Q222R polymorphism in the DNAse I gene is not associated with susceptibility to rheumatoid arthritis or to disease course in an Argentine patient cohort

Amulic, 2012, Neutrophil function: from mechanisms to disease, Annu Rev Immunol, 30, 459, 10.1146/annurev-immunol-020711-074942 Gupta, 2005, Induction of neutrophil extracellular DNA lattices by placental microparticles and IL-8 and their presence in preeclampsia, Hum Immunol, 66, 1146, 10.1016/j.humimm.2005.11.003 Kessenbrock, 2009, Netting neutrophils in autoimmune small-vessel vasculitis, Nat Med, 15, 623, 10.1038/nm.1959 Kahlenberg, 2013, Neutrophil extracellular trap-associated protein activation of the NLRP3 inflammasome is enhanced in lupus macrophages, J Immunol, 190, 1217, 10.4049/jimmunol.1202388 Neeli, 2008, Histone deimination as a response to inflammatory stimuli in neutrophils, J Immunol, 180, 1895, 10.4049/jimmunol.180.3.1895 Khandpur, 2013, NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis, Sci Transl Med, 5, 10.1126/scitranslmed.3005580 Pratesi, 2014, Antibodies from patients with rheumatoid arthritis target citrullinated histone 4 contained in neutrophils extracellular traps, Ann Rheum Dis, 73, 1414, 10.1136/annrheumdis-2012-202765 Sur Chowdhury, 2014, Enhanced neutrophil extracellular trap generation in rheumatoid arthritis: analysis of underlying signal transduction pathways and potential diagnostic utility, Arthritis Res Ther, 16, R122, 10.1186/ar4579 Darrah, 2013, NETs: the missing link between cell death and systemic autoimmune diseases?, Front Immunol, 3, 428, 10.3389/fimmu.2012.00428 Ueki, 2014, Evaluation of all non-synonymous single nucleotide polymorphisms (SNPs) in the genes encoding human deoxyribonuclease I and I-like 3 as a functional SNP potentially implicated in autoimmunity, FEBS J, 281, 376, 10.1111/febs.12608 Yasuda, 2010, A biochemical and genetic study on all non-synonymous single nucleotide polymorphisms of the gene encoding human deoxyribonuclease I potentially relevant to autoimmunity, Int J Biochem Cell Biol, 42, 1216, 10.1016/j.biocel.2010.04.012 Napirei, 2000, Features of systemic lupus erythematosus in Dnase1-deficient mice, Nat Genet, 25, 177, 10.1038/76032 Bodano, 2007, Study of DNASE I gene polymorphisms in systemic lupus erythematosus susceptibility, Ann Rheum Dis, 66, 560, 10.1136/ard.2006.067140 Panneer, 2013, Q222R polymorphism in DNAse I gene is a risk factor for nephritis in South Indian SLE patients, Lupus, 22, 996, 10.1177/0961203313498801 Shin, 2004, Common DNase I polymorphism associated with autoantibody production among systemic lupus erythematosus patients, Hum Mol Genet, 13, 2343, 10.1093/hmg/ddh275 Arnett, 1988, The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis, Arthritis Rheum, 31, 315, 10.1002/art.1780310302 Catelli, 2011, The impact of modern migrations on present-day multi-ethnic Argentina as recorded on the mitochondrial DNA genome, BMC Genet, 12, 77, 10.1186/1471-2156-12-77 Corach, 2010, Inferring continental ancestry of argentineans from Autosomal, Y-chromosomal and mitochondrial DNA, Ann Hum Genet, 74, 65, 10.1111/j.1469-1809.2009.00556.x Prevoo, 1995, Modified disease activity scores that include twenty-eight-joint counts: development and validation in a prospective longitudinal study of patients with rheumatoid arthritis, Arthritis Rheum, 38, 44, 10.1002/art.1780380107 Citera, 2004, Validation and cross cultural adaptation of an argentine spanish version of the health assessment questionnaire disability index, J Clin Rheumatol, 10, 110, 10.1097/01.rhu.0000128732.58292.cd van der Heijde, 2000, How to read radiographs according to the Sharp/van der Heijde method, J Rheumatol, 27, 261 Brinkmann, 2004, Neutrophil extracellular traps kill bacteria, Science, 303, 1532, 10.1126/science.1092385 Fuchs, 2010, Extracellular DNA traps promote thrombosis, Proc Natl Acad Sci USA, 107, 15880, 10.1073/pnas.1005743107 Martinod, 2014, Thrombosis: tangled up in NETs, Blood, 123, 2768, 10.1182/blood-2013-10-463646 Fuchs, 2012, Neutrophil extracellular trap (NET) impact on deep vein thrombosis, Arterioscler Thromb Vasc Biol, 32, 1777, 10.1161/ATVBAHA.111.242859 Demers, 2012, Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis, Proc Natl Acad Sci USA, 109, 13076, 10.1073/pnas.1200419109 Berger-Achituv, 2013, A proposed role for neutrophil extracellular traps in cancer immunoediting, Front Immunol, 4, 48, 10.3389/fimmu.2013.00048 Doring, 2014, Neutrophils cast NETs in atherosclerosis: employing peptidylarginine deiminase as a therapeutic target, Circ Res, 114, 931, 10.1161/CIRCRESAHA.114.303479 Knight, 2014, Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis, Circ Res, 114, 947, 10.1161/CIRCRESAHA.114.303312 Clark, 2007, Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood, Nat Med, 13, 463, 10.1038/nm1565 Camicia, 2014, Neutrophil extracellular traps in sepsis, Shock, 42, 286, 10.1097/SHK.0000000000000221 Wright, 2014, The multifactorial role of neutrophils in rheumatoid arthritis, Nat Rev Rheumatol, 10, 593, 10.1038/nrrheum.2014.80 Papayannopoulos, 2010, Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps, J Cell Biol, 191, 677, 10.1083/jcb.201006052 Wang, 2009, Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation, J Cell Biol, 184, 205, 10.1083/jcb.200806072 Rohrbach, 2012, Activation of PAD4 in NET formation, Front Immunol, 3, 360, 10.3389/fimmu.2012.00360 Li, 2010, PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps, J Exp Med, 207, 1853, 10.1084/jem.20100239 Hakkim, 2010, Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis, Proc Natl Acad Sci USA, 107, 9813, 10.1073/pnas.0909927107 McInnes, 2011, The pathogenesis of rheumatoid arthritis, N Engl J Med, 365, 2205, 10.1056/NEJMra1004965 Romero, 2013, Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis, Sci Transl Med, 5, 10.1126/scitranslmed.3006869 Suzuki, 2003, Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis, Nat Genet, 34, 395, 10.1038/ng1206 Yamada, 2003, Peptidylarginine deiminase type 4: identification of a rheumatoid arthritis-susceptible gene, Trends Mol Med, 9, 503, 10.1016/j.molmed.2003.09.010 Willis, 2011, N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-l-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis, J Immunol, 186, 4396, 10.4049/jimmunol.1001620 Leffler, 2012, Neutrophil extracellular traps that are not degraded in systemic lupus erythematosus activate complement exacerbating the disease, J Immunol, 188, 3522, 10.4049/jimmunol.1102404 Seredkina, 2013, Lupus nephritis: enigmas, conflicting models and an emerging concept, Mol Med, 19, 161, 10.2119/molmed.2013.00010 Kimura-Kataoka, 2014, Identification of the functional alleles of the nonsynonymous single-nucleotide polymorphisms potentially implicated in systemic lupus erythematosus in the human deoxyribonuclease I gene, DNA Cell Biol, 33, 492, 10.1089/dna.2014.2368