Quantitation of Lysosomal Trapping of Basic Lipophilic Compounds Using In Vitro Assays and In Silico Predictions Based on the Determination of the Full pH Profile of the Endo-/Lysosomal System in Rat Hepatocytes

Drug Metabolism and Disposition - Tập 47 Số 1 - Trang 49-57 - 2019
Maximilian V. Schmitt1,2, Philip Lienau1,2, Gert Fricker1,2, Andreas Reichel1,2
1Bayer AG, Pharmaceuticals R&D, Translational Sciences, Research Pharmacokinetics, Berlin, Germany (M.V.S., P.L., A.R.)
2Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany (M.V.S., G.F.)

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