Pyruvate-dehydrogenase complex in ataxic patients: Enzyme deficiency in ataxic encephalopathy plus lactic acidosis and normal activity in Friedreich ataxia

Springer Science and Business Media LLC - Tập 3 - Trang 317-321 - 1982
G. Uziel1, E. Bottacchi1, G. Moschen1,2, P. Giovanardi-Rossi1,2, G. Cardace1, S. Di Donato1
1Laboratorio Neuropatie Metaboliche, Istituto Neurologico “C. Besta”, Milano
2Clinica Neuropsichiatrica Infantile Bologna, Italia

Tóm tắt

Pyruvate dehydrogenase complex (PDHC) activity was measured in cultured fibroblasts from 12 patients with Friedreich's ataxia (FA), and in 1 patient with lactic acidosis and ataxia. The activities obtained after extraction of PDHC by different methods were compared. Triton-X-100 extraction yielded enzyme activities 5 to 10 times greater than those obtained with the older methods. With this sensitive technique, PDHC activity was markedly deficient in fibroblasts from the patient with lactic acidosis and ataxia but it was normal in the fibroblasts from FA patients. Mg++activation of the PDHC in FA fibroblasts was normal.

Tài liệu tham khảo

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