Recurrences, vaccinations and long‐term symptoms in GBS and CIDP

Journal of the Peripheral Nervous System - Tập 14 Số 4 - Trang 310-315 - 2009
Krista Kuitwaard1, Martine E. Bos‐Eyssen1, Patricia H. Blomkwist‐Markens2, Anneke J. van der Kooi1
1Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
2Vereniging Spierziekten Nederland (VSN), Baarn, The Netherlands

Tóm tắt

Abstract We determined the frequency of recurrent Guillain–Barré syndrome (GBS), whether vaccinations led to recurrences of GBS or an increase of disability in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and we assessed the prevalence of pain, fatigue and the impact on quality of life after GBS and CIDP. Additionally, we assessed the presence of common auto‐immune disorders. Four hundred and sixty‐one members of the Dutch society of neuromuscular disorders received a questionnaire. Two hundred and forty‐five GBS and seventy‐six CIDP patients were included (response rate 70%). Nine patients had a confirmed recurrent GBS, and two patients had experienced both GBS and CIDP. Common auto‐immune diseases were reported in 9% of GBS and 5% of CIDP patients. None of the 106 GBS patients who received a flu vaccination (range 1–37 times, total 775 vaccinations) reported a recurrence thereafter. Five out of twenty‐four CIDP patients who received a flu vaccination (range 1–17 times) reported an increase in symptoms. Pain or severe fatigue was reported in about 70% of patients after the diagnosis of GBS (median 10 years) or after onset of CIDP (median 6 years), and quality of life was significantly reduced. Flu vaccinations seem relatively safe. GBS and CIDP patients often experience pain, fatigue and a reduced quality of life for many years after the diagnosis.

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Tài liệu tham khảo

10.1016/S0895-4356(98)00097-3

Ad Hoc Subcommittee of the American Academy of Neurology AIDS Task Force, 1991, Research criteria for diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP). Report from an Ad Hoc Subcommittee of the American Academy of Neurology AIDS Task Force., Neurology, 41, 617, 10.1212/WNL.41.5.617

10.1002/ana.410270707

10.1016/j.jns.2006.12.012

10.1093/bja/aen103

10.1016/j.jaut.2007.05.002

10.1212/01.WNL.0000143055.09646.31

10.1093/brain/115.4.1093

Hughes RA, 1996, Immunization and risk of relapse of Guillain–Barré syndrome or chronic inflammatory demyelinating polyradiculoneuropathy, Muscle Nerve, 19, 1230

10.1016/S0140-6736(78)92644-2

10.1136/jnnp.2008.156463

10.1111/j.1529-8027.2009.00208.x

10.1212/WNL.59.1.84

10.1212/WNL.53.8.1648

10.1136/jnnp.73.3.348

10.1007/s00415-009-0018-z

10.1007/s00415-006-0515-2

10.1111/j.1529-8027.2008.00197.x

10.1093/aje/kwn310

Ware JE, 2007, User's Manual for the SF‐36v2 Health Survey. Quality Metric Inc, 53

Ware JE, 2005, SF‐36 Health Survey: Manual and Interpretation Guide, 6:5

Thông tin
Thông tin xuất bản

Journal of the Peripheral Nervous System

Tập 14 Số 4

310-315

Thông tin tác giả