Pyrimidine-morpholine hybrids as potent druggable therapeutics for Alzheimer’s disease: Synthesis, biochemical and in silico analyses

Bioorganic Chemistry - Tập 141 - Trang 106868 - 2023
Sumera Zaib1, Muhammad Tayyab Younas1, Imtiaz Khan2, Hafiz Saqib Ali3, Christopher John McAdam4, Jonathan M. White5, Fadi Jaber6,7, Nasser S. Awwad8, Hala A. Ibrahium9
1Department of Basic and Applied Chemistry, Faculty of Science and Technology, University of Central Punjab, Lahore 54590, Pakistan
2Department of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester MI 7DN, UK
3Chemistry Research Laboratory, Department of Chemistry and the INEOS Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK
4Department of Chemistry, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand
5School of Chemistry and Bio-21 Institute, University of Melbourne, 3052 Parkville, Australia
6Department of Biomedical Engineering, Ajman University, Ajman, United Arab Emirates
7Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates
8Department of Chemistry, King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia
9Biology Department, Faculty of Science, King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia

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