Radiologic assessment of age‐related knee joint space changes in women: A 4‐year longitudinal study

Wiley - Tập 61 Số 3 - Trang 336-343 - 2009
D. Gensburger1,2, M. Arlot1, Elisabeth Sornay‐Rendu1, Jean‐Paul Roux1, Pierre Delmas1
1INSERM Research Unit 831 and Université de Lyon, Lyon, France
2INSERM Unit 831, Pavillon F, Hopital E Herriot, 69437 Lyon cedex 03, France.

Tóm tắt

AbstractObjectiveTo analyze a population‐based cohort of women in order to establish normal values of joint space width (JSW) and to evaluate the existence of age‐related joint space loss (JSL).MethodsKnee radiographs were performed 4 years apart in women from the OFELY (Os des Femmes de Lyon) Cohort. Posteroanterior radiographs of both knees were taken in semiflexion with a standardized fluoroscopically assisted protocol. Radiographs were qualitatively evaluated using a scoring system based on the Altman score that assessed joint space narrowing, osteophytes, and sclerosis for each tibiofemoral compartment and each side. For quantitative assessment, radiographs were digitized using a video camera, and specific software was used to measure JSW in every compartment.ResultsWe evaluated the radiographs of 606 women (ages 39–90 years, mean 62 years) and found that in all subjects, JSW significantly decreased with age in every compartment (r = −0.12 to −0.16, P < 0.001), including in 358 subjects without any radiographic abnormality related to osteoarthritis (OA) at baseline. The longitudinal analysis confirmed a significant loss over 4 years of ∼0.30 mm (6%) for the medial compartment. Multiple regression analysis did not identify significant predictors of JSL among clinical risk factors and biochemical markers of bone and cartilage turnover.ConclusionIn this first longitudinal study of a population‐based cohort of women, we have established normal values of JSW and shown that JSW decreases with aging, especially at the medial compartment, even in subjects without any radiographic abnormalities related to OA.

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Wiley

Tập 61 Số 3

336-343

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