Rapamycin inhibits pre-B acute lymphoblastic leukemia cells by downregulating DNA and RNA polymerases

Leukemia Research - Tập 38 - Trang 940-947 - 2014
Zhijian Wang1, Fei Xu1, Na Yuan1, Yuna Niu1, Weiwei Lin1, Yan Cao1, Jinyang Cai1, Lin Song1, Xin Li1, Yixuan Fang1, Wenli Zhao1, Shaoyan Hu1, Suning Chen1, Suping Zhang1, Jianrong Wang1
1Hematology Center of Cyrus Tang Medical Institute, Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Jiangsu Key Laboratory for Stem Cell Research, Affiliated Children's Hospital, Soochow University School of Medicine, Soochow University, Suzhou 215123, China

Tài liệu tham khảo

Winick, 2004, Childhood leukemia – new advances and challenges, N Engl J Med, 351, 601, 10.1056/NEJMe048154 Pui, 2008, Acute lymphoblastic leukaemia, Lancet, 371, 1030, 10.1016/S0140-6736(08)60457-2 Vogler, 1978, Pre-B cell leukemia. A new phenotype of childhoodlymphoblastic leukemia, N Engl J Med, 298, 872, 10.1056/NEJM197804202981603 Carroll, 1984, Pre-B cell leukemia associated with chromosome translocation 1;19, Blood, 63, 721, 10.1182/blood.V63.3.721.721 Inaba, 2013, Acute lymphoblastic leukemia, Lancet, 381, 1943, 10.1016/S0140-6736(12)62187-4 Hunger, 1991, The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias, Blood, 77, 687, 10.1182/blood.V77.4.687.687 Crist, 1990, Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study, Blood, 76, 117, 10.1182/blood.V76.1.117.117 Kamps, 1991, The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials, Genes Dev, 5, 358, 10.1101/gad.5.3.358 Raimondi, 1990, Cytogenetics of pre-B-cell acute lymphoblastic leukemia with emphasis on prognostic implications of the t(1;19), J Clin Oncol, 8, 1380, 10.1200/JCO.1990.8.8.1380 Pui, 2010, Recent research advances in childhood acute lymphoblastic leukemia, J Formos Med Assoc, 109, 777, 10.1016/S0929-6646(10)60123-4 Nguyen, 2008, Factors influencing survival after relapse from acute lymphoblastic leukemia: a Children's Oncology Group study, Leukemia, 22, 2142, 10.1038/leu.2008.251 Oeffinger, 2000, Grading of late effects inyoung adult survivors of childhood cancer followed in an ambulatory adult setting, Cancer, 88, 1687, 10.1002/(SICI)1097-0142(20000401)88:7<1687::AID-CNCR24>3.0.CO;2-M Pui, 2007, New therapeutic strategies for the treatment of acute lymphoblastic leukaemia, Nat Rev Drug Discov, 6, 149, 10.1038/nrd2240 Jeha, 2009, New therapeutic strategies in acute lymphoblastic leukemia, Semin Hematol, 46, 76, 10.1053/j.seminhematol.2008.09.009 Klionsky, 2000, Autophagy as a regulated pathway of cellular degradation, Science, 290, 1717, 10.1126/science.290.5497.1717 Thoreen, 2009, Rapamycin inhibits mTORC1, but not completely, Autophagy, 5, 725, 10.4161/auto.5.5.8504 Levine, 2004, Development by self-digestion: molecular mechanisms and biological functions of autophagy, Dev Cell, 6, 463, 10.1016/S1534-5807(04)00099-1 Wang, 2008, Vitamin D3 induces autophagy of human myeloid leukemia cells, J Biol Chem, 283, 25596, 10.1074/jbc.M801716200 Wang, 2009, A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin1, J Biol Chem, 284, 21412, 10.1074/jbc.M109.026013 Récher, 2005, Antileukemic activity of rapamycin in acute myeloid leukemia, Blood, 105, 2527, 10.1182/blood-2004-06-2494 Avellino, 2005, Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells, Blood, 106, 1400, 10.1182/blood-2005-03-0929 Brown, 2003, Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling, Proc Natl Acad Sci USA, 100, 15113, 10.1073/pnas.2436348100 Zhao, 2008, Antiproliferative effect of rapamycin on human T-cell leukemia cell line Jurkat by cell cycle arrest and telomerase inhibition, Acta Pharmacol Sin, 29, 481, 10.1111/j.1745-7254.2008.00767.x Yang, 2014, Mammalian target of rapamycin inhibitor rapamycin enhances anti-leukemia effect of imatinib on Ph+ acute lymphoblastic leukemia cells, Eur J Hematol, 92, 111, 10.1111/ejh.12202 Husson, 2002, Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays, Blood, 99, 282, 10.1182/blood.V99.1.282 Chiarini, 2009, Dual inhibition of classIA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia, Cancer Res, 69, 3520, 10.1158/0008-5472.CAN-08-4884 Findley, 1982, Two new acute lymphoblastic leukemia cell lines with early B-cell phenotypes, Blood, 60, 1305, 10.1182/blood.V60.6.1305.1305 Klionsky, 2012, Guideline for the use and interpretation of assays for monitoring autophagy, Autophagy, 8, 445, 10.4161/auto.19496 Chung, 1991, Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene, Proc Natl Acad Sci USA, 88, 11197, 10.1073/pnas.88.24.11197 Johnson, 2005, Cellular DNA replicases: components and dynamics at the replication fork, Annu Rev Biochem, 74, 283, 10.1146/annurev.biochem.73.011303.073859 Fujimoto, 2009, Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation, J Biol Chem, 284, 27664, 10.1074/jbc.M109.041616 Dobson, 2013, Defining functional heterogeneity in acute lymphoblastic leukemia, Blood, 122, 1365, 10.1182/blood.V122.21.1365.1365