Brain magnetic resonance images were acquired on a 3T MRI and group differences in cortical thickness were analyzed using FreeSurfer. Our results confirmed that male adolescents with internet addiction have significantly decreased cortical thickness in the right lateral OFC (p<0.05). Conclusion This finding supports the view that the OFC alterations in adolescents with internet addiction reflect a shared neurobiological marker of addiction-related disorders in general.

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