ROS Scavenging and inflammation-directed polydopamine nanoparticles regulate gut immunity and flora therapy in inflammatory bowel disease

Kaplan, 2015, The global burden of IBD: from 2015 to 2025, Nat. Rev. Gastroenterol. Hepatol., 12, 720, 10.1038/nrgastro.2015.150 Xavier, 2007, Unravelling the pathogenesis of inflammatory bowel disease, Nature, 448, 427, 10.1038/nature06005 Nadeem, 2020, Risk of colorectal cancer in inflammatory bowel diseases, Semin. Cancer Biol, 64, 51, 10.1016/j.semcancer.2019.05.001 Kobayashi, 2020, Ulcerative colitis, Nat. Rev. Dis. Primers, 6, 74, 10.1038/s41572-020-0205-x Caruso, 2020, Host-microbiota interactions in inflammatory bowel disease, Nat. Rev. Immunol., 20, 411, 10.1038/s41577-019-0268-7 Fu, 2022, Probiotic-based nanoparticles for targeted microbiota modulation and immune restoration in bacterial pneumonia, Natl. Sci. Rev., nwac221 Fonseca-Camarillo, 2015, Immunoregulatory pathways involved in inflammatory bowel disease, Inflamm. Bowel Dis, 21, 2188, 10.1097/MIB.0000000000000477 Marchesi, 2016, The gut microbiota and host health: a new clinical frontier, Gut, 65, 330, 10.1136/gutjnl-2015-309990 McGovern, 2015, Genetics of inflammatory bowel diseases, Gastroenterology, 149, 10.1053/j.gastro.2015.08.001 Colombel, 2020, Outc. J. Crohns Colitis, 14, 254, 10.1093/ecco-jcc/jjz131 Duijvestein, 2018, Novel therapies and treatment strategies for patients with inflammatory bowel disease, Curr. Treat Options Gastroenterol., 16, 129, 10.1007/s11938-018-0175-1 Nishida, 2021, Can control of gut microbiota be a future therapeutic option for inflammatory bowel disease?, World J. Gastroenterol., 27, 3317, 10.3748/wjg.v27.i23.3317 Solitano, 2021, Anti-integrin drugs in clinical trials for inflammatory bowel disease (IBD): insights into promising agents, Expert Opin. Investig. Drugs, 30, 1037, 10.1080/13543784.2021.1974396 Villablanca, 2022, Mechanisms of mucosal healing: treating inflammatory bowel disease without immunosuppression?, Nat. Rev. Gastroenterol Hepatol., 19, 493, 10.1038/s41575-022-00604-y Mowat, 2014, Regional specialization within the intestinal immune system, Nat. Rev. Immunol, 14, 667, 10.1038/nri3738 Wallace, 2014, Immunopathology of inflammatory bowel disease, World J. Gastroenterol, 20, 6, 10.3748/wjg.v20.i1.6 Friedrich, 2019, Cytokine networks in the pathophysiology of inflammatory bowel disease, Immunity, 50, 992, 10.1016/j.immuni.2019.03.017 Khare, 2020, Natural product-based nanomedicine in treatment of inflammatory bowel disease, Int. J. Mol. Sci., 21, 10.3390/ijms21113956 Liu, 2022, Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for murine colitis therapy, J. Nanobiotechnol., 20, 206, 10.1186/s12951-022-01421-w Soni, 2021, Melatonin-loaded chitosan nanoparticles endows nitric oxide synthase 2 mediated anti-inflammatory activity in inflammatory bowel disease model, Mater. Sci. Eng. C, 124, 10.1016/j.msec.2021.112038 Fu, 2021, An engineered pseudo-macrophage for rapid treatment of bacteria-infected osteomyelitis via microwave-excited anti-infection and immunoregulation, Adv. Mater., 33, 10.1002/adma.202102926 Tan, 2020, Engineered probiotics biofilm enhances osseointegration via immunoregulation and anti-infection, Sci. Adv., 6, 10.1126/sciadv.aba5723 Liu, 2014, Polydopamine and its derivative materials: synthesis and promising applications in energy, environmental, and biomedical fields, Chem. Rev., 114, 5057, 10.1021/cr400407a Zhou, 2021, Stimuli-responsive dual drugs-conjugated polydopamine nanoparticles for the combination photothermal-cocktail chemotherapy, Chin. Chem. Lett. Song, 2018, Silver-incorporated mussel-inspired polydopamine coatings on mesoporous silica as an efficient nanocatalyst and antimicrobial agent, ACS. Appl. Mater. Interfaces, 10, 1792, 10.1021/acsami.7b18136 Li, 2022, Polydopamine nanoparticle-mediated dopaminergic immunoregulation in colitis, Adv. Sci., 9 Bao, 2018, Polydopamine nanoparticles as efficient scavengers for reactive oxygen species in periodontal disease, ACS. Nano., 12, 8882, 10.1021/acsnano.8b04022 Li, 2021, Broad-spectrum reactive oxygen species scavenging and activated macrophage-targeting microparticles ameliorate inflammatory bowel disease, Biomacromolecules, 22, 3107, 10.1021/acs.biomac.1c00551 Liu, 2021, Colon-targeted adhesive hydrogel microsphere for regulation of gut immunity and flora, Adv. Sci., 8 Schirmer, 2019, Microbial genes and pathways in inflammatory bowel disease, Nat. Rev. Microbiol., 17, 497, 10.1038/s41579-019-0213-6 Bevins, 2011, Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis, Nat. Rev. Microbiol., 9, 356, 10.1038/nrmicro2546 Zong, 2020, Interplay between gut microbiota and antimicrobial peptides, Anim. Nutr., 6, 389, 10.1016/j.aninu.2020.09.002 Yoo, 2015, Anti-fibrogenic effects of the anti-microbial peptide cathelicidin in murine colitis-associated fibrosis, Cell Mol. Gastroenterol Hepatol., 1, 55, 10.1016/j.jcmgh.2014.08.001 Sun, 2016, The roles of cathelicidin ll-37 in inflammatory bowel disease, Inflamm. Bowel Dis., 22, 1986, 10.1097/MIB.0000000000000804 Xu, 2021, IL-27 induces LL-37/CRAMP expression from intestinal epithelial cells: implications for immunotherapy of Clostridioides difficile infection, Gut Microbes, 13, 10.1080/19490976.2021.1968258 Zhang, 2022, Oral colon-targeted mucoadhesive micelles with enzyme-responsive controlled release of curcumin for ulcerative colitis therapy, Chin. Chem. Lett., 33, 6, 10.1016/j.cclet.2022.03.110 Zu, 2021, Oral delivery of natural active small molecules by polymeric nanoparticles for the treatment of inflammatory bowel diseases, Adv. Drug Deliv. Rev., 10.1016/j.addr.2021.113887 Reinholz, 2018, The challenges of oral drug delivery via nanocarriers, Drug Deliv., 25, 1694, 10.1080/10717544.2018.1501119 Khatoon, 2022, Macrophage membrane coated nanoparticles: a biomimetic approach for enhanced and targeted delivery, Biomater. Sci., 10, 1193, 10.1039/D1BM01664D Zhang, 2020, Polydopamine nanoparticles camouflaged by stem cell membranes for synergistic chemo-photothermal therapy of malignant bone tumors, Int. J. Nanomedicine, 15, 10183, 10.2147/IJN.S282931 Fan, 2019, Magainin-modified polydopamine nanoparticles for photothermal killing of bacteria at low temperature, Colloids Surf. B, 183, 10.1016/j.colsurfb.2019.110423 Gao, 2020, Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines, Nat. Commun., 11, 2622, 10.1038/s41467-020-16439-7 Wang, 2020, Bacterial vesicle-cancer cell hybrid membrane-coated nanoparticles for tumor specific immune activation and photothermal therapy, ACS Appl. Mater. Interfaces, 12, 41138, 10.1021/acsami.0c13169 Wang, 2022, Engineering ultrasmall ferroptosis-targeting and reactive oxygen/nitrogen species-scavenging nanozyme for alleviating acute kidney, Injury, 32 Liu, 2017, Role of taurine in BDE 209-induced oxidative stress in PC12 cells, Adv. Exp. Med. Biol., 975, 897, 10.1007/978-94-024-1079-2_71 Thamphiwatana, 2017, Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management, Proc. Natl. Acad. Sci. U S A, 114, 11488, 10.1073/pnas.1714267114 Wang, 2022, Polydopamine-based nanocomposite as a biomimetic antioxidant with a variety of enzymatic activities for Parkinson's disease, ACS Appl. Mater. Interfaces Huang, 2016, Self-assembly of multi-nanozymes to mimic an intracellular antioxidant defense system, Angew. Chem. Int. Ed. Engl., 55, 6646, 10.1002/anie.201600868 Yasui, 2006, Therapeutic potential of superoxide dismutase (SOD) for resolution of inflammation, Inflamm. Res., 55, 359, 10.1007/s00011-006-5195-y Song, 2020, Caveolin-1 protects against DSS-induced colitis through inhibiting intestinal nitrosative stress and mucosal barrier damage in mice, Biochem. Pharmacol., 180, 10.1016/j.bcp.2020.114153 Chami, 2018, Myeloperoxidase in the inflamed colon: a novel target for treating inflammatory bowel disease, Arch. Biochem. Biophys., 645, 61, 10.1016/j.abb.2018.03.012 Yu, 2018, Aryl hydrocarbon receptor activation modulates intestinal epithelial barrier function by maintaining tight junction integrity, Int. J. Biol. Sci., 14, 69, 10.7150/ijbs.22259 Kuo, 2019, Inflammation-induced occludin downregulation limits epithelial apoptosis by suppressing caspase-3 expression, Gastroenterology, 157, 1323, 10.1053/j.gastro.2019.07.058 Kuo, 2021, The tight junction protein ZO-1 is dispensable for barrier function but critical for effective mucosal repair, Gastroenterology, 161, 1924, 10.1053/j.gastro.2021.08.047 Moreira Lopes, 2020, Macrophage polarization in intestinal inflammation and gut homeostasis, Inflamm. Res., 69, 1163, 10.1007/s00011-020-01398-y Zhou, 2022, 16S rRNA sequencing-based evaluation of the protective effects of Hua-Zhuo-Jie-Du on rats with chronic atrophic gastritis, BMC Complement Med. Ther., 22, 71, 10.1186/s12906-022-03542-z Yang, 2021, Effects of ocean acidification and microplastics on microflora community composition in the digestive tract of the thick shell mussel mytilus coruscus through 16S RNA gene sequencing, Bull. Environ. Contam. Toxicol, 107, 616, 10.1007/s00128-020-03022-5 Jang, 2021, The effect of formula-based nutritional treatment on colitis in a murine model, J. Korean Med. Sci., 36, e342, 10.3346/jkms.2021.36.e342