Recent neuroendocrine facets of male reproductive aging
Tài liệu tham khảo
Abbasi, 1993, Low circulating levels of insulin-like growth factors and testosterone in chronically institutionalized elderly men, J. Am. Geriatr. Soc., 41, 975, 10.1111/j.1532-5415.1993.tb06764.x
Aloi, 1997, Pulsatile intravenous gonadotropin-releasing hormone administration averts fasting-induced hypogonadotropism and hypoandrogenemia in healthy, normal-weight men, J. Clin. Endocrinol. Metab., 82, 1543, 10.1210/jc.82.5.1543
Bagatell, 1994, The direct pituitary effect of testosterone to inhibit gonadotropin secretion in men is partially mediated by aromatization to estradiol, J. Androl., 15, 15
Baker, 1976, Changes in the pituitary–testicular system with age, Clin. Endocrinol., 5, 349, 10.1111/j.1365-2265.1976.tb01964.x
Barrett-Connor, 1999, Bioavailable testosterone and depressed mood in older men: the Rancho Bernardo study, J. Clin. Endocrinol. Metab., 84, 573, 10.1210/jc.84.2.573
Barrett-Connor, 1999, Endogenous sex hormones and congitive function in older men, J. Clin. Endocrinol. Metab., 84, 3681, 10.1210/jc.84.10.3681
van den Berg, 1997, Greater disorderliness of ACTH and cortisol release accompanies pituitary-dependent Cushing's Disease, Eur. J. Endocrinol., 136, 394, 10.1530/eje.0.1360394
Bergendahl, 1998, Fasting suppresses pulsatile luteinizing hormone (LH) secretion and enhances the orderliness of LH release in young but not older men, J. Clin. Endocrinol. Metab., 83, 1967, 10.1210/jc.83.6.1967
Bergendahl, M., Iranmanesh, A., Evans, W.S., Veldhuis, J.D., 2000. Short-term fasting selectively suppresses leptin pulse mass and 24-hour rhythmic leptin release in healthy mid-luteal phase women without disturbing leptin pulse frequency or its entropy control (pattern orderliness). J Clin Endocrinol Metab 85, 207–213.
Blackman, 1988, Comparison of the effects of lung cancer, benign lung disease, and normal aging on pituitary–gonadal function in men, J. Clin. Endocrinol. Metab., 66, 88, 10.1210/jcem-66-1-88
Bonavera, 1997, In the male Brown-Norway (BN) male rat reproductive aging is associated with decreased LH-pulse amplitude and area, J. Androl., 18, 359
Bremner, 1983, Loss of circadian rhythmicity in blood testosterone levels with aging in normal men, J. Clin. Endocrinol. Metab., 56, 1278, 10.1210/jcem-56-6-1278
Burger, 1995, The endocrinology of the menopausal transition, J. Clin. Endocrinol. Metab., 80, 3537, 10.1210/jc.80.12.3537
Carter, 1995, Effect of anabolic hormones and insulin-like growth factor-1 on muscle mass and strength in elderly persons, Clin. Geriatr. Med., 11, 735, 10.1016/S0749-0690(18)30268-4
Catt, 1974, Gonadotropin binding and activation of interstitial cells of the testis, 1
Celani, 1984, Effects of acute stimulation with gonadotropin releasing hormone (GnRH) on biologically active serum luteinizing hormone (LH) in elderly men, J. Endocrinol. Investig., 7, 589, 10.1007/BF03349491
Chase, 1988, Effects of pulsatile and continuous luteinizing hormone (LH) infusions on testosterone responses to LH in rams actively immunized against gonadotropin-releasing hormone, Endocrinology, 123, 816, 10.1210/endo-123-2-816
Chubb, 1984, Testicular function and neuroendocrine activity in senescent mice, Am. J. Physiol., 247, E410
Clarke, 1987, The significance of small pulses of gonadotropin-releasing hormone, J. Endocrinol., 113, 413, 10.1677/joe.0.1130413
Clement, 1998, Assessment of sexual function in the stallion, Point Veterinaire, 29, 343
Coquelin, 1982, Luteinizing hormone and testosterone secretion in young and old male mice, Am. J. Physiol., 243, E257
Cunningham, 1990, Testosterone replacement therapy and sleep-related erections in hypogonadal men, J. Clin. Endocrinol. Metab., 70, 792, 10.1210/jcem-70-3-792
Dabbs, 1990, Age and seasonal variation in serum testosterone concentration among men, Chronobiol. Int., 7, 245, 10.3109/07420529009056982
Davidson, 1983, Hormonal changes and sexual function in aging men, J. Clin. Endocrinol. Metab., 57, 71, 10.1210/jcem-57-1-71
Davies, 1981, The perifused Leydig cell: system characterization and rapid gonadotropin-induced desensitization, Endocrinology, 108, 1757, 10.1210/endo-108-5-1757
DeNicolao, 1993, Linear and nonlinear techniques for the deconvolution of hormone time-series, IEEE Trans. Biomed. Engng, 40, 440, 10.1109/10.243417
DeNicolao, 1999, LH and FSH secretory responses to GnRH in normal individuals: a nonparametric deconvolution approach, Eur. J. Endo., 141, 246, 10.1530/eje.0.1410246
Desleypere, 1981, Aging and tissue androgens, J. Clin. Endocrinol. Metab., 53, 530
Deslypere, 1984, Leydig cell function in normal men: effect of age, lifestyle, residence, diet and activity, J. Clin. Endocrinol. Metab., 59, 955, 10.1210/jcem-59-5-955
Deslypere, 1987, Influence of age on pulsatile luteinizing hormone release and responsiveness of the gonadotrophs to sex hormone feedback in men, J. Clin. Endocrinol. Metab., 64, 68, 10.1210/jcem-64-1-68
D'Occhio, 1982, Relationship between serum testosterone concentrations and patterns of luteinizing hormone secretion in male sheep, Endocrinology, 110, 1547, 10.1210/endo-110-5-1547
Dufau, 1978, Gonadotropin receptors and regulation of steroidogenesis in the testis and ovary, Vitam. Horm., 36, 461, 10.1016/S0083-6729(08)60989-9
Ellis, 1984, Orchidectomy unleashes pulsatile luteinizing hormone secretion in the rat, Biol. Reprod., 30, 619, 10.1095/biolreprod30.3.619
Engle, 1956, 1
Evans, 1992, Contemporary aspects of discrete peak detection algorithms. II. The paradigm of the luteinizing hormone pulse signal in women, Endocr. Rev., 13, 81
Foresta, 1997, Specific linkages among luteinizing hormone, follicle stimulating hormone, and testosterone release in the peripheral blood and human spermatic vein: evidence for both positive (feedforward) and negative (feedback) within-axis regulation, J. Clin. Endocrinol. Metab., 82, 3040, 10.1210/jc.82.9.3040
Freidl, 1990, High density lipoprotein cholesterol is not decreased if an aromatizable androgen is administered, Metabolism, 39, 69, 10.1016/0026-0495(90)90150-B
Genazzani, 1990, Estimation of instantaneous secretory rate of luteinizing hormone in women during the menstrual cycle and in men, Clin. Endocrinol., 32, 573, 10.1111/j.1365-2265.1990.tb00900.x
Giusti, 1975, Age-related secretion of androstenedione, testosterone and dihydrotestosterone by the human testis, Exp. Gerontol., 10, 241, 10.1016/0531-5565(75)90001-7
Giusti, 1990, Effect of pulsatile luteinizing hormone-releasing hormone administration on pituitary–gonadal function in elderly man, J. Endocrinol. Investig., 13, 127, 10.1007/BF03349521
Glass, 1980, Resensitization of testosterone production in men after human chorionic gonadotropin-induced desensitization, J. Clin. Endocrinol. Metab., 51, 1395, 10.1210/jcem-51-6-1395
Gray, 1991, An examination of research design effects on the association of testosterone and male aging: results of a meta-analysis, J. Clin. Epidemiol., 44, 671, 10.1016/0895-4356(91)90028-8
Gray, 1991, Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts male aging study, J. Clin. Endocrinol. Metab., 73, 1016, 10.1210/jcem-73-5-1016
Gruenewald, 1994, The Brown Norway rat as a model fo male reproductive aging: evidence for both primary and secondary testicular failure, J. Gerontol., 49, B42, 10.1093/geronj/49.2.B42
Grzywacz, 1998, Does age-associated reduced Leydig cell testosterone production in Brown Norway Rats result from under-stimulation by luteinizing hormone?, J. Androl., 19, 625
Hagenfeldt, 1992, Testosterone increases serum 1,25-dihydroxyvitamin D and insulin-like growth factor-I in hypogonadal men, Int. J. Androl., 15, 93, 10.1111/j.1365-2605.1992.tb01118.x
Haji, 1980, Age-related changes in the concentrations of cytosol receptors for sex steroid hormones in the hypothalamus and pituitary gland fo the rat, Brain Res., 204, 373, 10.1016/0006-8993(81)90596-5
Harman, 1992, Growth hormone, IGF-I, gonadal steroids, and aging, Aging, 4, 257
Harman, 1980, Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone, and Leydig cell response to human chorionic gonadotropin, J. Clin. Endocrinol. Metab., 51, 35, 10.1210/jcem-51-1-35
Harman, 1982, Reproductive hormones in aging men. II. Basal pituitary gonadotropins and gonadotropin responses to luteinizing hormone-releasing hormone, J. Clin. Endocrinol. Metab., 54, 547, 10.1210/jcem-54-3-547
Hollander, 1958, The microdetermination of testoterone in human spermatic vein blood, J. Clin. Endocrinol. Metab., 18, 966, 10.1210/jcem-18-9-966
Huang, 1987, Restoration of sexual function and fertility by fetal hypothalamic transplant in impotent aged male rats, Neurobiol. Aging, 8, 465, 10.1016/0197-4580(87)90042-X
Iranmanesh, 1998, Unequal impact of age, percentage body fat, and serum testosterone concentrations on the somatotropic, IGF-I, and IGF-binding protein responses to a three-day intravenous growth-hormone-releasing-hormone (GHRH) pulsatile infusion, Eur. J. Endocrinol., 139, 59, 10.1530/eje.0.1390059
Iranmanesh, 1999, Mechanisms subserving the physiological nocturnal relative hypoprolactinemia of healthy older men: dual decline in prolactin secretory burst mass and basal release with preservation of pulse duration, frequency, and interpulse interval, J. Clin. Endocrinol. Metab., 84, 1083, 10.1210/jc.84.3.1083
Irvine, 1987, A novel technique for measuring hypothalamic and pituitary hormone secretion rates from collection of pituitary venous effuent in the normal horse, J. Endocrinol., 113, 183, 10.1677/joe.0.1130183
Jackson, 1991, Testosterone inhibits gonadotropin-releasing hormone pulse frequency in the male sheep, Biol. Reprod., 45, 188, 10.1095/biolreprod45.1.188
Jarjour, 1986, Effects of aging on the in vitro release of gonadotropin-releasing hormone, Endocrinology, 119, 1113, 10.1210/endo-119-3-1113
Johnson, 1995, Evolution of deconvolution analysis as a hormone pulse detection method, Methods Neurosci., 28, 1, 10.1016/S1043-9471(06)80027-3
Kahn, 1969, REM sleep and sexuality in the ages, J. Geriatr. Psychiatr., 2, 181
Kaiser, 1994, Gonadotropins, testosterone, and the aging male, Neurobiol. Aging, 15, 559, 10.1016/0197-4580(94)90097-3
Kaiser, 1988, Impotence and aging: clinical and hormonal factors, J. Am. Geriatr. Soc., 36, 511, 10.1111/j.1532-5415.1988.tb04021.x
Kaler, 1984, Anterior pituitary luteinizing hormone secretion during continuous perifusion in aging male rats, Mech. Ageing. Dev., 25, 103, 10.1016/0047-6374(84)90133-7
Kaler, 1978, Attrition of the human Leydig cell population with advancing age, Anat. Rec., 192, 513, 10.1002/ar.1091920405
Karacan, 1975, Sleep-related penile tumescence as a function of age, Am. J. Psychiatr., 132, 932, 10.1176/ajp.132.9.932
Karpas, 1983, Diminished luteinizing hormone pulse frequency and amplitude with aging in the male rat, Endocrinology, 112, 788, 10.1210/endo-112-3-788
Katznelson, 1996, Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism, J. Clin. Endocrinol. Metab., 81, 4358, 10.1210/jc.81.12.4358
Kaufman, 1991, Influence of age on the responsiveness of the gonadotrophs to luteinizing hormone-releasing hormone in males, J. Clin. Endocrinol. Metab., 72, 1255, 10.1210/jcem-72-6-1255
Keenan, 1997, Stochastic model of admixed basal and pulsatile hormone secretion as modulated by a deterministic oscillator, Am. J. Physiol.: Reg. Integr. Comp. Physiol., 273, R1182
Keenan, 1998, A biomathematical model of time-delayed feedback in the human male hypothalamic-pituitary-Leydig cell axis, Am. J. Physiol., 275, E157
Keenan, 2000, Explicating hypergonadotropism in postmenopausal women: a statistical model, Am. J. Physiol.: Reg. Integr. Comp. Physiol.
Keenan, 2000, Neuroendocrine mechanisms underlying aging of the human male reproductive axis: novel hypothesis formulation and testing via a physiologically interlinked feedback and feedforward biomathematical construct, Am. J. Physiol.
Keenan, 1998, Joint recovery of pulsatile and basal hormone secretion by stochastic nonlinear random-effects analysis, Am. J. Physiol., 44, R1939
Keenan, 2000, A stochastic biomathematicl model of the male reproductive hormone system, SIAM J. Appl. Math., 10.1137/S0036139998334718
Kerrigan, 1994, Androgen-receptor blockade enhances pulsatile luteinizing hormone production in late pubertal males: evidence for a hypothalamic site of physiological androgen feedback action, Ped. Res., 35, 102, 10.1203/00006450-199401000-00021
Kicman, 1993, Potential use of ketoconazole in a dynamic endocrine test to differentiate between biological outliers and testosterone use by athletes, Clin. Chem., 39, 1798, 10.1093/clinchem/39.9.1798
Kiely, J.M., Quigg, M., Bretram, E.H., Veldhuis, J.D., 1999. Effect of epilepsy on pulsatile secretion of luteinizing hormone. Presented at the American Academy of Neurology Conference, San Diego, California, April 1999. (Abstract).
Kikuchi, 1993, Effects of age and season on diurnal variation and 24hour mean concentrations of plasma testosterone and dihydrotestosterone in stallions, J. Reprod. Devel., 39, J11, 10.1262/jrd.39.5_j17
Korenman, 1994, Androgen function after age 50 years and treatment of hypogonadism, Curr. Ther. Endocrinol. Metab., 5, 585
Lamberts, 1997, The endocrinology of aging, Science, 278, 419, 10.1126/science.278.5337.419
Laue, 1994, Familial male precocious puberty, Curr. Ther. Endocrinol. Metab., 5, 296
Laurentie, 1992, Pulsatile secretion of LH in the ram: a re-evaluation using a discrete deconvolution analysis, J. Endocrinol., 133, 75, 10.1677/joe.0.1330075
de Lignieres, 1993, Transdermal dihydrotestosterone treatment of ‘andropause’, Ann. Med., 25, 235, 10.3109/07853899309147869
Lincoln, 1974, Luteinizing hormone and testosterone in man, Nature, 252, 232, 10.1038/252232a0
Lincoln, 1979, Use of a pulsed infusion of luteinizing hormone releasing hormone to mimic seasonally induced endocrine changes in the ram, J. Endocrinol., 83, 251, 10.1677/joe.0.0830251
Longcope, 1973, The effect of human chorionic gonadotropin on plasma steroid levels in young and old men, Steroids, 21, 583, 10.1016/0039-128X(73)90046-9
Longcope, 1990, Androgens, estrogens, and sex hormone-binding globulin in middle-aged men, J. Clin. Endocrinol. Metab., 71, 1442, 10.1210/jcem-71-6-1442
Madersbacher, 1993, Serum glycoprotein hormones and their free alpha-subunit in a healthy elderly population selected according to the SENIEUR protocol. Analyses with ultrasensitive time resolved fluoroimmunoassays, Mech. Ageing Dev., 71, 223, 10.1016/0047-6374(93)90086-7
Mankin, 1986, Decreased bioavailable testosterone in aging normal and impotent men, J. Clin. Endocrinol. Metab., 63, 1418, 10.1210/jcem-63-6-1418
Manni, 1985, Bioavailability of albumin-bound testosterone, J. Clin. Endocrinol. Metab., 61, 705, 10.1210/jcem-61-4-705
Marrama, 1984, Decrease in luteinizing hormone biological activity/immunoreactivity ratio in elderly men, Maturitas, 5, 223, 10.1016/0378-5122(84)90015-X
Marshall, 1973, Human luteinizing hormone in man: studies of metabolism and biological action, J. Endocrinol., 56, 431, 10.1677/joe.0.0560431
Mastrogiacomo, 1982, Andropause: incidence and pathogenesis, Arch. Androl., 9, 293, 10.3109/01485018208990253
McIntosh, 1988, A comparison of the dynamics of secretion of human growth hormone and LH pulses, J. Endocrinol., 118, 339, 10.1677/joe.0.1180339
Meneilly, 1997, Increased disorderliness of basal insulin release, attenuated insulin secretory burst mass, and reduced ultradian rhythmicity of insulin secretion in older individuals, J. Clin. Endocrinol. Metab., 82, 4088, 10.1210/jc.82.12.4088
Meneilly, 1999, Disruption of the pulsatile and entropic modes of insulin release during an unvarying glucose stimulus in elderly individuals, J. Clin. Endocrinol. Metab., 84, 1938, 10.1210/jc.84.6.1938
Mitchell, 1995, Age-related changes in the pituitary–testicular axis in normal men; lower serum testosterone results from decreased bioactive LH drive, Clin. Endocrinol., 42, 501, 10.1111/j.1365-2265.1995.tb02669.x
Monet-Kuntz, 1985, Changes in intratesticular testosterone, cytoplasmic androgen receptors and ABP content of the ram testis after a single endogenous pulse of LH, Int. J. Androl., 8, 129, 10.1111/j.1365-2605.1985.tb00826.x
Monroe, 1981, Prolactin-secreting pituitary adenomas. V. Increased gonadotroph responsivity in hyperprolactinemic women with pituitary adenomas, J. Clin. Endocrinol. Metab., 52, 1171, 10.1210/jcem-52-6-1171
Morley, 1993, Hypogonadism in the elderly man, Adv. Endocrinol. Metab., 4, 241
Morley, 1997, Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men, Metab. Clin. Exp., 46, 410, 10.1016/S0026-0495(97)90057-3
Morley, 1993, Effects of testosterone on replacement therapy in old hypogonadal males: a preliminary study, J. Am. Geriatr. Soc., 41, 149, 10.1111/j.1532-5415.1993.tb02049.x
Morley, 1997, Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor I to growth hormone, Proc. Natl. Acad. Sci. USA, 94, 7537, 10.1073/pnas.94.14.7537
Mulligan, 1994, Validation of deconvolution analysis of LH secretion and half-life, Am. J. Physiol., 267, R202
Mulligan, 1995, Amplified nocturnal luteinizing hormone (LH) secretory burst frequency with selective attenuation of pulsatile (but not basal) testosterone secretion in healthy aged men: possible Leydig cell desensitization to endogenous LH signaling—a clinical research center study, J. Clin. Endocrinol. Metab., 80, 3025, 10.1210/jc.80.10.3025
Mulligan, 1997, Aging alters feedforward and feedback linkages between LH and testosterone in healthy men, Am. J. Physiol., 42, R1407
Mulligan, T., Iranmanesh, A., Veldhuis, J.D., 1998. Failed restitution of Leydig cell testosterone secretion despite full normalization of pulsatile release by two weeks of exogenous pulsatile GnRH pump/infusion therapy in older men. Presented at the 80th Endocrine Society Annual Meeting, June 24–27, New Orleans, LA.
Mulligan, 1999, Two-week pulsatile gonadotropin releasing hormone infusion unmasks dual (hypothalamic and Leydig-cell) defects in the healthy aging male gonadotropic axis, Eur. J. Endocrinol., 141, 257, 10.1530/eje.0.1410257
Mulligan, T., Kuno, H.L., Vij, S., Iranmanesh, A., Veldhuis, J.D., 1999b. Healthy older men show heightened LH secretory sensitivity and capacity to GnRH stimulation. Presented at the Annual Meeting of the American Geriatrics Society, Philadelphia, PA.
Mulligan, T., Kuno, H., Clore, J., Iranmanesh, A., Veldhuis, J.D., 2000b. Pulsatile infusions of recombinant human LH in leuprolide-downregulated older vs young men unmask impoverished Leydig-cell secretory response in aging to mid-physiological LH stimuli. Presented at the Endocrine Society 82nd Annual Meeting, June 21–24, Toronto, Canada.
Murphy, 1993, Sex hormones and bone mineral density in elderly men, Bone Miner., 20, 133, 10.1016/S0169-6009(08)80022-0
Nahoul, 1990, Age-related decline of plasma bioavailable testosterone in adult men, J. Steroid Biochem., 35, 293, 10.1016/0022-4731(90)90287-3
Nankin, 1986, Decreased bioavailable testosterone in aging normal and impotent men, J. Clin. Endocrinol. Metab., 63, 1418, 10.1210/jcem-63-6-1418
Nankin, 1981, The aging Leydig cell III. Gonadotropin stimulation in men, J. Androl., 2, 181, 10.1002/j.1939-4640.1981.tb00614.x
Neaves, 1984, Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men, J. Clin. Endocrinol. Metab., 59, 756, 10.1210/jcem-59-4-756
Nieschlag, 1973, Age and endocrine function of the testes in adult man, Dtsch. Med. Wochenschr., 98, 1281, 10.1055/s-0028-1107015
Nieschlag, 1982, Reproductive functions in young fathers and grandfathers, J. Clin. Endocrinol. Metab., 55, 676, 10.1210/jcem-55-4-676
Okuda, 1991, Age-related responses of serum testosterone to human chorionic gonadotropin in the stallion, Jpn J. Anim. Reprod., 37, 21, 10.1262/jrd1977.37.21
O'Sullivan, 1988, Deconvolution of episodic hormone data: an analysis of the role of season on the onset of puberty in cows, Biometrics, 44, 339, 10.2307/2531849
Paniagua, 1987, Testicular involution in elderly men: comparison of histologic quantitative studies with hormone patterns, Fertil. Steril., 47, 671, 10.1016/S0015-0282(16)59120-1
Partsch, 1994, Variability of pulsatile LH secretion in young male volunteers, Eur. J. Endocrinol., 131, 263, 10.1530/eje.0.1310263
Pepperell, 1975, Studies on the metabolic clearance rate and production rate of human luteinizing hormone and on the initial half-life of its subunits in man, J. Clin. Investig., 56, 118, 10.1172/JCI108060
Percy, 1992, Ketoconazole in advanced prostate cancer, Ann. Pharmacother., 26, 1527
Pincus, 1995, Quantifying complexity and regularity of neurobiological systems, Meth. Neurosci., 28, 336, 10.1016/S1043-9471(06)80040-6
Pincus, 1992, Quantification of hormone pulsatility via an approximate entropy algorithm, Am. J. Physiol., 262, E741
Pincus, 1996, Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males, Proc. Natl. Acad. Sci. USA, 93, 14100, 10.1073/pnas.93.24.14100
Pincus, 1996, Females secrete growth hormone with more process irregularity than males in both human and rat, Am. J. Physiol., 270, E107
Pincus, 1997, Effects of age on the irregularity of LH and FSH serum concentrations in women and men, Am. J. Physiol., 273, E989
Pincus, 1999, Hormone pulsatility discrimination via coarse and short time sampling, Am. J. Physiol., 277, E948
Pirke, 1975, Age related changes in free plasma testosterone, dihydrotestosterone and oestradiol, Acta Endocrinol. (Copenhagen), 80, 171, 10.1530/acta.0.0800171
Pont, 1982, Ketoconazole blocks testosterone synthesis, Arch. Int. Med., 142, 2137, 10.1001/archinte.142.12.2137
Rajfer, 1986, Mechanism of inhibition of human testicular steroidogenesis by oral ketoconazole, J. Clin. Endocrinol. Metab., 63, 1193, 10.1210/jcem-63-5-1193
Rebar, 1973, The estimation of pituitary luteinizing hormone secretion, J. Clin. Endocrinol. Metab., 37, 917, 10.1210/jcem-37-6-917
Reubens, 1976, Further studies on Leydig cell response to human choriogonadotropin, J. Clin. Endocrinol. Metab., 39, 40
Roelfsema, 1998, Patients with Cushing's disease secrete adrenocorticotropin and cortisol jointly more asynchronously than healthy subjects, J. Clin. Endocrinol. Metab., 83, 688, 10.1210/jc.83.2.688
Rowe, 1975, The temporal relationship between the secretion of luteinizing hormone and testosterone in man, J. Endocrinol., 64, 17, 10.1677/joe.0.0640017
Rudman, 1994, Unanswered questions concerning the treatment of hyposomatotropism and hypogonadism in elderly men, J. Am. Geriatr. Soc., 42, 522, 10.1111/j.1532-5415.1994.tb04975.x
Santen, 1973, Episodic luteinizing hormone secretion in man, J. Clin. Investig., 52, 2616, 10.1172/JCI107454
Santen, 1983, Site of action of low dose ketoconazole on androgen biosynthesis in men, J. Clin. Endocrinol. Metab., 57, 732, 10.1210/jcem-57-4-732
Sartin, 1984, FSH and LH response to testosterone and gonadotropin-releasing hormone in aging male rats, Exp. Aging Res., 10, 183, 10.1080/03610738408258461
Schiavi, 1992, Pituitary–gonadal function during sleep in healthy aging men, Psychoneuroendocrinology, 17, 599, 10.1016/0306-4530(92)90018-3
Schiavi, 1993, Hormones and nocturnal penile tumescence in healthy aging men, Arch. Sex Behav., 22, 207, 10.1007/BF01541766
Schnorr, J., Santen, R.J., Veldhuis, J.D., 1999. Role of endogenous aromatase in testosterone's short-term feedback regulation of 24hour LH, FSH, and GH release in young men. Presented at the Society for Gynecologic Investigation Annual Meeting, March 11, Atlanta, GA.
Schwartz, 1983, Semen characteristics as a function of age in 833 fertile men, Fertil. Steril., 39, 530, 10.1016/S0015-0282(16)46946-3
Schweizer, 1996, Basal and pulsatile secretion of human luteinizing hormone—new methods for the analysis of endocrine secretion processes, Endocrinol. Diabetes, 104, 235, 10.1055/s-0029-1211448
Shaar, 1974, Effects of castration and gonadal steroids on serum luteinizing hormone and prolactin in old and young rats, J. Endocrinol., 66, 45, 10.1677/joe.0.0660045
Shin, 1975, Effect of castration on luteinizing hormone and luteinizing hormone releasing hormone in the male rat, J. Endocrinol., 65, 447, 10.1677/joe.0.0650447
Shupnik, 1990, Effects of gonadotropin-releasing hormone on rat gonadotropin gene transcription in vitro: requirement for pulsatile administration for luteinizing hormone-beta gene stimulation, Mol. Endocrinol., 4, 1444, 10.1210/mend-4-10-1444
Simon, 1997, Association between plasma total testosterone and cardiovascular risk factors in healthy adult men: the Telecom study, J. Clin. Endocrinol. Metab., 82, 682, 10.1210/jc.82.2.682
Snyder, 1975, Serum LH and FSH responses to synthetic gonadotropin releasing hormone in normal men, J. Clin. Endocrinol. Metab., 41, 938, 10.1210/jcem-41-5-938
Sortino, 1996, Different responses of gonadotropin-releasing hormone (GnRH) release to glutamate receptor agonists during aging, Brain Res. Bull., 41, 359, 10.1016/S0361-9230(96)00199-2
Stearns, 1974, Declining testicular function with age, hormonal and clinical correlates, Am. J. Med., 57, 761, 10.1016/0002-9343(74)90850-X
Straume, M., Kovatchev, B.P., Johnson, M.L., Veldhuis, J.D., 2000. Time-of-day dependent deterioration of bidirectional LH–testosterone secretory coupling in healthy older men (submitted for publication).
Swerdloff, 1993, Androgen deficiency and aging in men, West. J. Med., 159, 579
Tenover, 1994, Androgen administration to aging men, Endocrinol. Metab. Clin. N. Am., 23, 877, 10.1016/S0889-8529(18)30073-2
Tenover, 1997, Testosterone in the aging male, J. Androl., 18, 103
Tenover, 1987, The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: response to clomiphene citrate, J. Clin. Endocrinol. Metab., 65, 1118, 10.1210/jcem-65-6-1118
Tenover, 1988, Age-related alterations in the circadian rhythms of pulsatile luteinizing hormone and testosterone secretion in healthy men, J. Gerontol., 43, M163, 10.1093/geronj/43.6.M163
Tilbrook, 1991, The negative feedback effects of testicular steroids are predominantly at the hypothalamus in the ram, Endocrinology, 129, 3080, 10.1210/endo-129-6-3080
Tillinger, 1955, The steroid production of the testicules and its relation to number and morphology of Leydig cells, Acta Endocrinol., 19, 340, 10.1530/acta.0.0190340
Urban, 1988, Hypothalamo-pituitary concomitants of aging, 41
Urban, 1988, Attenuated release of biologically active luteinizing hormone in healthy aging men, J. Clin. Investig., 81, 1020, 10.1172/JCI113412
Urban, 1988, Acute androgen receptor blockade increases luteinizing-hormone secretory activity in men, J. Clin. Endocrinol. Metab., 67, 1149, 10.1210/jcem-67-6-1149
Urban, 1988, Contemporary aspects of discrete peak detection algorithms. I. The paradigm of the luteinizing hormone pulse signal in men, Endocr. Rev., 9, 3, 10.1210/edrv-9-1-3
Urban, 1995, Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis, Am. J. Physiol., 269, E280
Van Cauter, 1979, Method for characterization of 24h temporal variation of blood components, Am. J. Physiol., 237, E255
Veldhuis, 1995, Pulsatile hormone release as a window into the brain's control of the anterior pituitary gland in health and disease: implications and consequences of pulsatile luteinizing hormone secretion, The Endocrinologist, 5, 454
Veldhuis, 1999, Recent insights into neuroendocrine mechanisms of aging of the human male hypothalamo-pituitary-gonadal axis, J. Androl., 20, 1
Veldhuis, 1999, Male hypothalamic-pituitary-gonadal axis, 622
Veldhuis, 1999, The neuroendocrine control of ultradian rhythms, 453
Veldhuis, 1986, Cluster analysis: a simple, versatile and robust algorithm for endocrine pulse detection, Am. J. Physiol., 250, E486
Veldhuis, 1992, Deconvolution analysis of hormone data, Methods Enzymol., 210, 539, 10.1016/0076-6879(92)10028-C
Veldhuis, 1995, Specific methodological approaches to selected contemporary issues in deconvolution analysis of pulsatile neuroendocrine data, Methods Neurosci., 28, 25, 10.1016/S1043-9471(06)80028-5
Veldhuis, J.D., Keenan, D.M., 2000. Neuroendocrine mechanisms underlying aging of the human male reproductive axis: novel hypothesis formulation and testing via a physiologically interlinked feedback and feedforward biomathematical construct. Presented at the 25th Annual Meeting of the American Society of Andrology, April 7–11, Boston, MA.
Veldhuis, 1998, Orderliness of hormone release patterns: a complementary measure to conventional pulsatile and circadian analyses, Eur. J. Endocrinol., 138, 358, 10.1530/eje.0.1380358
Veldhuis, 1984, Intensified rates of venous sampling unmask the presence of spontaneous high-frequency pulsations of luteinizing hormone in man, J. Clin. Endocrinol. Metab., 59, 96, 10.1210/jcem-59-1-96
Veldhuis, 1984, Performance of LH pulse detection algorithms at rapid rates of venous sampling in humans, Am. J. Physiol., 247, 554E
Veldhuis, 1984, Role of endogenous opiates in the expression of negative feedback actions of estrogen and androgen on pulsatile properties of luteinizing hormone secretion in man, J. Clin. Investig., 74, 47, 10.1172/JCI111417
Veldhuis, 1985, Minimizing false-positive errors in hormonal pulse detection, Am. J. Physiol., 248, E475
Veldhuis, 1985, Altered neuroendocrine regulation of gonadotropin secretion in women distance runners, J. Clin. Endocrinol. Metab., 61, 557, 10.1210/jcem-61-3-557
Veldhuis, 1986, Physiological properties of the luteinizing hormone pulse signal: Impact of intensive and extended venous sampling paradigms on their characterization in healthy men and women, J. Clin. Endocrinol. Metab., 62, 881, 10.1210/jcem-62-5-881
Veldhuis, 1986, Appraising endocrine pulse signals at low circulating hormone concentrations: use of regional coefficients of variation in the experimental series to analyze pulsatile luteinizing hormone release, Ped. Res., 20, 632, 10.1203/00006450-198607000-00011
Veldhuis, 1986, Metabolic clearance of biologically active luteinizing hormone in man, J. Clin. Investig., 77, 1122, 10.1172/JCI112411
Veldhuis, 1987, The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations, Proc. Natl. Acad. Sci. USA, 84, 7686, 10.1073/pnas.84.21.7686
Veldhuis, 1989, Pathophysiological features of the pulsatile secretion of biologically active luteinizing hormone in man, J. Steroid Biochem., 33, 739, 10.1016/0022-4731(89)90486-X
Veldhuis, 1989, Physiological attributes of endogenous bioactive luteinizing hormone secretory bursts in man: Assessment by deconvolution analysis and in vitro bioassay of LH, Am. J. Physiol., 256, E199
Veldhuis, 1990, Operating behavior of dual or multiple endocrine pulse generators, Am. J. Physiol., 259, E351
Veldhuis, 1992, Evidence that androgen negative-feedback regulates hypothalamic GnRH impulse strength and the burst-like secretion of biologically active luteinizing hormone in men, J. Clin. Endocrinol. Metab., 74, 1227, 10.1210/jc.74.6.1227
Veldhuis, 1992, Attenuation of luteinizing hormone secretory burst amplitude is a proximate basis for the hypoandrogenism of healthy aging in men, J. Clin. Endocrinol. Metab., 75, 52, 10.1210/jc.75.3.707
Veldhuis, 1994, Differential responses of biologically active LH secretion in older versus young men to interruption of androgen negative feedback, J. Clin. Endocrinol. Metab., 79, 1763, 10.1210/jc.79.6.1763
Veldhuis, 1994, Deconvolution analysis of neuroendocrine data: waveform-specific and waveform-independent methods and applications, Methods Neurosci., 20, 279, 10.1016/B978-0-12-185289-4.50021-8
Veldhuis, 1995, Complicating effects of highly correlated model variables on nonlinear least-squares estimates of unique parameter values and their statistical confidence intervals: estimating basal secretion and neurohormone half-life by deconvolution analysis, Methods Neurosci., 28, 130, 10.1016/S1043-9471(06)80031-5
Veldhuis, 1995, Differential impact of age, sex-steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay, J. Clin. Endocrinol. Metab., 80, 3209, 10.1210/jc.80.11.3209
Veldhuis, 1997, Neuroendocrine mechanisms by which selective Leydig-cell castration unleashes increased pulsatile LH release in the human: an experimental paradigm of short-term ketoconazole-induced hypoandrogenemia and deconvolution-estimated LH secretory enhancement, Am. J. Physiol., 272, R464
Veldhuis, 1997, Primary gonadal failure in men selectively amplifies the mass of follicle stimulating hormone (FSH) secreted per burst and increases the disorderliness of FSH release: reversibility with testosterone replacement, Int. J. Androl., 20, 297, 10.1046/j.1365-2605.1997.00073.x
Veldhuis, 1999, Joint basal and pulsatile hypersecretory mechanisms drive the monotropic follicle-stimulating hormone (FSH) elevation in healthy older men: concurrent preservation of the orderliness of the FSH release process, J. Clin. Endocrinol. Metab., 84, 3506, 10.1210/jc.84.10.3506
Veldhuis, 1999, Disruption of the young-adult synchrony between luteinizing hormone release and oscillations in follicle-stimulating hormone, prolactin, and nocturnal penile tumescence (NPT) in healthy older men, J. Clin. Endocrinol. Metab., 84, 3498, 10.1210/jc.84.10.3498
Veldhuis, 2000, Older men manifest multifold synchrony disruption of reproductive neurohormone outflow, J. Clin. Endocrinol. Metab., 85, 1477, 10.1210/jc.85.4.1477
Vermeulen, 1993, The male climacterium, Ann. Med., 25, 531, 10.1080/07853890.1993.12088579
Vermeulen, 1985, Long-term transdermal dihydrotestosterone therapy: effects on pituitary gonadal axis and plasma lipoproteins, Maturitas, 7, 281, 10.1016/0378-5122(85)90051-9
Vermeulen, 1985, Testicular endocrine function in the ageing male, Maturitas, 7, 273, 10.1016/0378-5122(85)90050-7
Vermeulen, 1969, Capacity of the testosterone-binding globulin in human plasma and influence of specific binding of testosterone on its metabolic clearance rate, J. Clin. Endocrinol. Metab., 29, 1470, 10.1210/jcem-29-11-1470
Vermeulen, 1971, The apparent free testosterone concentration, an index of androgenicity, J. Clin. Endocrinol. Metab., 33, 759, 10.1210/jcem-33-5-759
Vermeulen, 1989, A new look at the andropause: altered function of the gonadotrophs, J. Steroid Biochem., 32, 163, 10.1016/0022-4731(89)90158-1
Vermeulen, 1989, Influence of antiopioids on luteinizing hormone pulsatility in aging men, J. Clin. Endocrinol. Metab., 68, 68, 10.1210/jcem-68-1-68
Vermeulen, 1996, Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males, J. Clin. Endocrinol. Metab., 81, 1821, 10.1210/jc.81.5.1821
Vigersky, 1976, Effect of fluoxymesterone on the pituitary–gonadal axis: the role of testosterone-estradiol-binding globulin, J. Clin. Endocrinol. Metab., 43, 1, 10.1210/jcem-43-1-1
Wang, 1996, Testosterone replacement therapy improves mood in hypogonadal men—a clinical research center study, J. Clin. Endocrinol. Metab., 81, 3578, 10.1210/jc.81.10.3578
Wang, 1996, Sublingual testosterone replacement improves muscle mass and strength, decreases bone resportion and increases bone formation markers in hypogonadal men, J. Clin. Endocrinol. Metab., 81, 3654, 10.1210/jc.81.10.3654
Wang, 1998, Graded testosterone infusions distinguish gonadotropin negative-feedback responsiveness in Asians and white men—a clinical research center study, J. Clin. Endocrinol. Metab., 83, 870, 10.1210/jc.83.3.870
Warner, 1985, Effects of aging and illness on the pituitary testicular axis in men: qualitative as well as quantitative changes in luteinizing hormone, J. Clin. Endocrinol. Metab., 60, 163, 10.1210/jcem-60-2-263
Wide, 1968, Metabolic clearance of human chorionic gonadotropin administered to nonpregnant women, Acta Endocrinol. (Copenhagen), 59, 579, 10.1530/acta.0.0590579
Winters, 1997, Serum LH concentrations in hypogonadal men during transdermal testosterone replacement through scrotal skin: further evidence that aging enhances testosterone negative feedback, Clin. Endocrinol., 47, 317, 10.1046/j.1365-2265.1997.2551065.x
Winters, 1982, Episodic luteinizing hormone (LH) secretion and the response of LH and follicle-stimulating hormone to LH-releasing hormone in aged men: evidence for coexistent primary testicular insufficiency and an impairment in gonadotropin secretion, J. Clin. Endocrinol. Metab., 55, 560, 10.1210/jcem-55-3-560
Winters, 1986, Testosterone and estradiol are co-secreted episodically by the human testis, J. Clin. Investig., 78, 870, 10.1172/JCI112673
Winters, 1984, The gonadotropin-suppressive activity of androgen is increased in elderly men, Metabolism, 33, 1052, 10.1016/0026-0495(84)90237-3
Wise, 1994, Neuroendocrine concomitants of reproductive aging, Exp. Gerontol., 29, 275, 10.1016/0531-5565(94)90007-8
Wise, 1996, Menopause. The aging of multiple pacemakers, Science, 273, 53, 10.1126/science.273.5271.67
Wishart, 1995, Effect of age on bone density and bone turnover in men, Clin. Endocrinol., 42, 141, 10.1111/j.1365-2265.1995.tb01854.x
Witkin, 1987, Aging changes in synaptology of luteinizing hormone-releasing hormone neurons in male rat preoptic area, Neuroscience, 22, 1003, 10.1016/0306-4522(87)92976-9
Yahiro, 1987, Exaggerated gonadotropin response to luteinizing hormone-releasing hormone in amenorrheic runners, Am. J. Obstet. Gynecol., 156, 586, 10.1016/0002-9378(87)90058-5
Yen, 1968, Disappearance rates of endogenous luteinizing hormone and chorionic gonadotropin in man, J. Clin. Endocrinol. Metab., 28, 1763, 10.1210/jcem-28-12-1763
Zwart, 1996, Contrasts in the gonadotropin-releasing dose-response relationships for luteinizing hormone, follicle-stimulating hormone, and alpha-subunit release in young versus older men: appraisal with high-specificity immunoradiometric assay and deconvolution analysis, Eur. J. Endocrinol., 135, 399, 10.1530/eje.0.1350399
Zwart, 1997, Disparate serum free testosterone concentrations and degrees of hypothalamo-pituitary-LH suppression are achieved by continuous versus pulsatile intravenous androgen replacement in men: a clinical experimental model of ketoconazole-induced reversible hypoandrogenemia with controlled testosterone add-back, J. Clin. Endocrinol. Metab., 82, 2062, 10.1210/jc.82.7.2062