Rate of malignant transformation of oral lichen planus: A systematic review

Oral Diseases - Tập 25 Số 3 - Trang 693-709 - 2019
Michele Giuliani1, Giuseppe Troiano1, Massimo Cordaro2, Massimo Corsalini3, Gioele Gioco2, Lorenzo Lo Muzio1, Pamela Pignatelli4, Carlo Lajolo2
1Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy
2School of Dentistry, Catholic University of the Sacred Heart, Rome, Italy
3Interdisciplinary Department of Medicine (DIM), University of Bari, Bari, Italy
4Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy

Tóm tắt

AbstractObjectiveThe aim of this study was to systematically review the literature to determine: (a) the malignant transformation rate (TR) of oral lichen planus (OLP) and its risk factors; (b) whether or not oral lichenoid lesions (OLL) have a different malignant TR.Materials and MethodsPubMed, Scopus, and Web of Science were used as search engines: only observational, full‐length, English language studies were investigated. PRISMA protocol was used to evaluate and present results. PROSPERO registration code is CRD42016048529.ResultsAmong 7,429 records screened, only 21 were included in this review. Ninety‐two of 6,559 patients developed oral squamous cell carcinoma, with an overall TR of 1.40% (1.37% for OLP and 2.43% for OLL), an annual TR of 0.20%. Female gender, red clinical forms, and tongue site seem to slightly increase the transformation risk.ConclusionsThis systematic review confirms that both OLP and OLL, the latter with a slightly higher TR, may be considered potentially malignant disorders and suggest that erosive type, female gender and tongue site should be considered as risk factors for OLP transformation. Major efforts should be done to establish strict clinical and histological criteria to diagnose OLP and to perform sounder methodological observational studies.

Từ khóa


Tài liệu tham khảo

10.1016/j.tripleo.2011.03.042

10.1016/j.oraloncology.2017.03.012

10.1126/science.1206923

10.1111/adj.12382

10.1016/j.oraloncology.2014.11.008

Arreaza A., 2015, p53 expression in oral lichenoid lesions and oral lichen planus, General Dentistry, 63, 69

Bajaj D., 2010, Oral lichen planus: A clinical study, Journal of College of Physicians and Surgeons Pakistan, 20, 154

10.3109/00016357.2012.734407

10.1111/j.1600-0714.1993.tb00134.x

10.1038/nrg948

10.1111/j.1600-0714.2010.00894.x

10.1111/odi.12681

10.1016/j.tripleo.2011.04.009

Bornstein M., 2006, Oral lichen planus and malignant transformation: A retrospective follow‐up study of clinical and histopathologic data, Quintessence International, 37, 261

10.1111/j.1600-0714.1993.tb00046.x

Brzak B., 2012, The frequency and malignant transformation rate of oral lichen planus and leukoplakia – A retrospective study, Collegium Antropologicum, 36, 773

10.4317/medoral.18940

10.1111/j.1601-0825.2009.01516.x

10.1007/s10006-014-0469-y

10.14219/jada.archive.2001.0302

10.1016/j.oooo.2016.05.004

10.3322/caac.21293

Consortium India Project Team of the International Cancer Genome, 2013, Mutational landscape of gingivo‐buccal oral squamous cell carcinoma reveals new recurrently‐mutated genes and molecular subgroups, Nature Communications, 4, 1

10.1067/mjd.2002.120452

10.1016/j.clindermatol.2009.03.004

10.14219/jada.2013.10

10.4317/medoral.20832

10.1155/2012/759626

10.1097/MEG.0b013e32821f6134

10.1111/jop.12480

10.1155/2014/742826

10.4317/medoral.18356

10.1038/nrc798

10.1111/j.1601-0825.2005.01221.x

10.4103/0973-029X.190911

10.1097/SCS.0b013e31820fe1f0

10.1177/154405910608501201

10.1007/s12105-011-0318-3

Kesić L., 2009, Incidence and treatment outcome of oral lichen planus in southeast Serbia in a 10‐year period (1997–2007), Vonjnosanitetski Pregled, 66, 435

10.1016/S0300-9785(73)80012-2

10.1093/carcin/8.10.1543

10.1111/j.1600-0714.1978.tb01879.x

10.1016/0030-4220(85)90315-9

Laeijendecker R., 2005, Premalignant nature of oral lichen planus, Acta Dermato‐Venereologica, 85, 516, 10.1080/00015550510036676

Lauritano D., 2016, Oral lichen planus clinical characteristics in Italian patients: A retrospective analysis, Head & Face Medicine, 12

10.1111/j.1365-2133.2012.10821.x

10.1016/j.tripleo.2004.06.076

10.1111/j.1365-2133.2007.07883.x

10.3322/caac.21389

10.1111/odi.12399

10.1016/j.oraloncology.2006.09.006

10.1016/S1079-2104(99)70033-8

10.1016/S1079-2104(03)00305-6

10.1034/j.1600-0714.2003.00125.x

10.1016/j.ijsu.2010.02.007

Moro A., 2015, The GOCCLES® medical device is effective in detecting oral cancer and dysplasia in dental clinical setting. Results from a multicentre clinical trial, Acta Otorhinolaryngologica Italica, 35, 449

10.1111/j.1600-0714.1986.tb00580.x

10.1093/carcin/13.5.783

Pakfetrat A., 2009, Oral Lichen Planus: A retrospective study of 420 Iranian patients, Medicina Oral, Patologia Oral y Cirugia Bucal, 14, 315

10.1177/03946320110240S217

10.4317/jced.51784

10.1053/ejso.1999.0689

10.3906/sag-1511-94

Rode M., 2002, Malignant potential of the reticular form of oral lichen planus over a 25‐year observation period in 55 patients from Slovenia, Journal of Oral Science, 44, 109

10.1016/S1368-8375(03)00134-9

10.1111/j.1600-0714.2010.00946.x

10.1111/j.1600-0714.2006.00420.x

10.4317/medoral.17778

10.1016/0030-4220(91)90007-Y

Sousa L. V., 2016, Isolation and identification of Candida species in patients with orogastric cancer: Susceptibility to antifungal drugs, attributes of virulence in vitro and immune response phenotype, BMC Infectious Diseases, 10

10.1038/nrmicro2636

10.1111/j.1601-0825.2011.01792.x

10.1093/annonc/mdn372

10.1111/j.2041-1626.2010.00005.x

10.1111/j.1600-0714.1988.tb01527.x

10.1146/annurev.pathol.1.110304.100224

10.4317/medoral.15.e685

10.15430/JCP.2016.21.1.55

10.1111/j.1600-0714.1992.tb01020.x

Wang Y., 2014, Malignant transformation in 5071 southern Taiwanese patients with potentially malignant oral mucosal disorders, BMC Oral Health, 19, 1

10.1111/j.1600-0714.2007.00582.x

10.1111/j.1600-0714.2011.01054.x

10.1016/0030-4220(78)90383-3

10.1111/j.1600-0714.2005.00341.x

Thông tin
Thông tin xuất bản

Oral Diseases

Tập 25 Số 3

693-709

Thông tin tác giả