Rectal carcinoma with synchronous liver metastases

Journal of Coloproctology - Tập 39 - Trang 365-372 - 2019
Jiele Li1, Laura Elisabete Ribeiro Barbosa2,3
1Universidade do Porto, Faculdade de Medicina, Mestrado Integrado em Medicina, Porto, Portugal
2Centro Hospitalar de São João, Serviço de Cirurgia Geral, Porto, Portugal
3Universidade do Porto, Faculdade de Medicina, Departamento de Cirurgia, Porto, Portugal

Tóm tắt

AbstractIntroduction Colorectal cancer is amongst the most prevailing malignancies in the world and it is associated with a relatively high mortality rate. Rectal cancer occurs in 20–30% of all colorectal cancer cases, and 25% of this present synchronous metastatic disease. This study aims to review the current treatment approaches for rectal cancer patients with synchronous liver metastases, as there are no specific guidelines for the management of this group of patients.Methods A systematic literature search was performed on Pubmed database with a 10 year timeline limitation from 2008 to 2018.Results Currently, the only potentially curative approach remains to be the surgical resection. Conventionally, the classical strategy of these patients involves resection of rectal tumor, followed by liver resection, with chemotherapy sessions between the two procedures. However, recent studies have reported no inferiority, in safety and survival outcomes, when compared with other approaches (liver-first resection or simultaneous resection), except when symptoms of primary tumor are present. Hence, treatment strategy should be individualized based on the assessment of metastatic extent, primary tumor symptoms and the patient's overall clinical status. Chemotherapy and targeted agents have substantially contributed to overall survival improvements, allowing enhanced tumor down staging.Conclusion Complete resection of liver metastases is considered the major condition for a potential survival outcome in these patients. Management of these patients should include a multidisciplinary team with consideration of each individual specificities. Prospective randomized trials are needed to elucidate the optimal treatment strategy.

Tài liệu tham khảo

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