Reassessing neurodegenerative disease: immune protection pathways and antagonistic pleiotropy
Tài liệu tham khảo
Williams, 1957, Pleiotropy, natural selection, and the evolution of senescence, Evolution, 11, 398, 10.2307/2406060
Barreiro, 2010, From evolutionary genetics to human immunology: how selection shapes host defence genes, Nat. Rev. Genet., 11, 17, 10.1038/nrg2698
Aidoo, 2002, Protective effects of the sickle cell gene against malaria morbidity and mortality, Lancet, 359, 1311, 10.1016/S0140-6736(02)08273-9
Corder, 1993, Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families, Science, 261, 921, 10.1126/science.8346443
Hagberg, 2000, APO E gene and gene-environment effects on plasma lipoprotein-lipid levels, Physiol. Genomics, 4, 101, 10.1152/physiolgenomics.2000.4.2.101
Eichner, 2002, Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review, Am. J. Epidemiol., 155, 487, 10.1093/aje/155.6.487
Trumble, 2017, Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden, FASEB J., 31, 1508, 10.1096/fj.201601084R
van Exel, 2017, Effect of APOE epsilon4 allele on survival and fertility in an adverse environment, PLoS One, 12, 10.1371/journal.pone.0179497
Wozniak, 2002, Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus, Hepatology, 36, 456, 10.1053/jhep.2002.34745
Mueller, 2016, Apolipoprotein E allele frequencies in chronic and self-limited hepatitis C suggest a protective effect of APOE4 in the course of hepatitis C virus infection, Liver Int., 36, 1267, 10.1111/liv.13094
Corder, 1998, HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy, Nat. Med., 4, 1182, 10.1038/2677
Chang, 2011, Impact of apolipoprotein E epsilon4 and HIV on cognition and brain atrophy: antagonistic pleiotropy and premature brain aging, Neuroimage, 58, 1017, 10.1016/j.neuroimage.2011.07.010
Gale, 2014, APOepsilon4 is associated with enhanced in vivo innate immune responses in human subjects, J. Allergy Clin. Immunol., 134, 127, 10.1016/j.jaci.2014.01.032
Eimer, 2018, Alzheimer’s disease-associated beta-amyloid is rapidly seeded by Herpesviridae to protect against brain infection, Neuron, 99, 56, 10.1016/j.neuron.2018.06.030
Franceschi, 2000, Inflamm-aging. An evolutionary perspective on immunosenescence, Ann. N. Y. Acad. Sci., 908, 244, 10.1111/j.1749-6632.2000.tb06651.x
Jones, 2019, Metabolic disturbances of a high-fat diet are dependent on APOE genotype and sex, eNeuro, 6, 10.1523/ENEURO.0267-19.2019
Wang, 2015, Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China, Genes Immun., 16, 112, 10.1038/gene.2014.72
Wallings, 2019, LRRK2 regulation of immune-pathways and inflammatory disease, Biochem. Soc. Trans., 47, 1581, 10.1042/BST20180463
Gardet, 2010, LRRK2 is involved in the IFN-{gamma} response and host response to pathogens, J. Immunol., 185, 5577, 10.4049/jimmunol.1000548
Gillardon, 2012, Parkinson’s disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity, Neuroscience, 208, 41, 10.1016/j.neuroscience.2012.02.001
Panagiotakopoulou, 2020, Interferon-gamma signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells, Nat. Commun., 11, 5163, 10.1038/s41467-020-18755-4
Hartlova, 2018, LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages, EMBO J., 37, 10.15252/embj.201798694
Shutinoski, 2019, Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner, Sci. Transl. Med., 11, 10.1126/scitranslmed.aas9292
Fava, 2019, Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson’s disease, Proc. Natl. Acad. Sci. U. S. A., 116, 15616, 10.1073/pnas.1901805116
Liu, 2017, LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection, J. Exp. Med., 214, 3051, 10.1084/jem.20170014
Zhang, 2015, Commensal bacteria direct selective cargo sorting to promote symbiosis, Nat. Immunol., 16, 918, 10.1038/ni.3233
Feng, 2020, Oral P. gingivalis impairs gut permeability and mediates immune responses associated with neurodegeneration in LRRK2 R1441G mice, J. Neuroinflammation, 17, 347, 10.1186/s12974-020-02027-5
Weindel, 2020, LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis, eLife, 9, 10.7554/eLife.51071
Tischler, 2010, Contrasting persistence strategies in Salmonella and Mycobacterium, Curr. Opin. Microbiol., 13, 93, 10.1016/j.mib.2009.12.007
Spyropoulos, 1988, Tay-Sachs carriers and tuberculosis resistance, Nature, 331, 666, 10.1038/331666a0
Koo, 2008, Role for lysosomal enzyme beta-hexosaminidase in the control of mycobacteria infection, Proc. Natl. Acad. Sci. U. S. A., 105, 710, 10.1073/pnas.0708110105
Carette, 2011, Ebola virus entry requires the cholesterol transporter Niemann-Pick C1, Nature, 477, 340, 10.1038/nature10348
Cote, 2011, Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection, Nature, 477, 344, 10.1038/nature10380
Ng, 2015, Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats, eLife, 4, 10.7554/eLife.11785
Sadewasser, 2019, Anti-Niemann Pick C1 single-stranded oligonucleotides with locked nucleic acids potently reduce Ebola virus infection in vitro, Mol. Ther. Nucleic Acids, 16, 686, 10.1016/j.omtn.2019.04.018
Rhein, 2015, Ebola virus entry into host cells: identifying therapeutic strategies, Curr. Clin. Microbiol. Rep., 2, 115, 10.1007/s40588-015-0021-3
Lu, 2015, Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection, eLife, 4, 10.7554/eLife.12177
Sidransky, 2009, Multicenter analysis of glucocerebrosidase mutations in Parkinson’s disease, N. Engl. J. Med., 361, 1651, 10.1056/NEJMoa0901281
Drews, 2019, Glucosylceramidase maintains influenza virus infection by regulating endocytosis, J. Virol., 93, 10.1128/JVI.00017-19
Jeyakumar, 2003, Central nervous system inflammation is a hallmark of pathogenesis in mouse models of GM1 and GM2 gangliosidosis, Brain, 126, 974, 10.1093/brain/awg089
Ghosh, 2020, beta-Coronaviruses use lysosomes for egress instead of the biosynthetic secretory pathway, Cell, 183, 1520, 10.1016/j.cell.2020.10.039
Daniloski, 2021, Identification of required host factors for SARS-CoV-2 infection in human cells, Cell, 184, 92, 10.1016/j.cell.2020.10.030
Fierro, 2021, Gaucher disease and SARS-CoV-2 infection: experience from 181 patients in New York, Mol. Genet. Metab., 132, 44, 10.1016/j.ymgme.2020.12.288
Zimran, 2020, Impact of Gaucher disease on COVID-19, Intern. Med. J., 50, 894, 10.1111/imj.14894
Dugger, 2017, Pathology of neurodegenerative diseases, Cold Spring Harb. Perspect. Biol., 9, a028035, 10.1101/cshperspect.a028035
Wei, 2021, Therapeutic potential of alphaS evolvability for neuropathic Gaucher disease, Biomolecules, 11, 289, 10.3390/biom11020289
Grozdanov, 2019, Increased immune activation by pathologic alpha-synuclein in Parkinson’s disease, Ann. Neurol., 86, 593, 10.1002/ana.25557
Manczak, 2006, Mitochondria are a direct site of A beta accumulation in Alzheimer’s disease neurons: implications for free radical generation and oxidative damage in disease progression, Hum. Mol. Genet., 15, 1437, 10.1093/hmg/ddl066
Cieslik, 2020, Alterations of transcription of genes coding anti-oxidative and mitochondria-related proteins in amyloid beta toxicity: relevance to Alzheimer’s disease, Mol. Neurobiol., 57, 1374, 10.1007/s12035-019-01819-y
Nakamura, 2011, Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein, J. Biol. Chem., 286, 20710, 10.1074/jbc.M110.213538
Hu, 2019, Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity, Acta Neuropathol., 137, 939, 10.1007/s00401-019-01993-2
Van Laar, 2020, alpha-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo, Redox Biol., 37, 101695, 10.1016/j.redox.2020.101695
Drabik, 2020, Effect of amyloid-beta monomers on lipid membrane mechanical parameters-potential implications for mechanically driven neurodegeneration in Alzheimer’s disease, Int. J. Mol. Sci., 22, 18, 10.3390/ijms22010018
Zhao, 2020, APOE4 exacerbates alpha-synuclein pathology and related toxicity independent of amyloid, Sci. Transl. Med., 12, 10.1126/scitranslmed.aay1809
Bae, 2018, LRRK2 kinase regulates alpha-synuclein propagation via RAB35 phosphorylation, Nat. Commun., 9, 3465, 10.1038/s41467-018-05958-z
Bieri, 2019, LRRK2 modifies alpha-syn pathology and spread in mouse models and human neurons, Acta Neuropathol., 137, 961, 10.1007/s00401-019-01995-0
Mazzulli, 2011, Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies, Cell, 146, 37, 10.1016/j.cell.2011.06.001
Wickner, 2016, Yeast and fungal prions, Cold Spring Harb. Perspect. Biol., 8, 10.1101/cshperspect.a023531
Hashimoto, 2018, Evolvability and neurodegenerative disease: antagonistic pleiotropy phenomena derived from amyloid aggregates, J. Parkinsons Dis., 8, 405, 10.3233/JPD-181365
Michiels, 2020, Mechanisms and therapeutic potential of interactions between human amyloids and viruses, Cell. Mol. Life Sci., 78, 2485, 10.1007/s00018-020-03711-8
Soscia, 2010, The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide, PLoS One, 5, 10.1371/journal.pone.0009505
Spitzer, 2016, Amyloidogenic amyloid-beta-peptide variants induce microbial agglutination and exert antimicrobial activity, Sci. Rep., 6, 32228, 10.1038/srep32228
Bourgade, 2016, Anti-viral properties of amyloid-beta peptides, J. Alzheimers Dis., 54, 859, 10.3233/JAD-160517
Kumar, 2016, Amyloid-beta peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease, Sci. Transl. Med., 8, 10.1126/scitranslmed.aaf1059
Park, 2016, Functional characterization of alpha-synuclein protein with antimicrobial activity, Biochem. Biophys. Res. Commun., 478, 924, 10.1016/j.bbrc.2016.08.052
Beatman, 2015, Alpha-synuclein expression restricts RNA viral infections in the brain, J. Virol., 90, 2767, 10.1128/JVI.02949-15
Stolzenberg, 2017, A role for neuronal alpha-synuclein in gastrointestinal immunity, J. Innate Immun., 9, 456, 10.1159/000477990
Pasupuleti, 2009, Antimicrobial activity of human prion protein is mediated by its N-terminal region, PLoS One, 4, 10.1371/journal.pone.0007358
Kagan, 2012, Antimicrobial properties of amyloid peptides, Mol. Pharm., 9, 708, 10.1021/mp200419b
Fan, 2015, PI3K/AKT/mTOR/p70S6K Pathway Is Involved in Abeta25-35-induced autophagy, Biomed. Res. Int., 2015, 161020, 10.1155/2015/161020
Huang, 2014, Bacteria-autophagy interplay: a battle for survival, Nat. Rev. Microbiol., 12, 101, 10.1038/nrmicro3160
Dryden, 2018, Reactive oxygen species: a novel antimicrobial, Int. J. Antimicrob. Agents, 51, 299, 10.1016/j.ijantimicag.2017.08.029
Bombaca, 2019, Mitochondrial disfunction and ROS production are essential for anti-Trypanosoma cruzi activity of beta-lapachone-derived naphthoimidazoles, Free Radic. Biol. Med., 130, 408, 10.1016/j.freeradbiomed.2018.11.012
Silva, 2010, When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system, J. Leukoc. Biol., 87, 93, 10.1189/jlb.0809549
Rice, 2009, Mutations involved in Aicardi-Goutieres syndrome implicate SAMHD1 as regulator of the innate immune response, Nat. Genet., 41, 829, 10.1038/ng.373
Laguette, 2011, SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx, Nature, 474, 654, 10.1038/nature10117
Khan, 2020, SAMHD1 as the potential link between SARS-CoV-2 infection and neurological complications, Front. Neurol., 11, 562913, 10.3389/fneur.2020.562913
Coggins, 2019, Efficient pre-catalytic conformational change of reverse transcriptases from SAMHD1 non-counteracting primate lentiviruses during dNTP incorporation, Virology, 537, 36, 10.1016/j.virol.2019.08.010
Miller, 2015, Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis, Nat. Immunol., 16, 485, 10.1038/ni.3132
Kang, 2016, A novel PINK1- and PARK2-dependent protective neuroimmune pathway in lethal sepsis, Autophagy, 12, 2374, 10.1080/15548627.2016.1239678
Matheoud, 2019, Intestinal infection triggers Parkinson's disease-like symptoms in Pink1(-/-) mice, Nature, 571, 565, 10.1038/s41586-019-1405-y
Li, 2019, Parkin impairs antiviral immunity by suppressing the mitochondrial reactive oxygen species-Nlrp3 axis and antiviral inflammation, iScience, 16, 468, 10.1016/j.isci.2019.06.008
Patoli, 2020, Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis, J. Clin. Invest., 130, 5858, 10.1172/JCI130996
Sanket, 2021, Mitophagy antagonism by Zika virus reveals Ajuba as a regulator of PINK1-Parkin signaling, PKR-dependent inflammation, and viral invasion of tissues, BioRxiv
Forbester, 2015, Interaction of Salmonella enterica Serovar Typhimurium with intestinal organoids derived from human induced pluripotent stem cells, Infect. Immun., 83, 2926, 10.1128/IAI.00161-15
Wang, 2021, ApoE-isoform-dependent SARS-CoV-2 neurotropism and cellular response, Cell Stem Cell, 28, 331, 10.1016/j.stem.2020.12.018
Wagar, 2021, Modeling human adaptive immune responses with tonsil organoids, Nat. Med., 27, 125, 10.1038/s41591-020-01145-0
Raimondi, 2019, An organ-on-a-chip engineered platform to study the microbiota-gut-brain axis in neurodegeneration, Trends Mol. Med., 25, 737, 10.1016/j.molmed.2019.07.006
Trapecar, 2021, Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases, Sci. Adv., 7, 10.1126/sciadv.abd1707
Westermann, 2017, Resolving host-pathogen interactions by dual RNA-seq, PLoS Pathog., 13, 10.1371/journal.ppat.1006033
Chen, 2019, A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology, Cell, 177, 1217, 10.1016/j.cell.2019.03.036
Cumming, 2018, Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages, eLife, 7, 10.7554/eLife.39169
Cai, 2019, Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases, J. Clin. Invest., 129, 4539, 10.1172/JCI129987