Quillaja brasiliensis saponins induce robust humoral and cellular responses in a bovine viral diarrhea virus vaccine in mice

Samuel Paulo Cibulski1,2, Fernando Silveira3, Gustavo Mourglia‐Ettlin4, Thais Fumaco Teixeira1,2, Helton Fernandes dos Santos1,2, Anna Carolina Alves Yendo5, Fernanda de Costa5, Arthur Germano Fett‐Neto5, Grace Gosmann6, Paulo Michel Roehe1,2
1Departamento de Microbiologia Imunologia e Parasitologia, Laboratório de Virologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
2FEPAGRO Saúde Animal, Instituto de Pesquisas Veterinárias Desidério Finamor, Laboratório de Virologia, Eldorado do Sul, RS, Brazil
3Laboratorio de Carbohidratos y Glicoconjugados, Departamento de Desarrollo Biotecnológico – Facultad de Medicina, Universidad de la República (UdelaR), Av. Alfredo Navarro 3051, CP 11600, Montevideo, Uruguay
4Cátedra de Inmunología, Departamento de Biociencias – Facultad de Ciencias/Química, Universidad de la República (UdelaR), Av. Alfredo Navarro 3051, CP 11600, Montevideo, Uruguay
5Laboratório de Fisiologia Vegetal, Centro de Biotecnologia e Departamento de Botânica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
6Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, Porto Alegre 90610-000, RS, Brazil

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