Quantitative assessment of fatty liver using ultrasound attenuation imaging
Tóm tắt
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease, with an incidence of 20–40% worldwide, making it a major healthcare problem. Because NAFLD can progress to liver fibrosis and cirrhosis through non-alcoholic steatohepatitis, early detection and monitoring of hepatic steatosis are essential for management of NAFLD patients. Even though conventional B-mode ultrasound (US) has been widely used for the evaluation of NAFLD owing to its safety and easy accessibility, its subjective nature and limited accuracy in detecting mild steatosis are major limitations. To overcome the current limitations of conventional B-mode US, attenuation imaging (ATI) based on two-dimensional B-mode US has been developed. ATI can quantitatively assess the degree of hepatic steatosis by calculating the attenuation coefficient, which reflects the degree of US beam attenuation transmitted into the liver tissue. After the first study was published in 2019, several clinical studies using ATI to evaluate hepatic steatosis have reported promising results. In this review, the basic physics, measurement protocol, and reported diagnostic accuracy of ATI in evaluating hepatic steatosis will be discussed.
Tài liệu tham khảo
Angulo P. Nonalcoholic fatty liver disease. N Engl J Med. 2002;346:1221–31.
Bellentani S, Bedogni G, Miglioli L, et al. The epidemiology of fatty liver. Eur J Gastroenterol Hepatol. 2004;16:1087–93.
Browning JD, Szczepaniak LS, Dobbins R, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology. 2004;40:1387–95.
Sinn DH, Cho SJ, Gu S, et al. Persistent nonalcoholic fatty liver disease increases risk for carotid atherosclerosis. Gastroenterology. 2016;151:481-8.e481.
Sinn DH, Kang D, Chang Y, et al. Non-alcoholic fatty liver disease and progression of coronary artery calcium score: a retrospective cohort study. Gut. 2017;66:323–9.
Sinn DH, Kang D, Jang HR, et al. Development of chronic kidney disease in patients with non-alcoholic fatty liver disease: a cohort study. J Hepatol. 2017;67:1274–80.
Sanyal AJ, American GA. AGA technical review on nonalcoholic fatty liver disease. Gastroenterology. 2002;123:1705–25.
Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41:1313–21.
Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology. 2006;43:S99–112.
Bravo AA, Sheth SG, Chopra S. Liver biopsy. N Engl J Med. 2001;344:495–500.
Lee SS, Park SH. Radiologic evaluation of nonalcoholic fatty liver disease. World J Gastroenterol. 2014;20:7392–402.
Lee DH. Imaging evaluation of non-alcoholic fatty liver disease: focused on quantification. Clin Mol Hepatol. 2017;23:290–301.
Saadeh S, Younossi ZM, Remer EM, et al. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology. 2002;123:745–50.
Lee SS, Park SH, Kim HJ, et al. Non-invasive assessment of hepatic steatosis: prospective comparison of the accuracy of imaging examinations. J Hepatol. 2010;52:579–85.
van Werven JR, Marsman HA, Nederveen AJ, et al. Assessment of hepatic steatosis in patients undergoing liver resection: comparison of US, CT, T1-weighted dual-echo MR imaging, and point-resolved 1H MR spectroscopy. Radiology. 2010;256:159–68.
Hepburn MJ, Vos JA, Fillman EP, et al. The accuracy of the report of hepatic steatosis on ultrasonography in patients infected with hepatitis C in a clinical setting: a retrospective observational study. BMC Gastroenterol. 2005;5:14.
Palmentieri B, de Sio I, La Mura V, et al. The role of bright liver echo pattern on ultrasound B-mode examination in the diagnosis of liver steatosis. Dig Liver Dis. 2006;38:485–9.
Strauss S, Gavish E, Gottlieb P, et al. Interobserver and intraobserver variability in the sonographic assessment of fatty liver. AJR. 2007;189:W320–3.
de Ledinghen V, Vergniol J, Foucher J, et al. Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography. Liver Int. 2012;32:911–8.
Myers RP, Pollett A, Kirsch R, et al. Controlled Attenuation Parameter (CAP): a noninvasive method for the detection of hepatic steatosis based on transient elastography. Liver Int. 2012;32:902–10.
de Ledinghen V, Vergniol J, Capdepont M, et al. Controlled attenuation parameter (CAP) for the diagnosis of steatosis: a prospective study of 5323 examinations. J Hepatol. 2014;60:1026–31.
Lee DH, Cho EJ, Bae JS, et al. Accuracy of two-dimensional shear wave elastography and attenuation imaging for evaluation of patients with nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol. 2021;19:797-805.e797.
Jeon SK, Lee JM, Joo I, et al. Prospective evaluation of hepatic steatosis using ultrasound attenuation imaging in patients with chronic liver disease with magnetic resonance imaging proton density fat fraction as the reference standard. Ultrasound Med Biol. 2019;45:1407–16.
Bae JS, Lee DH, Lee JY, et al. Assessment of hepatic steatosis by using attenuation imaging: a quantitative, easy-to-perform ultrasound technique. Eur Radiol. 2019;29:6499–507.
Ferraioli G, Maiocchi L, Raciti MV, et al. Detection of liver steatosis with a novel ultrasound-based technique: a pilot study using MRI-derived proton density fat fraction as the gold standard. Clin Transl Gastroenterol. 2019;10:e00081.
Tada T, Iijima H, Kobayashi N, et al. Usefulness of attenuation imaging with an ultrasound scanner for the evaluation of hepatic steatosis. Ultrasound Med Biol. 2019;45:2679–87.
Dioguardi BM, Ronot M, Reizine E, et al. Quantification of hepatic steatosis with ultrasound: promising role of attenuation imaging coefficient in a biopsy-proven cohort. Eur Radiol. 2020;30:2293–301.
Sugimoto K, Moriyasu F, Oshiro H, et al. The role of multiparametric US of the liver for the evaluation of nonalcoholic steatohepatitis. Radiology. 2020;296:532–40.
Tada T, Kumada T, Toyoda H, et al. Attenuation imaging based on ultrasound technology for assessment of hepatic steatosis: a comparison with magnetic resonance imaging-determined proton density fat fraction. J Hepatol. 2020;50:1319–27.
Hsu PK, Wu LS, Yen HH, et al. Attenuation imaging with ultrasound as a novel evaluation method for liver steatosis. J Clin Med. 2021;10:965.
Kwon EY, Kim YR, Kang DM, et al. Usefulness of US attenuation imaging for the detection and severity grading of hepatic steatosis in routine abdominal ultrasonography. Clin Imaging. 2021;76:53–9.
Yoo J, Lee JM, Joo I, et al. Reproducibility of ultrasound attenuation imaging for the noninvasive evaluation of hepatic steatosis. Ultrasonography. 2020;39:121–9.