Rapid detection of donor cell free DNA in lung transplant recipients with rejections using donor-recipient HLA mismatch

Yusen, 2013, The registry of the international society for heart and lung transplantation: thirtieth adult lung and heart-lung transplant report–2013; focus theme: age, J. Heart Lung Transplant., 32, 965, 10.1016/j.healun.2013.08.007 Glanville, 2010, Bronchoscopic monitoring after lung transplantation, Semin. Respir. Crit. Care Med., 31, 208, 10.1055/s-0030-1249117 Scott, 1991, Prospective study of transbronchial biopsies in the management of heart-lung and single lung transplant patients, J. Heart Lung Transplant., 10, 626 Berastegui, 2013, Biomarkers of pulmonary rejection, Transplant. Proc., 45, 3163, 10.1016/j.transproceed.2013.06.013 Crowley, 2013, Liquid biopsy: monitoring cancer-genetics in the blood, Nat. Rev. Clin. Oncol., 10, 472, 10.1038/nrclinonc.2013.110 Garcia Moreira, 2009, Cell-free DNA as a noninvasive acute rejection marker in renal transplantation, Clin. Chem., 55, 1958, 10.1373/clinchem.2009.129072 Gadi, 2011, Soluble donor DNA and islet injury after transplantation, Transplantation, 92, 607, 10.1097/TP.0b013e318228d799 Gadi, 2006, Soluble donor DNA concentrations in recipient serum correlate with pancreas-kidney rejection, Clin. Chem., 52, 379, 10.1373/clinchem.2005.058974 Kanzow, 2014, Graft-derived cell-free DNA as an early organ integrity biomarker after transplantation of a marginal HELLP syndrome donor liver, Transplantation, 98, e43, 10.1097/TP.0000000000000303 Snyder, 2011, Universal noninvasive detection of solid organ transplant rejection, Proc. Natl. Acad. Sci. U.S.A., 108, 6229, 10.1073/pnas.1013924108 De Vlaminck, 2014, Circulating cell-free DNA enables noninvasive diagnosis of heart transplant rejection, Sci. Transl. Med., 6, 10.1126/scitranslmed.3007803 De Vlaminck, 2015, Noninvasive monitoring of infection and rejection after lung transplantation, Proc. Natl. Acad. Sci. U.S.A., 112, 13336, 10.1073/pnas.1517494112 Valapour, 2016, Lung, Am. J. Transplant., 16, 141, 10.1111/ajt.13671 Zheng, 2012, Nonhematopoietically derived DNA is shorter than hematopoietically derived DNA in plasma: a transplantation model, Clin. Chem., 58, 549, 10.1373/clinchem.2011.169318 Stewart, 2007, Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection, J. Heart Lung Transplant., 26, 1229, 10.1016/j.healun.2007.10.017 Beck, 2013, Digital droplet PCR for rapid quantification of donor DNA in the circulation of transplant recipients as a potential universal biomarker of graft injury, Clin. Chem., 59, 1732, 10.1373/clinchem.2013.210328 Lo, 1998, Presence of donor-specific DNA in plasma of kidney and liver-transplant recipients, Lancet, 351, 1329, 10.1016/S0140-6736(05)79055-3 Zec, 2014, Novel droplet platforms for the detection of disease biomarkers, Expert Rev. Mol. Diagn., 14, 787, 10.1586/14737159.2014.945437 Bhorade, 2013, Interobserver variability in grading transbronchial lung biopsy specimens after lung transplantation, Chest, 143, 1717, 10.1378/chest.12-2107 Barrett, 2014, Stability of cell-free DNA from maternal plasma isolated following a single centrifugation step, Prenat. Diagn., 34, 1283, 10.1002/pd.4468 Burton, 2008, Minimal acute cellular rejection remains prevalent up to 2 years after lung transplantation: a retrospective analysis of 2697 transbronchial biopsies, Transplantation, 85, 547, 10.1097/TP.0b013e3181641df9 Yousem, 1996, Significance of clinically silent untreated mild acute cellular rejection in lung allograft recipients, Hum. Pathol., 27, 269, 10.1016/S0046-8177(96)90068-4 Hachem, 2009, Lung allograft rejection: diagnosis and management, Curr. Opin. Organ Transplant., 14, 477, 10.1097/MOT.0b013e32832fb981