Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis

Advances in Rheumatology - Tập 61 - Trang 1-13 - 2021
Karina Rossi Bonfiglioli1, Licia Maria Henrique da Mota2, Ana Cristina de Medeiros Ribeiro1, Adriana Maria Kakehasi3, Ieda Maria Magalhães Laurindo4, Rina Dalva Neubarth Giorgi5, Angela Luzia Branco Pinto Duarte6, Ana Paula Monteiro Gomides Reis2, Mariana Peixoto Guimarães Ubirajara e Silva de Souza7, Claiton Viegas Brenol8, Geraldo da Rocha Castelar Pinheiro9, Cleandro Pires de Albuquerque2, Charlles Heldan de Moura Castro10, Gustavo Luiz Behrens Pinto11, Jose Fernando Verztman12, Luciana Feitosa Muniz13, Manoel Barros Bertolo14, Maria Raquel da Costa Pinto3, Paulo Louzada Júnior15, Vitor Alves Cruz16, Ivanio Alves Pereira17, Max Vitor Carioca de Freitas18, Bóris Afonso Cruz19, Eduardo Paiva20, Odirlei Monticielo8, José Roberto Provenza21, Ricardo Machado Xavier8
1Disciplina Reumatologia do Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HC-FMUSP), São Paulo, Brasil
2Serviço de Reumatologia do Hospital, Universitário de Brasília (HUB/UnB), Brasília, Brazil
3Serviço de Reumatologia, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil
4Disciplina de Reumatologia, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil
5Serviço de Reumatologia, Hospital do Servidor Público Estadual de São Paulo (HSPE-IAMSPE), São Paulo, Brazil
6Universidade Federal de Pernambuco (UFPE), Recife, Brazil
7Santa Casa de Belo Horizonte (MG), Belo Horizonte, Brazil
8Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (HCPA/UFRGS), Porto Alegre, Brazil
9Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, Brazil
10Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo – Brazil
11Universidade Federal da Bahia (UFBA), Salvador, Brazil
12Hospital Federal dos Servidores do Estado do RJ, Rio de Janeiro, Brazil
13Hospital Regional de Sobradinho (DF), Brasília, Brazil
14Disciplina de Reumatologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, Brazil
15Disciplina de Reumatologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP-RP), Ribeirão Preto, Brazil
16Disciplina de Reumatologia, Faculdade de Medicina, Universidade Federal de Goiás, Goiânia, Brazil
17Serviço de Reumatologia do Hospital Universitário, Universidade Federal de Santa Catarina-UFSC, Florianópolis, Brazil
18Universidade de Fortaleza - UNIFOR, Fortaleza, Brazil
19Pulsus – Belo Horizonte (MG), Belo Horizonte, Brazil
20Disciplina de Reumatologia, Universidade Federal do Paraná (UFPR), Curitiba, Brazil
21Disciplina de Reumatologia da Pontificia, Universidade Católica de Campinas, Campinas, Brazil

Tóm tắt

Rheumatoid arthritis (RA) is a chronic and autoimmune systemic inflammatory disease that can cause irreversible joint deformities, with increased morbidity and mortality and a significant impact on the quality of life of the affected individual. The main objective of RA treatment is to achieve sustained clinical remission or low disease activity. However, up to 40% of patients do not respond to available treatments, including bDMARDs. New therapeutic targets for RA are emerging, such as Janus kinases (JAKs). These are essential for intracellular signaling (via JAK-STAT) in response to many cytokines involved in RA immunopathogenesis. JAK inhibitors (JAKi) have established themselves as a highly effective treatment, gaining increasing space in the therapeutic arsenal for the treatment of RA. The current recommendations aim to present a review of the main aspects related to the efficacy and safety of JAKis in RA patients, and to update the recommendations and treatment algorithm proposed by the Brazilian Society of Rheumatology in 2017.

Tài liệu tham khảo

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