Puma, một tác nhân quan trọng trong tế bào chết — một thập kỷ sau khi được phát hiện

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Michalak, 2009, Puma and to a lesser extent Noxa are suppressors of Myc - induced lymphomagenesis, Cell Death Differ, 102

Hershko, 2004, Up - regulation of Bcl - homology BH ) - only proteins by mediates apoptosis http dx org, Biol Chem, 42, 3, 10.1074/jbc.M312866200

Dudgeon, 2010, PUMA induction by FoxO a mediates the anticancer activities of the broadrange kinase inhibitor UCN - http dx org, Mol Cancer Ther, 41, 2893

Sharma, 2011, MicroRNA regulates FAS - induced fulminant liver failure http dx org, Hepatology, 103, 1651, 10.1002/hep.24243

Luo, 2005, Transcriptional upregulation of PUMA modulates endoplasmic reticulum calcium pool depletioninduced apoptosis via Bax activation http dx org, Cell Death Differ, 63, 1310, 10.1038/sj.cdd.4401659

Ahn, 2008, Expressional and mutational analysis of proapoptotic Bcl - member PUMA in hepatocellular carcinomas Dig http dx org, Dis Sci, 100, 1395, 10.1007/s10620-007-9987-x

Yu, 2010, Deletion of Puma protects hematopoietic stem cells and confers long term survival in response to high - dose radiation http dx org, Blood, 105, 3472, 10.1182/blood-2009-10-248278

Garrison, 2008, Selection against PUMA gene expression in Myc - driven Bcell lymphomagenesis http dx org, Mol Cell Biol, 50, 5391, 10.1128/MCB.00907-07

Ming, 2006, PUMA dissociated Bax and Bcl - XL to induce apoptosis in colon cancer cells Bioch http dx org, Chem, 33, 16034, 10.1074/jbc.M513587200

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Ming, 2008, and p activate PUMA following serum starvation http dx org, Carcinogenesis, 38, 1878, 10.1093/carcin/bgn150

Webster, 2006, Puma joins the battery of BH - only proteins that promote death and infarction during myocardial ischemia of Physiol http dx org, Heart Circ Physiol, 46, 3, 10.1152/ajpheart.00111.2006

Nickson, 2007, PUMA is critical for neonatal cardiomyocyte apoptosis induced by endoplasmic reticulum stress Cardiovasc http dx org, Res, 45, 48, 10.1016/j.cardiores.2006.10.001

van Gurp, 2003, Mitochondrial intermembrane proteins in cell death http dx org, Biochem Biophys Res Commun, 10, 304, 10.1016/S0006-291X(03)00621-1

Michalak, 2008, In several cell types tumour suppressor p induces apoptosis largely via Puma but Noxa can contribute http dx org, Cell Death Differ, 55, 1019, 10.1038/cdd.2008.16

Labi, 2010, PUMA - mediated tumor suppression http dx org, Cell cycle, 112, 4269, 10.4161/cc.9.21.13666

Vaseva, 2009, The mitochondrial p pathway http dx org, Biochim Biophys Acta, 92, 1787, 10.1016/j.bbabio.2008.10.005

Chipuk, 2005, PUMA couples the nuclear and cytoplasmic proapoptotic function of http dx org, Science, 94, 309, 10.1126/science.1114297

Qiu, 2008, PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome http dx org, Cell Stem Cell, 56, 576, 10.1016/j.stem.2008.03.009

Willis, 2007, Apoptosis initiated when BH ligands engage multiple Bcl - homologs , not Bax or Bak http dx org, Science, 88, 315, 10.1126/science.1133289

Leber, 2007, Embedded Together : the life and death consequences of interaction of the Bcl - family with membranes http dx org, Apoptosis, 84, 897, 10.1007/s10495-007-0746-4

Hoque, 2003, PUMA in head and neck cancer http dx org, Cancer Lett, 99, 199, 10.1016/S0304-3835(03)00344-6

Gallenne, 2009, Bax activation by the BH - only protein Puma promotes cell dependence on antiapoptotic Bcl - family members http dx org, Cell Biol, 77, 3, 10.1083/jcb.200809153

Kim, 2007, Lee Pro - apoptotic PUMA and antiapoptotic phospho - BAD are highly expressed in colorectal carcinomas Dig http dx org, Dis Sci, 101, 2751, 10.1007/s10620-007-9799-z

Hill, 2003, Portrait of a killer : the mitochondrial apoptosome emerges from the shadows http dx org, Mol Interv, 12, 19, 10.1124/mi.3.1.19

Häcker, 2007, BH - only proteins trigger cytochrome c release , but how http dx org, Arch Biochem Biophys, 75, 462, 10.1016/j.abb.2006.12.022

Michalak, 2010, Apoptosis - promoted tumorgenesis : γ - irradiation - induced thymic lymphpomagenesis requires Puma - driven leukocyte death http dx org, Genes Dev, 107, 1608, 10.1101/gad.1940110

Chipuk, 2008, How do BCL - proteins induce mitochondria outer membrane permeabilization http dx org, Trends Cell Biol, 85, 157, 10.1016/j.tcb.2008.01.007

Jiang, 2008, Up - regulation of Mcl - is critical for survival of human melanoma cells upon endoplasmic reticulum stress http dx org, Cancer Res, 64, 6708, 10.1158/0008-5472.CAN-08-0349

You, 2006, FOXO a - dependent regulation of Puma in response to cytokine / growth factor withdrawal http dx org, Exp Med, 40, 203, 10.1084/jem.20060353

Ray, 2011, inhibition induces apoptosis in p deficient human colon cancer cells by activating p - and - mediated expression of PUMA and Siva - http dx org, Apoptosis, 39, 35, 10.1007/s10495-010-0538-0

Evan, 2001, Proliferation , cell cycle and apoptosis in cancer http dx org, Nature, 5, 342, 10.1038/35077213

Cazanave, 2010, CHOP and AP - cooperatively mediate PUMA expression during lipoapoptosis http dx org, Am J Physiol Gastrointest Liver Physiol, 48, 299, 10.1152/ajpgi.00091.2010

Chipuk, 2008, Mechanism of apoptosis induction by inhibition of the antiapoptotic BCL - proteins http dx org, Proc Natl Acad Sci USA, 90, 20327, 10.1073/pnas.0808036105

Shamas, 2010, BH - only proteins : orchestrators of apoptosis http dx org, Biochim Biophys Acta, 83, 1813, 10.1016/j.bbamcr.2010.11.024

Kuroda, 2009, Involvement of BH - only proteins in hematologic malignancies http dx org, Crit Rev Oncol Hematol, 97, 89, 10.1016/j.critrevonc.2008.10.004

Wu, 2007, independent induction of PUMA mediates intestinal apoptosis in response to ischaemia - reperfusion http dx org, Gut, 43, 645, 10.1136/gut.2006.101683

Westphalm, 2011, Molecular biology of Bax and Bak activation and action http dx org, Biochim Biophys Acta, 79, 1813, 10.1016/j.bbamcr.2010.12.019

Fisher, 2008, BH - only protein Puma contributes to death of antigen - specific T cells during shutdown of an immune response to acute viral infection http dx org, Proc Natl Acad Sci USA, 69, 3035, 10.1073/pnas.0706913105

Bauer, 2006, The NF - κB regulator Bcl - and the BH - only proteins Bim and Puma control the death of activated T cells http dx org, Proc Natl Acad Sci USA, 68, 3, 10.1073/pnas.0603625103

Qiu, 2011, PUMAmediated apoptosis drives chemical hepatocarcinogenesis in mice http dx org, Hepatology, 108, 1249, 10.1002/hep.24516

Yee, 2008, Contribution of membrane localization to the apoptotic activity of PUMA http dx org, Apoptosis, 29, 87, 10.1007/s10495-007-0140-2

Labi, 2010, Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation http dx org, Genes Dev, 106, 1602, 10.1101/gad.1940210

Yu, 2003, PUMA mediates the apoptotic response to p in colorectal cancer cells http dx org, Proc Natl Acad Sci USA, 28, 1931, 10.1073/pnas.2627984100

Cain, 2000, Apaf oligomerizes into biologically active approximately - kDa and inactive approximately MDa apoptosome complex http dx org, Biol Chem, 11, 275

Toth, 2006, Targeted deletion of Puma attenuates cardiomyocyte death and improves cardiac function during ischemia - reperfusion http dx org, Am J Physiol Heart Circ Physiol, 47, 291, 10.1152/ajpheart.01046.2005

Jeffers, 2003, Puma is an essential mediator of p - dependent and - independent apoptotic pathways http dx org, Cancer Cell, 23, 321, 10.1016/S1535-6108(03)00244-7

Llambi, 2011, Apoptosis and oncogenesis : give and take in the BLC - family http dx org, Curr Opin Genet Dev, 109, 12, 10.1016/j.gde.2010.12.001

Zhivotovsky, 2010, Cell cycle and cell death in disease : past , present and future http dx org, Intern Med, 2, 268, 10.1111/j.1365-2796.2010.02282.x

Letai, 2002, Distinct BH domains either sensitize or acrivate mitochondrial apoptosis , serving as prototype cancer therapeutics http dx org, Cancer Cell, 19, 183, 10.1016/S1535-6108(02)00127-7

Charvet, 2011, Phosphporylation of Tip by GSK - determines the induction of PUMA and apoptosis by http dx org, Mol Cell, 58, 60, 10.1016/j.molcel.2011.03.033

Ghiotto, 2010, BH - Only Proteins : The death puppeteer s wires, Cytometry A, 81, 11

Adams, 2007, The Bcl - apoptotic switch in cancer development and therapy http dx org, Oncogene, 15, 1324, 10.1038/sj.onc.1210220

Wolff, 2008, s mitochondrial translocation and MOMP action is independent of Puma and Bax and severaly disrupts mitochondrial membrane integrity http dx org, Cell Res, 95, 733, 10.1038/cr.2008.62

Steckley, 2007, Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis http dx org, Neurosci, 72, 12989, 10.1523/JNEUROSCI.3400-07.2007

Hengartner, 2000, The biochemistry of apoptosis http dx org, Nature, 7, 407, 10.1038/35037710

Pietsch, 2008, The p family and programmed cell death http dx org, Oncogene, 98, 6507, 10.1038/onc.2008.315

Ibrahim, 2011, Glycogen synthase kinase - GSK inhibition attenuates hepatocyte lipoapoptosis http dx org, Hepatol, 61, 765, 10.1016/j.jhep.2010.09.039

Baumgartner, 2011, Apoptosis : a barrier against cancer no more http dx org, Hepatology, 111, 1121, 10.1002/hep.24637

Li, 2010, Apoptotic cells activate the phoenix rising pathway to promote wound healing and tissue regeneration scisignal, Sci Signal, 110, 1126

Vousden, 2005, Apoptosis and PUMA : a deadly duo http dx org, Science, 93, 309, 10.1126/science.1118232

Li, 2006, Endoplasmic reticulum stress - induced apoptosis : multiple pathways and activation of p - up - regulated modulator of apoptosis PUMA and NOXA by http dx org, Biol Chem, 44, 281, 10.1074/jbc.M509868200

Elkholi, 2011, The role of BH - only proteins in tumor cell development , signaling and treatment http dx org, Genes Cancer, 21, 523, 10.1177/1947601911417177

Kuwana, 2005, and BH domains of BH - only proteins differentially regulate Bax - mediated mitochondrial membrane permeabilization both directly and indirectly http dx org, Mol Cell, 78, 525, 10.1016/j.molcel.2005.02.003

Wang, 2007, The nuclear function of p is required for PUMA - mediated apoptosis induced by DNA damage http dx org, Proc Natl Acad Sci USA, 57, 4054, 10.1073/pnas.0700020104

Gavathiotis, 2008, BAX activation is initiated at a novel interaction site http dx org, Nature, 87, 455, 10.1038/nature07396

Dewson, 2009, Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis http dx org, Cell Sci, 74, 2801, 10.1242/jcs.038166

Nakano, 2001, PUMA a novel proapoptotic gene , is induced by http dx org, Mol Cell, 26, 683, 10.1016/S1097-2765(01)00214-3

Lindsay, 2011, proteins and mitochondria - specificity in membrane targeting for death http dx org, Biochim Biophys Acta, 80, 1813, 10.1016/j.bbamcr.2010.10.017

Lozano, 2005, What have animals models taught us about the p pathway http dx org, Pathol, 53, 205, 10.1002/path.1704

Chen, 2005, Differential targeting of prosurvival Bcl - proteins by their BH - only ligands allows complementary apoptotic function http dx org, Mol Cell, 91, 393, 10.1016/j.molcel.2004.12.030

Perfettini, 2004, κB and p qre the dominant apoptosis - inducing transcription factors elicited by the HIV - envelope http dx org, Exp Med, 66, 199

Häcker, 2006, Apoptosis in activated T cells : what are the triggers , and what the signal transducers http dx org, Cell Cycle, 70, 2421, 10.4161/cc.5.21.3397

Zhang, 2010, MiR and miR - target PUMA to induce cell survival in glioblastoma, Mol Cancer, 36, 1

Tang, 2006, Tip - dependent acetylation of p modulates the decision between cell - cycle arrest and apoptosis http dx org, Mol Cell, 59, 827, 10.1016/j.molcel.2006.11.021

Zapaśnik, 2009, protein guardian of the genome in the viral infection Post, Biol Kom, 54, 565

Green, 2000, Apoptotic pathway : paper wraps stone blunts scissors http dx org, Cell, 6, 1, 10.1016/S0092-8674(00)00003-9

Riedl, 2007, The apoptosome : signaling platform of cell death http dx org, Nat Rev Mol Cell Biol, 13, 405, 10.1038/nrm2153

Sykes, 2006, Acetylation of the p DNA binding domain regulates apoptosis induction http dx org, Mol Cell, 60, 841, 10.1016/j.molcel.2006.11.026

Shao, 2010, Deletion of proapototic Puma selectively protects hematopoietic stem and progenitor cells against high dose radiation http dx org, Blood, 104, 4707, 10.1182/blood-2009-10-248872

Wang, 2008, is involved in - induced PUMA gene expression and apoptosis in colorectal cancer cells, Clin Cancer Res, 32, 27

Chipuk, 2010, The BCL - family reunion http dx org, Mol Cell, 20, 299, 10.1016/j.molcel.2010.01.025

Lomonosova, 2008, BH - only proteins in apoptosis and beyond : an overview http dx org, Oncogene, 18, 2, 10.1038/onc.2009.39

Yoo, 2007, Immunohistochemical analysis of pro - apoptotic PUMA protein and mutational analysis of PUMA gene in gastric carcinomas Dig http dx org, Liver Dis, 96, 222, 10.1016/j.dld.2006.11.006

Giam, 2009, BH - only proteins and their roles in programmed cell death http dx org, Oncogene, 82, 128, 10.1038/onc.2009.50

Chipuk, 2005, PUMA couples the nucler and cytoplasmic proapoptotic function of http dx org, Science, 34, 309, 10.1126/science.1114297

Borner, 2003, The Bcl - protein family : sensors and checkpoints for life - ordeath decisions http dx org, Mol Immunol, 14, 615, 10.1016/S0161-5890(02)00252-3

Shore, 2009, Apoptosis : it s BAK to VDAC http dx org, EMBO Rep, 86, 1311, 10.1038/embor.2009.249

Wei, 2008, Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p protein family http dx org, Gastroenterology, 65, 134, 10.1053/j.gastro.2008.01.072

Hetz, 2007, The daily job of night killers : alternative roles of the BCL - family in organelle physiology http dx org, Trends Cell Biol, 62, 38, 10.1016/j.tcb.2007.10.003

Caroppi, 2009, Apoptosis and human diseases : mitochondrion damage and lethal role of released cytochrome c as proapoptotic protein http dx org, Curr Med Chem, 3, 4058, 10.2174/092986709789378206

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Zhang, 2010, PUMA is a novel target of miR - in human epithelial cancers http dx org, Int J Oncol, 35, 222, 10.3892/ijo_00000662

Rodrigues, 2012, Crimean - congo hemorrhagic fever virus - infected hepatocytes induced ERstress and apoptosis crosstalk, PLoS, 67, 1

Fernandez, 2003, Genomic targets of the human c - Myc protein http dx org, Genes Dev, 49, 1115, 10.1101/gad.1067003

Kim, 2009, Stepwise activation of BAX and BAK by tBID and PUMA initiates mitochondrial apoptosis http dx org, Mol Cell, 76, 487, 10.1016/j.molcel.2009.09.030

Jabbour, 2010, Myeloid progenitor cells lacking p exhibit delayed up - regulation of Puma and prolonged survival after cytokine deprivation http dx org, Blood, 37, 344, 10.1182/blood-2009-07-230730

Cregan, 2004, activation domain is essential for PUMA upregulation and p - mediated neuronal cell death http dx org, Neurosci, 31, 10003, 10.1523/JNEUROSCI.2114-04.2004

Green, 2002, A matter of life and death http dx org, Cancer Cell, 8, 19, 10.1016/S1535-6108(02)00024-7

Hildeman, 2007, Apoptosis and the homeostatic control of immune responses http dx org, Curr Opin Immunol, 71, 516, 10.1016/j.coi.2007.05.005

Lanave, 2004, Comparative genomics : the evolutionary history of the Bcl - family http dx org, Gene, 16, 333, 10.1016/j.gene.2004.02.017

Yu, 2001, PUMA induces the rapid apoptosis of colorectal cancer cells http dx org, Mol Cell, 25, 673, 10.1016/S1097-2765(01)00213-1

Willis, 2005, Life in the balance : how BH - only proteins induce apoptosis http dx org, Curr Opin Cell Biol, 17, 617, 10.1016/j.ceb.2005.10.001

Day, 2008, Structure of the BH domains from the p - inducible BH - only proteins Noxa and Puma in complex with Mcl - http dx org, Mol Biol, 30, 3, 10.1016/j.jmb.2008.05.071

Han, 2001, Expression of bbc , a pro - apoptotic BH - only gene , is regulated by diverse cell death and survival signals http dx org, Proc Natl Acad Sci USA, 27, 11318, 10.1073/pnas.201208798

Plati, 2011, and Khosravi Far Apoptotic cell signaling in cancer progression and therapy http dx org, Integr Biol, 4, 279, 10.1039/c0ib00144a

Jabbour, 2009, Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim http dx org, Cell Death Differ, 89, 555, 10.1038/cdd.2008.179