Tiêu diệt nhanh chóng vi khuẩn kháng kháng sinh và biofilm bằng MXene và ánh sáng hồng ngoại gần thông qua sự hủy diệt photothermal

Science China Materials - Tập 64 - Trang 748-758 - 2020
Fan Wu1, Huiling Zheng2, Wenzhao Wang1, Qiong Wu2, Qi Zhang3, Jiayu Guo1, Bangzheng Pu1, Xinyuan Shi1, Jiebo Li1, Xiangmei Chen2, Weili Hong1
1Institute of Medical Photonics, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China
2Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
3State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of the Chemical Physics, Chinese Academy of Sciences, Dalian, China

Tóm tắt

Với sự phát triển và gia tăng kháng thuốc kháng sinh, việc tiêu diệt vi khuẩn nhanh chóng và hiệu quả trở nên cấp bách, đặc biệt là đối với vi khuẩn kháng kháng sinh và biofilm vi khuẩn thường khó điều trị bằng kháng sinh thông thường. Ở đây, một chiến lược kháng khuẩn nhanh chóng và rộng rãi được chứng minh thông qua sự hủy diệt photothermal với MXene và ánh sáng. MXene Ti3C2, khi kết hợp với ánh sáng 808 nm, cho thấy hiệu quả kháng khuẩn đáng kể chỉ trong 20 phút. Chiến lược kháng khuẩn này có hiệu quả với 15 loài vi khuẩn thử nghiệm, bao gồm Staphylococcus aureus kháng methicillin (MRSA) và Enterococcus kháng vancomycin (VRE). Ngoài ra, chiến lược kháng khuẩn nhanh chóng này còn hoạt động hiệu quả với biofilm MRSA, bằng cách làm hỏng cấu trúc cũng như tiêu diệt vi khuẩn trong biofilm. Hơn nữa, việc điều tra cơ chế kháng khuẩn cho thấy rằng Ti3C2 với ánh sáng tiêu diệt vi khuẩn chủ yếu theo cách vật lý thông qua việc cắm vào/liên hệ và tác động photothermal. Nghiên cứu này mở rộng các ứng dụng tiềm năng của MXene và cung cấp một cách để tiêu diệt vi khuẩn và biofilm một cách vật lý, mà không có khả năng phát triển kháng thuốc.

Từ khóa

#kháng sinh; vi khuẩn; biofilm; MXene; hủy diệt photothermal

Tài liệu tham khảo

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