Recombinant fusion protein linking factor VIIa with albumin (rVIIa­FP): Tissue distribution in rats

Thrombosis Research - Tập 134 - Trang 495-502 - 2014
Eva Herzog1, Stephen Harris2, Andrew McEwen2, Claire Henson2, Ingo Pragst1, Gerhard Dickneite1, Stefan Schulte1, Sabine Zollner1
1CSL Behring GmbH, Preclinical Research and Development, Marburg, Germany
2Quotient Bioresearch Metabolic Chemistry, Rushden, UK

Tài liệu tham khảo

Wight, 2003, The epidemiology of inhibitors in haemophilia A: a systematic review, Haemophilia, 9, 418, 10.1046/j.1365-2516.2003.00780.x Ehrenforth, 1992, Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs, Lancet, 339, 594, 10.1016/0140-6736(92)90874-3 Erhardtsen, 2000, Pharmacokinetics of recombinant activated factor VII (VIIa), Semin Thromb Hemost, 26, 385, 10.1055/s-2000-8457 Weimer, 2008, Prolonged in-vivo half-life of factor VIIa by fusion to albumin, Thromb Haemost, 99, 659, 10.1160/TH07-08-0525 Schulte, 2012, Pioneering designs for recombinant coagulation factors, Thromb Res, 128, S9 Zollner, 2014, Pharmacological characteristics of a novel, recombinant fusion protein linking coagulation factor VIIa with albumin (rVIIa-FP), J Thromb Haemost, 12, 220, 10.1111/jth.12477 Golor, 2013, Safety and pharmacokinetics of a recombinant fusion protein linking coagulation factor VIIa with albumin (rVIIa-FP) in healthy volunteers, J Thromb Haemost, 11, 1977, 10.1111/jth.12409 Herzog, 2013, Biodistribution of rVIIa-FP, a recombinant fusion protein linking coagulation factor VIIa with albumin, in rats, Haemostaseologie, 33, P2 Müller, 1980, Protein labelling with 3H-NSP (N-succinimidyl-[2,3,-3H]propionate), J Cell Sci, 43, 319, 10.1242/jcs.43.1.319 Herzog, 2014, Biodistribution of the recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in rats, Thromb Res, 133, 900, 10.1016/j.thromres.2014.02.010 Ullberg, 1954, Studies on the distribution and fate of S35-labelled benzylpenicillin in the body, Acta Radiol Suppl, 118, 1 Caster, 1956, Tissue weights of the rat. I. Normal values determined by dissection and chemical methods, Exp Biol Med, 91, 122, 10.3181/00379727-91-22186 Beeby, 1993, Distribution of the recombinant coagulation factor 125I-rFVIIa in rats, Thromb Haemost, 70, 465, 10.1055/s-0038-1649606 Nakatomi, 2012, Pharmacokinetics, distribution, and excretion of 125I-labeled human plasma-derived-FVIIa and -FIX with MC710 (FVIIa/FX mixture) in rats, Thromb Res, 129, 62, 10.1016/j.thromres.2011.04.013 Gopalakrishnan, 2010, Bio-distribution of pharmacologically administered recombinant VIIa (rFVIIa), J Thromb Haemost, 8, 301, 10.1111/j.1538-7836.2009.03696.x Thomsen, 1993, Accumulation of the recombinant factor VIIa in rat bone: importance of the Gla-domain and relevance to factor IX, another vitamin K-dependent clotting factor, Pharmacol Toxicol, 73, 127, 10.1111/j.1600-0773.1993.tb01549.x Manco-Johnson, 2007, Prophylaxis versus episodic treatment to prevent joint disease in boys with severe haemophilia, N Engl J Med, 357, 535, 10.1056/NEJMoa067659 Zollner, 2014, Pharmacological characteristics of a novel, recombinant fusion protein linking coagulation factor VIIa with albumin (rVIIa-FP), J Thromb Haemost, 12, 220, 10.1111/jth.12477 Weimer, 2013, Recombinant albumin fusion proteins, 163 Holton, 1987, Biodistribution of monoclonal IgG1, F(ab′)2, and Fab′ in mice after intravenous injection. Comparison between anti-B cell (anti-Lyb8.2) and irrelevant (MOPC-21) antibodies, J Immunol, 139, 3041, 10.4049/jimmunol.139.9.3041 Schnitzer, 1993, High affinity binding, endocytosis, and degradation of conformationally modified albumins. Potential role of gp30 and gp18 as novel scavenger receptors, J Biol Chem, 268, 7562, 10.1016/S0021-9258(18)53212-9 Zollner, 2013, Pre­clinical safety and prolonged pharmacokinetic/pharmacodynamic (PK/PD) properties of a recombinant fusion protein linking activated coagulation factor VII with albumin (rVIIa-FP), J Thromb Haemost, 11, 480