Recomendaciones del Grupo Español de Trabajo de Enfermedad de Crohn y Colitis Ulcerosa (GETECCU) sobre el uso de metotrexato en la enfermedad inflamatoria intestinal

Gastroenterología y Hepatología - Tập 38 Số 1 - Trang 24-30 - 2015
Fernando Gomollón1, S Rubio2, Mara Charro3, Santiago García‐López4, Fernándo Muñoz5, Javier P. Gisbert6, Eugeni Domènech7
1Servicio de Aparato Digestivo, Hospital Clínico Universitario Lozano Blesa, Zaragoza, IIS Aragón, España Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)
2Servicio de Aparato Digestivo, Hospital de Navarra, PamplonaEspaña
3Servicio de Aparato Digestivo, Hospital Royo Villanova. Zaragoza, España
4Servicio de Aparato Digestivo. Hospital Universitario Miguel Servet. Zaragoza. España
5Servicio de Aparato Digestivo. Hospital de León. León. España
6Servicio de Aparato Digestivo, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa (IP), Madrid España, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)
7Servicio de Aparato Digestivo, Hospital Germans Trías i Pujol, Badalona España, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)

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Chan, 2010, Methotrexate--how does it really work?, Nature reviews Rheumatology., 6, 175, 10.1038/nrrheum.2010.5

Chan, 2013, Mechanisms of action of methotrexate, Bulletin of the Hospital for Joint Disease., 71, S5

Choi, 2002, Methotrexate and mortality in patients with rheumatoid arthritis: a prospective study, Lancet., 359, 1173, 10.1016/S0140-6736(02)08213-2

Micha, 2011, Systematic review and meta-analysis of methotrexate use and risk of cardiovascular disease, Am J Cardiol., 108, 1362, 10.1016/j.amjcard.2011.06.054

Emery, 2008, Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial, Lancet., 372, 375, 10.1016/S0140-6736(08)61000-4

Ruderman, 2013, The role of concomitant methotrexate in biologic therapy for rheumatoid arthritis, Bulletin of the Hospital for Joint Disease., 71, S29

Kozarek, 1989, Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease, Ann Intern Med., 110, 353, 10.7326/0003-4819-110-5-353

Saibeni, 2012, The use of methotrexate for treatment of inflammatory bowel disease in clinical practice, Dig Liver Dis, 44, 123, 10.1016/j.dld.2011.09.015

Fraser, 2003, Methotrexate: first-line or second-line immunomodulator?, Eur J Gastroenterol Hepatol, 15, 225, 10.1097/00042737-200303000-00003

Miheller, 2013, Methotrexate: should we start using it in clinical practice?, Curr Durg Targets, 14, 1480, 10.2174/13894501113149990604

Van der Heijden, 2007, Drug insight: resistance to methotrexate and other disease-modifying antirheumatic drugs--from bench to bedside, Nat Clin Pract Rheumatol., 3, 26, 10.1038/ncprheum0380

Chan, 2006, Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma, Arthritis Rheum., 54, 2632, 10.1002/art.21974

Peng, 2008, Ecto-5’-nucleotidase (CD73)-mediated extracellular adenosine production plays a critical role in hepatic fibrosis, Nucleosides Nucleotides Nucleic Acids, 27, 821, 10.1080/15257770802146403

Chiang, 2013, Adenosine 2A receptor antagonist prevented and reversed liver fibrosis in a mouse model of ethanol-exacerbated liver fibrosis, PloS one., 8, e69114, 10.1371/journal.pone.0069114

Aslibekyan, 2014, Genetic variants associated with methotrexate efficacy and toxicity in early rheumatoid arthritis: results from the treatment of early aggressive rheumatoid arthritis trial, Pharmacogenomics J., 14, 48, 10.1038/tpj.2013.11

Cobb, 2014, Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases, Pharmacogenomics J., 14, 356, 10.1038/tpj.2014.3

Mena, 2011, Polymorphisms C677T and A1298C in the MTHFR gene in Mexican patients with rheumatoid arthritis treated with methotrexate: implication with elevation of transaminases, Pharmacogenomics J., 11, 287, 10.1038/tpj.2010.32

Mosli, 2014, Toward a personalized medicine approach to the management of inflammatory bowel disease, Am J Gastroenterol., 109, 994, 10.1038/ajg.2014.110

McDonald, 2012, Methotrexate for induction of remission in refractory Crohn's disease, Cochrane Database Syst Rev., 12, CD003459

McDonald, 2014, Methotrexate for induction of remission in refractory Crohn's disease, Cochrane Database Syst Rev., 8, CD003459

Feagan, 1995, Methotrexate for the treatment of Crohn's disease The North American Crohn's Study Group Investigators, N Eng J Med., 332, 292, 10.1056/NEJM199502023320503

Feagan, 2000, A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease North American Crohn's Study Group Investigators, N Engl J Med., 342, 1627, 10.1056/NEJM200006013422202

Patel, 2014, Methotrexate for maintenance of remission in Crohn's disease, Cochrane Database Syst Rev., 8, CD006884

Parker, 2010, Clinical experience of methotrexate in Crohn's disease: response, safety and monitoring of treatment, Postgrad Med J, 86, 208, 10.1136/pgmj.2009.085787

Gonzalez-Lama, 2012, Methotrexate in inflammatory bowel disease: a multicenter retrospective study focused on long-term efficacy and safety. The Madrid experience, Eur J Gastroenterol Hepatol, 24, 1086, 10.1097/MEG.0b013e3283556db5

Suares, 2012, Efficacy and tolerability of methotrexate therapy for refractory Crohn's disease: a large single-centre experience, Aliment Pharmacol Ther, 35, 284, 10.1111/j.1365-2036.2011.04925.x

Domenech, 2008, Long-term methotrexate for Crohn's disease: safety and efficacy in clinical practice, J Clin Gastroenterol., 42, 395, 10.1097/MCG.0b013e31802e6875

Seinen, 2013, Sustained clinical benefit and tolerability of methotrexate monotherapy after thiopurine therapy in patients with Crohn's disease Clinical gastroenterology and hepatology: the official clinical practice, Clin Gastroenterol Hepatol, 11, 667, 10.1016/j.cgh.2012.12.026

Mañosa, 2010, Does methotrexate induce mucosal healing in Crohn's disease?, Inflamm Bowel Dis., 16, 377, 10.1002/ibd.21015

Willot, 2011, Methotrexate in the treatment of inflammatory bowel disease: an 8-year retrospective study in a Canadian pediatric IBD center, Inflamm Bowel Dis., 17, 2521, 10.1002/ibd.21653

Weiss, 2009, Methotrexate treatment in pediatric Crohn disease patients intolerant or resistant to purine analogues, J Pediatr Gastroenterol Nutr., 48, 526, 10.1097/MPG.0b013e318196df3e

Boyle, 2010, A single-center experience with methotrexate after thiopurine therapy in pediatric Crohn disease, J Pediatr Gastroenterol Nutr., 51, 714, 10.1097/MPG.0b013e3181dd861a

Sunseri, 2014, Retrospective cohort study of methotrexate use in the treatment of pediatric Crohn's disease, Inflamm Bowel Dis., 20, 1341, 10.1097/MIB.0000000000000102

Oren, 1997, Methotrexate in chronic active Crohn's disease: a double-blind, randomized, Israeli multicenter trial, Am J Gastroenterol., 92, 2203

Arora, 1999, Methotrexate in Crohn's disease: results of a randomized, double-blind, placebo-controlled trial, Hepatogastroenterology, 46, 1724

Oren, 1996, Methotrexate in chronic active ulcerative colitis: a double-blind, randomized, Israeli multicenter trial, Gastroenterology., 110, 1416, 10.1053/gast.1996.v110.pm8613046

Mate-Jimenez, 2000, 6-mercaptopurine or methotrexate added to prednisone induces and maintains remission in steroid-dependent inflammatory bowel disease, Eur J Gastroenterol Hepatol, 12, 1227, 10.1097/00042737-200012110-00010

Cummings, 2005, Oral methotrexate in ulcerative colitis, Aliment Pharmacol Ther, 21, 385, 10.1111/j.1365-2036.2005.02331.x

Wahed, 2009, Efficacy of methotrexate in Crohn's disease and ulcerative colitis patients unresponsive or intolerant to azathioprine/mercaptopurine, Aliment Pharmacol Ther, 30, 614, 10.1111/j.1365-2036.2009.04073.x

Mañosa, 2011, Methotrexate in ulcerative colitis: a Spanish multicentric study on clinical use and efficacy, J Crohns Colitis, 5, 397, 10.1016/j.crohns.2011.03.012

Khan, 2013, Methotrexate in ulcerative colitis: a nationwide retrospective cohort from the Veterans Affairs Health Care System, Inflamm Bowel Dis., 19, 1379, 10.1097/MIB.0b013e31828133e8

Chande, 2014, Methotrexate for induction of remission in ulcerative colitis, Cochrane Database Syst Rev., 8, CD006618

Feagan, 2014, Methotrexate in combination with infliximab is no more effective than infliximab alone in patients with Crohn's disease, Gastroenterology., 146, 681, 10.1053/j.gastro.2013.11.024

Vermeire, 2007, Effectiveness of concomitant immunosuppressive therapy in suppressing the formation of antibodies to infliximab in Crohn's disease, Gut., 56, 1226, 10.1136/gut.2006.099978

Dassopoulos, 2013, American Gastroenterological Association Institute technical review on the use of thiopurines, methotrexate, and anti-TNF-alpha biologic drugs for the induction and maintenance of remission in inflammatory Crohn's disease, Gastroenterology., 145, 1464, 10.1053/j.gastro.2013.10.046

Sokol, 2010, Usefulness of co-treatment with immunomodulators in patients with inflammatory bowel disease treated with scheduled infliximab maintenance therapy, Gut., 59, 1363, 10.1136/gut.2010.212712

Laharie, 2011, Mucosal healing with methotrexate in Crohn's disease: a prospective comparative study with azathioprine and infliximab, Aliment Pharmacol Ther, 33, 714, 10.1111/j.1365-2036.2010.04569.x

Narula, 2014, Combination therapy with methotrexate in inflammatory bowel disease: time to COMMIT?, Gastroenterology., 146, 608, 10.1053/j.gastro.2014.01.040

Ardizzone, 2003, Comparison between methotrexate and azathioprine in the treatment of chronic active Crohn's disease: a randomised, investigator-blind study, Dig Liver Dis, 35, 619, 10.1016/S1590-8658(03)00372-4

Mahadevan, 2003, Fistula response to methotrexate in Crohn's disease: a case series, Aliment Pharmacol Ther, 18, 1003, 10.1046/j.1365-2036.2003.01790.x

Schroder, 2004, Combining infliximab and methotrexate in fistulizing Crohn's disease resistant or intolerant to azathioprine, Aliment Pharmacol Ther, 19, 295, 10.1111/j.1365-2036.2004.01850.x

Roumeguere, 2011, Combined approach with infliximab, surgery, and methotrexate in severe fistulizing anoperineal Crohn's disease: results from a prospective study, Inflamm Bowel Dis., 17, 69, 10.1002/ibd.21405

Chande, 2011, The safety and tolerability of methotrexate for treating patients with Crohn's disease, J Clin Gastroenterol., 45, 599, 10.1097/MCG.0b013e3181f593f9

Albrecht, 2010, Side effects and management of side effects of methotrexate in rheumatoid arthritis, Clin Exp Rheumatol, 28, S95

Salliot, 2009, Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research, Ann Rheum Dis, 68, 1100, 10.1136/ard.2008.093690

Conway, 2014, Methotrexate and lung disease in rheumatoid arthritis: a meta-analysis of randomized controlled trials, Arthritis Rheum., 66, 803, 10.1002/art.38322

D’Andrea, 2010, Methotrexate-induced pneumonitis in Crohn's disease Case report and review of the literature, Multidiscip Respir Med, 5, 312, 10.1186/2049-6958-5-5-312

Montaudie, 2011, Methotrexate in psoriasis: a systematic review of treatment modalities, incidence, risk factors and monitoring of liver toxicity, Journal of the European Academy of Dermatology and Venereology, JEADV, 25, 12

Maybury, 2014, Methotrexate and liver fibrosis in people with psoriasis: A systematic review of observational studies, Br J Dermatol.

Te, 2000, Hepatic effects of long-term methotrexate use in the treatment of inflammatory bowel disease, Am J Gastroenterol., 95, 3150, 10.1111/j.1572-0241.2000.03287.x

Dawwas, 2014, End-stage methotrexate-related liver disease is rare and associated with features of the metabolic syndrome, Aliment Pharmacol Ther, 10.1111/apt.12912

Khan, 2012, Incidence of liver toxicity in inflammatory bowel disease patients treated with methotrexate: a meta-analysis of clinical trials, Inflamm Bowel Dis., 18, 359, 10.1002/ibd.21820

Fournier, 2010, Changes in liver biochemistry during methotrexate use for inflammatory bowel disease, Am J Gastroenterol., 105, 1620, 10.1038/ajg.2010.21

Barbero-Villares, 2012, Evaluation of liver fibrosis by transient elastography (Fibroscan(R)) in patients with inflammatory bowel disease treated with methotrexate: a multicentric trial, Scand J Gastroenterol, 47, 575, 10.3109/00365521.2011.647412

Valentino, 2014, Hepatotoxicity caused by methotrexate therapy in children with inflammatory bowel disease: a systematic review and meta-analysis, Inflamm Bowel Dis., 20, 47, 10.1097/01.MIB.0000436953.88522.3e

Martinez Lopez, 2009, Systematic review on the safety of methotrexate in rheumatoid arthritis regarding the reproductive system (fertility, pregnancy, and breastfeeding), Clin Exp Rheumatol, 27, 678

Buchbinder, 2008, Incidence of melanoma and other malignancies among rheumatoid arthritis patients treated with methotrexate, Arthritis Rheum., 59, 794, 10.1002/art.23716

Krathen, 2010, Pharmacologic immunomodulation and cutaneous malignancy in rheumatoid arthritis, psoriasis, and psoriatic arthritis, J Rheumatol., 37, 2205, 10.3899/jrheum.100041

Beyaert, 2013, Cancer risk in immune-mediated inflammatory diseases (IMID), Mol Cancer, 12, 98, 10.1186/1476-4598-12-98

Beaugerie, 2012, Inflammatory bowel disease therapies and cancer risk: where are we and where are we going?, Gut., 61, 476, 10.1136/gutjnl-2011-301133

Dignass, 2012, Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 2: current management, J Crohns Colitis, 6, 991, 10.1016/j.crohns.2012.09.002

Dignass, 2010, The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management, J Crohns Colitis, 4, 28, 10.1016/j.crohns.2009.12.002

Ravikumara, 2007, Role of methotrexate in the management of Crohn disease, J Pediatr Gastroenterol Nutr., 44, 427, 10.1097/MPG.0b013e3180320689

Dulai, 2014, Systematic review: monotherapy with antitumour necrosis factor alpha agents versus combination therapy with an immunosuppressive for IBD, Gut., 10.1136/gutjnl-2014-307126

Ben-Horin, 2013, Addition of an immunomodulator to infliximab therapy eliminates antidrug antibodies in serum and restores clinical response of patients with inflammatory bowel disease, Clin Gastroenterol Hepatol, 11, 444, 10.1016/j.cgh.2012.10.020

Khan, 2012, Methotrexate: a detailed review on drug delivery and clinical aspects, Expert Opin Drug Deliv, 9, 151, 10.1517/17425247.2012.642362

Mouterde, 2011, Optimizing methotrexate therapy in rheumatoid arthritis: a systematic literature review, Joint Bone Spine, 78, 587, 10.1016/j.jbspin.2011.01.010

Yazici, 2013, Parenteral methotrexate for the treatment of rheumatoid arthritis, Bull Hosp Jt Dis, 71, 46

Wilson, 2013, Pharmacokinetic profiles for oral and subcutaneous methotrexate in patients with Crohn's disease, Aliment Pharmacol Ther, 37, 340, 10.1111/apt.12161

Stephens, 2005, The bioavailability of oral methotrexate in children with inflammatory bowel disease, J Pediatr Gastroenterol Nutr., 40, 445, 10.1097/01.MPG.0000157588.27125.50

Rahier, 2014, Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease, J Crohns Colitis, 8, 443, 10.1016/j.crohns.2013.12.013

Ortiz, 1998, The efficacy of folic acid and folinic acid in reducing methotrexate gastrointestinal toxicity in rheumatoid arthritis. A metaanalysis of randomized controlled trials, J Rheumatol., 25, 36

van Ede, 2001, Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis: a forty-eight week, multicenter, randomized, double-blind, placebo-controlled study, Arthritis Rheum, 44, 1515, 10.1002/1529-0131(200107)44:7<1515::AID-ART273>3.0.CO;2-7

Morgan, 2010, Folate supplementation during methotrexate therapy for rheumatoid arthritis, Clin Exp Rheumatol, 28, S102

Kempinska, 2011, Short-course ondansetron for the prevention of methotrexate-induced nausea in children with Crohn disease, J Pediatr Gastroenterol Nutr., 53, 389, 10.1097/MPG.0b013e31822855e7

Maybury, 2014, Diagnostic accuracy of noninvasive markers of liver fibrosis in patients with psoriasis taking methotrexate: a systematic review and meta-analysis, Br J Dermatol, 170, 1237, 10.1111/bjd.12905

Garrick, 2009, Successful implementation of a nurse-led teaching programme to independently administer subcutaneous methotrexate in the community setting to children with Crohn's disease, Aliment Pharmacol Ther, 29, 90, 10.1111/j.1365-2036.2008.03861.x