Reduced cognitive dysfunctions in rats when the temporal-entorhinal cortices and hippocampal region are denervated simultaneously
Tóm tắt
Transections of the fiber connections between the temporal cortex (TC) and the lateral entorhinal cortex (LEC) result in decreased ability to retain visual information, whereas transections of the hippocampal perforant path (PP) fibers cause decreased ability to acquire visual information. It was assumed that a combination of these two lesion types would mimic the pathology of some neurogenerative disorders and produce severe impairment in both acquiring and retaining new information. Surprisingly, TC/LEC + PP lesions did not cause any effects in a visual discrimination task, whereas separate TC/LEC or PP lesions affected behavior as described above (Experiment 1). In Experiment 2, a novelty test was employed to validate further the lack of effects seen to follow TC/LEC + PP lesions. Initially, an effect of TC/LEC + PP lesions appeared, but vanished as testing proceeded. Separate TC/LEC or PP lesions resulted in reduced preference for novelty throughout all test sessions. Experiment 3 was undertaken to highlight potential neurochemical mechanisms involved in the compensatory processes apparently initiated by the combined lesions. Relatively enhanced cholinergic activity in the hippocampus was found in TC/LEC + PP animals, whereas glutamatergic measures seemed to be unresponsive. The results are discussed in terms of possible compensatory mechanisms underlying the recovery of function seen in rats bearing TC/LEC + PP transections.
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