Réirradiation de métastases ganglionnaires d’un adénocarcinome œsogastrique par une technique de tomothérapie associée à de l’évérolimus

Cancer/Radiothérapie - Tập 18 - Trang 681-684 - 2014
V. Pernin1, P. Beuzeboc1, D. Peurien1, C. Louvet1, Y. Kirova1
1Département de radiothérapie oncologie, Institut Curie, 26, rue d’Ulm, 75248 Paris cedex 05, France

Tài liệu tham khảo

Bang, 2010, Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial, Lancet, 376, 687, 10.1016/S0140-6736(10)61121-X Weber, 2012, Deconvoluting mTOR biology, Cell Cycle, 11, 236, 10.4161/cc.11.2.19022 Lang, 2007, Mammalian target of rapamycin is activated in human gastric cancer and serves as a target for therapy in an experimental model, Int J Cancer, 120, 1803, 10.1002/ijc.22442 Fuereder, 2010, mTOR inhibition by everolimus counteracts VEGF induction by sunitinib and improves anti-tumor activity against gastric cancer in vivo, Cancer Lett, 296, 249, 10.1016/j.canlet.2010.04.015 Yoon, 2012, Phase II study of everolimus with biomarker exploration in patients with advanced gastric cancer refractory to chemotherapy including fluoropyrimidine and platinum, Br J Cancer, 106, 1039, 10.1038/bjc.2012.47 Murphy, 2009, Inhibition of mTOR radiosensitizes soft tissue sarcoma and tumor vasculature, Clin Cancer Res, 15, 589, 10.1158/1078-0432.CCR-08-1019 Chen, 2011, The mTOR inhibitor rapamycin suppresses DNA double-strand break repair, Radiat Res, 175, 214, 10.1667/RR2323.1 Eshleman, 2002, Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy, Cancer Res, 62, 7291 Kirova, 2012, Further developments for improving response and tolerance to irradiation for advanced renal cancer: concurrent (mTOR) inhibitor RAD001 and helical tomotherapy, Invest New Drugs, 30, 1241, 10.1007/s10637-010-9613-1 Shinohara, 2005, Enhanced radiation damage of tumor vasculature by mTOR inhibitors, Oncogene, 24, 5414, 10.1038/sj.onc.1208715 Garcia-Barros, 2003, Tumor response to radiotherapy regulated by endothelial cell apoptosis, Science, 300, 1155, 10.1126/science.1082504 Moeller, 2004, Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules, Cancer Cell, 5, 429, 10.1016/S1535-6108(04)00115-1 Manegold, 2008, Antiangiogenic therapy with mammalian target of rapamycin inhibitor RAD001 (Everolimus) increases radiosensitivity in solid cancer, Clin Cancer Res, 14, 892, 10.1158/1078-0432.CCR-07-0955 Lorin, 2008, L’autophagie : un nouveau concept en cancérologie, Bull Cancer, 95, 43 Palumbo, 2013, Autophagy and ionizing radiation in tumors: the “survive or not survive” dilemma, J Cell Physiol, 228, 1, 10.1002/jcp.24118 Altmeyer, 2012, The mTOR inhibitor RAD001 augments radiation-induced growth inhibition in a hepatocellular carcinoma cell line by increasing autophagy, Int J Oncol, 41, 1381, 10.3892/ijo.2012.1583