Redox‐ and pH‐Responsive Cysteamine‐Modified Poly(aspartic acid) Showing a Reversible Sol–Gel Transition

Macromolecular Bioscience - Tập 13 Số 5 - Trang 633-640 - 2013
Benjámin Gyarmati1, Balázs Vajna2, Árpád Némethy1, Krisztina László1, András Szilágyi1
1Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Budapest H-1111, Hungary.
2Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest H‐1111, Hungary

Tóm tắt

AbstractSynthesis and characterization of a pH‐ and redox‐sensitive hydrogel of poly(aspartic acid) are reported. Reversible gelation and dissolution are achieved both in dimethylformamide and in aqueous medium via a thiol‐disulphide interconversion in the side chain of the polymers. Structural changes are confirmed by Raman microscopy and rheological measurements. Injectable aqueous solutions of thiolated poly(aspartic acid) can be converted into mechanically stable gels by oxidation, which can be useful for drug encapsulation and targeted delivery. Reduction‐facilitated release of an entrapped drug from disulphide cross‐linked hydrogels is studied. magnified image

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