Rearrangement of 21-hydroxylase genes in disease-associated MHC supratypes

Immunogenetics - Tập 23 Số 2 - Trang 100-105 - 1986
Michael J. Garlepp1, Alan N. Wilton2, Roger L. Dawkins3, Perrin C. White4
1Department of Medicine, The University of Calgary Health Services Center, Calgary, Canada
2University of Adelaide
3The Departments of Clinical Immunology, Royal Perth Hospital and The Queen Elizabeth II Medical Centre, Perth, Western Australia
4Laboratory of Human Immunogenetics, Memorial Sloan-Kettering Cancer Center, New York,

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Alper, C. A., Boenisch, T., and Watson, L.: Genetic polymorphism in human glycine-rich beta glycoprotein. J. Exp. Med. 135: 68?80, 1972

Awdeh, Z. L. and Alper, C. A.: Inherited structural polymorphism of the fourth component of human complement. Proc. Natl. Acad. Sci. U.S.A. 77: 3576?3580, 1980

Awdeh, Z. L., Raven, D., Yunis, E. J., and Alper, C. A.: Extended HLA-complement-glyoxylase allele haplotypes: Evidence for T/t-like complex in man. Proc. Natl. Acad. Sci. U.S.A. 80: 259?263, 1983

Belt, K. T., Carroll, M. C., and Porter, R. R.: The structural basis of the multiple forms of human complement component C4. Cell 36: 907?914, 1984

Carroll, M. C., Belt, T., Palsdottir, A., and Porter, R. R.: Structure and organisation of the C4 genes. Philos. Trans. R. Soc. Lond. (Biol.) 306: 379?388, 1984

Carroll, M. C., Campbell, R. D., and Porter, R. R.: Mapping of steroid 21-hydroxylase genes adjacent to complement component C4 genes in HLA, the major histocompatibility complex in man. Proc. Natl. Acad. Sci. U.S.A. 82: 521?525, 1985a

Carroll, M. C., Belt, K. T., Palsdottir, A., and Yu, Y.: Molecular genetics of the fourth component of human complement and steroid 21-hydroxylase. Immunol. Rev., in press, 1985b

Christiansen, F. T., Dawkins, R. L., Uko, G., McCluskey, J., Kay, P. H., and Zilko, P. J.: Complement allotyping in SLE Association with C4A null. Aust. N. Z. J. Med. 13: 483?488, 1983

Cobain, T. J., Stuckey, M. S., McCluskey, J., Wilton, A. N., Gedeon, A., Garlepp, M. J., Christiansen, F. T., Wilson, R. G., and Dawkins, R. L.: The coexistence of IgA deficiency and 21-hydroxylase deficiency marked by specific supratypes. Ann. N. Y. Acad. Sci., 458: 76?84, 1985

Dawkins, R. L., Christiansen, F. T., Kay, P. H., Garlepp, M., McCluskey, J., Hollingsworth, P. N., and Zilko P. J.: Disease associations with complotypes, supratypes and haplotypes. Immunol. Rev. 70: 5?22, 1983

Dupont, B., Pollack, M. S., Levine, L. S., O'Neill, G. J., Hawkins, B., and New, M. I.: Congenital adrenal hyperplasia and HLA: Joint report from the Eighth Histocompatibility Workshop. In P.I. Terasaki (ed.): Histocompatibility Testing 1980, pp. 693?706, UCLA Tissue Typing Laboratory, Los Angeles, 1980

Maniatis, T., Fritsch, E. F., and Sambrook, J.: Molecular Cloning, a Laboratory Manual, Cold Spring Harbor Laboratory, New York, 1982

McCluskey, J., Kay, P. H., Dawkins, R. L., Komori, K., Christiansen, F. T., and McCann, V. J.: Association of specific MHC supratypes with rheumatoid arthritis and insulin dependent diabetes mellitus. Disease Markers 1: 197?212, 1983

Raum, D., Awdeh, Z., Yunis, E. J., Alper, C. A., and Gabbay, K. H.: Extended major histocompatibility complex haplotypes in type I diabetes mellitus. J. Clin. Immunol. 74: 449?454, 1984

Scholz, S., Holler, W., Krom, D., Bidlingmeier, F., Zanden, H., and Albert, E. D.: Three different HLA associations in the three types of 21-hydroxylase congenital adrenal hyperplasia. In E. D. Albert, M. P. Baur, and W. R. Mayr (eds.): Histocompatibility Testing 1984, pp. 658?658, Springer-Verlag, Berlin, 1984

Southern, E. M.: Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 95: 503?517, 1975

Terasaki, P. I. (ed.): Histocompatibility Testing 1980, UCLA Tissue Typing Laboratory, Los Angeles, 1980

White, P. C., New, M. I., and Dupont, B. E.: HLA-linked congenital adrenal hyperplasia results from a defective gene encoding a cytochrome P-450 specific for steroid 21-hydroxylation. Proc. Nutl. Acad. Sci. U.S.A. 81: 7505?7509, 1984

White, P. C., Grossberger, D., Onufer, B. J., Chaplin, D., New, M. I., Dupont, B., and Strominger, J. L.: Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man. Proc. Natl. Acad. Sci. U.S.A. 82: 1089?1093, 1985

Wilton, A. N., Cobain, T. J., and Dawkins, R. L.: Family studies of IgA deficiency. Immunogenetics 21: 333?342, 1985

Zilko, P. J., Dawkins, R. L., Holmes, K., and Witt, C.: Genetic control of suppressor lymphocyte function in myasthenia gravis: Relationship of impaired suppressor function to HLA-B8/DRw3 and cold reactive lymphocytotoxic antibodies. Clin. Immunol. Immunopathol. 14: 222?230, 1979