Recent advances in the discovery of senolytics
Tài liệu tham khảo
Amor, 2020, Senolytic CAR T cells reverse senescence-associated pathologies, Nature, 583, 127, 10.1038/s41586-020-2403-9
Baar, 2017, Targeted apoptosis of senescent cells restores tissue homeostasis in response to Chemotoxicity and aging, Cell, 169, 132, 10.1016/j.cell.2017.02.031
Baker, 2011, Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders, Nature, 479, 232, 10.1038/nature10600
Baker, 2016, Naturally occurring p16Ink4a-positive cells shorten healthy lifespan, Nature, 530, 184, 10.1038/nature16932
Barnett, 2012, Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study, Lancet, 380, 37, 10.1016/S0140-6736(12)60240-2
Bielak-Zmijewska, 2019, The Role of Curcumin in the Modulation of Ageing, Int. J. Mol. Sci., 20, 1239, 10.3390/ijms20051239
Borghesan, 2020, A senescence-centric view of aging: implications for longevity and disease, Trends Cell Biol., 30, 777, 10.1016/j.tcb.2020.07.002
Burslem, 2020, Proteolysis-targeting chimeras as therapeutics and tools for biological discovery, Cell, 181, 102, 10.1016/j.cell.2019.11.031
Cai, 2020, Elimination of senescent cells by beta-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice, Cell Res., 30, 574, 10.1038/s41422-020-0314-9
Chang, 2016, Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice, Nat. Med., 22, 78, 10.1038/nm.4010
Chapman, 2019, Mitochondrial dysfunction and cell senescence: deciphering a complex relationship, FEBS Lett., 593, 1566, 10.1002/1873-3468.13498
Cherif, 2019, Curcumin and o-vanillin exhibit evidence of senolytic activity in human IVD cells in vitro, J. Clin. Med., 8, 433, 10.3390/jcm8040433
Cherif, 2020, Senotherapeutic drugs for human intervertebral disc degeneration and low back pain, Elife, 9, 10.7554/eLife.54693
Childs, 2015, Cellular senescence in aging and age-related disease: from mechanisms to therapy, Nat. Med., 21, 1424, 10.1038/nm.4000
Childs, 2017, Senescent cells: an emerging target for diseases of ageing, Nat. Rev. Drug Discov., 16, 718, 10.1038/nrd.2017.116
Cho, 2020, Identification of SYK inhibitor, R406 as a novel senolytic agent, Aging (Albany NY), 12, 8221, 10.18632/aging.103135
Coppe, 2010, The senescence-associated secretory phenotype: the dark side of tumor suppression, Annu. Rev. Pathol., 5, 99, 10.1146/annurev-pathol-121808-102144
Demaria, 2014, An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA, Dev. Cell, 31, 722, 10.1016/j.devcel.2014.11.012
Di Micco, 2021, Cellular senescence in ageing: from mechanisms to therapeutic opportunities, Nat. Rev. Mol. Cell Biol., 22, 75, 10.1038/s41580-020-00314-w
Dutta Gupta, 2020, Recent update on discovery and development of Hsp90 inhibitors as senolytic agents, Int. J. Biol. Macromol., 161, 1086, 10.1016/j.ijbiomac.2020.06.115
Dutta Gupta, 2019, Inhibiting protein-protein interactions of Hsp90 as a novel approach for targeting cancer, Eur. J. Med. Chem., 178, 48, 10.1016/j.ejmech.2019.05.073
Fleury, 2019, Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence, Nat. Commun., 10, 2556, 10.1038/s41467-019-10460-1
Fuhrmann-Stroissnigg, 2017, Identification of HSP90 inhibitors as a novel class of senolytics, Nat. Commun., 8, 422, 10.1038/s41467-017-00314-z
Fuhrmann-Stroissnigg, 2018, Hsp90 inhibitors as senolytic drugs to extend healthy aging, Cell Cycle, 1
Galiana, 2020, Preclinical antitumor efficacy of senescence-inducing chemotherapy combined with a nanoSenolytic, J. Control. Release, 323, 624, 10.1016/j.jconrel.2020.04.045
Gonzalez-Gualda, 2020, Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity, Aging Cell, 19, 10.1111/acel.13142
Guerrero, 2019, Cardiac glycosides are broad-spectrum senolytics, Nat Metab, 1, 1074, 10.1038/s42255-019-0122-z
Guerrero, 2020, Galactose-modified duocarmycin prodrugs as senolytics, Aging Cell, 19, 10.1111/acel.13133
Guo, 2020, Flavonoid GL-V9 induces apoptosis and inhibits glycolysis of breast cancer via disrupting GSK-3beta-modulated mitochondrial binding of HKII, Free Radic. Biol. Med., 146, 119, 10.1016/j.freeradbiomed.2019.10.413
He, 2017, Senescence in health and disease, Cell, 169, 1000, 10.1016/j.cell.2017.05.015
He, 2020, Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity, Aging Cell, 19, 10.1111/acel.13117
He, 2020, Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity, Nat. Commun., 11, 1996, 10.1038/s41467-020-15838-0
https://clinicaltrials.gov/ct2/show/NCT04229225.
Hubackova, 2019, Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2, Cell Death Differ., 26, 276, 10.1038/s41418-018-0118-3
Jeon, 2017, Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment, Nat. Med., 23, 775, 10.1038/nm.4324
Kennedy, 2014, Geroscience: linking aging to chronic disease, Cell, 159, 709, 10.1016/j.cell.2014.10.039
Khan, 2013, Fisetin: a dietary antioxidant for health promotion, Antioxid. Redox Signal., 19, 151, 10.1089/ars.2012.4901
Kirkland, 2017, Cellular senescence: a translational perspective, EBioMedicine, 21, 21, 10.1016/j.ebiom.2017.04.013
Lai, 2017, Induced protein degradation: an emerging drug discovery paradigm, Nat. Rev. Drug Discov., 16, 101, 10.1038/nrd.2016.211
Leverson, 2015, Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy, Sci. Transl. Med., 7, 10.1126/scitranslmed.aaa4642
Li, 2002, Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization, Nature, 416, 648, 10.1038/nature737
Li, 2011, GL-V9, a newly synthetic flavonoid derivative, induces mitochondrial-mediated apoptosis and G2/M cell cycle arrest in human hepatocellular carcinoma HepG2 cells, Eur. J. Pharmacol., 670, 13, 10.1016/j.ejphar.2011.08.054
Li, 2011, Inhibitory effects of GL-V9 on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-2/9, Eur. J. Pharm. Sci., 43, 393, 10.1016/j.ejps.2011.06.001
Li, 2019, The curcumin analog EF24 is a novel senolytic agent, Aging (Albany NY), 11, 771, 10.18632/aging.101787
Li, 2020, Mitotic catastrophe and p53-dependent senescence induction in T-cell malignancies exposed to nonlethal dosage of GL-V9, Arch. Toxicol., 94, 305, 10.1007/s00204-019-02623-2
Liu, 2016, D-peptides as recognition molecules and therapeutic agents, Chem. Rec., 16, 1772, 10.1002/tcr.201600005
Liu, 2018, Senolytic activity of piperlongumine analogues: synthesis and biological evaluation, Bioorg. Med. Chem., 26, 3925, 10.1016/j.bmc.2018.06.013
Lopez-Otin, 2013, The hallmarks of aging, Cell, 153, 1194, 10.1016/j.cell.2013.05.039
Marengoni, 2011, Aging with multimorbidity: a systematic review of the literature, Ageing Res. Rev., 10, 430, 10.1016/j.arr.2011.03.003
Mérino, 2012, Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells, Blood, 119, 5807, 10.1182/blood-2011-12-400929
Mijit, 2020, Role of p53 in the regulation of cellular senescence, Biomolecules, 10, 420, 10.3390/biom10030420
Mohamad Anuar, 2020, Clinical review: navitoclax as a pro-apoptotic and anti-fibrotic agent, Front. Pharmacol., 11
Moll, 2003, The MDM2-p53 interaction, Mol. Cancer Res., 1, 1001
Munoz-Espin, 2014, Cellular senescence: from physiology to pathology, Nat. Rev. Mol. Cell Biol., 15, 482, 10.1038/nrm3823
Munoz-Espin, 2018, A versatile drug delivery system targeting senescent cells, EMBO Mol. Med., 10, e9355, 10.15252/emmm.201809355
Niedernhofer, 2018, Senotherapeutics for healthy ageing, Nat. Rev. Drug Discov., 17, 377, 10.1038/nrd.2018.44
Nogueira-Recalde, 2019, Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy, EBioMedicine, 45, 588, 10.1016/j.ebiom.2019.06.049
Oltersdorf, 2005, An inhibitor of Bcl-2 family proteins induces regression of solid tumours, Nature, 435, 677, 10.1038/nature03579
Ozsvari, 2018, Azithromycin and Roxithromycin define a new family of "senolytic" drugs that target senescent human fibroblasts, Aging (Albany NY), 10, 3294, 10.18632/aging.101633
Peilin, 2019, Directed elimination of senescent cells attenuates development of osteoarthritis by inhibition of c-IAP and XIAP, Biochim. Biophys. Acta Mol. Basis Dis., 1865, 2618, 10.1016/j.bbadis.2019.05.017
Pignolo, 2020, Reducing senescent cell burden in aging and disease, Trends Mol. Med., 26, 630, 10.1016/j.molmed.2020.03.005
Robbins, 2021, Senolytic drugs: reducing senescent cell viability to extend health span, Annu. Rev. Pharmacol. Toxicol., 61, 779, 10.1146/annurev-pharmtox-050120-105018
Samaraweera, 2017, A novel indication for Panobinostat as a senolytic drug in NSCLC and HNSCC, Sci. Rep., 7, 1900, 10.1038/s41598-017-01964-1
Schoenwaelder, 2011, Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets, Blood, 118, 1663, 10.1182/blood-2011-04-347849
Sieben, 2018, Two-step senescence-focused cancer therapies, Trends Cell Biol., 28, 723, 10.1016/j.tcb.2018.04.006
Souers, 2013, ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets, Nat. Med., 19, 202, 10.1038/nm.3048
Sundarraj, 2018, A review on the chemotherapeutic potential of fisetin: in vitro evidences, Biomed. Pharmacother., 97, 928, 10.1016/j.biopha.2017.10.164
Syed, 2016, Exploring the molecular targets of dietary flavonoid fisetin in cancer, Semin. Cancer Biol., 40
Taipale, 2010, HSP90 at the hub of protein homeostasis: emerging mechanistic insights, Nat. Rev. Mol. Cell Biol., 11, 515, 10.1038/nrm2918
Triana-Martinez, 2019, Identification and characterization of Cardiac Glycosides as senolytic compounds, Nat. Commun., 10, 4731, 10.1038/s41467-019-12888-x
Tse, 2008, ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor, Cancer Res., 68, 3421, 10.1158/0008-5472.CAN-07-5836
Vu, 2013, Discovery of RG7112: a small-molecule MDM2 inhibitor in clinical development, ACS Med. Chem. Lett., 4, 466, 10.1021/ml4000657
Wakita, 2020, A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells, Nat. Commun., 11, 1935, 10.1038/s41467-020-15719-6
Wang, 2016, Discovery of piperlongumine as a potential novel lead for the development of senolytic agents, Aging (Albany NY), 8, 2915, 10.18632/aging.101100
Wang, 2017, High-throughput functional genetic and compound screens identify targets for senescence induction in cancer, Cell Rep., 21, 773, 10.1016/j.celrep.2017.09.085
Wissler Gerdes, 2020, Discovery, development, and future application of senolytics: theories and predictions, FEBS J., 287, 2418, 10.1111/febs.15264
Yang, 2021, Identification of GL-V9 as a novel senolytic agent against senescent breast cancer cells, Life Sci., 272, 10.1016/j.lfs.2021.119196
Yosef, 2016, Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL, Nat. Commun., 7, 11190, 10.1038/ncomms11190
Yousefzadeh, 2018, Fisetin is a senotherapeutic that extends health and lifespan, EBioMedicine, 36, 18, 10.1016/j.ebiom.2018.09.015
Zhang, 2015, Monitoring lipid peroxidation within foam cells by lysosome-targetable and ratiometric probe, Anal. Chem., 87, 8292, 10.1021/acs.analchem.5b01428
Zhang, 2018, Oxidation resistance 1 is a novel senolytic target, Aging Cell, 17, 10.1111/acel.12780
Zhang, 2020, FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice, Aging (Albany NY), 12, 1272, 10.18632/aging.102682
Zhang, 2021, Roxithromycin attenuates bleomycin-induced pulmonary fibrosis by targeting senescent cells, Acta Pharmacol. Sin.
Zhu, 2015, The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs, Aging Cell, 14, 644, 10.1111/acel.12344
Zhu, 2016, Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors, Aging Cell, 15, 428, 10.1111/acel.12445
Zhu, 2017, New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463, Aging (Albany NY), 9, 955, 10.18632/aging.101202
Zhu, 2020, The synthetic flavonoid derivative GL-V9 induces apoptosis and autophagy in cutaneous squamous cell carcinoma via suppressing AKT-Regulated HK2 and mTOR signals, Molecules, 25, 5033, 10.3390/molecules25215033