Rabies virus infection: An update

Journal of NeuroVirology - Tập 9 - Trang 253-258 - 2003
Alan C. Jackson1,2
1Departments of Medicine and Microbiology and Immunology, Queen’s University, Kingston, Canada
2Kingston General Hospital, Kingston, Canada

Tóm tắt

There are still many unanswered questions in the pathogenesis of rabies, but recent progress has been made. During most of the long incubation period of rabies, the virus likely remains close the site of viral entry. Centripetal spread to the central nervous system and spread within the central nervous system occur by fast axonal transport. Neuronal dysfunction, rather than neuronal death, is responsible for the clinical features and fatal outcome in natural rabies. Recent work has changed our perspective on the ecology of rabies virus under particular circumstances in certain species. Hopefully, advances in our understanding of rabies pathogenesis will lead to advances in the treatment of this dreaded disease.

Tài liệu tham khảo

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