Recent advances with liposomes as pharmaceutical carriers

Nature Reviews Drug Discovery - Tập 4 Số 2 - Trang 145-160 - 2005
Vladimir P. Torchilin1
1Dept of Pharmaceutical Sciences, Northeastern University, Boston, USA

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Li, H., Song, J. H., Park, J. S. & Han, K. Polyethylene glycol-coated liposomes for oral delivery of recombinant human epidermal growth factor. Int. J. Pharm. 258, 11–19 (2003).

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Vyas, S. P., Kannan, M. E., Jain, S., Mishra, V. & Singh, P. Design of liposomal aerosols for improved delivery of rifampicin to alveolar macrophages. Int. J. Pharm. 269, 37–49 (2004).

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Copland, M. J. et al. Liposomal delivery of antigen to human dendritic cells. Vaccine 21, 883–890 (2003).

Torchilin, V. P. Liposomes as delivery agents for medical imaging. Mol. Med. Today. 2, 242–249 (1996).

Tilcock, C. in Liposomes as Tools in Basic Research and Industry (eds Philippot, J. R. & Schuber, F.) 225–240 (CRC, Boca Raton, 1995).

Torchilin, V. P. Surface-modified liposomes in γ and MR-imaging. Adv. Drug Deliv. Rev. 24, 301–313 (1997).

Torchilin, V. P. Polymeric contrast agents for medical imaging. Current. Pharm. Biotech. 1, 183–215 (2000).

Weissig, V., Babich, J. & Torchilin, V. P. Long-circulating gadolinium-loaded liposomes: potential use for magnetic resonance imaging of the blood pool. Coll. Surf. B: Biointerfaces. 18, 293–299 (2000).

Lokling, K. E., Fossheim, S. L., Klaveness, J. & Skurtveit, R. Biodistribution of pH-responsive liposomes for MRI and a novel approach to improve the pH-responsiveness. J. Control. Release 98, 87–95 (2004).

Vigilanti, B. L. et al. In vivo monitoring of tissue pharmacokinetics of liposome/drug using MRI: illustration of targeted delivery. Magn. Res. Med. 51, 1153–1162 (2004).

Bao, A. et al. A novel liposome radiolabeling method using 99mTc-'SNS/S' complexes: in vitro and in vivo evaluation. J. Pharm. Sci. 92, 1893–1904 (2003).

Bao, A., Goins, B., Klipper, R., Negrete, G. & Phillips, W. T. 186Re-liposome labeling using 186Re-SNS/S complexes: in vitro stability, imaging, and biodistribution in rats. J. Nucl. Med. 44, 1992–1994 (2003).

Sachse, A., Leike, J. U., Robling, G. L., Wagner, S. E. & Krause, W. Preparation and evaluation of lyophilized iopromide-carrying liposomes for liver tumor detection. Invest. Radiol. 28, 838–844 (1993).

Sachse, A. et al. Biodistribution and computed tomography blood-pool imaging properties of polyethylene glycol-coated Iopromide-carrying liposomes. Invest. Radiol. 32, 44–50 (1997).

Dagar, S., Rubinstein, I. & Onyuksel, H. Liposomes in ultrasound and gamma-scintigraphic imaging. Meth. Enzymol. 373, 198–214 (2003).

Kaneda, Y. Virosomes: evolution of the liposome as a targeted drug delivery system. Adv. Drug Deliv. Rev. 43, 197–205 (2000). Good review on virosomes.

Sarkar, D. P., Ramani, K. & Tyagi, S. K. Targeted gene delivery by virosomes. Methods Mol. Biol. 199, 163–173 (2002).

Cusi, M. G. et al. Efficient delivery of DNA to dendritic cells mediated by influenza virosomes. Vaccine 22, 735–739 (2004).

Bungener, L., Huckriede, A., Wilschut, J. & Daemen, T. Delivery of protein antigens to the immune system by fusion-active virosomes: a comparison with liposomes and ISCOMs. Biosci. Rep. 22, 323–338 (2002).

Bungener, L. et al. Virosome-mediated delivery of protein antigens to dendritic cells. Vaccine 20, 2287–2295 (2002).

Huckriede, A., Bungener, L., Daemen, T. & Wilschut, J. Influenza virosomes in vaccine. development. Meth. Enzymol. 373, 74–91 (2003).

Herzog, C., Metcalfe, I. C. & Schaad, U. B. Virosome influenza vaccine in children. Vaccine 20 (Suppl. 5), B24–B28 (2002).

Usonis, V. et al. Antibody titres after primary and booster vaccination of infants and young children with a virosomal hepatitis A vaccine (Epaxal). Vaccine 21, 4588–4592 (2003).

Ambrosch, F., Finkel, B., Herzog, C., Koren, A. & Kollaritsch, H. Rapid antibody response after vaccination with a virosomal hepatitis a Vaccine. Infection. 32, 149–152 (2004).

Ruf, B. R., Colberg, K., Frick, M. & Preusche, A. Open, randomized study to compare the immunogenicity and reactogenicity of an influenza split vaccine with an MF59-adjuvanted subunit vaccine and a virosome-based subunit vaccine in elderly. Infection. 32, 191–198 (2004).

Gluck, R., Moser, C., Metcalfe, I. C. Influenza virosomes as an efficient system for adjuvanted vaccine delivery. Expert Opin. Biol. Ther. 4, 1139–1145 (2004).

Moser, C., Metcalfe, I. C. & Viret, J. F. Virosomal adjuvanted antigen delivery systems. Expert Rev Vaccines. 2, 189–196 (2003).

Nobuto, H. et al. Evaluation of systemic chemotherapy with magnetic liposomal doxorubicin and a dipole external electromagnet. Int. J. Cancer 109, 627–635 (2004).

Kubo, T. et al. Targeted systemic chemotherapy using magnetic liposomes with incorporated adriamycin for osteosarcoma in hamsters. Int. J. Oncol. 18, 121–125 (2001).

Babincova, M. et al. Site-specific in vivo targeting of magnetoliposomes using externally applied magnetic field. Z. Naturforsch [C]. 55, 278–281 (2000).

Khaw, B. A. et al. Monoclonal antibody to cardiac myosin: imaging of experimental myocardial infarction. Hybridoma. 3, 11–23 (1984).

Khaw, B. A., Torchilin, V. P., Vural, I. & Narula, J. Plug and seal: prevention of hypoxic cardiocyte death by sealing membrane lesions with antimyosin-liposomes. Nature Med. 1, 1195–1198 (1995). Important paper on the use of cytoskeleton-specific immunoliposomes.

Khudairi, T. & Khaw, B. A. Preservation of ischemic myocardial function and integrity with targeted cytoskeleton-specific immunoliposomes. J. Am. Coll. Cardiol. 43, 1683–1689 (2004).

Asahi, M. et al. Antiactin-targeted immunoliposomes ameliorate tissue plasminogen activator-induced hemorrhage after focal embolic stroke. J. Cerebral Blood Flow Metab. 23, 895–899 (2003).

Khaw, B. A., daSilva, J., Vural, I., Narula, J. & Torchilin, V. P. Intracytoplasmic gene delivery for in vitro transfection with cytoskeleton-specific immunoliposomes. J. Control. Release 75, 199–210 (2001).

Awasthi, V. D., Garcia, D., Klipper, R., Goins, B. A. & Phillips, W. T. Neutral and anionic liposome-encapsulated hemoglobin: effect of postinserted poly(ethylene glycol)-distearoylphosphatidylethanolamine on distribution and circulation kinetics. J. Pharmacol. Exp. Ther. 309, 241–248 (2004).

Sakai, H., Tomiyama, K. I., Sou, K., Takeoka, S. & Tsuchida, E. Poly(ethylene glycol)-conjugation and deoxygenation enable long-term preservation of hemoglobin-vesicles as oxygen carriers in a liquid state. Bioconjug. Chem. 11, 425–432 (2000).

Phillips, W. T. et al. Polyethylene glycol-modified liposome-encapsulated hemoglobin: a long circulating red cell substitute. J. Pharmacol. Exp. Ther. 288, 665–670 (1999). Nice paper on liposomal haemoglobin.

Takeoka, S., Teramura, Y., Atoji, T. & Tsuchida, E. Effect of Hb-encapsulation with vesicles on H2O2 reaction and lipid peroxidation. Bioconjug. Chem. 13, 1302–1308 (2002).

Sakai, H. et al. Microvascular responses to hemodilution with Hb vesicles as red blood cell substitutes: influence of O2 affinity. Am. J. Physiol. 276, H553–H562 (1999).

Sakai, H. et al. Hemoglobin-vesicles suspended in recombinant human serum albumin for resuscitation from hemorrhagic shock in anesthetized rats. Crit. Care Med. 32, 539–545 (2004).

Shibuya-Fujiwara, N., Hirayama, F., Ogata, Y., Ikeda, H. & Ikebuchi, K. Phagocytosis in vitro of polyethylene glycol-modified liposome-encapsulated hemoglobin by human peripheral blood monocytes plus macrophages through scavenger receptors. Life Sci. 70, 291–300 (2001).

Szebeni, J. & Alving, C. R. Complement-mediated acute effects of liposome-encapsulated hemoglobin. Artif. Cells Blood Substit. Immobil. Biotechnol. 27, 23–41 (1999). Important paper on complement activation with PEG-liposomes.

Han, Y. Y. et al. Liposomal atp or NAD+ protects human endothelial cells from energy failure in a cell culture model of sepsis. Res. Commun. Mol. Pathol. Pharmacol. 110, 107–116 (2001).

Laham, A. et al. Liposomally entrapped adenosine triphosphate. Improved efficiency against experimental brain ischaemia in the rat. J. Chromatogr. 440, 455–458 (1988).

Konno, H., Matin, A. F., Maruo, Y., Nakamura, S. & Baba, S. Liposomal ATP protects the liver from injury during shock. Eur. Surg. Res. 28, 140–145 (1996).

Neveux, N., De Bandt, J. P., Chaumeil, J. C. & Cynober, L. Hepatic preservation, liposomally entrapped adenosine triphosphate and nitric oxide production: a study of energy state and protein metabolism in the cold-stored rat liver. Scand. J. Gastroenterol. 37, 1057–1063 (2002).

Niibori, K., Wroblewski, K. P., Yokoyama, H., Crestanello, J. A. & Whitman, G. J. Bioenergetic effect of liposomal coenzyme Q10 on myocardial ischemia reperfusion injury. Biofactors 9, 307–313 (1999).

Xu, G. X. et al. Adenosine triphosphate liposomes: encapsulation and distribution studies. Pharm. Res. 7, 553–557 (1990).

Verma, D. D., Levchenko, T. S., Bernstein, E. & Torchilin, V. P. ATP-Loaded liposomes effectively protect mechanical functions of the myocardium from global ischemia in an isolated rat heart model. Transactions of the 31th Annual Meeting of the Controlled Release Society, Controlled Release Society, Abs 572 (2004).

Liang, W., Levchenko, T., Khaw, B.-A. & Torchilin, V. P. ATP-containing immunoliposomes specific for cardiac myosin. Curr. Drug Deliv. 1, 1–7 (2004). The first example of ATP-containing immunoliposomes specific for hypoxic cells.

Derycke, A. S. & de Witte, P. A. Liposomes for photodynamic therapy. Adv. Drug Deliv. Rev. 56, 17–30 (2004). Good review on the use of liposomes for photo-dynamic therapy.

Takeuchi, Y. et al. Intracellular target for photosensitization in cancer antiangiogenic photodynamic therapy mediated by polycation liposome. J. Control. Release 97, 231–240 (2004).

Ichikawa, K. et al. Antiangiogenic photodynamic therapy (PDT) using Visudyne causes effective suppression of tumor growth. Cancer Lett. 205, 39–48 (2004).

Igarashi, A. et al. Liposomal photofrin enhances therapeutic efficacy of photodynamic therapy against the human gastric cancer. Toxicol. Lett. 145, 133–141 (2003).

Bourre, L., Thibaut, S., Fimiani, M., Ferrand, Y., Simonneaux, G. & Patrice, T. In vivo photosensitizing efficiency of a diphenylchlorin sensitizer: interest of a DMPC liposome formulation. Pharmacol. Res. 47, 253–261 (2003).

Jezek, P. et al. Experimental photodynamic therapy with MESO-tetrakisphenylporphyrin (TPP) in liposomes leads to disintegration of human amelanotic melanoma implanted to nude mice. Int. J. Cancer 103, 693–702 (2003).

Frankel, A. D. & Pabo, C. O. Cellular uptake of the tat protein from human immunodeficiency virus. Cell. 55, 1189–1193 (1988).

Wadia, J. S., Stan, R. V. & Dowdy, S. F. Transducable TAT-HA fusogenic peptide enhances escape of TAT fusion proteins after lipid raft macropinocytosis. Nature Med. 10, 310–315 (2004). An important paper regarding the mechanism of transduction.

Rothbard, J. B., Jessop, T. C., Lewis, R. S., Murray, B. A. & Wender, P. A. Role of membrane potential and hydrogen bonding in the mechanism of translocation of guanidinium-rich peptides into cells. J. Am. Chem. Soc. 126, 9506–9507 (2004). An important paper regarding the mechanism of transduction.

Torchilin, V. P., Rammohan, R., Weissig, V. & Levchenko, T. TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors. Proc. Natl Acad. Sci. USA 98, 8786–8791 (2001).

Tseng, Y. L., Liu, J. J. & Hong, R. L. Translocation of liposomes into cancer cells by cell-penetrating peptides penetratin and TAT: a kinetic and efficacy study. Mol. Pharmacol. 62, 864–872 (2002).

Gorodetsky, R. et al. Liposome transduction into cells enhanced by haptotactic peptides (Haptides) homologous to fibrinogen C-termini. J. Control. Release 95, 477–488 (2004).

Torchilin, V. P. et al. Cell transfection in vitro and in vivo with nontoxic TAT peptide–liposome–DNA complexes. Proc. Natl Acad. Sci. USA 100, 1972–1977 (2003).

Crommelin, D. J. & Storm, G. Liposomes: from the bench to the bed. J. Liposome Res. 13, 33–36 (2003).

Gregoriadis, G. (ed.). Liposome Technology vol. 1–3 (CRC, Boca Raton, 1984).

Gregoriadis, G. (ed.). Liposomes as Drug Carriers (John Wiley & Sons, Chichester, 1988).

Lasic, D. D. Liposomes: From Physics to Applications (Elsevier, Amsterdam, 1993).

Martin, F. & Lasic, D. (eds.). Stealth Liposomes (CRC, Boca Raton, 1995).

Woodle, M.C. & Storm, G. (eds.). Long Circulating Liposomes: Old Drugs, New Therapeutics (Springer, Berlin, 1997).

Lasic, D. D. & Papahadjopoulos, D. (eds.). Medical Applications of Liposomes (Elsevier, Amsterdam, 1998).

Torchilin, V. P. & Weissig, V. (eds.). Liposomes. Practical Approach (Oxford Univ. Press, Oxford, 2003).