Rapamycin protects against apoptotic neuronal death and improves neurologic function after traumatic brain injury in mice via modulation of the mTOR-p53-Bax axis

Journal of Surgical Research - Tập 194 - Trang 239-247 - 2015
Ke Ding1, Handong Wang1, Yong Wu1, Li Zhang1, Jianguo Xu1, Tao Li1, Yu Ding1, Lin Zhu1, Jin He1
1Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China

Tài liệu tham khảo

Langlois, 2006, The epidemiology and impact of traumatic brain injury: a brief overview, J Head Trauma Rehabil, 21, 375, 10.1097/00001199-200609000-00001 Cernak, 2005, Animal models of head trauma, NeuroRX, 2, 410, 10.1602/neurorx.2.3.410 Yatsiv, 2005, Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury, FASEB J, 19, 1701, 10.1096/fj.05-3907fje Xu, 2013, Inhibition of cathepsin S produces neuroprotective effects after traumatic brain injury in mice, Mediators Inflamm, 2013, 187873, 10.1155/2013/187873 Cornelius, 2013, Traumatic brain injury: oxidative stress and neuroprotection, Antioxid Redox Signal, 19, 836, 10.1089/ars.2012.4981 Hu, 2009, Ketogenic diet reduces cytochrome c release and cellular apoptosis following traumatic brain injury in juvenile rats, Ann Clin Lab Sci, 39, 76 Hu, 2009, The protective effect of the ketogenic diet on traumatic brain injury-induced cell death in juvenile rats, Brain Inj, 23, 459, 10.1080/02699050902788469 Campolo, 2013, Combination therapy with melatonin and dexamethasone in a mouse model of traumatic brain injury, J Endocrinol, 217, 291, 10.1530/JOE-13-0022 Ahmad, 2013, Absence of TLR4 reduces neurovascular unit and secondary inflammatory process after traumatic brain injury in mice, PLoS One, 8, e57208, 10.1371/journal.pone.0057208 Lopez, 2012, Ghrelin prevents disruption of the blood-brain barrier after traumatic brain injury, J Neurotrauma, 29, 385, 10.1089/neu.2011.2053 Colicos, 1996, Apoptotic morphology of dentate gyrus granule cells following experimental cortical impact injury in rats: possible role in spatial memory deficits, Brain Res, 739, 120, 10.1016/S0006-8993(96)00824-4 Rink, 1995, Evidence of apoptotic cell death after experimental traumatic brain injury in the rat, Am J Pathol, 147, 1575 Clark, 1999, Increases in Bcl-2 and cleavage of caspase-1 and caspase-3 in human brain after head injury, FASEB J, 13, 813, 10.1096/fasebj.13.8.813 Ang, 2003, Poly(adenosine diphosphate-ribose) polymerase expression in human traumatic brain injury, J Neurosurg, 99, 125, 10.3171/jns.2003.99.1.0125 Zhang, 2005, Bench-to-bedside review: apoptosis/programmed cell death triggered by traumatic brain injury, Crit Care, 9, 66, 10.1186/cc2950 Clark, 2000, Caspase-3 mediated neuronal death after traumatic brain injury in rats, J Neurochem, 74, 740, 10.1046/j.1471-4159.2000.740740.x Itoh, 2010, Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats, Neurochem Res, 35, 348, 10.1007/s11064-009-0061-2 Lopez, 2012, Early ghrelin treatment attenuates disruption of the blood brain barrier and apoptosis after traumatic brain injury through a UCP-2 mechanism, Brain Res, 1489, 140, 10.1016/j.brainres.2012.10.031 Chong, 2010, Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders, Oxid Med Cell Longev, 3, 374, 10.4161/oxim.3.6.14787 Erlich, 2007, Rapamycin is a neuroprotective treatment for traumatic brain injury, Neurobiol Dis, 26, 86, 10.1016/j.nbd.2006.12.003 Flierl, 2009, Mouse closed head injury model induced by a weight-drop device, Nat Protoc, 4, 1328, 10.1038/nprot.2009.148 Viscomi, 2012, Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage, Autophagy, 8, 222, 10.4161/auto.8.2.18599 Raghupathi, 1998, BCL-2 overexpression attenuates cortical cell loss after traumatic brain injury in transgenic mice, J Cereb Blood Flow Metab, 18, 1259, 10.1097/00004647-199811000-00013 Cheng, 2012, Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies, Br J Pharmacol, 167, 699, 10.1111/j.1476-5381.2012.02025.x Graham, 2000, Bcl-2 family gene products in cerebral ischemia and traumatic brain injury, J Neurotrauma, 17, 831, 10.1089/neu.2000.17.831 Kroemer, 2007, Mitochondrial membrane permeabilization in cell death, Physiol Rev, 87, 99, 10.1152/physrev.00013.2006 Concha, 2002, Controlling apoptosis by inhibition of caspases, Curr Med Chem, 9, 713, 10.2174/0929867023370761 Hong, 2010, p53-mediated neuronal cell death in ischemic brain injury, Neurosci Bull, 26, 232, 10.1007/s12264-010-1111-0 Vogelstein, 2000, Surfing the p53 network, Nature, 408, 307, 10.1038/35042675 Dazert, 2011, mTOR signaling in disease, Curr Opin Cell Biol, 23, 744, 10.1016/j.ceb.2011.09.003 Castedo, 2001, Human immunodeficiency virus 1 envelope glycoprotein complex-induced apoptosis involves mammalian target of rapamycin/FKBP12-rapamycin-associated protein-mediated p53 phosphorylation, J Exp Med, 194, 1097, 10.1084/jem.194.8.1097 Castedo, 2002, Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope, EMBO J, 21, 4070, 10.1093/emboj/cdf391 Koehl, 2004, Rapamycin protects allografts from rejection while simultaneously attacking tumors in immunosuppressed mice, Transplantation, 77, 1319, 10.1097/00007890-200405150-00002 Xia, 2013, Ischemia preconditioning is neuroprotective in a rat cerebral ischemic injury model through autophagy activation and apoptosis inhibition, Braz J Med Biol Res, 46, 580, 10.1590/1414-431X20133161 Yin, 2012, Rapamycin preconditioning attenuates transient focal cerebral ischemia/reperfusion injury in mice, Int J Neurosci, 122, 748, 10.3109/00207454.2012.721827 Napieralski, 1999, The tumor-suppressor gene, p53, is induced in injured brain regions following experimental traumatic brain injury, Brain Res Mol Brain Res, 71, 78, 10.1016/S0169-328X(99)00155-2 Martin, 2001, Injury-induced apoptosis of neurons in adult brain is mediated by p53-dependent and p53-independent pathways and requires Bax, J Comp Neurol, 433, 299, 10.1002/cne.1141 Wan, 2014, Downregulation of UBE2Q1 is associated with neuronal apoptosis in rat brain cortex following traumatic brain injury, J Neurosci Res, 92, 1, 10.1002/jnr.23305