Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression

Cell Stem Cell - Tập 22 - Trang 514-528.e5 - 2018
Xiuxing Wang1, Briana C. Prager1,2,3, Qiulian Wu1, Leo J.Y. Kim1,2, Ryan C. Gimple1,2, Yu Shi4, Kailin Yang3, Andrew R. Morton5, Wenchao Zhou6, Zhe Zhu1, Elisabeth Anne Adanma Obara7, Tyler E. Miller2, Anne Song3, Sisi Lai6, Christopher G. Hubert6, Xun Jin6, Zhi Huang6, Xiaoguang Fang6, Deobrat Dixit1, Weiwei Tao6
1Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, USA
2Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
3Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA
4Institute of Pathology and Southwest Cancer Center, Southwest Hospital, The Third Military Medical University, and The Key Laboratory of Tumor Immunopathology, The Ministry of Education of China, Chongqing, China
5Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA
6Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA
7Brain Tumor Biology, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen 2100, Denmark

Tài liệu tham khảo

Ahn, 2016, Glioma invasion mediated by the p75 neurotrophin receptor (p75(NTR)/CD271) requires regulated interaction with PDLIM1, Oncogene, 35, 1411, 10.1038/onc.2015.199 Alder, 2003, Brain-derived neurotrophic factor-induced gene expression reveals novel actions of VGF in hippocampal synaptic plasticity, J. Neurosci., 23, 10800, 10.1523/JNEUROSCI.23-34-10800.2003 Assimakopoulou, 2007, Neurotrophin receptors expression and JNK pathway activation in human astrocytomas, BMC Cancer, 7, 202, 10.1186/1471-2407-7-202 Auton, 2015, A global reference for human genetic variation, Nature, 526, 68, 10.1038/nature15393 Bao, 2006, Glioma stem cells promote radioresistance by preferential activation of the DNA damage response, Nature, 444, 756, 10.1038/nature05236 Bao, 2006, Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor, Cancer Res., 66, 7843, 10.1158/0008-5472.CAN-06-1010 Bergers, 2005, The role of pericytes in blood-vessel formation and maintenance, Neuro-oncol., 7, 452, 10.1215/S1152851705000232 Bernstein, 2010, The NIH Roadmap Epigenomics Mapping Consortium, Nat. Biotechnol., 28, 1045, 10.1038/nbt1010-1045 Bleau, 2009, PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells, Cell Stem Cell, 4, 226, 10.1016/j.stem.2009.01.007 Bonni, 1995, Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals, Mol. Cell Neurosci., 6, 168, 10.1006/mcne.1995.1015 Bowman, 2017, GlioVis data portal for visualization and analysis of brain tumor expression datasets, Neuro. Oncol., 19, 139, 10.1093/neuonc/now247 Brennan, 2013, The somatic genomic landscape of glioblastoma, Cell, 155, 462, 10.1016/j.cell.2013.09.034 Calabrese, 2007, A perivascular niche for brain tumor stem cells, Cancer Cell, 11, 69, 10.1016/j.ccr.2006.11.020 Chao, 2003, Neurotrophins and their receptors: a convergence point for many signalling pathways, Nat. Rev. Neurosci., 4, 299, 10.1038/nrn1078 Charles, 2010, Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells, Cell Stem Cell, 6, 141, 10.1016/j.stem.2010.01.001 Chen, 2012, A restricted cell population propagates glioblastoma growth after chemotherapy, Nature, 488, 522, 10.1038/nature11287 Cheng, 2013, Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth, Cell, 153, 139, 10.1016/j.cell.2013.02.021 Chopin, 2016, Neurotrophin signaling in cancer stem cells, Cell Mol. Life Sci., 73, 1859, 10.1007/s00018-016-2156-7 Cingolani, 2012, A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3, Fly (Austin), 6, 80, 10.4161/fly.19695 Davies, 1996, Paracrine and autocrine actions of neurotrophic factors, Neurochem. Res., 21, 749, 10.1007/BF02532296 DePristo, 2011, A framework for variation discovery and genotyping using next-generation DNA sequencing data, Nat. Genet., 43, 491, 10.1038/ng.806 Eyler, 2008, Brain cancer stem cells display preferential sensitivity to Akt inhibition, Stem Cells, 26, 3027, 10.1634/stemcells.2007-1073 Ferri, 2011, VGF: an inducible gene product, precursor of a diverse array of neuro-endocrine peptides and tissue-specific disease biomarkers, J. Chem. Neuroanat., 42, 249, 10.1016/j.jchemneu.2011.05.007 Flavahan, 2013, Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake, Nat. Neurosci., 16, 1373, 10.1038/nn.3510 Forsyth, 2014, p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells, J. Biol. Chem., 289, 8067, 10.1074/jbc.M113.513762 Gilbertson, 2007, Making a tumour’s bed: glioblastoma stem cells and the vascular niche, Nat. Rev. Cancer, 7, 733, 10.1038/nrc2246 Hu, 2009, ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays, J. Immunol. Methods, 347, 70, 10.1016/j.jim.2009.06.008 Hunsberger, 2007, Antidepressant actions of the exercise-regulated gene VGF, Nat. Med., 13, 1476, 10.1038/nm1669 Hwang, 2017, Expression of neuroendocrine factor VGF in lung cancer cells confers resistance to EGFR kinase inhibitors and triggers epithelial-to-mesenchymal transition, Cancer Res., 77, 3013, 10.1158/0008-5472.CAN-16-3168 Kim, 2004, Paracrine and autocrine functions of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in brain-derived endothelial cells, J. Biol. Chem., 279, 33538, 10.1074/jbc.M404115200 Kuilman, 2015, CopywriteR: DNA copy number detection from off-target sequence data, Genome Biol., 16, 49, 10.1186/s13059-015-0617-1 Lathia, 2010, Integrin alpha 6 regulates glioblastoma stem cells, Cell Stem Cell, 6, 421, 10.1016/j.stem.2010.02.018 Lathia, 2011, Deadly teamwork: neural cancer stem cells and the tumor microenvironment, Cell Stem Cell, 8, 482, 10.1016/j.stem.2011.04.013 Lathia, 2012, Laminin alpha 2 enables glioblastoma stem cell growth, Ann. Neurol., 72, 766, 10.1002/ana.23674 Lawn, 2015, Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells, J. Biol. Chem., 290, 3814, 10.1074/jbc.M114.599373 Lek, 2016, Analysis of protein-coding genetic variation in 60,706 humans, Nature, 536, 285, 10.1038/nature19057 Levi, 1985, Molecular cloning of a gene sequence regulated by nerve growth factor, Science, 229, 393, 10.1126/science.3839317 Levi, 2004, Processing, distribution, and function of VGF, a neuronal and endocrine peptide precursor, Cell. Mol. Neurobiol., 24, 517, 10.1023/B:CEMN.0000023627.79947.22 Lewis, 2015, Neuroendocrine role for VGF, Front. Endocrinol. (Lausanne), 6, 3, 10.3389/fendo.2015.00003 Li, 2010, Fast and accurate long-read alignment with Burrows-Wheeler transform, Bioinformatics, 26, 589, 10.1093/bioinformatics/btp698 Li, 2009, The Sequence Alignment/Map format and SAMtools, Bioinformatics, 25, 2078, 10.1093/bioinformatics/btp352 Liu, 2006, Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma, Mol. Cancer, 5, 67, 10.1186/1476-4598-5-67 Lorger, 2009, Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain, Proc. Natl. Acad. Sci. USA, 106, 10666, 10.1073/pnas.0903035106 Malberg, 2008, VGF, a new player in antidepressant action?, Sci. Signal., 1, pe19, 10.1126/stke.118pe19 Mani, 2008, The epithelial-mesenchymal transition generates cells with properties of stem cells, Cell, 133, 704, 10.1016/j.cell.2008.03.027 McKenna, 2010, The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data, Genome Res., 20, 1297, 10.1101/gr.107524.110 Ni, 2017, Tyrosine receptor kinase B is a drug target in astrocytomas, Neuro-oncol., 19, 22, 10.1093/neuonc/now139 Ostrom, 2016, American Brain Tumor Association adolescent and young adult primary brain and central nervous system tumors diagnosed in the United States in 2008-2012, Neuro-oncol., 18, i1, 10.1093/neuonc/nov297 Pastrana, 2011, Eyes wide open: a critical review of sphere-formation as an assay for stem cells, Cell Stem Cell, 8, 486, 10.1016/j.stem.2011.04.007 Piccirillo, 2006, Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells, Nature, 444, 761, 10.1038/nature05349 Ramirez, 2016, deepTools2: a next generation web server for deep-sequencing data analysis, Nucleic Acids Res., 44, W160, 10.1093/nar/gkw257 Reichardt, 2006, Neurotrophin-regulated signalling pathways, Philos. Trans. R. Soc. Lond. B Biol. Sci., 361, 1545, 10.1098/rstb.2006.1894 Reynolds, 1992, Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system, Science, 255, 1707, 10.1126/science.1553558 Samaras, 2007, Application of the ELISPOT method for comparative analysis of interleukin (IL)-6 and IL-10 secretion in peripheral blood of patients with astroglial tumors, Mol. Cell. Biochem., 304, 343, 10.1007/s11010-007-9517-3 Sarkar, 2014, Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells, Nat. Neurosci., 17, 46, 10.1038/nn.3597 Sato, 2011, Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts, Nature, 469, 415, 10.1038/nature09637 Sharma, 2016, Cancer stem cell-vascular endothelial cell interactions in glioblastoma, Biochem. Biophys. Res. Commun., 473, 688, 10.1016/j.bbrc.2015.12.022 Shi, 2015, Hostile takeover: glioma stem cells recruit TAMs to support tumor progression, Cell Stem Cell, 16, 219, 10.1016/j.stem.2015.02.008 Stupp, 2009, Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial, Lancet Oncol., 10, 459, 10.1016/S1470-2045(09)70025-7 Suvà, 2014, Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells, Cell, 157, 580, 10.1016/j.cell.2014.02.030 Van der Auwera, 2013, From FastQ data to high confidence variant calls: the Genome Analysis Toolkit best practices pipeline, Curr. Protoc. Bioinformatics, 43, 10.1002/0471250953.bi1110s43 Wadhwa, 2003, Expression of the neurotrophin receptors Trk A and Trk B in adult human astrocytoma and glioblastoma, J. Biosci., 28, 181, 10.1007/BF02706217 Wakimoto, 2009, Human glioblastoma-derived cancer stem cells: establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectors, Cancer Res., 69, 3472, 10.1158/0008-5472.CAN-08-3886 Wang, 2008, Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor, PLoS Biol., 6, e289, 10.1371/journal.pbio.0060289 Wang, 2017, MYC-regulated mevalonate metabolism maintains brain tumor-initiating cells, Cancer Res., 77, 4947, 10.1158/0008-5472.CAN-17-0114 Watson, 2009, Analysis of knockout mice suggests a role for VGF in the control of fat storage and energy expenditure, BMC Physiol., 9, 19, 10.1186/1472-6793-9-19 Wen, 2012, Current clinical development of PI3K pathway inhibitors in glioblastoma, Neuro-oncol., 14, 819, 10.1093/neuonc/nos117 Yamashita, 2016, Neurotrophin signaling endosomes: biogenesis, regulation, and functions, Curr. Opin. Neurobiol., 39, 139, 10.1016/j.conb.2016.06.004 Yan, 2014, Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy, Genes Dev., 28, 1085, 10.1101/gad.235515.113 Zhang, 2017, A pan-cancer proteogenomic atlas of PI3K/AKT/mTOR pathway alterations, Cancer Cell, 31, 820, 10.1016/j.ccell.2017.04.013 Zhou, 2009, Tumour-initiating cells: challenges and opportunities for anticancer drug discovery, Nat. Rev. Drug Discov., 8, 806, 10.1038/nrd2137 Zhou, 2015, Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth, Nat. Cell Biol., 17, 170, 10.1038/ncb3090 Zhu, 2011, Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells, Cancer Res., 71, 6061, 10.1158/0008-5472.CAN-10-4269