Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

Cell Metabolism - Tập 21 Số 1 - Trang 65-80 - 2015
Eva M. Pålsson‐McDermott1, Annie M. Curtis1, Gautam Goel2,3,4, Mario A. Lauterbach1, Frederick J. Sheedy5, Laura E. Gleeson5, Mirjam W.M. van den Bosch1, Susan R. Quinn1, Raquel Domingo-Fernandéz1, Daniel Johnston1, Joonsoo Kang6, William J. Israelsen7, Joseph Keane5, Craig J. Thomas6, Clary B. Clish2, Matthew G. Vander Heiden8,7, Ramnik J. Xavier2,3,4, Luke O'neill1
1School of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin 2, Ireland
2Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
3Centre for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA
4Gastrointestinal Unit and Centre for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
5Department of Clinical Medicine, School of Medicine, Trinity College, Dublin 2, Ireland
6National Institutes of Health (NIH), Chemical Genomics Centre, National Centre for Advancing Translational Sciences, NIH, Bethesda, MD 20892, USA
7Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA
8Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA

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