RNF216 is essential for spermatogenesis and male fertility†

Biology of Reproduction - Tập 100 Số 5 - Trang 1132-1134 - 2019
Ashley Melnick1, Yuen Gao1, Jiali Liu1,2, Deqiang Ding1, Alicia Predom1, Matt Kelly1, Rex A. Hess3, C. Chen1,4,5
1Department of Animal Science, Michigan State University, East Lansing, Michigan, USA
2State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China
3Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USA
4Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, Michigan, USA
5Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan, USA

Tóm tắt

Abstract Ring finger protein 216 (RNF216) belongs to the RING family of E3 ubiquitin ligases that are involved in cellular protein degradation. Mutations in human Rnf216 gene have been identified in Gordon Holmes syndrome, which is defined by ataxia, dementia, and hypogonadotropism. However, the gene function of Rnf216 in mammalian species remains unknown. Here, we show that targeted deletion of Rnf216 in mice results in disruption in spermatogenesis and male infertility. RNF216 is not required for female fertility. These findings reveal an essential function of RNF216 in spermatogenesis and male fertility and suggest a critical role for RNF216 in human gonadal development.

Từ khóa


Tài liệu tham khảo

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Biology of Reproduction

Tập 100 Số 5

1132-1134

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