Quercetin, ascorbic acid, caffeine and ellagic acid are more efficient than rosiglitazone, metformin and glimepiride in interfering with pathways leading to the development of neurological complications associated with diabetes: A comparative in-vitro study

2015 Nouwen, 2011, Prevalence of depression in individuals with impaired glucose metabolism or undiagnosed diabetes a systematic review and meta-analysis of the European Depression in Diabetes (EDID) research consortium, Diabetes Care, 34, 752, 10.2337/dc10-1414 Patel, 2016, Urtica dioica modulates hippocampal insulin signaling and recognition memory deficit in streptozotocin induced diabetic mice, Metab. Brain Dis., 31, 601, 10.1007/s11011-016-9791-4 Patel, 2015, Urtica dioica leaves modulates muscarinic cholinergic system in the hippocampus of streptozotocin-induced diabetic mice, Metab. Brain Dis., 30, 803, 10.1007/s11011-014-9646-9 Patel, 2013, Effect of Urtica dioica on memory dysfunction and hypoalgesia in an experimental model of diabetic neuropathy, Neurosci. Lett., 552, 114, 10.1016/j.neulet.2013.07.029 Lupien, 2003, Systemic insulin-like growth factor-I administration prevents cognitive impairment in diabetic rats, and brain IGF regulates learning/memory in normal adult rats, J. Neurosci. Res., 74, 512, 10.1002/jnr.10791 Patel, 2014, Urtica dioica extract attenuates depressive like behavior and associative memory dysfunction in dexamethasone induced diabetic mice, Metab. Brain Dis., 29, 121, 10.1007/s11011-014-9480-0 Mehta, 2016, Flavonoids: Prospective strategy for the management of diabetes and its associated complications, 286 Rodrigues, 2015, Association of a large panel of cytokine gene polymorphisms with complications and comorbidities in type 2 diabetes patients, J. Diabetes Res., 2015, 605965, 10.1155/2015/605965 Alquier, 2006, Translocable glucose transporters in the brain, Diabetes, 55, S131, 10.2337/db06-S021 Winter, 2002 Prasad, 2015, Bioactive plant metabolites in the management of non-communicable metabolic diseases: looking at opportunities beyond the horizon, Metabolites, 5, 733, 10.3390/metabo5040733 2003 Vattem, 2005, Biological functionality of ellagic acid: a review, J. Food Biochem., 29, 234, 10.1111/j.1745-4514.2005.00031.x Kaleem, 2005, Protective effects of Piper nigrum and Vinca rosea in alloxan induced diabetic rats, Indian J. Physiol. Pharmacol., 49, 65 Mesripour, 2016, The effect of Cinnamomum zeylanicum bark water extract on memory performance in alloxan-induced diabetic mice, Res. Pharm. Sci., 11, 318, 10.4103/1735-5362.189308 Henry-Vitrac, 2010, Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract, J. Agric. Food Chem., 58, 4141, 10.1021/jf9044827 Trott, 2010, AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading, J. Comput. Chem., 31, 455 Mehta, 2016, In-vitro and in-silico evaluation of the antidiabetic effect of hydroalcoholic leaf extract of Centella asiatica, Int. J. Pharm. Pharm. Sci., 8, 357 Shah, 2013, Investigation on flavonoid composition and anti free radical potential of Sida cordata, BMC Complement. Altern. Med., 3, 276, 10.1186/1472-6882-13-276 Olive, 2006, The comet assay: a method to measure DNA damage in individual cells, Nat. Protoc., 1, 23, 10.1038/nprot.2006.5 Udayabanu, 2012, Free chelatable zinc modulates the cholinergic function during hypobaric hypoxia-induced neuronal damage: an in-vivo study, Neuroscience, 202, 434, 10.1016/j.neuroscience.2011.11.022 Cheng, 2013, Carboxypeptidase E/NFα1: a new neurotrophic factor against oxidative stress-induced apoptotic cell death mediated by ERK and PI3-K/AKT pathways, PLoS One, 8, e71578, 10.1371/journal.pone.0071578 McCloy, 2014, Partial inhibition of Cdk1 in G2 phase overrides the SAC and decouples mitotic events, Cell Cycle, 13, 1400, 10.4161/cc.28401 Rollinger, 2008, Structure-based virtual screening for the discovery of natural inhibitors for human rhinovirus coat protein, J. Med. Chem., 51, 842, 10.1021/jm701494b Ganugapati, 2012, Molecular docking studies of banana flower flavonoids as insulin receptor tyrosine kinase activators as a cure for diabetes mellitus, Bioinformation, 8, 216, 10.6026/97320630008216 Ming, 2014, CMHX008, a novel peroxisome proliferator-activated receptor γ partial agonist, enhances insulin sensitivity in vitro and in vivo, PLoS One, 9, e102102, 10.1371/journal.pone.0102102 Röhrborn, 2015, DPP4 in diabetes, Front. Immunol., 6, 386, 10.3389/fimmu.2015.00386 Sharma, 2009, DPPH antioxidant assay revisited, Food Chem., 113, 1202, 10.1016/j.foodchem.2008.08.008 Banakou, 2010, Involvement of Na+/H+ exchanger and respiratory burst enzymes NADPH oxidase and NO synthase, in Cd-induced lipid peroxidation and DNA damage in haemocytes of mussels, Comp. Biochem. Physiol. C. Toxicol. Pharmacol., 152, 346, 10.1016/j.cbpc.2010.06.001 Kanigür-Sultuybek, 1995, The effect of metformin on insulin receptors and lipid peroxidation in alloxan and streptozotocin induced diabetes, J. Basic Clin. Physiol. Pharmacol., 6, 271, 10.1515/JBCPP.1995.6.3-4.271 Von Bibra, 2008, Rosiglitazone, but not glimepiride, improves myocardial diastolic function in association with reduction in oxidative stress in type 2 diabetic patients without overt heart disease, Diab. Vasc. Dis. Res., 5, 310, 10.3132/dvdr.2008.045 Del Rio, 2005, A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress, Nutr. Metab. Cardiovasc. Dis., 15, 316, 10.1016/j.numecd.2005.05.003 Giridharan, 2012, Schisandrin B, attenuates cisplatin-induced oxidative stress, genotoxicity and neurotoxicity through modulating NF-κB pathway in mice, Free Radic. Res., 46, 50, 10.3109/10715762.2011.638291 Picada, 2005, Genotoxic, neurotoxic and neuroprotective activities of apomorphine and its oxidized derivative 8-oxo-apomorphine, Braz. J. Med. Biol. Res., 38, 477, 10.1590/S0100-879X2005000400001 Tripathi, 2013 Kumar, 2013, Enzymes inhibition and antidiabetic effect of isolated constituents from Dillenia indica, Biomed. Res. Int., 2013, 382063, 10.1155/2013/382063 Kam, 2013, A comparative study on the inhibitory effects of different parts and chemical constituents of pomegranate on α-amylase and α-glucosidase, Phytother. Res., 27, 1614, 10.1002/ptr.4913 Wang, 2014, Quercetin suppresses insulin receptor signaling through inhibition of the insulin ligand–receptor binding and therefore impairs cancer cell proliferation, Biochem. Biophys. Res. Commun., 452, 1028, 10.1016/j.bbrc.2014.09.039