Magdi E. A. Zaki1, Hanan A. Soliman1, Ola A. Hiekal2, Aymn E. Rashad1
1Photochemistry Department, National Research Centre, Dokki, Cairo, Egypt
2Biology Department, German University in Cairo, Cairo, Egypt
Tóm tắt
Abstract Pyrazolopyranopyrimidines 6a-c and 8a-c were prepared from the reaction of compounds 4a-c or 7a-c with methylamine or ammonium hydroxide solutions. Treatment of compounds 6a-c or 8a-c with 2-chloroethyl methyl ether afforded their corresponding acyclonucleosides 9a-c or 10a-c, respectively, as a new class of acyclonucleosides. All prepared compounds were tested as anti-inflammatory agents and some of them revealed moderate to potent antiinflammatory activity
