Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence

Bannister, 2001, Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain, Nature, 410, 120, 10.1038/35065138

Brasher, 2000, The structure of mouse HP1 suggests a unique mode of single peptide recognition by the shadow chromo domain dimer, EMBO J., 19, 1587, 10.1093/emboj/19.7.1587

Brookes, 2002, INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence, EMBO J., 21, 2936, 10.1093/emboj/cdf289

Campisi, 2001, Cellular senescence as a tumor-suppressor mechanism, Trends Cell Biol., 11, S27, 10.1016/S0962-8924(01)02151-1

Chang, 1999, A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents, Cancer Res., 59, 3761

Cheniclet, 1990, Comparative pyrimidine- and purine-specific RNAse-gold labeling on pancreatic acinar cells and isolated hepatocytes, J. Histochem. Cytochem., 38, 551, 10.1177/38.4.1690766

Clemson, 1996, XIST RNA paints the inactive X chromosome at interphase, J. Cell Biol., 132, 259, 10.1083/jcb.132.3.259

Dai, 2000, p16INK4a can initiate an autonomous senescence program, Oncogene, 19, 1613, 10.1038/sj.onc.1203438

Dannenberg, 2000, Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions, Genes Dev., 14, 3051, 10.1101/gad.847700

Dillon, 2002, Unravelling heterochromatin, Trends Genet., 18, 252, 10.1016/S0168-9525(02)02648-3

Dimri, 1994, Regulation of two E2F-related genes in presenescent and senescent human fibroblasts, J. Biol. Chem., 269, 16180, 10.1016/S0021-9258(17)33990-X

Dimri, 1995, A biomarker that identifies senescent human cells in culture and in aging skin in vivo, Proc. Natl. Acad. Sci. USA, 92, 9363, 10.1073/pnas.92.20.9363

Dimri, 1996, Replicative senescence, aging and growth-regulatory transcription factors, Biol. Signals, 5, 154, 10.1159/000109185

Dirac, 2003, Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53, J. Biol. Chem., 278, 11731, 10.1074/jbc.C300023200

Ferbeyre, 2002, Oncogenic ras and p53 cooperate to induce cellular senescence, Mol. Cell. Biol., 22, 3497, 10.1128/MCB.22.10.3497-3508.2002

Ferbeyre, 2000, PML is induced by oncogenic ras and promotes premature senescence, Genes Dev., 14, 2015, 10.1101/gad.14.16.2015

Good, 1996, Regulation of dihydrofolate reductase gene expression and E2F components in human diploid fibroblasts during growth and senescence, J. Cell. Physiol., 168, 580, 10.1002/(SICI)1097-4652(199609)168:3<580::AID-JCP10>3.0.CO;2-3

Hahn, 2002, Rules for making human tumor cells, N. Engl. J. Med., 347, 1593, 10.1056/NEJMra021902

Hayflick, 1965, The limited in vitro lifetime of human diploid cell strains, Exp. Cell Res., 37, 614, 10.1016/0014-4827(65)90211-9

Heard, 2001, Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation, Cell, 107, 727, 10.1016/S0092-8674(01)00598-0

Henikoff, 2000, Heterochromatin function in complex genomes, Biochim. Biophys. Acta, 1470, O1

Humbert, 2000, E2F3 is critical for normal cellular proliferation, Genes Dev., 14, 690, 10.1101/gad.14.6.690

Jenuwein, 2001, Re-SET-ting heterochromatin by histone methyltransferases, Trends Cell Biol., 11, 266, 10.1016/S0962-8924(01)02001-3

Lachner, 2002, The many faces of histone lysine methylation, Curr. Opin. Cell Biol., 14, 286, 10.1016/S0955-0674(02)00335-6

Lachner, 2001, Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins, Nature, 410, 116, 10.1038/35065132

Lee, 2000, Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53, Proc. Natl. Acad. Sci. USA, 97, 8302, 10.1073/pnas.150024397

Leone, 1998, E2F3 activity is regulated during the cell cycle and is required for the induction of S phase, Genes Dev., 12, 2120, 10.1101/gad.12.14.2120

Leuba, 1994, On the location of linker DNA in the chromatin fiber. Studies with immobilized and soluble micrococcal nuclease, J. Mol. Biol., 235, 871, 10.1006/jmbi.1994.1045

Lin, 1998, Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling, Genes Dev., 12, 3008, 10.1101/gad.12.19.3008

Lowe, 1993, Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis, Genes Dev., 7, 535, 10.1101/gad.7.4.535

Lowe, 2003, Tumor suppression by Ink4a-Arf, Curr. Opin. Genet. Dev., 13, 77, 10.1016/S0959-437X(02)00013-8

Lundberg, 2000, Genes involved in senescence and immortalization, Curr. Opin. Cell Biol., 12, 705, 10.1016/S0955-0674(00)00155-1

Mathon, 2001, Cell senescence and cancer, Nat. Rev. Cancer, 1, 203, 10.1038/35106045

Nahle, 2002, Direct coupling of the cell cycle and cell death machinery by E2F, Nat. Cell Biol., 4, 859, 10.1038/ncb868

Nielsen, 2001, Heterochromatin formation in mammalian cells, Mol. Cell, 7, 729, 10.1016/S1097-2765(01)00218-0

Nielsen, 2001, Rb targets histone H3 methylation and HP1 to promoters, Nature, 412, 561, 10.1038/35087620

Peters, 2002, Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin, Nat. Genet., 30, 77, 10.1038/ng789

Peters, 2001, Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability, Cell, 107, 323, 10.1016/S0092-8674(01)00542-6

Rayman, 2002, E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex, Genes Dev., 16, 933, 10.1101/gad.969202

Sage, 2000, Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization, Genes Dev., 14, 3037, 10.1101/gad.843200

Samuelson, 1997, Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins, Proc. Natl. Acad. Sci. USA, 94, 12094, 10.1073/pnas.94.22.12094

Schmitt, 2002, A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy, Cell, 109, 335, 10.1016/S0092-8674(02)00734-1

Serrano, 1997, Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a, Cell, 88, 593, 10.1016/S0092-8674(00)81902-9

Shay, 1991, A role for both RB and p53 in the regulation of human cellular senescence, Exp. Cell Res., 196, 33, 10.1016/0014-4827(91)90453-2

Shelton, 1999, Microarray analysis of replicative senescence, Curr. Biol., 9, 939, 10.1016/S0960-9822(99)80420-5

Spector, 2001, Nuclear domains, J. Cell Sci., 114, 2891, 10.1242/jcs.114.16.2891

Steele-Perkins, 2001, Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily, Genes Dev., 15, 2250, 10.1101/gad.870101

Stott, 1998, The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2, EMBO J., 17, 5001, 10.1093/emboj/17.17.5001

Sugrue, 1997, Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53, Proc. Natl. Acad. Sci. USA, 94, 9648, 10.1073/pnas.94.18.9648

Takahashi, 2000, Analysis of promoter binding by the E2F and pRB families in vivo, Genes Dev., 14, 804, 10.1101/gad.14.7.804

te Poele, 2002, DNA damage is able to induce senescence in tumor cells in vitro and in vivo, Cancer Res., 62, 1876

Trimarchi, 2002, Sibling rivalry in the E2F family, Nat. Rev. Mol. Cell Biol., 3, 11, 10.1038/nrm714

Woo, 1998, Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes, Genes Dev., 12, 806, 10.1101/gad.12.6.806