Rapidly separable microneedle patches for controlled release of therapeutics for long-acting therapies

Chen, 2020, Nanoparticles-encapsulated polymeric microneedles for transdermal drug delivery, J Control Release, 325, 163, 10.1016/j.jconrel.2020.06.039 Gu, 2020, Outer membrane vesicles derived from E. coli as novel vehicles for transdermal and tumor targeting delivery, Nanoscale, 12, 18965, 10.1039/D0NR03698F Jiang, 2020, Progress in transdermal drug delivery systems for cancer therapy, Nano Res, 13, 1810, 10.1007/s12274-020-2664-5 Prausnitz, 2008, Transdermal drug delivery, Nat Biotechnol, 26, 1261, 10.1038/nbt.1504 Li, 2021, Progress and perspective of microneedle system for anti-cancer drug delivery, Biomaterials, 264, 120410, 10.1016/j.biomaterials.2020.120410 Hu, 2021, Microneedle array patches integrated with nanoparticles for therapy and diagnosis, Small Struct, 2, 2000097, 10.1002/sstr.202000097 Arora, 2010, Multicomponent chemical enhancer formulations for transdermal drug delivery: More is not always better, J Control Release, 144, 175, 10.1016/j.jconrel.2010.02.015 Kováčik, 2020, Permeation enhancers in transdermal drug delivery: Benefits and limitations, Expert Opin Drug Deliv, 17, 145, 10.1080/17425247.2020.1713087 Singh, 1994, Iontophoresis in drug delivery: basic principles and applications, Crit Rev Ther Drug Carrier Syst, 11, 161 Guy, 2000, Iontophoresis: electrorepulsion and electroosmosis, J Control Release, 64, 129, 10.1016/S0168-3659(99)00132-7 Gehl, 2003, Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research, Acta Physiol Scand, 177, 437, 10.1046/j.1365-201X.2003.01093.x Mitragotri, 2005, Innovation - Healing sound: the use of ultrasound in drug delivery and other therapeutic applications, Nat Rev Drug Discovery, 4, 255, 10.1038/nrd1662 Prausnitz, 2004, Microneedles for transdermal drug delivery, Adv Drug Deliv Rev, 56, 581, 10.1016/j.addr.2003.10.023 Kim, 2012, Microneedles for drug and vaccine delivery, Adv Drug Deliver Rev, 64, 1547, 10.1016/j.addr.2012.04.005 McAlister, 2021, The role of microneedle arrays in drug delivery and patient monitoring to prevent diabetes induced fibrosis, Adv Drug Deliv Rev, 175, 113825, 10.1016/j.addr.2021.06.002 Duarah, 2019, Recent advances in microneedle-based drug delivery: Special emphasis on its use in paediatric population, Eur J Pharm Biopharm, 136, 48, 10.1016/j.ejpb.2019.01.005 Gerstel M, Place V. Drug delivery device. US Patent No. 3964482. 1976. Zhu, 2017, Structural optimization of rapidly separating microneedles for efficient drug delivery, J Ind Eng Chem, 51, 178, 10.1016/j.jiec.2017.02.030 Jamaledin, 2020, Engineered microneedle patches for controlled release of active compounds: recent advances in release profile tuning, Adv Therapeut, 3, 2000171, 10.1002/adtp.202000171 He, 2018, Dissolving microneedles loaded with etonogestrel microcrystal particles for intradermal sustained delivery, J Pharm Sci, 107, 1037, 10.1016/j.xphs.2017.11.013 Yavuz, 2020, Silk fibroin microneedle patches for the sustained release of levonorgestrel, ACS Appl Biol Mater, 3, 5375, 10.1021/acsabm.0c00671 Zhang, 2018, Synergistic immunoreaction of acupuncture-like dissolving microneedles containing thymopentin at acupoints in immune-suppressed rats, Acta Pharm Sin B, 8, 449, 10.1016/j.apsb.2017.12.006 Kim, 2019, Biodegradable microneedle patch delivering antigenic peptide-hyaluronate conjugate for cancer immunotherapy, ACS Biomater Sci Eng, 5, 5150, 10.1021/acsbiomaterials.9b00961 Kim, 2020, Implantable powder-carrying microneedles for transdermal delivery of high-dose insulin with enhanced activity, Biomaterials, 232, 119733, 10.1016/j.biomaterials.2019.119733 Kim, 2018, Enhanced cancer vaccination by in situ nanomicelle-generating dissolving microneedles, ACS Nano, 12, 9702, 10.1021/acsnano.8b04146 Ruan, 2018, Coated microneedles mediated intradermal delivery of octaarginine/BRAF siRNA nanocomplexes for anti-melanoma treatment, Int J Pharm, 553, 298, 10.1016/j.ijpharm.2018.10.043 Pan, 2018, Intradermal delivery of STAT3 siRNA to treat melanoma via dissolving microneedles, Sci Rep, 8, 1117, 10.1038/s41598-018-19463-2 Chang, 2021, Cryomicroneedles for transdermal cell delivery, Nat Biomed Eng, 5, 1008, 10.1038/s41551-021-00720-1 Abdelkader, 2021, Polymeric long-acting drug delivery systems (LADDS) for treatment of chronic diseases: inserts, patches, wafers, and implants, Adv Drug Deliver Rev, 177, 113957, 10.1016/j.addr.2021.113957 Du, 2020, Current advances in sustained release microneedles, Pharm Fronts, 02, e11, 10.1055/s-0040-1701435 Chen, 2020, Long-acting microneedles: a progress report of the state-of-the-art techniques, Drug Discov Today, 25, 1462, 10.1016/j.drudis.2020.05.006 Park, 2006, Polymer microneedles for controlled-release drug delivery, Pharm Res, 23, 1008, 10.1007/s11095-006-0028-9 Kim, 2019, Biodegradable microneedle patch delivering antigenic peptide–hyaluronate conjugate for cancer immunotherapy, ACS Biomater Sci Eng, 5, 5150, 10.1021/acsbiomaterials.9b00961 Lee, 2020, Rapidly detachable microneedles using porous water-soluble layer for ocular drug delivery, Adv Mater Technol, 5, 1901145, 10.1002/admt.201901145 Hong, 2013, Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine, Drug Des Devel Ther, 7, 945 Li, 2019, Rapidly separable microneedle patch for the sustained release of a contraceptive, Nat Biomed Eng, 3, 220, 10.1038/s41551-018-0337-4 Lee, 2019, A tearable dissolving microneedle system for shortening application time, Expert Opin Drug Deliv, 16, 199, 10.1080/17425247.2019.1583645 Chu, 2011, Separable arrowhead microneedles, J Control Release, 149, 242, 10.1016/j.jconrel.2010.10.033 Choi, 2018, Insertion-responsive microneedles for rapid intradermal delivery of canine influenza vaccine, J Control Release, 286, 460, 10.1016/j.jconrel.2018.08.017 Kim, 2012, Hydrogel swelling as a trigger to release biodegradable polymer microneedles in skin, Biomaterials, 33, 668, 10.1016/j.biomaterials.2011.09.074 Kuwentrai, 2021, Intradermal delivery of receptor-binding domain of SARS-CoV-2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice, Bioeng Transl Med, 6, 10.1002/btm2.10202 Chang, 2020, Advances in the formulations of microneedles for manifold biomedical applications, Adv Mater Technol, 5, 1900552, 10.1002/admt.201900552 Leone, 2017, Dissolving microneedle patches for dermal vaccination, Pharm Res, 34, 2223, 10.1007/s11095-017-2223-2 Lee, 2008, Dissolving microneedles for transdermal drug delivery, Biomaterials, 29, 2113, 10.1016/j.biomaterials.2007.12.048 Herwadkar, 2012, Peptide and protein transdermal drug delivery, Drug Discov Today technol, 9, e147, 10.1016/j.ddtec.2011.11.007 Su, 2017, Efficient delivery of nanoparticles to deep skin layers using dissolvable microneedles with an extended-length design, J Mater Chem B, 5, 3355, 10.1039/C7TB00451F Hou, 2019, Rational design of rapidly separating dissolving microneedles for precise drug delivery by balancing the mechanical performance and disintegration rate, Adv Healthc Mater, 8, 1900898, 10.1002/adhm.201900898 Li, 2019, Long-acting reversible contraception by effervescent microneedle patch, Sci Adv, 5, eaaw8145, 10.1126/sciadv.aaw8145 Lee, 2021, Immediate detachment of microneedles by interfacial fracture for sustained delivery of a contraceptive hormone in the skin, J Control Release, 337, 676, 10.1016/j.jconrel.2021.08.012 Chu, 2010, Fabrication of dissolving polymer microneedles for controlled drug encapsulation and delivery: bubble and pedestal microneedle designs, J Pharm Sci, 99, 4228, 10.1002/jps.22140 Park, 2007, Polymer particle-based micromolding to fabricate novel microstructures, Biomed Microdev, 9, 223, 10.1007/s10544-006-9024-4 Chen, 2013, Fully embeddable chitosan microneedles as a sustained release depot for intradermal vaccination, Biomaterials, 34, 3077, 10.1016/j.biomaterials.2012.12.041 He, 2018, Assessment of mechanical stability of rapidly separating microneedles for transdermal drug delivery, Drug Deliv Transl Re, 8, 1034, 10.1007/s13346-018-0547-z Kang, 2021, Microneedles for drug delivery: recent advances in materials and geometry for preclinical and clinical studies, Expert Opin Drug Deliv, 18, 929, 10.1080/17425247.2021.1828860 DeMuth, 2014, Implantable silk composite microneedles for programmable vaccine release kinetics and enhanced immunogenicity in transcutaneous immunization, Adv Healthc Mater, 3, 47, 10.1002/adhm.201300139 Boopathy, 2019, Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination, Proc Natl Acad Sci, 116, 16473, 10.1073/pnas.1902179116 Zhang, 2010, Modulate the phase transition temperature of hydrogels with both thermosensitivity and biodegradability, Carbohydr Polym, 79, 131, 10.1016/j.carbpol.2009.07.040 Yoshida, 2010, Stimuli-responsive hydrogels and their application to functional materials, 19 Singh, 2019, Polymeric microneedles for controlled transdermal drug delivery, J Control Release, 315, 97, 10.1016/j.jconrel.2019.10.022 Ma, 2017, Microneedle, bio-microneedle and bio-inspired microneedle: A review, J Control Release, 251, 11, 10.1016/j.jconrel.2017.02.011 Paredes, 2021, Microarray patches: poking a hole in the challenges faced when delivering poorly soluble drugs, Adv Funct Mater, 31, 2005792, 10.1002/adfm.202005792 Nguyen, 2021, Progress in microneedle array patch (MAP) for vaccine delivery, Hum Vaccin Immunother, 17, 316, 10.1080/21645515.2020.1767997 Tenforde, 2021, Influenza vaccine effectiveness in inpatient and outpatient settings in the United States, 2015–2018, Clin Infect Dis, 73, 386, 10.1093/cid/ciaa407 Uppu, 2020, Temporal release of a three-component protein subunit vaccine from polymer multilayers, J Control Release, 317, 130, 10.1016/j.jconrel.2019.11.022 Tran, 2021, Transdermal microneedles for the programmable burst release of multiple vaccine payloads, Nat Biomed Eng, 5, 998, 10.1038/s41551-020-00650-4 DeMuth, 2013, Polymer multilayer tattooing for enhanced DNA vaccination, Nat Mater, 12, 367, 10.1038/nmat3550 Horejs C-M. A sharp contraceptive patch. Nat Rev Mater 2019;4(2):80–80. Gualeni, 2021, Human-centred design of a new microneedle-based hormonal contraceptive delivery system, Gates Open Res, 5, 96, 10.12688/gatesopenres.13233.3 Tian, 2017, Effects of ginsenoside Rg1 on glucose metabolism and liver injury in streptozotocin-induced type 2 diabetic rats, Genet Mol Res, 16, 10.4238/gmr16019463 Oumeish, 2008, Skin disorders in patients with diabetes, Clin Dermatol, 26, 235, 10.1016/j.clindermatol.2007.10.015 Umpierrez, 2018, Diabetes technology update: use of insulin pumps and continuous glucose monitoring in the hospital, Diabetes Care, 41, 1579, 10.2337/dci18-0002 Veiseh, 2015, A smart insulin patch, Nature, 524, 39, 10.1038/524039a Zong, 2021, Design and development of insulin microneedles for diabetes treatment. Drug Deliv, Transl Res, 9922 Yu, 2015, Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery, Proc Natl Acad Sci U S A, 112, 8260, 10.1073/pnas.1505405112 Liu, 2021, Fabrication of rapidly separable microneedles for transdermal delivery of metformin on diabetic rats, J Pharm Sci, 110, 3004, 10.1016/j.xphs.2021.04.009 Chen, 2020, A basal-bolus insulin regimen integrated microneedle patch for intraday postprandial glucose control, Sci Adv, 6, eaba7260, 10.1126/sciadv.aba7260 Moreira, 2019, Microneedle-based delivery devices for cancer therapy: A review, Pharmacol Res, 148, 104438, 10.1016/j.phrs.2019.104438 Addo, 2016, Anatomy of the eye and common diseases affecting the eye, 11 Nayak, 2018, A review on recent drug delivery systems for posterior segment of eye, Biomed Pharmacother, 107, 1564, 10.1016/j.biopha.2018.08.138 Roy, 2019, Amphotericin B containing microneedle ocular patch for effective treatment of fungal keratitis, Int J Pharm, 572, 118808, 10.1016/j.ijpharm.2019.118808 Yellepeddi, 2016, Recent advances in topical ocular drug delivery, J Ocul Pharmacol Ther, 32, 67, 10.1089/jop.2015.0047 Mitra, 2013 Amer, 2020, Self-adhesive microneedles with interlocking features for sustained ocular drug delivery, Macromol Biosci, 20, 2000089, 10.1002/mabi.202000089 Khandan, 2016, Fenestrated microneedles for ocular drug delivery, Sensor Actuat B Chem, 223, 15, 10.1016/j.snb.2015.09.071 Than, 2018, Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery, Nat Commun, 9, 4433, 10.1038/s41467-018-06981-w Siegel, 2020, Cancer statistics, 2020, CA Cancer J Clin, 70, 7, 10.3322/caac.21590 Zhao, 2019, Erythrocyte leveraged chemotherapy (ELeCt): Nanoparticle assembly on erythrocyte surface to combat lung metastasis, Sci Adv, 5, eaax9250, 10.1126/sciadv.aax9250 Sung, 2021, Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries, CA Cancer J Clin, 71, 209, 10.3322/caac.21660 Wang, 2022, Flav7+ DOX co-loaded separable microneedle for light-triggered chemo-thermal therapy of superficial tumors, Chem Eng J, 428, 10.1016/j.cej.2021.131913 Pei, 2018, Composite-dissolving microneedle patches for chemotherapy and photothermal therapy in superficial tumor treatment, Biomater Sci, 6, 1414, 10.1039/C8BM00005K Chen, 2021, In situ self-assembly nanomicelle microneedles for enhanced photoimmunotherapy via autophagy regulation strategy, ACS Nano, 15, 3387, 10.1021/acsnano.0c10396 Qin, 2020, Dissolving microneedles with spatiotemporally controlled pulsatile release nanosystem for synergistic chemo-photothermal therapy of melanoma, Theranostics, 10, 8179, 10.7150/thno.44194 Duong, 2018, Smart vaccine delivery based on microneedle arrays decorated with ultra-pH-responsive copolymers for cancer immunotherapy, Biomaterials, 185, 13, 10.1016/j.biomaterials.2018.09.008 Li, 2019, Cutaneous microenvironment responsive microneedle patch for rapid gene release to treat subdermal tumor, J Control Release, 314, 72, 10.1016/j.jconrel.2019.10.016 Chen, 2016, Near-infrared light-activatable microneedle system for treating superficial tumors by combination of chemotherapy and photothermal therapy, ACS Nano, 10, 93, 10.1021/acsnano.5b05043 Houck, 2005, Transdermal analgesia with local anesthetics in children: review, update and future directions, Expert Rev Neurother, 5, 625, 10.1586/14737175.5.5.625 Gupta, 2012, Rapid local anesthesia in human subjects using minimally invasive microneedles, Clin J Pain, 28, 129, 10.1097/AJP.0b013e318225dbe9 Xie, 2017, Analgesic microneedle patch for neuropathic pain therapy, ACS Nano, 11, 395, 10.1021/acsnano.6b06104 Batra, 2020, Microneedles and nanopatches-based delivery devices in dentistry, Discoveries, 8, e116, 10.15190/d.2020.13 Chen, 2017, Implantable polymeric microneedles with phototriggerable properties as a patient-controlled transdermal analgesia system, J Mater Chem B, 5, 496, 10.1039/C6TB02718K Stulberg, 2002, Common bacterial skin infections, Am Fam Physician, 66, 119 Hay, 2016, 1 Gao, 2021, Intradermal administration of green synthesized nanosilver (NS) through film-coated PEGDA microneedles for potential antibacterial applications, Biomater Sci, 9, 2244, 10.1039/D0BM02136A Jamaledin, 2020, Advances in antimicrobial microneedle patches for combating infections, Adv Mater, 32, 2002129, 10.1002/adma.202002129 González García, 2019, Self-sterilizing antibacterial silver-loaded microneedles, Chem Commun (Camb), 55, 171, 10.1039/C8CC06035E Zhang, 2020, Active pharmaceutical ingredient poly(ionic liquid)-based microneedles for the treatment of skin acne infection, Acta Biomater, 115, 136, 10.1016/j.actbio.2020.08.023 Peng, 2021, Hydrogel-forming microneedles for rapid and efficient skin deposition of controlled release tip-implants, Mater Sci Eng C Mater Biol Appl, 127, 112226, 10.1016/j.msec.2021.112226 Zhang, 2018, The potential of a microneedle patch for reducing obesity, Expert Opin Drug Deliv, 15, 431, 10.1080/17425247.2018.1449831 Pilitsi, 2019, Pharmacotherapy of obesity: available medications and drugs under investigation, Metabolism, 92, 170, 10.1016/j.metabol.2018.10.010 Huang, 2019, Polymeric carriers for controlled drug delivery in obesity treatment, Trends Endocrinol Metab, 30, 974, 10.1016/j.tem.2019.09.004 Kim, 2013, Antiobesity pharmacotherapy: new drugs and emerging targets, Clin Pharmacol Ther, 95, 53, 10.1038/clpt.2013.204 Than, 2017, Transdermal delivery of anti-obesity compounds to subcutaneous adipose tissue with polymeric microneedle patches, Small Methods, 1, 1700269, 10.1002/smtd.201700269 Bao, 2021, Microneedle patch delivery of capsaicin-containing α-lactalbumin nanomicelles to adipocytes achieves potent anti-obesity effects, Adv Funct Mater, 31, 2011130, 10.1002/adfm.202011130 Zhang, 2017, Locally induced adipose tissue browning by microneedle patch for obesity treatment, ACS Nano, 11, 9223, 10.1021/acsnano.7b04348 Peng, 2020, Black phosphorus modified soluble microneedle patch for painless, effective and accurate body slimming, Appl Mater Today, 19, 100577, 10.1016/j.apmt.2020.100577 Tsioris, 2012, Fabrication of silk microneedles for controlled-release drug delivery, Adv Funct Mater, 22, 330, 10.1002/adfm.201102012 Makvandi, 2021, Engineering microneedle patches for improved penetration: analysis, skin models and factors affecting needle insertion, Nano-Micro Lett, 13, 1, 10.1007/s40820-021-00611-9