Recent progress of autophagy signaling in tumor microenvironment and its targeting for possible cancer therapeutics
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Klionsky, 2008, Autophagy revisited: a conversation with Christian de Duve, Autophagy, 4, 740, 10.4161/auto.6398
Mejlvang, 2018, Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy, J. Cell Biol., 217, 3640, 10.1083/jcb.201711002
Akhtar, 2019, Paget’s “seed and soil” theory of cancer metastasis: an idea whose time has come, Adv. Anat. Pathol., 26, 69, 10.1097/PAP.0000000000000219
Pyonteck, 2013, CSF-1R inhibition alters macrophage polarization and blocks glioma progression, Nat. Med., 19, 1264, 10.1038/nm.3337
Quail, 2016, The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas, Science, 352, aad3018, 10.1126/science.aad3018
DeNardo, 2011, Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy, Cancer Discov., 1, 54, 10.1158/2159-8274.CD-10-0028
Lin, 2017, Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop, Oncotarget, 8, 110426, 10.18632/oncotarget.22786
Wang, 2009, Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway, Cancer Res., 69, 2400, 10.1158/0008-5472.CAN-08-4312
Li, 2018, Autophagy regulates chemoresistance of gastric cancer stem cells via the Notch signaling pathway, Eur. Rev. Med. Pharmacol. Sci., 22, 3402
Hwang, 2020, ULK1 inhibition as a targeted therapeutic strategy for FLT3-ITD-mutated acute myeloid leukemia, J. Exp. Clin. Cancer Res., 39, 85, 10.1186/s13046-020-01580-4
Mao, 2020, ULK1 phosphorylates Exo70 to suppress breast cancer metastasis, Nat. Commun., 11, 117, 10.1038/s41467-019-13923-7
Liu, 2019, Blocking AMPK/ULK1-dependent autophagy promoted apoptosis and suppressed colon cancer growth, Cancer Cell Int., 19, 336, 10.1186/s12935-019-1054-0
Mukhopadhyay, 2015, Autophagy protein Ulk1 promotes mitochondrial apoptosis through reactive oxygen species, Free Radic. Biol. Med., 89, 311, 10.1016/j.freeradbiomed.2015.07.159
Deng, 2021, ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer, Nat. Cancer, 2, 503, 10.1038/s43018-021-00208-6
Dower, 2018, Targeted inhibition of ULK1 promotes apoptosis and suppresses tumor growth and metastasis in neuroblastoma, Mol. Cancer Ther., 17, 2365, 10.1158/1535-7163.MCT-18-0176
Jiménez-Mora, 2021, V600EBRAF inhibition induces cytoprotective autophagy through AMPK in thyroid cancer cells, Int. J. Mol. Sci., 22, 6033, 10.3390/ijms22116033
Chen, 2016, Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model, Genes Dev., 30, 856, 10.1101/gad.276428.115
Russell, 2013, ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase, Nat. Cell Biol., 15, 741, 10.1038/ncb2757
Wu, 2019, Beclin1 inhibition enhances paclitaxel‑mediated cytotoxicity in breast cancer in vitro and in vivo, Int. J. Mol. Med., 43, 1866
Hamasaki, 2013, Autophagosomes form at ER-mitochondria contact sites, Nature, 495, 389, 10.1038/nature11910
Mukhopadhyay, 2017, ATG14 facilitated lipophagy in cancer cells induce ER stress mediated mitoptosis through a ROS dependent pathway, Free Radic. Biol. Med., 104, 199, 10.1016/j.freeradbiomed.2017.01.007
Ge, 2013, The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis, Elife, 2, e00947, 10.7554/eLife.00947
Wijshake, 2021, Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin, Proc. Natl. Acad. Sci. U. S. A., 118, 10.1073/pnas.2020478118
Fan, 2011, Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L), Proc. Natl. Acad. Sci. U. S. A., 108, 7769, 10.1073/pnas.1016472108
Noman, 2020, Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy [published correction appears in Sci Adv. 2021 Apr 9;7(15):], Sci. Adv., 6, eaax7881, 10.1126/sciadv.aax7881
Mukhopadhyay, 2016, Clinical relevance of autophagic therapy in cancer: investigating the current trends, challenges, and future prospects, Crit. Rev. Clin. Lab. Sci., 53, 228, 10.3109/10408363.2015.1135103
Cunha, 2018, LC3-associated phagocytosis in myeloid cells promotes tumor immune tolerance, Cell, 175, 429, 10.1016/j.cell.2018.08.061
Sun, 2021, GLUT1 participates in tamoxifen resistance in breast cancer cells through autophagy regulation, Naunyn Schmiedebergs Arch. Pharmacol., 394, 205, 10.1007/s00210-020-01893-3
Roy, 2017, Autophagy-dependent shuttling of TBC1D5 controls plasma membrane translocation of GLUT1 and glucose uptake, Mol. Cell, 67, 84, 10.1016/j.molcel.2017.05.020
Lashinger, 2016, Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors, Cancer Metab., 4, 18, 10.1186/s40170-016-0158-4
Karsli-Uzunbas, 2014, Autophagy is required for glucose homeostasis and lung tumor maintenance, Cancer Discov., 4, 914, 10.1158/2159-8290.CD-14-0363
Roberts, 2014, Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition, Mol. Cell, 53, 521, 10.1016/j.molcel.2013.12.019
Chen, 2018, Deregulation of hexokinase II is associated with glycolysis, autophagy, and the epithelial-mesenchymal transition in tongue squamous cell carcinoma under hypoxia, Biomed Res. Int., 2018
Ikeda, 2020, Hypoxia-inducible hexokinase-2 enhances anti-apoptotic function via activating autophagy in multiple myeloma, Cancer Sci., 111, 4088, 10.1111/cas.14614
Zhang, 2018, Hexokinase 2 confers resistance to cisplatin in ovarian cancer cells by enhancing cisplatin-induced autophagy, Int. J. Biochem. Cell Biol., 95, 9, 10.1016/j.biocel.2017.12.010
Jiao, 2018, Regulation of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of HK2 (hexokinase 2), Autophagy, 14, 671, 10.1080/15548627.2017.1381804
Das, 2019, Lactate dehydrogenase A regulates autophagy and tamoxifen resistance in breast cancer, Biochim. Biophys. Acta Mol. Cell. Res., 1866, 1004, 10.1016/j.bbamcr.2019.03.004
Brisson, 2016, Lactate dehydrogenase B controls lysosome activity and autophagy in cancer, Cancer Cell, 30, 418, 10.1016/j.ccell.2016.08.005
Wu, 2020, Lipid droplets maintain energy homeostasis and glioblastoma growth via autophagic release of stored fatty acids, iScience, 23, 101569, 10.1016/j.isci.2020.101569
Bosc, 2020, Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites, Nat. Commun., 11, 4056, 10.1038/s41467-020-17882-2
Shajahan-Haq, 2014, MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer, Mol. Cancer, 13, 239, 10.1186/1476-4598-13-239
Seo, 2016, Autophagy is required for PDAC glutamine metabolism, Sci. Rep., 6, 37594, 10.1038/srep37594
Jeong, 2016, Enhanced mitochondrial glutamine anaplerosis suppresses pancreatic cancer growth through autophagy inhibition, Sci. Rep., 6, 30767, 10.1038/srep30767
Guo, 2016, Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells, Genes Dev., 30, 1704, 10.1101/gad.283416.116
Strohecker, 2013, Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors, Cancer Discov., 3, 1272, 10.1158/2159-8290.CD-13-0397
Khan, 2018, Inhibition of mTOR complexes protects cancer cells from glutamine starvation induced cell death by restoring Akt stability, Biochim. Biophys. Acta Mol. Basis Dis., 1864, 2040, 10.1016/j.bbadis.2018.03.013
Zhang, 2018, Increased amino acid uptake supports autophagy-deficient cell survival upon glutamine deprivation, Cell Rep., 23, 3006, 10.1016/j.celrep.2018.05.006
Villar, 2017, mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation, Nat. Commun., 8, 14124, 10.1038/ncomms14124
Halama, 2018, Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis, Cancer Lett., 430, 133, 10.1016/j.canlet.2018.05.017
Kim, 2018, Enhanced glycolysis supports cell survival in EGFR-Mutant lung adenocarcinoma by inhibiting autophagy-mediated EGFR degradation, Cancer Res., 78, 4482, 10.1158/0008-5472.CAN-18-0117
Poillet-Perez, 2018, Autophagy maintains tumour growth through circulating arginine, Nature, 563, 569, 10.1038/s41586-018-0697-7
Sousa, 2016, Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion, Nature, 536, 479, 10.1038/nature19084
Mukhopadhyay, 2021, Autophagy is required for proper cysteine homeostasis in pancreatic cancer through regulation of SLC7A11, Proc. Natl. Acad. Sci. U. S. A., 118, 10.1073/pnas.2021475118
Guo, 2013, Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis, Genes Dev., 27, 1447, 10.1101/gad.219642.113
Bhatt, 2019, Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis, Genes Dev., 33, 150, 10.1101/gad.320481.118
Su, 2021, Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis, Cancer Cell, 39, 678, 10.1016/j.ccell.2021.02.016
Bellot, 2009, Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains, Mol. Cell. Biol., 29, 2570, 10.1128/MCB.00166-09
Jung, 2019, Mitochondrial NIX promotes tumor survival in the hypoxic niche of glioblastoma, Cancer Res., 79, 5218, 10.1158/0008-5472.CAN-19-0198
Hu, 2012, Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma, Cancer Res., 72, 1773, 10.1158/0008-5472.CAN-11-3831
Liu, 2012, Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells, Nat. Cell Biol., 14, 177, 10.1038/ncb2422
Yang, 2018, Hypoxia-induced autophagy promotes gemcitabine resistance in human bladder cancer cells through hypoxia-inducible factor 1α activation, Int. J. Oncol., 53, 215
Zhu, 2014, Upregulation of autophagy by hypoxia-inducible factor-1α promotes EMT and metastatic ability of CD133+ pancreatic cancer stem-like cells during intermittent hypoxia, Oncol. Rep., 32, 935, 10.3892/or.2014.3298
Li, 2021, HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation, Signal Transduct. Target. Ther., 6, 76, 10.1038/s41392-020-00453-8
Feng, 2021, Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5, Autophagy, 17, 723, 10.1080/15548627.2020.1731266
Ma, 2020, PTBP3 promotes malignancy and hypoxia-induced chemoresistance in pancreatic cancer cells by ATG12 up-regulation, J. Cell. Mol. Med., 24, 2917, 10.1111/jcmm.14896
Qureshi-Baig, 2020, Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway, Autophagy, 16, 1436, 10.1080/15548627.2019.1687213
Mao, 2021, Hypoxia-induced autophagy enhances cisplatin resistance in human bladder cancer cells by targeting hypoxia-inducible factor-1α, J. Immunol. Res., 2021, 8887437, 10.1155/2021/8887437
Liang, 2020, Hypoxia induces sorafenib resistance mediated by autophagy via activating FOXO3a in hepatocellular carcinoma, Cell Death Dis., 11, 1017, 10.1038/s41419-020-03233-y
Di Conza, 2017, The mTOR and PP2A pathways regulate PHD2 phosphorylation to fine-tune HIF1α levels and colorectal cancer cell survival under hypoxia, Cell Rep., 18, 1699, 10.1016/j.celrep.2017.01.051
Zhao, 2021, YAP promotes autophagy and progression of gliomas via upregulating HMGB1, J. Exp. Clin. Cancer Res., 40, 99, 10.1186/s13046-021-01897-8
Wang, 2020, Hypoxia-autophagy axis induces VEGFA by peritoneal mesothelial cells to promote gastric cancer peritoneal metastasis through an integrin α5-fibronectin pathway, J. Exp. Clin. Cancer Res., 39, 221, 10.1186/s13046-020-01703-x
Deng, 2020, HIF-1a regulates hypoxia-induced autophagy via translocation of ANKRD37 in colon cancer, Exp. Cell Res., 395, 112175, 10.1016/j.yexcr.2020.112175
Dong, 2020, SATB2 knockdown decreases hypoxia-induced autophagy and stemness in oral squamous cell carcinoma, Oncol. Lett., 20, 794, 10.3892/ol.2020.11589
Sahni, 2020, NDRG1 suppresses basal and hypoxia-induced autophagy at both the initiation and degradation stages and sensitizes pancreatic cancer cells to lysosomal membrane permeabilization, Biochim. Biophys. Acta Gen. Subj., 1864, 129625, 10.1016/j.bbagen.2020.129625
Zhou, 2018, Hypoxia-inducible factor-1α-dependent autophagy plays a role in glycolysis switch in mouse granulosa cells, Biol. Reprod., 99, 308, 10.1093/biolre/ioy061
Liu, 2012, Proline oxidase promotes tumor cell survival in hypoxic tumor microenvironments, Cancer Res., 72, 3677, 10.1158/0008-5472.CAN-12-0080
Tian, 2015, Autophagy inhibits oxidative stress and tumor suppressors to exert its dual effect on hepatocarcinogenesis, Cell Death Differ., 22, 1025, 10.1038/cdd.2014.201
Kudo, 2020, PKCλ/ι loss induces autophagy, oxidative phosphorylation, and NRF2 to promote liver cancer progression, Cancer Cell, 38, 247, 10.1016/j.ccell.2020.05.018
Liu, 2019, BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration, Nat. Commun., 10, 4614, 10.1038/s41467-019-12573-z
Chen, 2016, ROS-induced CXCR4 signaling regulates mantle cell lymphoma (MCL) cell survival and drug resistance in the bone marrow microenvironment via autophagy [published correction appears in Clin Cancer Res. 2017 Apr 1;23 (7):1875-1876], Clin. Cancer Res., 22, 187, 10.1158/1078-0432.CCR-15-0987
Yang, 2011, Pancreatic cancers require autophagy for tumor growth, Genes Dev., 25, 717, 10.1101/gad.2016111
Song, 2021, LRPPRC regulates metastasis and glycolysis by modulating autophagy and ROS/HIF1-α pathway in retinoblastoma, Mol. Ther. Oncolytics, 10.1016/j.omto.2021.06.009
Avivar-Valderas, 2011, PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment, Mol. Cell. Biol., 31, 3616, 10.1128/MCB.05164-11
Marsh, 2021, The pleiotropic functions of autophagy in metastasis, J. Cell. Sci., 134, jcs247056, 10.1242/jcs.247056
Sharifi, 2016, Autophagy promotes focal adhesion disassembly and cell motility of metastatic tumor cells through the direct interaction of paxillin with LC3, Cell Rep., 15, 1660, 10.1016/j.celrep.2016.04.065
Marsh, 2020, Autophagic degradation of NBR1 restricts metastatic outgrowth during mammary tumor progression, Dev. Cell, 52, 591, 10.1016/j.devcel.2020.01.025
Poillet-Perez, 2019, Role of tumor and host autophagy in cancer metabolism, Genes Dev., 33, 610, 10.1101/gad.325514.119
Pavlides, 2009, The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma, Cell Cycle, 8, 3984, 10.4161/cc.8.23.10238
Katheder, 2017, Microenvironmental autophagy promotes tumour growth, Nature, 541, 417, 10.1038/nature20815
Yang, 2018, Autophagy sustains pancreatic cancer growth through both cell-autonomous and nonautonomous mechanisms, Cancer Discov., 8, 276, 10.1158/2159-8290.CD-17-0952
Kim, 2020, LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells [published online ahead of print, 2020 Aug 14], Autophagy, 17, 1978, 10.1080/15548627.2020.1805214
Li, 2020, Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation, Nat. Commun., 11, 3806, 10.1038/s41467-020-17395-y
Noman, 2020, Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy, Sci. Adv., 6, eaax7881, 10.1126/sciadv.aax7881
Yamamoto, 2020, Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I, Nature, 581, 100, 10.1038/s41586-020-2229-5
Mgrditchian, 2017, Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner, Proc. Natl. Acad. Sci. U. S. A., 114, E9271, 10.1073/pnas.1703921114
Baginska, 2013, Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia, Proc. Natl. Acad. Sci. U. S. A., 110, 17450, 10.1073/pnas.1304790110
Noman, 2011, Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression, Cancer Res., 71, 5976, 10.1158/0008-5472.CAN-11-1094
Khazen, 2016, Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse, Nat. Commun., 7, 10823, 10.1038/ncomms10823
DeVorkin, 2019, Autophagy regulation of metabolism is required for CD8+ T cell anti-tumor immunity, Cell Rep., 27, 502, 10.1016/j.celrep.2019.03.037
Alissafi, 2018, Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells, J. Clin. Invest., 128, 3840, 10.1172/JCI120888
Parker, 2016, High-mobility group box protein 1 promotes the survival of myeloid-derived suppressor cells by inducing autophagy, J. Leukoc. Biol., 100, 463, 10.1189/jlb.3HI0715-305R
Alexander, 2020, Polyamine blocking therapy decreases survival of tumor-infiltrating immunosuppressive myeloid cells and enhances the antitumor efficacy of PD-1 blockade, Mol. Cancer Ther., 19, 2012, 10.1158/1535-7163.MCT-19-1116
Chen, 2018, Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype, Nat. Commun., 9, 873, 10.1038/s41467-018-03225-9
Zamame Ramirez, 2020, Blocking drug-induced autophagy with chloroquine in HCT-116 colon cancer cells enhances DC maturation and T cell responses induced by tumor cell lysate, Int. Immunopharmacol., 84, 106495, 10.1016/j.intimp.2020.106495
Wei, 2016, Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis, Nat. Immunol., 17, 277, 10.1038/ni.3365
Bocci, 2019, Toward understanding cancer stem cell heterogeneity in the tumor microenvironment, Proc. Natl. Acad. Sci. U. S. A., 116, 148, 10.1073/pnas.1815345116
Gong, 2013, Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells, Oncogene, 32, 2261, 10.1038/onc.2012.252
Cufí, 2011, Autophagy positively regulates the CD44(+) CD24(-/low) breast cancer stem-like phenotype, Cell Cycle, 10, 3871, 10.4161/cc.10.22.17976
Rothe, 2014, The core autophagy protein ATG4B is a potential biomarker and therapeutic target in CML stem/progenitor cells, Blood, 123, 3622, 10.1182/blood-2013-07-516807
Sharif, 2017, Autophagic homeostasis is required for the pluripotency of cancer stem cells, Autophagy, 13, 264, 10.1080/15548627.2016.1260808
Yeo, 2016, Autophagy differentially regulates distinct breast Cancer Stem-like cells in murine models via EGFR/Stat3 and tgfβ/Smad signaling, Cancer Res., 76, 3397, 10.1158/0008-5472.CAN-15-2946
Maycotte, 2015, Autophagy supports breast cancer stem cell maintenance by regulating IL6 secretion, Mol. Cancer Res., 13, 651, 10.1158/1541-7786.MCR-14-0487
Bie, 2021, IL-17B/IL-17RB signaling cascade contributes to self-renewal and tumorigenesis of cancer stem cells by regulating Beclin-1 ubiquitination, Oncogene, 40, 2200, 10.1038/s41388-021-01699-4
Gao, 2020, IGF2 loss of imprinting enhances colorectal cancer stem cells pluripotency by promoting tumor autophagy, Aging (Albany NY), 12, 21236, 10.18632/aging.103837
Wang, 2021, Autophagy augments the self-renewal of lung cancer stem cells by the degradation of ubiquitinated p53, Cell. Death Dis., 12, 98, 10.1038/s41419-021-03392-6
Song, 2013, Autophagy contributes to the survival of CD133+ liver cancer stem cells in the hypoxic and nutrient-deprived tumor microenvironment, Cancer Lett., 339, 70, 10.1016/j.canlet.2013.07.021
Zhu, 2014, Upregulation of autophagy by hypoxia-inducible factor-1α promotes EMT and metastatic ability of CD133+ pancreatic cancer stem-like cells during intermittent hypoxia, Oncol. Rep., 32, 935, 10.3892/or.2014.3298
Andrique, 2018, Calpain-6 controls the fate of sarcoma stem cells by promoting autophagy and preventing senescence, JCI Insight, 3, e121225, 10.1172/jci.insight.121225
Talukdar, 2018, MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells, Proc. Natl. Acad. Sci. U. S. A., 115, 5768, 10.1073/pnas.1721650115
Zhu, 2019, CD44s is a crucial ATG7 downstream regulator for stem-like property, invasion, and lung metastasis of human bladder cancer (BC) cells, Oncogene, 38, 3301, 10.1038/s41388-018-0664-7
Zhou, 2021, ATG7-mediated autophagy involves in miR-138-5p regulated self-renewal and invasion of lung cancer stem-like cells derived from A549 cells, Anticancer Drugs, 32, 376, 10.1097/CAD.0000000000000979
Galavotti, 2013, The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells, Oncogene, 32, 699, 10.1038/onc.2012.111
Ma, 2021, Down-regulation of autophagy-associated protein increased acquired radio-resistance bladder cancer cells sensitivity to taxol, Int. J. Radiat. Biol., 97, 507, 10.1080/09553002.2021.1872812
Naik, 2018, Autophagy regulates cisplatin-induced stemness and chemoresistance via the upregulation of CD44, ABCB1 and ADAM17 in oral squamous cell carcinoma, Cell Prolif., 51, e12411, 10.1111/cpr.12411
Zhu, 2021, SOX2 promotes chemoresistance, cancer stem cells properties, and epithelial-mesenchymal transition by β-catenin and Beclin1/autophagy signaling in colorectal cancer, Cell Death Dis., 12, 449, 10.1038/s41419-021-03733-5
Horne, 2020, A randomised phase II trial of hydroxychloroquine and imatinib versus imatinib alone for patients with chronic myeloid leukaemia in major cytogenetic response with residual disease, Leukemia, 34, 1775, 10.1038/s41375-019-0700-9
Malhotra, 2019, Phase Ib/II study of hydroxychloroquine in combination with chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC), Cancer Treat. Res. Commun., 21, 100158, 10.1016/j.ctarc.2019.100158
Rangwala, 2014, Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma, Autophagy, 10, 1369, 10.4161/auto.29118
Rangwala, 2014, Combined MTOR and autophagy inhibition: phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma, Autophagy, 10, 1391, 10.4161/auto.29119
Mehnert, 2019, A phase I trial of MK-2206 and hydroxychloroquine in patients with advanced solid tumors, Cancer Chemother. Pharmacol., 84, 899, 10.1007/s00280-019-03919-x
Arnaout, 2019, A randomized, double-blind, window of opportunity trial evaluating the effects of chloroquine in breast cancer patients, Breast Cancer Res. Treat., 178, 327, 10.1007/s10549-019-05381-y
Compter, 2020, Chloroquine combined with concurrent radiotherapy and temozolomide for newly diagnosed glioblastoma: a phase IB trial, Autophagy, 1
Wiedmer, 2017, Autophagy inhibition improves sunitinib efficacy in pancreatic neuroendocrine tumors via a lysosome-dependent mechanism, Mol. Cancer Ther., 16, 2502, 10.1158/1535-7163.MCT-17-0136
Jarauta, 2016, Inhibition of autophagy with chloroquine potentiates carfilzomib-induced apoptosis in myeloma cells in vitro and in vivo, Cancer Lett., 382, 1, 10.1016/j.canlet.2016.08.019
Karasic, 2019, Effect of gemcitabine and nab-paclitaxel with or without hydroxychloroquine on patients with advanced pancreatic cancer: a phase 2 randomized clinical trial, JAMA Oncol., 5, 993, 10.1001/jamaoncol.2019.0684
Haas, 2019, Autophagy inhibition to augment mTOR inhibition: a phase I/II trial of everolimus and hydroxychloroquine in patients with previously treated renal cell carcinoma, Clin. Cancer Res., 25, 2080, 10.1158/1078-0432.CCR-18-2204
Mahalingam, 2014, Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors, Autophagy, 10, 1403, 10.4161/auto.29231
Musabayane, 1994, The effects of oral chloroquine administration on kidney function, Ren. Fail., 16, 221, 10.3109/08860229409044862
Mubagwa, 2020, Cardiac effects and toxicity of chloroquine: a short update, Int. J. Antimicrob. Agents, 56, 106057, 10.1016/j.ijantimicag.2020.106057
McAfee, 2012, Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency, Proc. Natl. Acad. Sci. U. S. A., 109, 8253, 10.1073/pnas.1118193109
Petherick, 2015, Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy, J. Biol. Chem., 290, 11376, 10.1074/jbc.C114.627778
Egan, 2015, Small molecule inhibition of the autophagy kinase ULK1 and identification of ULK1 substrates, Mol. Cell, 59, 285, 10.1016/j.molcel.2015.05.031
Martin, 2018, A potent and selective ULK1 inhibitor suppresses autophagy and sensitizes cancer cells to nutrient stress, iScience, 8, 74, 10.1016/j.isci.2018.09.012
Bago, 2014, Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase, Biochem. J., 463, 413, 10.1042/BJ20140889
Nejman, 2020, The human tumor microbiome is composed of tumor type-specific intracellular bacteria, Science, 368, 973, 10.1126/science.aay9189
Jin, 2020, The updated landscape of tumor microenvironment and drug repurposing, Signal Transduct. Target. Ther., 5, 166, 10.1038/s41392-020-00280-x