Quercetin suppresses the proliferation and metastasis of metastatic osteosarcoma cells by inhibiting parathyroid hormone receptor 1

Li, 2018, β-Alanine mediated inhibition of PTHR1 suppresses the proliferation, invasion and tumorigenesis in metastatic human osteosarcoma U2OS cells, Int. J. Biol. Macromol., 111, 1255, 10.1016/j.ijbiomac.2018.01.106 Luetke, 2014, Osteosarcoma treatment-where do we stand? A state of the art review, Cancer Treat. Rev., 40, 523, 10.1016/j.ctrv.2013.11.006 Ottaviani, 2009, The epidemiology of osteosarcoma Moreno, 2017, Childhood osteosarcoma: incidence and survival in Argentina. Report from the National Pediatric Cancer Registry, ROHA Network 2000-2013, Pediatr. Blood Cancer, 64, 10.1002/pbc.26533 Lupp, 2010, Immunohistochemical identification of the PTHR1 parathyroid hormone receptor in normal and neoplastic human tissues, Eur. J. Endocrino, 162, 979, 10.1530/EJE-09-0821 Ho, 2014, PTHR1 signaling regulates the invasion and differentiation stage of osteosarcoma, Cancer Res., 74, A54, 10.1158/1538-7445.PEDCAN-A54 Yeh, 2016, Comparing the metabolism of quercetin in rats, mice, and gerbils, Eur. J. Nutr., 55, 413, 10.1007/s00394-015-0862-9 Ross, 2002, Dietary flavonoids: bioavailability, metabolic effects, and safety, Annu. Rev. Nutr., 22, 19, 10.1146/annurev.nutr.22.111401.144957 Chuang, 2016, Quercetin metabolites inhibit MMP-2 expression in A549 lung cancer cells by PPAR-γ associated mechanisms, J. Nutr. Biochem., 33, 45, 10.1016/j.jnutbio.2016.03.011 Capasso, 2003 Duarte, 2002, Protective effects of the flavonoid quercetin in chronic nitric oxide deficient rats, J. Hypertens., 20, 1843, 10.1097/00004872-200209000-00031 Murota, 2003, Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism, Arch. Biochem. Biophys., 417, 12, 10.1016/S0003-9861(03)00284-4 Fusi, 2003, Effects of quercetin and rutin on vascular preparations: a comparison between mechanical and electrophysiological phenomena, Eur. J. Nutr., 42, 10, 10.1007/s00394-003-0395-5 Gharzouli, 2004, Inhibition of guinea pig intestinal peristalsis by the flavonoids quercetin, naringenin, apigenin, and genistein, Pharmacology, 70, 5, 10.1159/000074237 Janbaz, 2004, Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents, Phytomedicine, 11, 424, 10.1016/j.phymed.2003.05.002 Berndt, 2013, Evaluation of quercetin as a potential drug in osteosarcoma treatment, Anticancer Res., 33, 1297 Lan, 2017, Quercetin Inhibits Cell Migration and Invasion in Human Osteosarcoma Cells, Cell. Physiol. Biochem., 43, 553, 10.1159/000480528 Yin, 2012, Effect and mechanism of quercetin on proliferation and apoptosis of human osteosarcoma cell U-2OS/MTX300, Chinese Journal of Medical Sciences., 37, 611 Voigt, 2005, Sulforhodamine B assay and chemosensitivity, Methods Mol. Med., 110, 39 Franken, 2006, Clonogenic assay of cells in vitro, Nat. Protoc., 1, 2315, 10.1038/nprot.2006.339 Weitz-Schmidt, 2012, Cell adhesion assays, Methods Mol. Biol., 757, 15, 10.1007/978-1-61779-166-6_2 Justus, 2014, In vitro cell migration and invasion assays, J. Vis. Exp., 1 Rieger, 2011, Modified annexin V/propidium iodide apoptosis assay for accurate assessment of cell death, J. Vis. Exp., 24, 2597 Alfonso, 2002, Analysis of gene expression in the rat hippocampus using Real Time PCR reveals high inter-individual variation in mRNA expression levels, J. Neurosci. Res., 67, 225, 10.1002/jnr.10105 Chen, 2017, Proliferation and invasion of ovarian cancer cells are suppressed by knockdown of TRIM11, Oncol. Lett., 14, 2125, 10.3892/ol.2017.6432 Bhattacharyya, 2010, High-quality immunofluorescence of cultured cells, Methods Mol. Biol., 619, 403, 10.1007/978-1-60327-412-8_24 Yang, 2007, Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma, Int. J. Cancer, 121, 943, 10.1002/ijc.22749 Hashemzaei, 2017, Anticancer and apoptosis-inducing effects of quercetin in vitro and in vivo, Oncol. Rep., 38, 819, 10.3892/or.2017.5766 Rofstad, 2006, Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice, Cancer Res., 66, 6699, 10.1158/0008-5472.CAN-06-0983 Sung-Jin, 2015, Autophagy Inhibition Promotes Quercetin Induced Apoptosis in MG-63 Human Osteosarcoma cells, Int. J. Oral Biol., 40, 85, 10.11620/IJOB.2015.40.2.085 Zhang, 2015, Quercetin Enhances Cisplatin Sensitivity of Human Osteosarcoma Cells by Modulating microRNA-217-KRAS Axis, Mol. Cells, 38, 638, 10.14348/molcells.2015.0037 Catanzaro, 2015, Effect of Quercetin on Cell Cycle and Cyclin Expression in Ovarian Carcinoma and Osteosarcoma Cell Lines, Nat. Prod. Commun., 10, 1365 Do Thi, 2014, Effects of laver extract on adhesion, invasion, and migration in SK-Hep1 human hepatoma cancer cells, Biosci. Biotechnol. Biochem., 78, 1044, 10.1080/09168451.2014.912116 Yang, 2007, Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma, Int. J. Cancer, 121, 943, 10.1002/ijc.22749 Walkley, 2014, PTHrP, its receptor, and protein kinase A activation in osteosarcoma, Mol. Cell. Oncol., 1 Nikitovic, 2016, Parathyroid hormone/parathyroid hormone-related peptide regulates osteosarcoma cell functions: focus on the extracellular matrix (review), Oncol. Rep., 36, 1787, 10.3892/or.2016.4986