Randomized Trial of Tocilizumab in Systemic Juvenile Idiopathic Arthritis

New England Journal of Medicine - Tập 367 Số 25 - Trang 2385-2395 - 2012
Fabrizio De Benedetti1, Hermine I. Brunner2, Nicolino Ruperto3, A. Kenwright4, Stephen Wright4, Inmaculada Calvo5, Rubén Cuttica6, Angelo Ravelli3,7, Rayfel Schneider8, Patricia Woo9, Carine Wouters10, Ricardo Machado Xavier11, Lawrence Zemel12, Eileen Baildam13, Rubén Burgos‐Vargas14, Pavla Doležalová15, Stella Maris Garay16, Rosa Merino17, Rik Joos18, Alexei A. Grom2, Nico Wulffraat19, Zbigniew Żuber20, Francesco Zulian21, Daniel J. Lovell2, Alberto Martini3,7
1Ospedale Pediatrico Bambino Gesù, Rome
2Coordinating Center, Cincinnati
3Coordinating Center, Genoa
4Hoffmann–La Roche, Welwyn Garden City
5Pediatric Rheumatology Department, Hospital Universitario La Fe, Valencia
6Rheumatology Section, Hospital Gral de Niños Pedro Elizalde, Buenos Aires
7Dipartimento di Pediatria, Università degli Studi di Genova, Genoa
8Department of Pediatrics, Division of Rheumatology, Hospital for Sick Children, University of Toronto, Toronto
9Department of Rheumatology, Great Ormond Street Hospital for Sick Children, London
10Division of Pediatric Rheumatology, Department of Pediatrics, University Hospital Gasthuisberg, Leuven
11Rheumatology Service, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, Departmento de Reumatologia, Hospital General de Mexico
12Pediatric Rheumatology, Connecticut Children's Medical Center, Hartford, Departmento de Reumatologia, Hospital General de Mexico
13Alder Hey Children's National Health Service Foundation Trust, Liverpool
14Faculty of Medicine, Universidad Nacional Autonoma de Mexico, Mexico City
15Department of Pediatrics and Adolescent Medicine, Charles University in Prague, and General University Hospital, Prague, Czech Republic
16Unidad de Reumatologia, Hospital Sor Maria Ludovica, La Plata
17Unidad de Reumatologia Pediatrica, Hospital Universitario La Paz, Madrid
18Centrum voor Kinderreumatologie, Universitair Ziekenhuis, Ghent
19Department of Pediatric Immunology and Rheumatology, Wilhelmina Kinderziekenhuis, Universitair Medisch Centrum, Utrecht, the Netherlands
20Department of Rheumatology, Oddzial Dzieci Starszych, Wojewodzki Specjalistyczny Szpital Dzieciecy Sw Ludwika, Krakow, Poland
21Department of Pediatrics, Unita di Reumatologia Pediatrica, Università di Padova, Padua

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Tài liệu tham khảo

Petty RE, 2004, J Rheumatol, 31, 390

Lomater C, 2000, J Rheumatol, 27, 491

10.1016/S0140-6736(07)60363-8

10.1002/1529-0131(200008)43:8<1849::AID-ANR22>3.0.CO;2-F

10.1136/ard.2007.087593

10.1136/ard.2007.087411

10.1002/art.23437

10.1136/ard.2007.076034

10.1136/ard.2010.134254

De Benedetti F, 1998, J Rheumatol, 25, 203

10.1002/art.1780340912

De Benedetti F, 1997, J Rheumatol, 24, 1403

10.1172/JCI119207

10.1002/art.22175

Cazzola M, 1996, Blood, 87, 4824, 10.1182/blood.V87.11.4824.bloodjournal87114824

10.1016/S0140-6736(08)60454-7

10.1136/adc.2010.188946

Brunner HI, 2002, J Rheumatol, 29, 1058

10.1056/NEJM200003163421103

10.1002/1529-0131(199707)40:7<1202::AID-ART3>3.0.CO;2-R

10.1002/art.1780371209

Ruperto N, 2001, Clin Exp Rheumatol, 19, S1

Wallace CA, 2004, J Rheumatol, 31, 2290

10.1002/art.33496

10.1002/art.1780341216

10.1002/1529-0131(200011)43:11<2402::AID-ANR5>3.0.CO;2-C

10.1186/1546-0096-9-S1-O18

Hashkes PJ, 2010, Arthritis Rheum, 62, 599, 10.1002/art.27218