REAC Non-invasive Neurobiological Stimulation for Mitigating the Impact of Internalizing Disorders in Autism Spectrum Disorder

Springer Science and Business Media LLC - Tập 5 Số 4 - Trang 446-456 - 2021
Arianna Rinaldi1,2, Margherita Maioli1,2, Márcia C. Marins Martins3, Pollyanna Celso Felipe de Castro3, Natália Almeida Prado de Oliveira Silva3, Jaqueline Albieri Vieira de Mattos3, Vania Fontani4, Salvatore Rinaldi4
1Department of Adaptive Neuro Psycho Physio Pathology and Neuro Psycho Physical Optimization, Rinaldi Fontani Institute, Florence, Italy
2Department of Biomedical Sciences, University of Sassari, Sassari, Italy
3International Scientific Society of Neuro Psycho Physical Optimization With REAC Technology, Brazilian Branch, São Paulo, Brazil
4Research Department, Rinaldi Fontani Foundation, Florence, Italy

Tóm tắt

Abstract Objectives Allostatic overload occurs when environmental factors become excessive for the individual capacity of neurobiological response and can trigger internalizing disorders. These disorders have a strong impact on individuals with autism spectrum disorder (ASD) and can exacerbate ASD symptoms and deficits. A non-invasive neurobiological stimulation technology, called the radio electric asymmetric conveyer (REAC), has been shown to be effective in improving internalizing disorders and remodeling the individual allostatic response. On these premises, REAC neurobiological stimulation treatments have been introduced for the treatment of internalizing disorders in ASD. The aim of this current research was to retrospectively verify the effects of REAC treatments on motor, cognitive, and behavioral skills and symptoms, assessed using the Autism Profiling Questionnaire (APQ). Methods Data were collected through administration of the APQ to the caregivers of 112 individuals with ASD. The caregivers rated every cluster of the questionnaire with a score based on an evaluation scale ranging from 0 to 10. Results At the 3-month follow-up, the caregivers perceived and rated a global improvement of the individuals with ASD in all clusters. Conclusions This research suggests that the mitigating effects of REAC neuromodulation treatments in relation to the severity of internalizing disorders can enhance the quality of life and the autonomy of individuals with ASD, as shown by the shift in the median values in all 21 items of the APQ toward an improvement in symptoms and skills.

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Tài liệu tham khảo

Adams, D., & Emerson, L. M. (2021). The impact of anxiety in children on the autism spectrum. Journal of Autism and Developmental Disorders, 51(6), 1909–1920. https://doi.org/10.1007/s10803-020-04673-3

Amatachaya, A., Auvichayapat, N., Patjanasoontorn, N., Suphakunpinyo, C., Ngernyam, N., Aree-Uea, B., ... Auvichayapat, P. (2014). Effect of anodal transcranial direct current stimulation on autism: A randomized double-blind crossover trial. Behavioral Neurology, 2014, 173073. https://doi.org/10.1155/2014/173073

Baer, M. L., & Colello, R. J. (2016). Endogenous bioelectric fields: A putative regulator of wound repair and regeneration in the central nervous system. Neural Regeneration Research, 11(6), 861–864. https://doi.org/10.4103/1673-5374.184446

Becker, E. B., & Stoodley, C. J. (2013). Autism spectrum disorder and the cerebellum. International Review of Neurobiology, 113, 1–34. https://doi.org/10.1016/B978-0-12-418700-9.00001-0

Chernet, B., & Levin, M. (2013). Endogenous voltage potentials and the microenvironment: Bioelectric signals that reveal, induce and normalize cancer. Journal of Clinical & Experimental Oncology, (Supplement 1). https://doi.org/10.4172/2324-9110.S1-002

Corbett, B. A., Muscatello, R. A., Klemencic, M. E., & Schwartzman, J. M. (2021). The impact of COVID-19 on stress, anxiety, and coping in youth with and without autism and their parents. Autism Research. https://doi.org/10.1002/aur.2521

D’Mello, A. M., Crocetti, D., Mostofsky, S. H., & Stoodley, C. J. (2015). Cerebellar gray matter and lobular volumes correlate with core autism symptoms. Neuroimage Clinical, 7, 631–639. https://doi.org/10.1016/j.nicl.2015.02.007

D’Mello, A. M., & Stoodley, C. J. (2015). Cerebro-cerebellar circuits in autism spectrum disorder. Frontiers in Neuroscience, 9, 408. https://doi.org/10.3389/fnins.2015.00408

DeFilippis, M. (2018). Depression in children and adolescents with autism spectrum disorder. Children (Basel, Switzerland), 5(9). https://doi.org/10.3390/children5090112

Enticott, P. G., Kirkovski, M., & Oberman, L. M. (2019). Transcranial magnetic stimulation in autism spectrum disorder. In L. M. Oberman & P. G. Enticott (Eds.), Neurotechnology and brain stimulation in pediatric psychiatric and neurodevelopmental disorders (pp. 83–113). Academic Press. https://doi.org/10.1016/b978-0-12-812777-3.00005-2

Fontani, V., Mannu, P., Castagna, A., & Rinaldi, S. (2011a). Social anxiety disorder: Radio electric asymmetric conveyor brain stimulation versus sertraline. Patient Preference and Adherence, 5, 581–586. https://doi.org/10.2147/PPA.S27409

Fontani, V., Rinaldi, S., Aravagli, L., Mannu, P., Castagna, A., & Margotti, M. L. (2011b). Noninvasive radioelectric asymmetric brain stimulation in the treatment of stress-related pain and physical problems: Psychometric evaluation in a randomized, single-blind placebo-controlled, naturalistic study. International Journal of General Medicine, 4, 681–686. https://doi.org/10.2147/IJGM.S24628

Fontani, V., Rinaldi, S., Castagna, A., & Margotti, M. L. (2012). Noninvasive radioelectric asymmetric conveyor brain stimulation treatment improves balance in individuals over 65 suffering from neurological diseases: Pilot study. Therapeutics and Clinical Risk Management, 8, 73–78. https://doi.org/10.2147/TCRM.S28812

Garcia-Gonzalez, S., Lugo-Marin, J., Setien-Ramos, I., Gisbert-Gustemps, L., Arteaga-Henriquez, G., Diez-Villoria, E., & Ramos-Quiroga, J. A. (2021). Transcranial direct current stimulation in Autism Spectrum Disorder: A systematic review and meta-analysis. European Neuropsychopharmacoly. https://doi.org/10.1016/j.euroneuro.2021.02.017

Gegelashvili, M. (2019). Autism and depression (review). Georgian Medical News(292–293), 54–56. https://www.ncbi.nlm.nih.gov/pubmed/31560663

Gobel, A., Henning, A., Moller, C., & Aschersleben, G. (2016). The relationship between emotion comprehension and internalizing and externalizing behavior in 7- to 10-year-old children. Frontiers in Psychology, 7, 1917. https://doi.org/10.3389/fpsyg.2016.01917

Hampson, D. R., & Blatt, G. J. (2015). Autism spectrum disorders and neuropathology of the cerebellum. Frontiers in Neuroscience, 9(420), 420. https://doi.org/10.3389/fnins.2015.00420

Hashimoto, T., Tayama, M., Murakawa, K., Yoshimoto, T., Miyazaki, M., Harada, M., & Kuroda, Y. (1995). Development of the brainstem and cerebellum in autistic patients. Journal of Autism and Developmental Disorders, 25(1), 1–18. https://doi.org/10.1007/BF02178163

Johnson, B., Stanley-Cary, C., Fielding, J., Rinehart, N., & Papadopoulos, N. (2014). Cerebellum and the psychopathology of autism and Asperger’s disorder. In V. B. Patel, V. R. Preedy, & C. R. Martin (Eds.), Comprehensive guide to autism (pp. 845–863). Springer, New York. https://doi.org/10.1007/978-1-4614-4788-7_44

Khaleghi, A., Zarafshan, H., Vand, S. R., & Mohammadi, M. R. (2020). Effects of non-invasive neurostimulation on autism spectrum disorder: A systematic review. Clinical Psychopharmacology and Neuroscience, 18(4), 527–552. https://doi.org/10.9758/cpn.2020.18.4.527

Kim, S. Y., Kim, Y. A., Song, D. Y., Bong, G., Kim, J. M., Kim, J. H., & Yoo, H. J. (2021). State and trait anxiety of adolescents with autism spectrum disorders. Psychiatry Investigation, 18(3), 257–265. https://doi.org/10.30773/pi.2020.0328

Levin, M. (2014). Molecular bioelectricity: How endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo. Molecular Biology of the Cell, 25(24), 3835–3850. https://doi.org/10.1091/mbc.E13-12-0708

Levin, M., Pezzulo, G., & Finkelstein, J. M. (2017). Endogenous bioelectric signaling networks: Exploiting voltage gradients for control of growth and form. Annual Review of Biomedical Engineering, 19, 353–387. https://doi.org/10.1146/annurev-bioeng-071114-040647

Lorenzini, L., Giuliani, A., Sivilia, S., Baldassarro, V. A., Fernandez, M., Lotti Margotti, M., ... Calza, L. (2016). REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer’s disease mouse model. Scientific Reports, 6(1), 35719. https://doi.org/10.1038/srep35719

Maioli, M., Rinaldi, S., Santaniello, S., Castagna, A., Pigliaru, G., Delitala, A., ... Ventura, C. (2014). Anti-senescence efficacy of radio-electric asymmetric conveyer technology. Age (Dordr), 36(1), 9-20. https://doi.org/10.1007/s11357-013-9537-8

Maioli, M., Rinaldi, S., Santaniello, S., Castagna, A., Pigliaru, G., Gualini, S., ... Ventura, C. (2013). Radio electric conveyed fields directly reprogram human dermal skin fibroblasts toward cardiac, neuronal, and skeletal muscle-like lineages [Research Support, Non-U.S. Gov’t]. Cell Transplantation, 22(7), 1227–1235. https://doi.org/10.3727/096368912X657297

Maioli, M., Rinaldi, S., Santaniello, S., Castagna, A., Pigliaru, G., Gualini, S., ... Ventura, C. (2012). Radiofrequency energy loop primes cardiac, neuronal, and skeletal muscle differentiation in mouse embryonic stem cells: A new tool for improving tissue regeneration. Cell Transplantation, 21(6), 1225-1233. https://doi.org/10.3727/096368911X600966

Manto, M. (2009). Mechanisms of human cerebellar dysmetria: Experimental evidence and current conceptual bases. Journal of NeuroEngineering and Rehabilitation, 6, 10. https://doi.org/10.1186/1743-0003-6-10

Mura, M., Castagna, A., Fontani, V., & Rinaldi, S. (2012). Preliminary pilot fMRI study of neuropostural optimization with a noninvasive asymmetric radioelectric brain stimulation protocol in functional dysmetria. Neuropsychiatric Disease and Treatment, 8, 149–154. https://doi.org/10.2147/NDT.S29971

Oerbeck, B., Overgaard, K. R., Attwood, T., & Bjaastad, J. F. (2021). “Less stress”: A pilot study on a cognitive behavioral treatment program for anxiety in children with autism spectrum disorders. Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, 9, 30–40. https://doi.org/10.21307/sjcapp-2021-005

Olazaran, J., Gonzalez, B., Lopez-Alvarez, J., Castagna, A., Osa-Ruiz, E., Herrero-Cano, V., ... Martinez-Martin, P. (2013). Motor effects of REAC in advanced Alzheimer’s disease: Results from a pilot trial. Journal of Alzheimer’s Disease, 36(2), 297-302. https://doi.org/10.3233/JAD-130077

Olazaran, J., Gonzalez, B., Osa-Ruiz, E., Felipe-Ruiz, S., Boyano, I., Fontani, V., ... Martinez-Martin, P. (2014). Motor effects of radio electric asymmetric conveyer in Alzheimer’s disease: Results from a cross-over trial. Journal of Alzheimer’s Disease, 42(1), 325-332. https://doi.org/10.3233/JAD-140417

Olivieri, E. B., Vecchiato, C., Ignaccolo, N., Mannu, P., Castagna, A., Aravagli, L., ... Rinaldi, S. (2011). Radioelectric brain stimulation in the treatment of generalized anxiety disorder with comorbid major depression in a psychiatric hospital: A pilot study. Neuropsychiatric Disease and Treatment, 7, 449-455. https://doi.org/10.2147/NDT.S23420

Panaro, M. A., Aloisi, A., Nicolardi, G., Lofrumento, D. D., De Nuccio, F., La Pesa, V., ... Rinaldi, S. (2018). Radio electric asymmetric conveyer technology modulates neuroinflammation in a mouse model of neurodegeneration. Neuroscience Bulletin, 34(2), 270-282. https://doi.org/10.1007/s12264-017-0188-0

Parsons, P. A. (1990). Fluctuating asymmetry: An epigenetic measure of stress. Biological Review of the Cambridge Philosophical Society, 65(2), 131–145. https://doi.org/10.1111/j.1469-185x.1990.tb01186.x

Pinheiro Barcessat, A. R., Nolli Bittencourt, M., Duarte Ferreira, L., de Souza Neri, E., Coelho Pereira, J. A., Bechelli, F., & Rinaldi, A. (2020a). REAC cervicobrachial neuromodulation treatment of depression, anxiety, and stress during the COVID-19 pandemic. Psychology Research and Behavior Management, 13(13), 929–937. https://doi.org/10.2147/PRBM.S275730

Pinheiro Barcessat, A. R., NolliBittencourt, M., Goes Goncalves, R., de Oliveira, Goncalves, Cruz, A. V., Coelho Pereira, J. A., Bechelli, F. A., & Rinaldi, A. (2020). REAC neuromodulation treatments in depression, anxiety and stress. A comparative retrospective study. Psychology Research and Behavior Management, 13(13), 1247–1256. https://doi.org/10.2147/PRBM.S287143

Rinaldi, A., Rinaldi, C., Coelho Pereira, J. A., Lotti Margotti, M., Bittencourt, M. N., Barcessat, A. R. P., ... Rinaldi, S. (2019). Radio electric asymmetric conveyer neuromodulation in depression, anxiety, and stress. Neuropsychiatric Disease and Treatment, 15, 469-480. https://doi.org/10.2147/NDT.S195466

Rinaldi, S., Calza, L., Giardino, L., Biella, G. E., Zippo, A. G., & Fontani, V. (2015). Radio electric asymmetric conveyer: A novel neuromodulation technology in Alzheimer’s and other neurodegenerative diseases. Frontiers in Psychiatry, 6, 22. https://doi.org/10.3389/fpsyt.2015.00022

Rinaldi, S., Fontani, V., Aravagli, L., & Margotti, M. L. (2010). Psychological and symptomatic stress-related disorders with radio-electric treatment: Psychometric evaluation. Stress and Health, 26(5), 350–358. https://doi.org/10.1002/smi.1298

Rinaldi, S., Maioli, M., Pigliaru, G., Castagna, A., Santaniello, S., Basoli, V., ... Ventura, C. (2014). Stem cell senescence. Effects of REAC technology on telomerase-independent and telomerase-dependent pathways. Scientific Reports, 4, 6373. https://doi.org/10.1038/srep06373

Rinaldi, S., Mura, M., Castagna, A., & Fontani, V. (2014). Long-lasting changes in brain activation induced by a single REAC technology pulse in Wi-Fi bands. Randomized double-blind fMRI qualitative study. Scientific Reports, 4, 5668. https://doi.org/10.1038/srep05668

Taylor, E. C., Livingston, L. A., Callan, M. J., Ashwin, C., & Shah, P. (2021). Autonomic dysfunction in autism: The roles of anxiety, depression, and stress. Autism, 25(3), 744–752. https://doi.org/10.1177/1362361320985658

Timmann, D., & Daum, I. (2007). Cerebellar contributions to cognitive functions: A progress report after two decades of research. Cerebellum, 6(3), 159–162. https://doi.org/10.1080/14734220701496448

Tuszynski, J. A. (2019). The bioelectric circuitry of the cell. In S. Makarov, M. Horner, & G. Noetscher (Eds.), Brain and human body modeling: Computational human modeling at EMBC 2018 (pp. 195–208). Springer International Publishing. https://doi.org/10.1007/978-3-030-21293-3_11

Vasa, R. A., Keefer, A., McDonald, R. G., Hunsche, M. C., & Kerns, C. M. (2020). A scoping review of anxiety in young children with autism spectrum disorder. Autism Research, 13(12), 2038–2057. https://doi.org/10.1002/aur.2395

Zippo, A. G., Rinaldi, S., Pellegata, G., Caramenti, G. C., Valente, M., Fontani, V., & Biella, G. E. (2015). Electrophysiological effects of non-invasive Radio Electric Asymmetric Conveyor (REAC) on thalamocortical neural activities and perturbed experimental conditions. Scientic Reports, 5, 18200. https://doi.org/10.1038/srep18200

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Tập 5 Số 4

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