Recommendations for the clinical and radiological evaluation of response to treatment in metastatic renal cell cancer

Springer Science and Business Media LLC - Tập 9 - Trang 9-24 - 2013
Luís León1,2, Roberto García-Figueras3, Cristina Suárez4, Antonia Arjonilla5, Javier Puente6, Blanca Vargas7, Maria José Méndez Vidal8, Carmen Sebastiá9
1Medical Oncology Department, Complejo Hospitalario Universitario de Santiago, A Coruña, Spain
2Medical Oncology Department, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain
3Radiology Department, Complejo Hospitalario Universitario de Santiago, A Coruña, Spain
4Medical Oncology Department, Hospital Universitari Vall d’Hebron, Barcelona, Spain
5Radiology Department, Hospital Universitario Rey Juan Carlos, Madrid, Spain
6Medical Oncology Department, Hospital Clínico San Carlos, Madrid, Spain
7Radiology Department, Hospital Universitario Virgen del Rocío, Sevilla, Spain
8Medical Oncology Department, Hospital Universitario Reina Sofía, Córdoba, Spain
9Radiology Department, Hospital Universitari Clinic, Barcelona, Spain

Tóm tắt

The evaluation of response to treatment is a critical step for determining the effectiveness of oncology drugs. Targeted therapies such as tyrosine kinase inhibitors and mammalian target of rapamycin inhibitors are active drugs in patients with metastatic renal cell carcinoma (mRCC). However, treatment with this type of drugs may not result in significant reductions in tumor size, so standard evaluation criteria based on tumor size, such as Response Evaluation Criteria in Solid Tumors (RECIST), may be inappropriate for evaluating response to treatment in patients with mRCC. In fact, targeted therapies apparently yield low response rates that do not reflect increased disease control they may cause and, consequently, the benefit in terms of time to progression. To improve the clinical and radiological evaluation of response to treatment in patients with mRCC treated with targeted drugs, a group of 32 experts in this field have reviewed different aspects related to this issue and have put together a series of recommendations with the intention of providing guidance to clinicians on this matter.

Tài liệu tham khảo

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