Recent progress on peripheral neural interface technology towards bioelectronic medicine

Springer Science and Business Media LLC - Tập 6 Số 1 - 2020
Youngjun Cho1, Jaeu Park1, Chengkuo Lee2, Sanghoon Lee1
1Daegu Geongbuk Institute of Science and Technology (DGIST), Daegu, 42899, Republic of Korea
2Electrical & Computer Engineering, National University of Singapore, Singapore, 117583, Singapore

Tóm tắt

AbstractModulation of the peripheral nervous system (PNS) has a great potential for therapeutic intervention as well as restore bodily functions. Recent interest has focused on autonomic nerves, as they regulate extensive functions implicated in organ physiology, chronic disease state and appear tractable to targeted modulation of discrete nerve units. Therapeutic interventions based on specific bioelectronic neuromodulation depend on reliable neural interface to stimulate and record autonomic nerves. Furthermore, the function of stimulation and recording requires energy which should be delivered to the interface. Due to the physiological and anatomical challenges of autonomic nerves, various forms of this active neural interface need to be developed to achieve next generation of neural interface for bioelectronic medicine. In this article, we present an overview of the state-of-the-art for peripheral neural interface technology in relation to autonomic nerves. Also, we reveal the current status of wireless neural interface for peripheral nerve applications. Recent studies of a novel concept of self-sustainable neural interface without battery and electronic components are presented. Finally, the recent results of non-invasive stimulation such as ultrasound and magnetic stimulation are covered and the perspective of the future research direction is provided.

Từ khóa


Tài liệu tham khảo

Anand S, Hotson J. Transcranial magnetic stimulation: neurophysiological applications and safety. Brain Cogn. 2002;50:366–86.

Bonaz B, Sinniger V, Hoffmann D, Clarençon D, Mathieu N, Dantzer C, et al. Chronic vagus nerve stimulation in Crohn’s disease: a 6-month follow-up pilot study. Neurogastroenterol Motil. 2016;28:948–53.

Brocker DT, Grill WM. Principles of electrical stimulation of neural tissue. 1st ed. Elsevier B.V.; 2013.

Caravaca AS, Tsaava T, Goldman L, Silverman H, Riggott G, Chavan SS, et al. A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve. J Neural Eng. IOP Publishing. 2017;14:066005.

Chew DJ, Zhu L, Delivopoulos E, Minev IR, Musick KM, Mosse CA, et al. A microchannel neuroprosthesis for bladder control after spinal cord injury in rat. Sci Transl Med. 2013;5:210ra155.

Cogan SF. Neural stimulation and recording electrodes. Annu Rev Biomed Eng. 2008;10:275–309.

Davids M, Guérin B, Malzacher M, Schad LR, Wald LL. Predicting magnetostimulation thresholds in the peripheral nervous system using realistic body models. Sci Rep. 2017;7:1–14.

de Lartigue G. Role of the vagus nerve in the development and treatment of diet-induced obesity. J Physiol. 2016;594:5791–815.

Dong B, Yang Y, Shi Q, Xu S, Sun Z, Zhu S, Zhang Z, Kwong DL, Zhou G, Ang KW, Lee C. Wearable triboelectric–human–machine Interface (THMI) using robust nanophotonic readout. ACS Nano. 2020;14:8915–30.

Downs ME, Lee SA, Yang G, Kim S, Wang Q, Konofagou EE. Non-invasive peripheral nerve stimulation via focused ultrasound in vivo. Phys Med Biol. 2018;63:35011.

Gillis WF, Lissandrello CA, Shen J, Pearre BW, Mertiri A, Deku F, et al. Carbon fiber on polyimide ultra-microelectrodes. J Neural Eng. IOP Publishing. 2018;15:016010.

González-González MA, Kanneganti A, Joshi-Imre A, Hernandez-Reynoso AG, Bendale G, Modi R, et al. Thin film multi-electrode softening cuffs for selective neuromodulation. Sci Rep. 2018;8:1–15.

Guo Q, Koo J, Xie Z, Avila R, Yu X, Ning X, et al. A bioresorbable magnetically coupled system for low-frequency wireless power transfer. Adv Funct Mater. 2019;29:1–8.

Gutruf P, Yin RT, Lee KB, Ausra J, Brennan JA, Qiao Y, et al. Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models. Nat Commun. 2019;10:5742.

Hameroff S, Trakas M, Duffield C, Annabi E, Gerace MB, Boyle P, et al. Transcranial ultrasound (TUS) effects on mental states: a pilot study. Brain Stimul. 2013;6:409–15.

He T, Wang H, Wang J, Tian X, Wen F, Shi Q, Ho JS, Lee C. Self-sustainable wearable textile nano-energy nano-system (NENS) for next-generation healthcare applications. Adv Sci. 2019;6:1901437.

Hinchet R, Yoon H-J, Ryu H, Kim M-K, Choi E-K, Kim D-S, et al. Transcutaneous ultrasound energy harvesting using capacitive triboelectric technology. Science (80- ). 2019;365:491–4.

Horvath JC, Mathews J, Demitrack MA, Pascual-Leone A. The NeuroStar TMS device: conducting the FDA approved protocol for treatment of depression. JoVE. 2010;(45):e2345.

Jiang T, Pang H, An J, Lu P, Feng Y, Liang X, et al. Robust swing-structured Triboelectric Nanogenerator for efficient blue energy harvesting. Adv Energy Mater. 2020;10:2000064.

Johnson BC, Shen K, Piech D, Ghanbari MM, Li KY, Neely R, et al. StimDust: A 6.5 mm 3, wireless ultrasonic peripheral nerve stimulator with 82% peak chip efficiency. In: 2018 IEEE Custom Integrated Circuits Conference (CICC). San Diego: IEEE; 2018. pp. 1–4.

Kagan ZB, RamRakhyani AK, Lazzi G, Normann RA, Warren DJ. In vivo magnetic stimulation of rat sciatic nerve with centimeter-and millimeter-scale solenoid coils. IEEE Trans Neural Syst Rehabil Eng. 2016;24:1138–47.

Koo J, MacEwan MR, Kang SK, Won SM, Stephen M, Gamble P, et al. Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy. Nat Med. 2018;24:1830–6. Available from: https://doi.org/10.1038/s41591-018-0196-2. Springer US.

Koopman FA, Chavan SS, Miljko S, Grazio S, Sokolovic S, Schuurman PR, et al. Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2016;113:8284–9.

Kubanek J. Neuromodulation with transcranial focused ultrasound. Neurosurg Focus. 2018;44:E14.

Lee S, Peh WYX, Wang J, Yang F, Ho JS, Thakor NV, et al. Toward bioelectronic medicine—Neuromodulation of small peripheral nerves using flexible neural clip. Adv Sci. 2017a;4:1700149.

Lee S, Sheshadri S, Xiang Z, Delgado-Martinez I, Xue N, Sun T, et al. Selective stimulation and neural recording on peripheral nerves using flexible split ring electrodes. Sensors Actuators B Chem. 2017b;242:1165–70.

Lee S, Wang H, Peh WYX, Thakor NV, Yen S-C, Lee C. Direct Stimulation of Bladder Pelvic Nerve using Battery-Free Neural Clip Interface. In: 2019 9th International IEEE/EMBS Conference on Neural Engineering (NER). San Francisco: IEEE; 2019. pp. 706-709.

Lee S, Wang H, Wang J, Shi Q, Yen S-C, Thakor NV, et al. Battery-free neuromodulator for peripheral nerve direct stimulation. Nano Energy. 2018a;50:148–58.

Lee S, Yen S-C, Sheshadri S, Delgado-Martinez I, Xue N, Xiang Z, et al. Flexible epineural strip electrode for recording in fine nerves. IEEE Trans Biomed Eng. 2015;63:581–7.

Lee SW, Fallegger F, Casse BDF, Fried SI. Implantable microcoils for intracortical magnetic stimulation. Sci Adv. 2016;2:e1600889.

Lee SW, Thyagarajan K, Fried SI. Micro-coil design influences the spatial extent of responses to intracortical magnetic stimulation. IEEE Trans Biomed Eng. 2018b;66:1680–94.

Lissandrello CA, Gillis WF, Shen J, Pearre BW, Vitale F, Pasquali M, et al. A micro-scale printable nanoclip for electrical stimulation and recording in small nerves. J Neural Eng. IOP Publishing. 2017;14:036006.

Liu L, Shi Q, Lee C. A novel hybridized blue energy harvester aiming at all-weather IoT applications. Nano Energy. 2020;76:105052.

Liu Z, Li H, Shi B, Fan Y, Wang ZL, Li Z. Wearable and implantable triboelectric nanogenerators. Adv Funct Mater. 2019;29:1808820.

McCallum GA, Sui X, Qiu C, Marmerstein J, Zheng Y, Eggers TE, et al. Chronic interfacing with the autonomic nervous system using carbon nanotube (CNT) yarn electrodes. Sci. Rep. 2017;7:1–14. Available from: https://doi.org/10.1038/s41598-017-10639-w. Springer US.

McGee MJ, Amundsen CL, Grill WM. Electrical stimulation for the treatment of lower urinary tract dysfunction after spinal cord injury. J Spinal Cord Med. 2015;38:135–46.

Meregnani J, Clarençon D, Vivier M, Peinnequin A, Mouret C, Sinniger V, et al. Anti-inflammatory effect of vagus nerve stimulation in a rat model of inflammatory bowel disease. Auton Neurosci Basic Clin. 2011;160:82–9.

Meyers EE, Kronemberger A, Lira V, Rahmouni K, Stauss HM. Contrasting effects of afferent and efferent vagal nerve stimulation on insulin secretion and blood glucose regulation. Physiol Rep. 2016;4:1–9.

O’Reardon JP, Cristancho P, Peshek AD. Vagus nerve stimulation (VNS) and treatment of depression: to the brainstem and beyond. Psychiatry (Edgmont). 2006;3:54–63.

Öberg PÅ. Magnetic stimulation of nerve tissue. Med Biol Eng. 1973;11:55–64.

Seo D, Neely RM, Shen K, Singhal U, Alon E, Rabaey JM, et al. wireless recording in the peripheral nervous system with ultrasonic neural dust. Neuron. 2016;91:529–39.

Shi Q, He T, Lee C. More than energy harvesting–combining triboelectric nanogenerator and flexible electronics technology for enabling novel micro−/nano-systems. Nano Energy. 2019;57:851–71.

Shon A, Chu JU, Jung J, Kim H, Youn I. An implantablewireless neural interface system for simultaneous recording and stimulation of peripheral nerve with a single cuff electrode. Sensors (Switzerland). 2018;18:1–26.

Tanabe Y, Ho JS, Liu J, Liao SY, Zhen Z, Hsu S, et al. High-performance wireless powering for peripheral nerve neuromodulation systems. PLoS One. 2017;12:1–13.

Wang H, Wang J, Thow XY, Lee S, Peh WY, Ng KA, He T, Thakor NV, Lee C. Unveiling stimulation secrets of electrical excitation of neural tissue using a circuit probability theory. Front Comput Neurosci. 2020c;14:50.

Wang H, Zhu J, He T, Zhang Z, Lee C. Programmed-triboelectric nanogenerators—a multi-switch regulation methodology for energy manipulation. Nano Energy. 2020a;14:105241.

Wang J, He T, Lee C. Development of neural interfaces and energy harvesters towards self-powered implantable systems for healthcare monitoring and rehabilitation purposes. Nano Energy. 2019b;65:104039.

Wang J, Wang H, He T, He B, Thakor NV, Lee C. Investigation of low-current direct stimulation for rehabilitation treatment related to muscle function loss using self-powered TENG system. Adv Sci. 2019a;6:1900149.

Wang Z, Yan J, Wang X, Yuan Y, Li X. Transcranial ultrasound stimulation directly influences the cortical excitability of the motor cortex in Parkinsonian mice. Mov Disord. 2020b;35:693–8.

Wen F, Sun Z, He T, Shi Q, Zhu M, Zhang Z, Li L, Zhang T, Lee C. Machine learning glove using self-powered conductive Superhydrophobic Triboelectric textile for gesture recognition in VR/AR applications. Adv Sci. 2020;7:2000261.

Wright CJ, Haqshenas SR, Rothwell J, Saffari N. Unmyelinated peripheral nerves can be stimulated in vitro using pulsed ultrasound. Ultrasound Med Biol. 2017;43:2269–83.

Xiang Z, Sheshadri S, Lee S, Wang J, Xue N, Thakor NV, et al. Mapping of small nerve trunks and branches using adaptive flexible electrodes. Adv Sci. 2016;3:1500386.

Yang KW, Oh K, Ha S. Challenges in scaling down of free-floating implantable neural interfaces to millimeter scale. IEEE Access. 2020;8:133295–320.

Yao G, Kang L, Li J, Long Y, Wei H, Ferreira CA, et al. Effective weight control via an implanted self-powered vagus nerve stimulation device. Nat Commun. 2018;9:1–10.

Zhang Y, Mickle AD, Gutruf P, McIlvried LA, Guo H, Wu Y, et al. Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves. Sci Adv. 2019;5:1–12.

Zhu J, Wang H, Zhang Z, Ren Z, Shi Q, Liu W, Lee C. Continuous direct current by charge transportation for next-generation IoT and real-time virtual reality applications. Nano Energy. 2020;73:104760.

Thông tin
Thông tin xuất bản

Springer Science and Business Media LLC

Tập 6 Số 1

Thông tin tác giả