Radiosensitizing activity of novel small molecule BRCA1 and DNA-PK inhibitors in lung and colon carcinoma

JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES - Tập 10 - Trang 204-213 - 2017
Suraj Radhamani1,2, Rejitha Suraj1, Terri Meehan-Andrews3, Jasim Al-Rawi1, Christopher Bradley1
1School of Pharmacy and Applied Science, Latrobe Institute of Molecular Sciences, La Trobe University, P.O. Box 199, Bendigo, VIC, 3552, Australia
2School of Pharmacy, Gulf Medical University, Ajman, United Arab Emirates
3La Trobe Rural Health School, La Trobe University, P.O. Box 199, Bendigo, VIC, 3552, Australia

Tài liệu tham khảo

Amrein, 2007, Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)benzo-[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase, Journal of Pharmacology and Experimental Therapeutics, 321, 848, 10.1124/jpet.106.118356 Bennett, 1993, Lethality induced by a single site-specific double-strand break in a dispensable yeast plasmid, Proceedings of the National Academy of Sciences of the United States of America, 90, 5613, 10.1073/pnas.90.12.5613 Beskow, 2009, Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86, British Journal of Cancer, 101, 816, 10.1038/sj.bjc.6605201 Brazil, 2001, Ten years of protein kinase B signalling: A hard Akt to follow, Trends in Biochemical Sciences, 26, 657, 10.1016/S0968-0004(01)01958-2 Brenner, 1992, Constraints on energy deposition and target size of multiply damaged sites associated with DNA double-strand breaks, International Journal of Radiation Biology, 61, 737, 10.1080/09553009214551591 Bressenot, 2013, Methyl donor deficiency affects small-intestinal differentiation and barrier function in rats, British Journal of Nutrition, 109, 667, 10.1017/S0007114512001869 Bromley, 2006, A preliminary investigation of cell growth after irradiation using a modulated X-ray intensity pattern, Physics in Medicine and Biology, 51, 3639, 10.1088/0031-9155/51/15/003 Bromley, 2009, Predicting the clonogenic survival of A549 cells after modulated x-ray irradiation using the linear quadratic model, Physics in Medicine and Biology, 54, 187, 10.1088/0031-9155/54/2/002 Chen, 2007, Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break, Journal of Biological Chemistry, 282, 6582, 10.1074/jbc.M611605200 Chen, 2005, Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks, Journal of Biological Chemistry, 280, 14709, 10.1074/jbc.M408827200 Ciszewski, 2014, DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin, Breast Cancer Research and Treatment, 143, 47, 10.1007/s10549-013-2785-6 Desai, 2005, High LET-induced H2AX phosphorylation around the Bragg curve, Space Life Sciences: Ground-Based Iron-Ion Biology and Physics, Including Shielding, 35, 236 Ding, 2003, Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair, Molecular and Cellular Biology, 23, 5836, 10.1128/MCB.23.16.5836-5848.2003 Dueva, 2013, Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer, Translational Cancer Research, 2, 163 Durant, 2003, Vanillins–a novel family of DNA-PK inhibitors, Nucleic Acids Research, 31, 5501, 10.1093/nar/gkg753 Falzon, 1993, Ebp-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single-strand to double-strand transitions in DNA, Journal of Biological Chemistry, 268, 10546, 10.1016/S0021-9258(18)82233-5 Francisco, 2008, Induction and processing of complex DNA damage in human breast cancer cells MCF-7 and nonmalignant MCF-10A cells, Free Radical Biology and Medicine, 44, 558, 10.1016/j.freeradbiomed.2007.10.045 Frankfurt, 2008, Application of anti-ssDNA monoclonal antibody to study exogenous and apoptosis-associated DNA damage, Cytometry Part A, 73A, 1114, 10.1002/cyto.a.20629 Gene, 2005, DNA-dependent protein kinase is a molecular target for the development of non-cytotoxic radiation sensitizing drugs, International Journal of Radiation Oncology Biology Physics, 63, S144, 10.1016/j.ijrobp.2005.07.246 Ghiassi-Nejad, 2002, Very high background radiation areas of Ramsar, Iran: Preliminary biological studies, Health Physics, 82, 87, 10.1097/00004032-200201000-00011 Guertin, 2006, Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKC alpha but not S6K1, Developmental Cell, 11, 859, 10.1016/j.devcel.2006.10.007 Hollick, 2003, 2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK), Bioorganic & Medicinal Chemistry Letters, 13, 3083, 10.1016/S0960-894X(03)00652-8 Huen, 2010, BRCA1 and its toolbox for the maintenance of genome integrity, Nature Reviews Molecular Cell Biology, 11, 138, 10.1038/nrm2831 Ihmaid, 2012, Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1,3-benzoxazines and DNA-PK and PI3K inhibition, homology modelling studies of 2-morpholino-(7,8-di and 8-substituted)-1,3-benzoxazines, European Journal of Medicinal Chemistry, 57, 85, 10.1016/j.ejmech.2012.08.035 Ismail, 2004, SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization, Oncogene, 23, 873, 10.1038/sj.onc.1207303 Ismail, 2007, An optimized method for detecting gamma-H2AX in blood cells reveals a significant interindividual variation in the gamma-H2AX response among humans, Nucleic Acids Research, 35, 10.1093/nar/gkl1169 Jeggo, 2007, DNA double-strand breaks: Their cellular and clinical impact? Introduction, Oncogene, 26, 7717, 10.1038/sj.onc.1210868 Kashishian, 2003, DNA-dependent protein kinase inhibitors as drug candidates for the treatment of cancer, Molecular Cancer Therapeutics, 2, 1257 Kim, 2002, A targeted inhibition of DNA-dependent protein kinase sensitizes breast cancer cells following ionizing radiation, Journal of Pharmacology and Experimental Therapeutics, 303, 753, 10.1124/jpet.102.038505 Kunkl, 2000, Detection of apoptotic T lymphocytes in peripheral blood of human immunodeficiency virus (HIV)-infected subjects by Apostain, Cytometry, 42, 67, 10.1002/(SICI)1097-0320(20000215)42:1<67::AID-CYTO10>3.0.CO;2-1 Langland, 2010, Radiosensitivity profiles from a panel of ovarian cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent protein kinase activities, Oncology Reports, 23, 1021, 10.3892/or_00000728 Leahy, 2004, Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries, Bioorganic & Medicinal Chemistry Letters, 14, 6083, 10.1016/j.bmcl.2004.09.060 Lee, 2006, Phosphatidylinositol 3-kinase inhibition by LY294002 radiosensitizes human cervical cancer cell lines, Clinical Cancer Research, 12, 250, 10.1158/1078-0432.CCR-05-1084 Lempiainen, 2009, Emerging common themes in regulation of PIKKs and PI3Ks, Embo Journal, 28, 3067, 10.1038/emboj.2009.281 MacPhail, 2003, Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X-rays, International Journal of Radiation Biology, 79, 351, 10.1080/0955300032000093128 Ma, 2004, A biochemically defined system for mammalian nonhomologous DNA end joining, Molecular Cell, 16, 701, 10.1016/j.molcel.2004.11.017 Martin, 2001, DNA repair inhibition and cancer therapy, Journal of Photochemistry and Photobiology B Biology, 63, 162, 10.1016/S1011-1344(01)00213-5 McKinnon, 2007, DNA strand break repair and human genetic disease, Annual Review of Genomics and Human Genetics, 8, 37, 10.1146/annurev.genom.7.080505.115648 Mimori, 1981, Characterization of a high molecular-weight acidic nuclear-protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap, Journal of Clinical Investigation, 68, 611, 10.1172/JCI110295 Nagasawa, 2011, Differential role of DNA-PKcs phosphorylations and kinase activity in radiosensitivity and chromosomal instability, Radiation Research, 175, 83, 10.1667/RR2092.1 Neal, 2011, Choosing the right path: Does DNA-PK help make the decision?, Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 711, 73, 10.1016/j.mrfmmm.2011.02.010 Nutley, 2005, Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026, British Journal of Cancer, 93, 1011, 10.1038/sj.bjc.6602823 Paillard, 1991, Analysis of the mechanism of interaction of simian Ku protein with DNA, Nucleic Acids Research, 19, 5619, 10.1093/nar/19.20.5619 Pajonk, 2005, The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism, BMC Cancer, 5, 76, 10.1186/1471-2407-5-76 Pauwels, 2003, Comparison of the sulforhodamine B assay and the clonogenic assay for in vitro chemoradiation studies, Cancer Chemotherapy and Pharmacology, 51, 221, 10.1007/s00280-002-0557-9 Pessetto, 2012, Inhibition of BRCT(BRCA1)-phosphoprotein interaction enhances the cytotoxic effect of olaparib in breast cancer cells: A proof of concept study for synthetic lethal therapeutic option, Breast Cancer Research and Treatment, 134, 511, 10.1007/s10549-012-2079-4 Prendergast, 2011, Activation of DNA damage response pathways in human mesenchymal stem cells exposed to cisplatin or gamma-irradiation, Cell Cycle, 10, 3768, 10.4161/cc.10.21.17972 Reddy, 2004, Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends, Journal of Biological Chemistry, 279, 39408, 10.1074/jbc.M406432200 Redon, 1999, Megabase chromatin domains involved in DNA double-strand breaks in vivo, Molecular Biology of the Cell, 10, 282a Sarbassov, 2005, Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex, Science, 307, 1098, 10.1126/science.1106148 Shaheen, 2011, Targeting the DNA double strand break repair machinery in prostate cancer, Plos One, 6, 10.1371/journal.pone.0020311 Shawi, 2013, Telomerase contributes to fludarabine resistance in primary human leukemic lymphocytes, Plos One, 8, 10.1371/journal.pone.0070428 Shintani, 2003, Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma, Cancer Science, 94, 894, 10.1111/j.1349-7006.2003.tb01372.x Sun, 2010, Suberoylanilide hydroxamic acid induces apoptosis and sub-G1 arrest of 320 HSR colon cancer cells, Journal of Biomedical Science, 17, 10.1186/1423-0127-17-76 Takahashi, 2005, Does gamma H2AX foci formation depend on the presence of DNA double strand breaks?, Cancer Letters, 229, 171, 10.1016/j.canlet.2005.07.016 Walker, 2001, Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair, Nature, 412, 607, 10.1038/35088000 Wang, 1996, Arsenite induces apoptosis in Chinese hamster ovary cells by generation of reactive oxygen species, Journal of Cellular Physiology, 169, 256, 10.1002/(SICI)1097-4652(199611)169:2<256::AID-JCP5>3.0.CO;2-N Wang, 2005, Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression, DNA Repair, 4, 556, 10.1016/j.dnarep.2005.02.001 Wrann, 2013, HIF mediated and DNA damage independent histone H2AX phosphorylation in chronic hypoxia, Biological Chemistry, 394, 519, 10.1515/hsz-2012-0311 Yuan, 2005, G0/G1 arrest and apoptosis induced by SARS-CoV 3b protein in transfected cells, Virology Journal, 2, 10.1186/1743-422X-2-66 Yu, 2004, DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains, Molecular and Cellular Biology, 24, 9478, 10.1128/MCB.24.21.9478-9486.2004 Yu, 2011, hMTERF4 knockdown in HeLa cells results in sub-G1 cell accumulation and cell death, Acta Biochimica Et Biophysica Sinica, 43, 372, 10.1093/abbs/gmr020 Zhao, 2006, Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441, Cancer Research, 66, 5354, 10.1158/0008-5472.CAN-05-4275