Recent advances in tumor associated carbohydrate antigen based chimeric antigen receptor T cells and bispecific antibodies for anti-cancer immunotherapy

Seminars in Immunology - Tập 47 - Trang 101390 - 2020
Zahra Rashidijahanabad1,2, Xuefei Huang3,2,4
1Department of Chemistry, Michigan State University, East Lansing, MI, 48824, USA
2Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48824, USA
3Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA
4Department of Biomedical Engineering, Michigan State University, East Lansing, MI 48824, USA

Tài liệu tham khảo

World Health Organisation, 2018, Latest global cancer data, Int. Agency Res. Cancer, 13 International Agency for Research on Cancer, 2019, 1 Couzin-Frankel, 2013, Breakthrough of the year 2013, Cancer immunotherapy., Science., 342, 1432 Hakomori, 2001, Tumor-associated carbohydrate antigens defining tumor malignancy: basis for development of anti-cancer vaccines, 369, 10.1007/978-1-4615-1267-7_24 Buskas, 2009, Immunotherapy for cancer: synthetic carbohydrate-based vaccines, Chem. Commun. (Camb.), 5335, 10.1039/b908664c Jing, 2019, Overexpression of MUC1 predicts poor prognosis in patients with breast cancer, Oncol. Rep., 41, 801 Danishefsky, 2000, From the laboratory to the clinic: A retrospective on fully synthetic carbohydrate-based anticancer vaccines frequently used abbreviations are listed in the appendix, Angew. Chem. Int. Ed. Engl., 39, 836, 10.1002/(SICI)1521-3773(20000303)39:5<836::AID-ANIE836>3.0.CO;2-I Yin, 2012, Recent development in carbohydrate based anticancer vaccines, J. Carbohydr. Chem., 31, 143, 10.1080/07328303.2012.659364 Wei, 2018, Carbohydrate-based vaccines for oncotherapy, Med. Res. Rev., 38, 1003, 10.1002/med.21493 Feng, 2016, Recent advance in tumor-associated carbohydrate antigens (TACAs)-based antitumor vaccines, ACS Chem. Biol., 11, 850, 10.1021/acschembio.6b00084 Guo, 2009, Recent development in carbohydrate-based cancer vaccines, Curr. Opin. Chem. Biol., 13, 608, 10.1016/j.cbpa.2009.08.010 Riley, 2019, Delivery technologies for cancer immunotherapy, Nat. Rev. Drug Discov., 18, 175, 10.1038/s41573-018-0006-z Lloyd, 1989, Human monoclonal antibodies to glycolipids and other carbohydrate antigens: dissection of the humoral immune response in cancer patients, Cancer Res., 49, 3445 Sait, 2017, Anti-GD2 immunotherapy for neuroblastoma, Expert Rev. Anticancer Ther., 17, 889, 10.1080/14737140.2017.1364995 Hung, 2019, GD2-targeted immunotherapy of neuroblastoma, 63 Battula, 2012, Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis, J. Clin. Invest., 122, 2066, 10.1172/JCI59735 Cheever, 2009, The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research, Clin. Cancer Res., 15, 5323, 10.1158/1078-0432.CCR-09-0737 Gillies, 1989, High-level expression of chimeric antibodies using adapted cDNA variable region cassettes, J. Immunol. Methods, 125, 191, 10.1016/0022-1759(89)90093-8 D’Aloia, 2018, CAR-T cells: the long and winding road to solid tumors review-article, Cell Death Dis., 9, 10.1038/s41419-018-0278-6 Rossig, 2001, Targeting of GD2-positive tumor cells by human T lymphocytes engineered to express chimeric T-cell receptor genes, Int. J. Cancer, 94, 228, 10.1002/ijc.1457 Richards, 2018, CAR T cell therapy for neuroblastoma, Front. Immunol., 9, 2380, 10.3389/fimmu.2018.02380 Pule, 2008, Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma, Nat. Med., 14, 1264, 10.1038/nm.1882 Louis, 2011, Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma, Blood., 118, 6050, 10.1182/blood-2011-05-354449 Chen, 2019, Eradication of neuroblastoma by T cells redirected with an optimized GD2-specific chimeric antigen receptor and interleukin-15, Clin. Cancer Res., 25, 2915, 10.1158/1078-0432.CCR-18-1811 You, 2016, Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells, Sci. China Life Sci., 59, 386, 10.1007/s11427-016-5024-7 Song, 2012, CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo, Blood., 119, 696, 10.1182/blood-2011-03-344275 Craddock, 2010, Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b, J. Immunother., 33, 780, 10.1097/CJI.0b013e3181ee6675 Bocca, 2017, Bevacizumab-mediated tumor vasculature remodelling improves tumor infiltration and antitumor efficacy of GD2-CAR T cells in a human neuroblastoma preclinical model, Oncoimmunology. Caruana, 2015, Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes, Nat. Med., 21, 524, 10.1038/nm.3833 Gargett, 2016, GD2-specific CAR T cells undergo potent activation and deletion following antigen encounter but can be protected from activation-induced cell death by PD-1 blockade, Mol. Ther., 24, 1135, 10.1038/mt.2016.63 Gibbons, 2012, B7-H1 limits the entry of effector CD8+ T cells to the memory pool by upregulating bim, Oncoimmunology., 1, 1061, 10.4161/onci.20850 Latchman, 2004, PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells, Proc. Natl. Acad. Sci. U. S. A., 101, 10691, 10.1073/pnas.0307252101 Rowe, 2008, PDL-1 blockade impedes T Cell expansion and protective immunity primed by attenuated listeria monocytogenes, J. Immunol., 180, 7553, 10.4049/jimmunol.180.11.7553 Heczey, 2017, CAR T cells administered in combination with lymphodepletion and PD-1 Inhibition to patients with neuroblastoma, Mol. Ther., 25, 2214, 10.1016/j.ymthe.2017.05.012 John, 2013, Blockade of PD-1 immunosuppression boosts CAR T-cell therapy, Oncoimmunology., 2, 10.4161/onci.26286 Cherkassky, 2016, Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition, J. Clin. Invest., 126, 3130, 10.1172/JCI83092 Chong, 2017, PD-1 blockade modulates chimeric antigen receptor (CAR)-modified T cells: refueling the CAR, Blood., 129, 1039, 10.1182/blood-2016-09-738245 Thomas, 2016, An optimized GD2-targeting retroviral cassette for more potent and safer cellular therapy of neuroblastoma and other cancers, PLoS One, 11, 10.1371/journal.pone.0152196 Richman, 2018, High-Affinity GD2-specific CAR T cells induce fatal encephalitis in a preclinical neuroblastoma model, Cancer Immunol. Res., 6, 36, 10.1158/2326-6066.CIR-17-0211 Gargett, 2014, The inducible caspase-9 suicide gene system as a “safety switch” to limit on-target, off-tumor toxicities of chimeric antigen receptor T-cells, Front. Pharmacol., 5, 235, 10.3389/fphar.2014.00235 Mitwasi, 2017, Development of novel target modules for retargeting of UniCAR T cells to GD2 positive tumor cells, Oncotarget., 8, 108584, 10.18632/oncotarget.21017 Apostolopoulos Vasso, 2004, MUC1: a molecule of many talents, Curr. Trends Immunol., 6, 39 Kufe, 2013, MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches, Oncogene., 32, 1073, 10.1038/onc.2012.158 Ibrahim, 2011, Randomized phase II trial of letrozole plus Anti-MUC1 antibody AS1402 in hormone receptor-positive locally advanced or metastatic breast cancer, Clin. Cancer Res., 17, 6822, 10.1158/1078-0432.CCR-11-1151 Steentoft, 2018, Glycan-directed CAR-T cells, Glycobiology., 28, 656, 10.1093/glycob/cwy008 Hossain, 2016, Immunological evaluation of recent MUC1 glycopeptide cancer vaccines, Vaccines., 4, 25, 10.3390/vaccines4030025 Taylor-Papadimitriou, 2018, Latest developments in MUC1 immunotherapy, Biochem. Soc. Trans., 46, 659, 10.1042/BST20170400 Wilkie, 2008, Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor, J. Immunol., 180, 4901, 10.4049/jimmunol.180.7.4901 You, 2016, Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells, Sci. China Life Sci., 59, 386, 10.1007/s11427-016-5024-7 Maher, 2009, CAR mechanics: driving T cells into the MUC of cancer, Cancer Res., 69, 4559, 10.1158/0008-5472.CAN-09-0564 Gheybi, 2014, Designing a recombinant chimeric construct contain MUC1 and HER2 extracellular domain for prediagnostic breast cancer, Tumor Biol., 35, 11489, 10.1007/s13277-014-2483-y Sørensen, 2006, Chemoenzymatically synthesized multimeric Tn/STn MUC1 glycopeptides elicit cancer-specific anti-MUC1 antibody responses and override tolerance, Glycobiology., 16, 96, 10.1093/glycob/cwj044 Posey, 2016, Engineered CAR T cells targeting the cancer-associated Tn-glycoform of the membrane mucin MUC1 control adenocarcinoma, Immunity, 44, 1444, 10.1016/j.immuni.2016.05.014 Zhou, 2019, CAR T cells targeting the tumor MUC1 glycoprotein reduce triple-negative breast cancer growth, Front. Immunol., 10, 1, 10.3389/fimmu.2019.01149 Wei, 2017, PSCA and MUC1 in non-small-cell lung cancer as targets of chimeric antigen receptor T cells, Oncoimmunology, 6, 10.1080/2162402X.2017.1284722 Dotti, 2009, Fifteen years of gene therapy based on chimeric antigen receptors: Are we nearly there yet?, Hum. Gene Ther., 20, 1229, 10.1089/hum.2009.142 Büning, 2010, Do CARs need a driver’s license? Adoptive cell therapy with chimeric antigen receptor-redirected T cells has caused serious adverse events, Hum. Gene Ther., 21, 1039, 10.1089/hum.2010.131 Szymczak, 2004, Correction of multi-gene deficiency in vivo using a single “self-cleaving” 2A peptide-based retroviral vector, Nat. Biotechnol., 22, 589, 10.1038/nbt957 Wilkie, 2012, Dual targeting of ErbB2 and MUC1 in breast cancer using chimeric antigen receptors engineered to provide complementary signaling, J. Clin. Immunol., 32, 1059, 10.1007/s10875-012-9689-9 Kloss, 2013, Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells, Nat. Biotechnol., 31, 71, 10.1038/nbt.2459 Lanitis, 2013, Chimeric antigen receptor T Cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo, Cancer Immunol. Res., 1, 43, 10.1158/2326-6066.CIR-13-0008 Fan, 2015, Bispecific antibodies and their applications, J. Hematol. Oncol., 8, 130, 10.1186/s13045-015-0227-0 Kontermann, 2015, Bispecific antibodies; different formats, Drug Discov. Today, 20, 838, 10.1016/j.drudis.2015.02.008 Bhutani, 2015, Activated T cells armed with bispecific antibodies kill tumor targets, Curr. Opin. Hematol., 22, 476, 10.1097/MOH.0000000000000176 Husain, 2018, Expanding the boundaries of biotherapeutics with bispecific antibodies, BioDrugs., 32, 441, 10.1007/s40259-018-0299-9 Holmes, 2011, Buy buy bispecific antibodies, Nat. Rev. Drug Discov., 10, 798, 10.1038/nrd3581 Yankelevich, 2012, Anti-CD3×anti-GD2 bispecific antibody redirects T-cell cytolytic activity to neuroblastoma targets, Pediatr. Blood Cancer, 59, 1198, 10.1002/pbc.24237 Xu, 2015, Retargeting T cells to GD2 pentasaccharide on human tumors using bispecific humanized antibody, Cancer Immunol. Res., 3, 266, 10.1158/2326-6066.CIR-14-0230-T Cheng, 2016, Successful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumors, Oncoimmunology, 5, 1, 10.1080/2162402X.2016.1168557 Deppisch, 2017, Potent CD4+ T cell-associated antitumor memory responses induced by trifunctional bispecific antibodies in combination with immune checkpoint inhibition, Oncotarget., 8, 4520, 10.18632/oncotarget.13888 Katayose, 1996, MUC1-specific targeting immunotherapy with bispecific antibodies: inhibition of xenografted human bile duct carcinoma growth, Cancer Res., 56, 4205 Modak, 2018, Adoptive immunotherapy with haploidentical natural killer cells and Anti-GD2 monoclonal antibody m3F8 for resistant neuroblastoma: results of a phase I study, Oncoimmunology, 7 Tarek, 2012, Unlicensed NK cells target neuroblastoma following anti-GD2 antibody treatment, J. Clin. Invest., 122, 3260, 10.1172/JCI62749 Schettini, 2012, Intratumoral delivery of CpG-conjugated anti-MUC1 antibody enhances NK cell anti-tumor activity, Cancer Immunol. Immunother., 61, 2055, 10.1007/s00262-012-1264-y Li, 2018, Single domain based bispecific antibody, Muc1-Bi-1, and its humanized form, Muc1-Bi-2, induce potent cancer cell killing in muc1 positive tumor cells, PLoS One, 13, 1 Hoseini, 2017, Bispecific antibody does not induce T-cell death mediated by chimeric antigen receptor against disialoganglioside GD2, Oncoimmunology, 6, 10.1080/2162402X.2017.1320625 Alvarez-Rueda, 2011, A monoclonal antibody to O-Acetyl-GD2 ganglioside and not to GD2 shows potent anti-tumor activity without peripheral nervous system cross-reactivity, PLoS One, 6, e25220, 10.1371/journal.pone.0025220 Samraj, 2014, Involvement of a non-human sialic acid in human cancer, Front. Oncol., 4, 33 Inoue, 2010, Extensive enrichment of N-glycolylneuraminic acid in extracellular sialoglycoproteins abundantly synthesized and secreted by human cancer cells, Glycobiology, 20, 752, 10.1093/glycob/cwq030