Rapid and effective treatment of traumatic spinal cord injury using stem cell derived exosomes

2016, 2019, Traumatic Brain Injury and Spinal Cord Injury Collaborators. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016, Lancet Neurol, 18, 56, 10.1016/S1474-4422(18)30415-0

Rubiano, 2015, Global neurotrauma research challenges and opportunities, Nature, 527, S193, 10.1038/nature16035

Bellák, 2020, Grafted human induced pluripotent stem cells improve the outcome of spinal cord injury: modulation of the lesion microenvironment, Sci Rep, 10, 22414, 10.1038/s41598-020-79846-2

Li, 2019, A MnO2 nanoparticle-dotted hydrogel promotes spinal cord repair via regulating reactive oxygen species microenvironment and synergizing with mesenchymal stem cells, ACS Nano, 13, 14283, 10.1021/acsnano.9b07598

Liu, 2012, A novel first aid stretcher for immobilization and transportation of spine injured patients, PLoS One, 7, e39544, 10.1371/journal.pone.0039544

Sharwood, 2018, Emergency and acute care management of traumatic spinal cord injury: a survey of current practice among senior clinicians across Australia, BMC Emerg Med, 18, 57, 10.1186/s12873-018-0207-0

Todd, 2015, Secondary neurological deterioration in traumatic spinal injury: data from medicolegal cases, Bone Jt J, 97-B, 527, 10.1302/0301-620X.97B4.34328

Sahni, 2010, Stem cell therapies for spinal cord injury, Nat Rev Neurol, 6, 363, 10.1038/nrneurol.2010.73

Tsuji, 2019, Concise review: laying the groundwork for a first-in-human study of an induced pluripotent stem cell-based intervention for spinal cord injury, Stem Cells, 37, 6, 10.1002/stem.2926

Chhabra, 2017, Clinical translation of stem cell based interventions for spinal cord injury - are we there yet?, Adv Drug Deliv Rev, 120, 41, 10.1016/j.addr.2017.09.021

Gong, 2020, Stem cell transplantation: a promising therapy for spinal cord injury, Curr Stem Cell Res Ther, 15, 321, 10.2174/1574888X14666190823144424

Veneruso, 2019, Stem cell paracrine effect and delivery strategies for spinal cord injury regeneration, J Control Release, 300, 141, 10.1016/j.jconrel.2019.02.038

Luo, 2016, Role of stromal-derived factor-1 in mesenchymal stem cell paracrine-mediated tissue tepair, Curr Stem Cell Res Ther, 11, 585, 10.2174/1574888X11666160614102629

Kusuma, 2017, Effect of the microenvironment on mesenchymal stem cell paracrine signaling: opportunities to engineer the therapeutic effect, Stem Cells Dev, 26, 617, 10.1089/scd.2016.0349

Lankford, 2018, Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord, PLoS One, 13, 10.1371/journal.pone.0190358

Huang, 2017, Systemic administration of exosomes released from mesenchymal stromal cells attenuates apoptosis, inflammation, and promotes angiogenesis after spinal cord injury in rats, J Neurotrauma, 34, 3388, 10.1089/neu.2017.5063

Li, 2020, Transplantation of human mesenchymal stem-cell-derived exosomes immobilized in an adhesive hydrogel for effective treatment of spinal cord injury, Nano Lett, 20, 4298, 10.1021/acs.nanolett.0c00929

Liu, 2019, Role and prospects of regenerative biomaterials in the repair of spinal cord injury, Neural Regen Res, 14, 1352, 10.4103/1673-5374.253512

Tran, 2018, The biology of regeneration failure and success after spinal cord injury, Physiol Rev, 98, 881, 10.1152/physrev.00017.2017

Brosius, 2014, Contrasting the glial response to axon injury in the central and peripheral nervous systems, Dev Cell, 28, 7, 10.1016/j.devcel.2013.12.002

Davies, 1997, Regeneration of adult axons in white matter tracts of the central nervous system, Nature, 390, 680, 10.1038/37776

Li, 2017, Peptide-tethered hydrogel scaffold promotes recovery from spinal cord transection via synergism with mesenchymal stem cells, ACS Appl Mater Interfaces, 9, 3330, 10.1021/acsami.6b12829

Ducker, 1971, Pathological findings in acute experimental spinal cord trauma, J Neurosurg, 35, 700, 10.3171/jns.1971.35.6.0700

Xu, 2001, iNOS and nitrotyrosine expression after spinal cord injury, J Neurotrauma, 18, 523, 10.1089/089771501300227323

Satake, 2000, Nitric oxide via macrophage iNOS induces apoptosis following traumatic spinal cord injury, Brain Res Mol Brain Res, 85, 114, 10.1016/S0169-328X(00)00253-9

D'Autreaux, 2007, ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis, Nat Rev Mol Cell Biol, 8, 813, 10.1038/nrm2256

Bell, 2013, Insight into a neuron's preferential susceptibility to oxidative stress, Biochem Soc Trans, 41, 1541, 10.1042/BST20130245

Lidal, 2007, Mortality after spinal cord injury in Norway, J Rehabil Med, 39, 145, 10.2340/16501977-0017

Wyndaele, 2016, The management of neurogenic lower urinary tract dysfunction after spinal cord injury, Nat Rev Urol, 13, 705, 10.1038/nrurol.2016.206

Milligan, 2020, A primary care provider's guide to management of neurogenic lower urinary tract dysfunction and urinary tract infection after spinal cord injury, Top Spinal Cord Inj Rehabil, 26, 108, 10.46292/sci2602-108

Parent, 2011, The impact of specialized centers of care for spinal cord injury on length of stay, complications, and mortality: a systematic review of the literature, J Neurotrauma, 28, 1363, 10.1089/neu.2009.1151